Pub Date : 2023-05-31DOI: 10.14739/2310-1210.2023.3.275223
B. I. Slonetskyi, I. V. Verbytskyi, V. O. Kotsiubenko
The aim of the study is to substantiate the possibilities and analyze the results of fast-track technologies in patients with strangulated abdominal hernias without hollow organ resection. Materials and methods. The work was based on the result analysis of surgical treatment for 691 patients with strangulated abdominal hernias without resection of a hollow organ, who were divided into 2 groups depending on the specifics of diagnostic and therapeutic tactics, and into 2 subgroups depending on the localization of strangulated hernias. For patients of group 2, in contrast to group 1, the following diagnostic tactics: mandatory and justified laparoscopic intra-abdominal assessment of the strangulated organ condition; mandatory physicochemical intraoperative assessment of the hernial fluid condition; mandatory intraoperative instrumental assessment of the strangulated organ condition; as well as the therapeutic tactics: mandatory use of a comprehensive fast-track program; expansion of indications for laparoscopic surgery were used. The clinical and diagnostic algorithms included laboratory, instrumental and biochemical methods of examination. Results. It has been found that the proposed diagnostic and therapeutic tactics in group 2 patients with strangulated abdominal hernias without hollow organ resection, in contrast to group 1 patients, allowed to increase the number of laparoscopic operations by 51.15 % as well as the number of surgical interventions using fast-track technology by 51.21 %. This was accompanied by a decrease in complications according to the Clavien-Dindo scale from 83 (24.56 %) in group 1 patients to 39 (11.05 %) in group 2 patients. In addition, in group 2 patients, in contrast to group 1, a decrease in the acute pain severity in the early postoperative period and chronic pain according to the sf-IPQ in the late postoperative period has been revealed. Conclusions. The indication expansion for fast-track technologies in group 2 patients with strangulated abdominal hernias without hollow organ resection has allowed using these procedures in 238 (67.23 %) cases, while there were only 54 (16.02 %) such cases in group 1 patients. The proposed diagnostic and therapeutic tactics in group 2 patients with strangulated abdominal hernias without hollow organ resection, in contrast to group 1 patients, have enabled an increase in the number of laparoscopic operations from 16.27 % in group 1 patients to 67.42 % in group 2, which was accompanied by a decrease in postoperative complications according to the Clavien-Dindo scale from 24.56 % to 11.05 %.
{"title":"The place of fast-track technologies in patients with strangulated abdominal hernias without hollow organ resection","authors":"B. I. Slonetskyi, I. V. Verbytskyi, V. O. Kotsiubenko","doi":"10.14739/2310-1210.2023.3.275223","DOIUrl":"https://doi.org/10.14739/2310-1210.2023.3.275223","url":null,"abstract":"The aim of the study is to substantiate the possibilities and analyze the results of fast-track technologies in patients with strangulated abdominal hernias without hollow organ resection.\u0000Materials and methods. The work was based on the result analysis of surgical treatment for 691 patients with strangulated abdominal hernias without resection of a hollow organ, who were divided into 2 groups depending on the specifics of diagnostic and therapeutic tactics, and into 2 subgroups depending on the localization of strangulated hernias. For patients of group 2, in contrast to group 1, the following diagnostic tactics: mandatory and justified laparoscopic intra-abdominal assessment of the strangulated organ condition; mandatory physicochemical intraoperative assessment of the hernial fluid condition; mandatory intraoperative instrumental assessment of the strangulated organ condition; as well as the therapeutic tactics: mandatory use of a comprehensive fast-track program; expansion of indications for laparoscopic surgery were used. The clinical and diagnostic algorithms included laboratory, instrumental and biochemical methods of examination.