Zeitschrift Fur Kristallographie-new Crystal Structures最新文献

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Crystal structure of bis{N′-[1,3-diphenylprop-2-en-1-ylidene]-N-phenylcarbamohydrazonothioato}zinc(II), C₄₄H₃₆N₆S₂Zn 双{N ' -[1,3-二苯基丙烷-2-烯-1-乙基]-N-苯基氨基氨基腙硫代锌(II)， C44H36N6S2Zn的晶体结构

4区化学 Q4 CRYSTALLOGRAPHY

Zeitschrift Fur Kristallographie-new Crystal Structures

Pub Date : 2023-10-10 DOI: 10.1515/ncrs-2023-0369

Ming Yueh Tan, Karen A. Crouse, Sang Loon Tan, Edward R. T. Tiekink

Abstract C 44 H 36 N 6 S 2 Zn, monoclinic, P 2 1 / c (no. 14), a = 14.5676(4) Å, b = 26.1767(8) Å, c = 10.0963(3) Å, β = 99.140(3)°, V = 3801.2(2) Å 3 , Z = 4, R gt ( F ) = 0.0397, wR ref ( F 2 ) = 0.1000, T = 100 K.

摘要 C 44 H 36 N 6 S 2 Zn，单斜，P 2 1 / c（编号 14），a = 14.5676（4）埃，b = 26.1767（8）埃，c = 10.0963（3）埃，β = 99.140（3）°，V = 3801.2（2）埃 3，Z = 4，R gt ( F ) = 0.0397，wR ref ( F 2 ) = 0.1000，T = 100 K。

引用次数: 0

Crystal structure of 1,4-dibromo-2,5-bis(2-methoxyethoxy)benzene-1,4-diol, C₁₂H₁₆Br₂O₄ 1,4-二溴-2,5-二(2-甲氧基乙氧基)苯-1,4-二醇C12H16Br2O4晶体结构

4区化学 Q4 CRYSTALLOGRAPHY

Zeitschrift Fur Kristallographie-new Crystal Structures

Pub Date : 2023-10-10 DOI: 10.1515/ncrs-2023-0394

Zhi-Yong Wang, Wan-Li Lu, Xu Zhou, Xian-Jiong Yang, Qi-Long Zhang, Hong Xu

Abstract C 12 H 16 Br 2 O 4 , monoclinic, P 2 1 / n (no. 14), a = 12.594(5) Å, b = 4.4613(16) Å, c = 12.878(4) Å, β = 91.209(12) ∘ , V = 723.4(4) Å 3 , Z = 2, R gt ( F ) = 0.0450, wR ref ( F 2 ) = 0.1103, T = 293 (2) K.

摘要 C 12 H 16 Br 2 O 4 ，单斜，P 2 1 / n（编号 14），a = 12.594（5）埃，b = 4.4613（16）埃，c = 12.878（4）埃，β = 91.209（12）∘，V = 723.4（4）埃 3，Z = 2，R gt ( F ) = 0.0450，wR ref ( F 2 ) = 0.1103，T = 293 (2) K。

引用次数: 0

Crystal structure of (1E,1′E)-4,4′-(9,9-diethyl-9H-fluorene-2,7-diyl)dibenzaldehyde dioxime, C₃₁H₂₈N₂O₂ (1E, 1E)-4,4′-(9,9-二乙基- 9h -芴-2,7-二基)二苯甲醛二肟C31H28N2O2的晶体结构

4区化学 Q4 CRYSTALLOGRAPHY

Zeitschrift Fur Kristallographie-new Crystal Structures

Pub Date : 2023-10-10 DOI: 10.1515/ncrs-2023-0385

Ying-Hong Ma, Hong-Yan Zhao, Yu Tian, Yi Wu, Lei Wang

Abstract C 31 H 28 N 2 O 2 , triclinic, P 1 ‾ $Poverline{1}$ (no. 2), a = 9.0809(9) Å, b = 9.2626(9) Å, c = 14.8540(15) Å, α = 93.574(8)°, β = 98.554(8)°, γ = 99.558(8)°, V = 99.558(8) Å 3 , Z = 2, R gt ( F ) = 0.0541, wR ref ( F 2 ) = 0.1424, T = 293(2) K.

