New chelates complexes of general formulae [Cr(H 2 L) 2 Cl 3 .EtOH], [Fe(H 2 L)(OH)SO 4 (H 2 O).2H 2 O], [Fe(HL) 2 (OH)]. H 2 O, and [Co(H 2 L)(HL) 2 .1/2 EtOH] were prepared and identified by spectral techniques and thermogravimetric analysis Derivative thermo gravimetric analysis. The results confirmed that the ligand behaved as neutral tetradentate, bidentate, or monobasic tridentate. Coordination has occurred via carbonyl oxygen (C=O) and N(2)H or (C-S) groups in complex (3). Moreover, complex (3) was more stable than the analogs (1–3). The prepared mononuclear complexes exhibited an octahedral conformation. The ligand and Cr(III), Fe(III), and Co(II) complexes were investigated for their inhibitory action on the growth of Streptococcus pyogenes and Escherichia coli as Gram-positive and negative bacteria, respectively. The results indicated the effective behavior of Cr(III), Fe(III), and Co(II) complexes as being antibacterial compared to the ligand. The in vitro antitumor activity also displayed the potent action of compounds. In addition, it was revealed that the majority of complexes were more effective than their free ligand. Furthermore, molecular docking implementation demonstrated the intriguing possible interactions of the ligands and complexes with amino acid active sites of the ribosyltransferase moiety (PDB ID).
{"title":"N","authors":"S. Dossi","doi":"10.7560/710573-018","DOIUrl":"https://doi.org/10.7560/710573-018","url":null,"abstract":"New chelates complexes of general formulae [Cr(H 2 L) 2 Cl 3 .EtOH], [Fe(H 2 L)(OH)SO 4 (H 2 O).2H 2 O], [Fe(HL) 2 (OH)]. H 2 O, and [Co(H 2 L)(HL) 2 .1/2 EtOH] were prepared and identified by spectral techniques and thermogravimetric analysis Derivative thermo gravimetric analysis. The results confirmed that the ligand behaved as neutral tetradentate, bidentate, or monobasic tridentate. Coordination has occurred via carbonyl oxygen (C=O) and N(2)H or (C-S) groups in complex (3). Moreover, complex (3) was more stable than the analogs (1–3). The prepared mononuclear complexes exhibited an octahedral conformation. The ligand and Cr(III), Fe(III), and Co(II) complexes were investigated for their inhibitory action on the growth of Streptococcus pyogenes and Escherichia coli as Gram-positive and negative bacteria, respectively. The results indicated the effective behavior of Cr(III), Fe(III), and Co(II) complexes as being antibacterial compared to the ligand. The in vitro antitumor activity also displayed the potent action of compounds. In addition, it was revealed that the majority of complexes were more effective than their free ligand. Furthermore, molecular docking implementation demonstrated the intriguing possible interactions of the ligands and complexes with amino acid active sites of the ribosyltransferase moiety (PDB ID).","PeriodicalId":235365,"journal":{"name":"Counting-Out Rhymes","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1980-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129541623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Recently, it has been proposed that the winds of non-pulsating and non-dusty K and M giants and supergiants may be driven by some form of magnetic pressure acting on highly clumped wind material. While many researchers believe that magnetic processes are responsible for cool evolved stellar winds, existing MHD and Alfvén wave-driven wind models have magnetic fields that are essentially radial and tied to the photosphere. The clumped magnetic wind scenario is quite different in that the magnetic flux is also being carried away from the star with the wind. We test this clumped wind hypothesis by computing continuum radio fluxes from the ζ Aur semiempirical model of Baade et al., which is based on wind-scattered line profiles. The radio continuum opacity is proportional to the electron density squared, while the line scattering opacity is proportional to the gas density. This difference in proportionality provides a test for the presence of large clumping factors. We derive the radial distribution of clump factors (CFs) for ζ Aur by comparing the nonthermal pressures required to produce the semiempirical velocity distribution with the expected thermal pressures. The CFs are ∼5 throughout the sub-sonic inner wind region and then decline outward. These implied clumping factors lead to excess radio emission at 2.0 cm, while at 6.2 cm it improves agreement with the smooth unclumped model. Smaller clumping factors of ∼2 lead to better overall agreement but also increase the discrepancy at 2 cm. These results do not support the magnetic clumped wind hypothesis and instead suggest that inherent uncertainties in the underlying semiempirical model probably dominate uncertainties in predicted radio fluxes. However, new ultraviolet line and radio continuum observations are needed to test the new generations of inhomogeneous magnetohydrodynamic wind models.