\u0000Results. It has been found that the proposed diagnostic and therapeutic tactics in group 2 patients with strangulated abdominal hernias without hollow organ resection, in contrast to group 1 patients, allowed to increase the number of laparoscopic operations by 51.15 % as well as the number of surgical interventions using fast-track technology by 51.21 %. This was accompanied by a decrease in complications according to the Clavien-Dindo scale from 83 (24.56 %) in group 1 patients to 39 (11.05 %) in group 2 patients. In addition, in group 2 patients, in contrast to group 1, a decrease in the acute pain severity in the early postoperative period and chronic pain according to the sf-IPQ in the late postoperative period has been revealed.\u0000Conclusions. The indication expansion for fast-track technologies in group 2 patients with strangulated abdominal hernias without hollow organ resection has allowed using these procedures in 238 (67.23 %) cases, while there were only 54 (16.02 %) such cases in group 1 patients. The proposed diagnostic and therapeutic tactics in group 2 patients with strangulated abdominal hernias without hollow organ resection, in contrast to group 1 patients, have enabled an increase in the number of laparoscopic operations from 16.27 % in group 1 patients to 67.42 % in group 2, which was accompanied by a decrease in postoperative complications according to the Clavien-Dindo scale from 24.56 % to 11.05 %.","PeriodicalId":23832,"journal":{"name":"Zaporozhye Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91098806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-31DOI: 10.14739/2310-1210.2023.3.271656
Y. Yarov
In periodontal surgery, advanced technologies such as the use of platelet-enriched plasma, the technique of directed tissue regeneration, applying various osteoplastic materials are widely spread. Despite the undoubted achievements, there is a risk of postoperative complications. The aim of the work was to study the intensity and duration of the wound healing phases after surgical treatment of spontaneous periodontitis accompanied by normo-, hyper- or hyporeactivity of the body by bone morphometry. Materials and methods. Wistar rats were selected for the study ‒ 90 nonlinear white adult male rats weighing 270 ± 58 grams, aged 11–12 months with spontaneous periodontitis. The animals were divided into three equal groups depending on the condition of their organism reactivity. All the animals underwent surgery on the periodontium: one half of the animals in each of the three groups underwent flap operations, the other – flap operations with osteoplasty (Kolapan-L, Hypro-sorb F). The specific weight of microhemocirculatory bed, connective tissue and bone granulation tissue, bone trabeculae, bone marrow cavities, polymorphonuclear leukocytes, lymphocytes, macrophages, plasma cells was studied by a morphometric method. Results. Morphometric study of bone wound preparations from animals with spontaneous periodontitis accompanied by normoreactivity of the body has allowed to identify the following phases of healing during the wound process: degenerative-inflammatory changes (the 10th day), an increase in reparative processes (the 20th day) and active regeneration (the 30th day). In cases of hyper- and hyporeactivity, the intensity and duration of the wound healing phases differed. In case of hyperreaction, the granulocyte-macrophage reaction was more expressed and lasted longer until the 20th day, therefore later, only on the 30th day, the signs of regeneration could be observed. In case of hyporeaction, the granulocyte reaction appeared later (only on the 20th day) and lasted longer, signs of active regeneration were noticed later, on the 30th day. The identified patterns occurred regardless of the absence or presence of osteoplastic material in a wound. Conclusions. In case of normoreactivity, the intensity and timing of the wound process phases were optimal. In case of impaired (hyper- and hypo-) reactions, altered intensity of the cellular phase (increased or decreased) and terms (accelerated or slowed down) resulted in delayed bone wound healing, that is, a complicated course was observed. It justifies the feasibility and necessity of developing methods of targeted drug correction for transforming the wound process phases with impaired body reactivity into those that are typical of normoreaction.