引用次数: 0

Histone deacetylase inhibitor sodium butyrate regulates the activation of toll-like receptor 4/interferon regulatory factor-3 signaling pathways in prostate cancer cells. 组蛋白去乙酰化酶抑制剂丁酸钠能调节前列腺癌细胞中 toll-like receptor 4/interferon regulatory factor-3 信号通路的激活。

IF 1.3 4区化学 Q4 CRYSTALLOGRAPHY

Zeitschrift Fur Kristallographie-new Crystal Structures

Pub Date : 2023-10-01 Epub Date: 2022-03-28 DOI: 10.4103/jcrt.jcrt_2032_21

Asuman Deveci Ozkan, Gamze Guney Eskiler, Nur Kazan, Ozge Turna

Context: The covalent acetylation and deacetylation of histone proteins by the histone deacetylase (HDAC) enzymes can be considered a novel therapeutic target in prostate cancer (PCa) cells. Sodium butyrate (NaBu) is a HDAC inhibitor (HDACi) which is a promising potential anticancer drug. Toll-like receptor 4 (TLR4) expression is increased in PCa cells and HDACi alter TLR-inducible gene expressions.

Aims: We aimed to evaluate the effects of NaBu on TLR4 mediating signaling pathways in two different PCa cells (DU-145 and LNCaP) for the first time.

Subjects and methods: The cytotoxic and apoptotic effects of NaBu were determined by the water-soluble tetrazolium salt (WST-1) and Annexin V-AO/PI assays, respectively. Subcellular localization of TLR4, interferon regulatory factor-3 (IRF3) and Nuclear factor kappa B proteins was evaluated by IF assay.

Statistical analysis used: All data were statistically analyzed by GraphPad Prism software (V60.1, CA). Obtained data were expressed in a mean ± standard deviation of the three repeated experiments. The differences between control and NaBu treated cells were compared by one-way-ANOVA. P < 0.05 value was considered statistically significant.

Results: Our results showed that NaBu significantly inhibited the viability of PCa cells and increased the percentage of apoptotic cells. However, DU-145 cells were more sensitive to NaBu than LNCaP cells. Furthermore, NaBu can induce the cytoplasmic TLR4 and IRF3 expression in particularly DU-145 cells without affecting nuclear translocation of NF-kB in PCa cells.

Conclusions: NaBu induces apoptotic cell death and regulated the TLR4/IRF3 signaling pathways in DU-145 cells but not in LNCaP cells. Therefore, PCa cells differentially responded to NaBu treatment due to probably androgen receptor status.

背景：组蛋白去乙酰化酶（HDAC）对组蛋白的共价乙酰化和去乙酰化可被视为前列腺癌（PCa）细胞的新型治疗靶点。丁酸钠（NaBu）是一种 HDAC 抑制剂（HDACi），是一种很有前景的潜在抗癌药物。目的：我们首次评估了NaBu对两种不同PCa细胞（DU-145和LNCaP）中TLR4介导信号通路的影响：NaBu的细胞毒性和细胞凋亡效应分别通过水溶性四唑盐（WST-1）和Annexin V-AO/PI检测法确定。TLR4、干扰素调节因子-3（IRF3）和核因子卡巴B蛋白的亚细胞定位采用 IF 法进行评估：所有数据均采用 GraphPad Prism 软件（V60.1，CA）进行统计分析。所得数据以三次重复实验的平均值 ± 标准差表示。对照组与 NaBu 处理过的细胞之间的差异采用单因素方差分析进行比较。P<0.05为差异有统计学意义：结果表明，NaBu 能显著抑制 PCa 细胞的活力，并增加凋亡细胞的比例。然而，与 LNCaP 细胞相比，DU-145 细胞对 NaBu 更为敏感。此外，NaBu 尤其能诱导 DU-145 细胞中细胞质 TLR4 和 IRF3 的表达，而不会影响 PCa 细胞中 NF-kB 的核转位：结论：NaBu能诱导DU-145细胞的细胞凋亡并调节TLR4/IRF3信号通路，但不影响LNCaP细胞。因此，PCa细胞对NaBu处理的反应可能因雄激素受体状态而异。

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引用次数: 0

Crystal structure of poly[(μ₆-ammoniotris(methylene))tris(hydrogen phosphonato)cadmium(II)], C₃H₁₀CdNO₉P₃ 聚[(μ6-氨三(亚甲基))三(磷酸氢)镉(II)]， C3H10CdNO9P3的晶体结构