{"title":"C","authors":"G. Harper","doi":"10.7560/710573-007","DOIUrl":"https://doi.org/10.7560/710573-007","url":null,"abstract":"Recently, it has been proposed that the winds of non-pulsating and non-dusty K and M giants and supergiants may be driven by some form of magnetic pressure acting on highly clumped wind material. While many researchers believe that magnetic processes are responsible for cool evolved stellar winds, existing MHD and Alfvén wave-driven wind models have magnetic fields that are essentially radial and tied to the photosphere. The clumped magnetic wind scenario is quite different in that the magnetic flux is also being carried away from the star with the wind. We test this clumped wind hypothesis by computing continuum radio fluxes from the ζ Aur semiempirical model of Baade et al., which is based on wind-scattered line profiles. The radio continuum opacity is proportional to the electron density squared, while the line scattering opacity is proportional to the gas density. This difference in proportionality provides a test for the presence of large clumping factors. We derive the radial distribution of clump factors (CFs) for ζ Aur by comparing the nonthermal pressures required to produce the semiempirical velocity distribution with the expected thermal pressures. The CFs are ∼5 throughout the sub-sonic inner wind region and then decline outward. These implied clumping factors lead to excess radio emission at 2.0 cm, while at 6.2 cm it improves agreement with the smooth unclumped model. Smaller clumping factors of ∼2 lead to better overall agreement but also increase the discrepancy at 2 cm. These results do not support the magnetic clumped wind hypothesis and instead suggest that inherent uncertainties in the underlying semiempirical model probably dominate uncertainties in predicted radio fluxes. However, new ultraviolet line and radio continuum observations are needed to test the new generations of inhomogeneous magnetohydrodynamic wind models.","PeriodicalId":235365,"journal":{"name":"Counting-Out Rhymes","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1980-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132391480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Islets organoids would have value in the cell replacement therapy for diabetes apart from usual personalized drug screening routes. Generation of a large number of Islets like clusters, with ability to respond to glucose stimulation appears to be an ideal choice. In this study we have generated islet organoids with the ability to respond to glucose stimulation by insulin release. The source of the cells was an iPSC cell line differentiated into the pancreatic progenitors. These cells were assembled in matrigel or cross-linked collagen scaffold and compared for their efficacy to release insulin upon stimulation with glucose. The assembled organoids were examined by immunohistochemistry and expression of the relevant marker genes. The organoids showed expression of islet like markers in both matrigel and crosslinked collagen scaffold. The islet organoids in both the cases showed release of insulin upon stimulation with glucose. The crosslinked collagen scaffold is quite stable and supports islet cells growth and function.
{"title":"D","authors":"Shruti Sandilya, Shashi Singh","doi":"10.7560/710573-008","DOIUrl":"https://doi.org/10.7560/710573-008","url":null,"abstract":"Islets organoids would have value in the cell replacement therapy for diabetes apart from usual personalized drug screening routes. Generation of a large number of Islets like clusters, with ability to respond to glucose stimulation appears to be an ideal choice. In this study we have generated islet organoids with the ability to respond to glucose stimulation by insulin release. The source of the cells was an iPSC cell line differentiated into the pancreatic progenitors. These cells were assembled in matrigel or cross-linked collagen scaffold and compared for their efficacy to release insulin upon stimulation with glucose. The assembled organoids were examined by immunohistochemistry and expression of the relevant marker genes. The organoids showed expression of islet like markers in both matrigel and crosslinked collagen scaffold. The islet organoids in both the cases showed release of insulin upon stimulation with glucose. The crosslinked collagen scaffold is quite stable and supports islet cells growth and function.","PeriodicalId":235365,"journal":{"name":"Counting-Out Rhymes","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1980-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131744886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：