Pub Date : 2023-01-01DOI: 10.5847/wjem.j.1920-8642.2023.017
Filippo Numeroso, Ivo Casagranda
{"title":"Improving the approach to non-cardiac syncope in the emergency department observation unit.","authors":"Filippo Numeroso, Ivo Casagranda","doi":"10.5847/wjem.j.1920-8642.2023.017","DOIUrl":"https://doi.org/10.5847/wjem.j.1920-8642.2023.017","url":null,"abstract":"","PeriodicalId":23685,"journal":{"name":"World journal of emergency medicine","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9999131/pdf/WJEM-14-128.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9109713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5847/wjem.j.1920-8642.2023.014
Ge Yu, Dong-Po Wei, Hui Xie, Jian Lu, Jun-Li Zhao, Shuang Li, Wei Chen, Rui-Lan Wang
{"title":"Salvage of venoarterial extracorporeal membrane oxygenation following prolonged cardiopulmonary resuscitation and failure of catheter-directed thrombectomy for massive pulmonary embolism in a young patient.","authors":"Ge Yu, Dong-Po Wei, Hui Xie, Jian Lu, Jun-Li Zhao, Shuang Li, Wei Chen, Rui-Lan Wang","doi":"10.5847/wjem.j.1920-8642.2023.014","DOIUrl":"https://doi.org/10.5847/wjem.j.1920-8642.2023.014","url":null,"abstract":"","PeriodicalId":23685,"journal":{"name":"World journal of emergency medicine","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9999134/pdf/WJEM-14-161.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9109718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5847/wjem.j.1920-8642.2023.039
Qi-Fang Shi, Jin-Song Zhang
{"title":"Is procalcitonin to cortisol ratio really the right combination?","authors":"Qi-Fang Shi, Jin-Song Zhang","doi":"10.5847/wjem.j.1920-8642.2023.039","DOIUrl":"https://doi.org/10.5847/wjem.j.1920-8642.2023.039","url":null,"abstract":"","PeriodicalId":23685,"journal":{"name":"World journal of emergency medicine","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9999129/pdf/WJEM-14-171.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9109720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5847/wjem.j.1920-8642.2023.003
Xiao-Lu Ma, Wu-Chao Wang, Chang Du, Ting Zhang, Tai-Feng Li, Yang Guo, Ji-Hong Zhu
{"title":"A case of unusual acquired factor V deficiency.","authors":"Xiao-Lu Ma, Wu-Chao Wang, Chang Du, Ting Zhang, Tai-Feng Li, Yang Guo, Ji-Hong Zhu","doi":"10.5847/wjem.j.1920-8642.2023.003","DOIUrl":"https://doi.org/10.5847/wjem.j.1920-8642.2023.003","url":null,"abstract":"","PeriodicalId":23685,"journal":{"name":"World journal of emergency medicine","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9842461/pdf/WJEM-14-78.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9136787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Unexplained hyperammonemia and encephalopathy in the emergency department: Abernethy malformation in elderly patients.","authors":"Yan-Ying Gao, Qing Tang, Yan-Cun Liu, Xiao-He Liu, Bao-Xin Qian, Yan-Fen Chai, Li-Jun Wang","doi":"10.5847/wjem.j.1920-8642.2023.008","DOIUrl":"https://doi.org/10.5847/wjem.j.1920-8642.2023.008","url":null,"abstract":"","PeriodicalId":23685,"journal":{"name":"World journal of emergency medicine","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9842458/pdf/WJEM-14-69.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9136788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5847/wjem.j.1920-8642.2023.059
Michael Morris, James Espinosa, Alan Lucerna, Robin Lahr
{"title":"A case of phenibut withdrawal and treatment with baclofen.","authors":"Michael Morris, James Espinosa, Alan Lucerna, Robin Lahr","doi":"10.5847/wjem.j.1920-8642.2023.059","DOIUrl":"https://doi.org/10.5847/wjem.j.1920-8642.2023.059","url":null,"abstract":"","PeriodicalId":23685,"journal":{"name":"World journal of emergency medicine","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10323501/pdf/WJEM-14-338.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9813017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: This study aimed to explore the changes of programmed death-ligand 1 (PD-L1) and programmed death-1 (PD-1) expression on antigen-presenting cells (APCs) and evaluate their association with organ failure and mortality during early sepsis.