4区化学 Q4 CRYSTALLOGRAPHY

Zeitschrift Fur Kristallographie-new Crystal Structures

Pub Date : 2023-09-26 DOI: 10.1515/ncrs-2023-0332

Si N. Gu, Zhi Y. Ou, Ting T. Wu, Ting Y. Nie, Yang Liu

Abstract C 3 H 10 CdNO 9 P 3 , monoclinic, P 2 1 / c (no. 14), a = 9.1770(5) Å, b = 8.3742(4) Å, c = 15.4660(6) Å, β = 119.657(2)°, V = 1032.86(9) Å 3 , Z = 4, R gt ( F ) = 0.0202, w R ref ( F 2 ) = 0.0515, T = 296 K.

Abstract C 3 H 10 CdNO 9 P 3 , monoclinic, P 2 1 /c (no. 14), a = 9.1770(5) Å, b = 8.3742(4) Å, c = 15.4660(6) Å, β = 119.657(2)°, V = 1032.86(9) Å 3 , Z = 4, R gt ( F ) = 0.0202, w R ref ( F 2 ) = 0.0515, T = 296 K.

引用次数: 0

The crystal structure of 18-crown-6 ― tetraaqua-dichlorido-di-μ₂-chloridodicopper(II) (2/1), C₁₂H₃₂O₁₀Cu₂Cl₄ 18-冠-6 -四水-二氯-二-μ -二氯铜(II) (2/1)， C12H32O10Cu2Cl4的晶体结构

4区化学 Q4 CRYSTALLOGRAPHY

Zeitschrift Fur Kristallographie-new Crystal Structures

Pub Date : 2023-09-22 DOI: 10.1515/ncrs-2023-0361

Zhaolong Liu, Shifeng Jin

Abstract C 12 H 32 O 10 Cu 2 Cl 4 , monoclinic, P 2 1 / n (no. 14), a = 9.0202(4) Å, b = 9.5791(4) Å, c = 13.6994(6) Å, β = 92.555(1) ° , V = 1182.53(9) Å 3 , Z = 2, R gt ( F ) = 0.0308, wR ref ( F 2 ) = 0.0800, T = 293(2) K.

摘要 C 12 H 32 O 10 Cu 2 Cl 4 ，单斜，P 2 1 / n（no. 14），a = 9.0202(4) Å，b = 9.5791(4) Å，c = 13.6994(6) Å，β = 92.555(1) °，V = 1182.53(9) Å 3，Z = 2，R gt ( F ) = 0.0308，wR ref ( F 2 ) = 0.0800，T = 293(2) K。

引用次数: 0

The crystal structure of ethyl 4-hydroxy-2-(4-methoxyphenyl)-5-oxo-1-(2-oxo-2H-chromen-6-yl)-2,5-dihydro-1H-pyrrole-3-carboxylate, C₂₃H₁₉NO₇ 4-羟基-2-(4-甲氧基苯基)-5-氧-1-(2-氧- 2h -铬-6-基)-2,5-二氢- 1h -吡咯-3-羧酸酯C23H19NO7的晶体结构

4区化学 Q4 CRYSTALLOGRAPHY

Zeitschrift Fur Kristallographie-new Crystal Structures

Pub Date : 2023-09-22 DOI: 10.1515/ncrs-2023-0350

Bimal Bhushan Chakraborty, Saurav Paul, Siddique Anwar, Sudip Choudhury

Abstract C 23 H 19 NO 7 , monoclinic, P 2 1 / n (no. 14), a = 17.9964(9) Å, b = 5.9211 Å, c = 18.8608(10) Å, β = 98.201(3)°, V = 1989.23(18) Å 3 , Z = 4, R gt ( F ) = 0.0496, wR ref ( F 2 ) = 0.1561, T = 296 K.

摘要 C 23 H 19 NO 7，单斜，P 2 1 / n（编号 14），a = 17.9964(9)埃，b = 5.9211 埃，c = 18.8608(10)埃，β = 98.201(3)°，V = 1989.23(18) 埃 3，Z = 4，R gt ( F ) = 0.0496，wR ref ( F 2 ) = 0.1561，T = 296 K。

引用次数: 0

Crystal structure of N-cyclopropyl-3-hydroxy-4-methoxybenzamide, C₁₁H₁₃NO₃ n -环丙基-3-羟基-4-甲氧基苯甲酰胺C11H13NO3的晶体结构

4区化学 Q4 CRYSTALLOGRAPHY

Zeitschrift Fur Kristallographie-new Crystal Structures

Pub Date : 2023-09-21 DOI: 10.1515/ncrs-2023-0379

Hongjuan Tong, Xiaona Xu, Zhoujing Zhu, Bin Liu

Abstract C 11 H 13 NO 3 , monoclinic, P 2 1 / n (no. 14), a = 8.0478(3) Å, b = 9.8093(4) Å, c = 13.1602(5) Å, β = 104.712(2)°, V = 1004.85(7) Å 3 , Z = 1, R gt ( F ) = 0.0395, wR ref ( F 2 ) = 0.1010, T = 170 K.

摘要 C 11 H 13 NO 3，单斜，P 2 1 / n（编号 14），a = 8.0478(3)埃，b = 9.8093(4)埃，c = 13.1602(5)埃，β = 104.712(2)°，V = 1004.85(7)埃 3，Z = 1，R gt ( F ) = 0.0395，wR ref ( F 2 ) = 0.1010，T = 170 K。

引用次数: 0

The crystal structure of 5-chloro-6′-methyl-3-(4-(methylsulfonyl)phenyl)-[2,3′-bipyridin]-1′-ium 4-methylbenzenesulfonate 5-氯-6′-甲基-3-(4-(甲基磺酰基)苯基)-[2,3′-联吡啶]-1′-ium - 4-甲基苯磺酸盐的晶体结构

4区化学 Q4 CRYSTALLOGRAPHY

Zeitschrift Fur Kristallographie-new Crystal Structures

Pub Date : 2023-09-20 DOI: 10.1515/ncrs-2023-0285

Yu Fang, Cheng Zhang, Meng-Qing Yin, Xiao-Die Yang, Wen-Jing Ma

Abstract C 18 H 16 ClN 2 O 2 S·C 7 H 7 O 3 S, monoclinic, C 2/ c (no. 15), a = 36.911(9) Å, b = 9.931(2) Å, c = 14.795(3) Å, β = 112.32(3)°, V = 5017(2) Å 3 , Z = 8, R gt ( F ) = 0.0500, wR ref ( F 2 ) = 0.1447, T = 293 K.

摘要 C 18 H 16 ClN 2 O 2 S-C 7 H 7 O 3 S，单斜，C 2/ c（编号 15），a = 36.911(9)埃，b = 9.931(2)埃，c = 14.795(3)埃，β = 112.32(3)°，V = 5017(2)埃 3，Z = 8，R gt ( F ) = 0.0500，wR ref ( F 2 ) = 0.1447，T = 293 K。

引用次数: 0

The crystal structure of poly[bis(μ ₂−3−aminopyridine−4−carboxylato−κ ² N:O)Zinc(II)], [Zn(C₆H₅N₂O₂)₂]_n 聚[双(μ 2−3−氨基吡啶−4−羧酸- κ 2 N:O)锌(II)]， [Zn(C6H5N2O2)2] N的晶体结构

4区化学 Q4 CRYSTALLOGRAPHY

Zeitschrift Fur Kristallographie-new Crystal Structures

Pub Date : 2023-09-19 DOI: 10.1515/ncrs-2023-0358

Fang-Fang Liu, Zhao-Yan Ping, Wei-Wei Zhou, Wang Zhao

Abstract [Zn ( C 6 H 5 N 2 O 2 ) 2 ${left({mathrm{C}}_{6}{mathrm{H}}_{5}{mathrm{N}}_{2}{mathrm{O}}_{2}right)}_{2}$ ] n , orthorhombic, P 2 1 2 1 2 1 (no. 19), a = 7.6139(7) Å, b = 12.4890(13) Å, c = 13.9382(13) Å, V = 1325.4(2) Å 3 , Z = 4, R gt ( F ) = 0.0391, wR ref ( F 2 ) = 0.0710, T = 296 K.

19), a = 7.6139(7) Å, b = 12.4890(13) Å, c = 13.9382(13) Å, V = 1325.4(2) Å 3 , Z = 4, R gt ( F ) = 0.0391, wR ref ( F 2 ) = 0.0710, T = 296 K。

引用次数: 0

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