Methods: In total, 40 healthy controls and 198 patients with sepsis were included in this study. Peripheral blood was collected within the first 24 h after the diagnosis of sepsis. The expression of PD-L1 and PD-1 was determined on APCs, such as B cells, monocytes, and dendritic cells (DCs), by flow cytometry. Cytokines in plasma, such as interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), interleukin-4 (IL-4), IL-6, IL-10, and IL-17A were determined by Luminex assay.
Results: PD-1 expression decreased significantly on B cells, monocytes, myeloid DCs (mDCs), and plasmacytoid DCs (pDCs) as the severity of sepsis increased. PD-1 expression was also markedly decreased in non-survivors compared with survivors. In contrast, PD-L1 expression was markedly higher on mDCs, pDCs, and monocytes in patients with sepsis than in healthy controls and in non-survivors than in survivors. The PD-L1 expression on APCs (monocytes and DCs) was weakly related to organ dysfunction and inflammation. The area under the receiver operating characteristic curve (AUC) of the PD-1 percentage of monocytes (monocyte PD-1%)+APACHE II model (0.823) and monocyte PD-1%+SOFA model (0.816) had higher prognostic value than other parameters alone. Monocyte PD-1% was an independent risk factor for 28-day mortality.
Conclusion: The severity of sepsis was correlated with PD-L1 or PD-1 over-expression on APCs. PD-L1 in monocytes and DCs was weakly correlated with inflammation and organ dysfunction during early sepsis. The combination of SOFA or APACHE II scores with monocyte PD-1% could improve the prediction ability for mortality.
{"title":"Over-expression of programmed death-ligand 1 and programmed death-1 on antigen-presenting cells as a predictor of organ dysfunction and mortality during early sepsis: a prospective cohort study.","authors":"Jia-Bao Li, Miao-Rong Xie, Mei-Li Duan, Ya-Nan Yu, Chen-Chen Hang, Zi-Ren Tang, Chun-Sheng Li","doi":"10.5847/wjem.j.1920-8642.2023.041","DOIUrl":"https://doi.org/10.5847/wjem.j.1920-8642.2023.041","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to explore the changes of programmed death-ligand 1 (PD-L1) and programmed death-1 (PD-1) expression on antigen-presenting cells (APCs) and evaluate their association with organ failure and mortality during early sepsis.</p><p><strong>Methods: </strong>In total, 40 healthy controls and 198 patients with sepsis were included in this study. Peripheral blood was collected within the first 24 h after the diagnosis of sepsis. The expression of PD-L1 and PD-1 was determined on APCs, such as B cells, monocytes, and dendritic cells (DCs), by flow cytometry. Cytokines in plasma, such as interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), interleukin-4 (IL-4), IL-6, IL-10, and IL-17A were determined by Luminex assay.</p><p><strong>Results: </strong>PD-1 expression decreased significantly on B cells, monocytes, myeloid DCs (mDCs), and plasmacytoid DCs (pDCs) as the severity of sepsis increased. PD-1 expression was also markedly decreased in non-survivors compared with survivors. In contrast, PD-L1 expression was markedly higher on mDCs, pDCs, and monocytes in patients with sepsis than in healthy controls and in non-survivors than in survivors. The PD-L1 expression on APCs (monocytes and DCs) was weakly related to organ dysfunction and inflammation. The area under the receiver operating characteristic curve (AUC) of the PD-1 percentage of monocytes (monocyte PD-1%)+APACHE II model (0.823) and monocyte PD-1%+SOFA model (0.816) had higher prognostic value than other parameters alone. Monocyte PD-1% was an independent risk factor for 28-day mortality.</p><p><strong>Conclusion: </strong>The severity of sepsis was correlated with PD-L1 or PD-1 over-expression on APCs. PD-L1 in monocytes and DCs was weakly correlated with inflammation and organ dysfunction during early sepsis. The combination of SOFA or APACHE II scores with monocyte PD-1% could improve the prediction ability for mortality.</p>","PeriodicalId":23685,"journal":{"name":"World journal of emergency medicine","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10156529/pdf/WJEM-14-179.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9436011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5847/wjem.j.1920-8642.2023.002
Hayri Ramadan
{"title":"Hyoscine N-butylbromide inhalation: they know, how about you?","authors":"Hayri Ramadan","doi":"10.5847/wjem.j.1920-8642.2023.002","DOIUrl":"https://doi.org/10.5847/wjem.j.1920-8642.2023.002","url":null,"abstract":"","PeriodicalId":23685,"journal":{"name":"World journal of emergency medicine","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9842457/pdf/WJEM-14-81.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10585469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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