{"title":"Morphometric indicators of wound bone tissue condition after surgical treatment of spontaneous periodontitis accompanied by different functional state of organism reactivity","authors":"Y. Yarov","doi":"10.14739/2310-1210.2023.3.271656","DOIUrl":"https://doi.org/10.14739/2310-1210.2023.3.271656","url":null,"abstract":"In periodontal surgery, advanced technologies such as the use of platelet-enriched plasma, the technique of directed tissue regeneration, applying various osteoplastic materials are widely spread. Despite the undoubted achievements, there is a risk of postoperative complications.\u0000The aim of the work was to study the intensity and duration of the wound healing phases after surgical treatment of spontaneous periodontitis accompanied by normo-, hyper- or hyporeactivity of the body by bone morphometry.\u0000Materials and methods. Wistar rats were selected for the study ‒ 90 nonlinear white adult male rats weighing 270 ± 58 grams, aged 11–12 months with spontaneous periodontitis. The animals were divided into three equal groups depending on the condition of their organism reactivity. All the animals underwent surgery on the periodontium: one half of the animals in each of the three groups underwent flap operations, the other – flap operations with osteoplasty (Kolapan-L, Hypro-sorb F). The specific weight of microhemocirculatory bed, connective tissue and bone granulation tissue, bone trabeculae, bone marrow cavities, polymorphonuclear leukocytes, lymphocytes, macrophages, plasma cells was studied by a morphometric method.\u0000Results. Morphometric study of bone wound preparations from animals with spontaneous periodontitis accompanied by normoreactivity of the body has allowed to identify the following phases of healing during the wound process: degenerative-inflammatory changes (the 10th day), an increase in reparative processes (the 20th day) and active regeneration (the 30th day). In cases of hyper- and hyporeactivity, the intensity and duration of the wound healing phases differed. In case of hyperreaction, the granulocyte-macrophage reaction was more expressed and lasted longer until the 20th day, therefore later, only on the 30th day, the signs of regeneration could be observed. In case of hyporeaction, the granulocyte reaction appeared later (only on the 20th day) and lasted longer, signs of active regeneration were noticed later, on the 30th day. The identified patterns occurred regardless of the absence or presence of osteoplastic material in a wound.\u0000Conclusions. In case of normoreactivity, the intensity and timing of the wound process phases were optimal. In case of impaired (hyper- and hypo-) reactions, altered intensity of the cellular phase (increased or decreased) and terms (accelerated or slowed down) resulted in delayed bone wound healing, that is, a complicated course was observed. It justifies the feasibility and necessity of developing methods of targeted drug correction for transforming the wound process phases with impaired body reactivity into those that are typical of normoreaction.","PeriodicalId":23832,"journal":{"name":"Zaporozhye Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80956012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-31DOI: 10.14739/2310-1210.2023.3.278726
O. H. Kotenko, I. O. Kotenko, M. S. Hryhorian, A. Minich, O. S. Mykhailiuk, A. O. Matvienkiv
Aim. Тo study the treatment result of unresectable liver metastases from colorectal cancer by the technique of transplantation. Case report. A man, born in 1963, applied to the Medical Center “Universal Clinic “Oberig” with a diagnosis of rectal adenocarcinoma pT3bN0M1 (hep) G2, synchronous colorectal liver metastases with multifocal bilobar lesions, stage IV after laparoscopic rectal extirpation and adjuvant FOLFIRI + Cetuximab polychemotherapy. Following a thorough examination of the patient, a decision was made to treat by transplanting a liver lobe graft donated by a living related donor (son). On April 12, 2022, the patient underwent orthotopic living related donor transplantation of the liver right lobe. In the early postoperative period, the patient developed an acute perforated ulcer of the small intestine, and he therefore was reoperated. The postoperative period was severe, but the condition stabilization was achieved with conservative treatment, and on the 38th postoperative day, the recipient was discharged from the hospital in a satisfactory condition. According to the control abdominal MRI during follow-up examinations, no signs of recurrence or progression were detected, however, 2 isolated metastatic foci in the lung parenchyma were detected bilaterally on the control CT scan of the chest 11 months after the liver lobe transplantation from the living related donor. Resection of metastatic foci was performed and systemic polychemotherapy was prescribed in that regard. Based on the control laboratory and instrumental examinations from 05.05.2023 (CT scan, MRI), there were no signs of the disease recurrence, the level of carcinoembryonic antigen was 1.5 ng/ml. Conclusions. Liver transplantation is an effective and radical method of treatment for patients with unresectable liver metastases from colorectal cancer. Transplantation using liver lobe from a living related donor in unresectable isolated liver metastases from colorectal cancer has advantages over all other methods and is safe for donors in highly specialized centers with sufficient experience in living related liver transplantation.
{"title":"Orthotopic living related donor transplantation of the liver right lobe in the treatment of unresectable bilobular liver metastases from colorectal cancer","authors":"O. H. Kotenko, I. O. Kotenko, M. S. Hryhorian, A. Minich, O. S. Mykhailiuk, A. O. Matvienkiv","doi":"10.14739/2310-1210.2023.3.278726","DOIUrl":"https://doi.org/10.14739/2310-1210.2023.3.278726","url":null,"abstract":"Aim. Тo study the treatment result of unresectable liver metastases from colorectal cancer by the technique of transplantation.\u0000Case report. A man, born in 1963, applied to the Medical Center “Universal Clinic “Oberig” with a diagnosis of rectal adenocarcinoma pT3bN0M1 (hep) G2, synchronous colorectal liver metastases with multifocal bilobar lesions, stage IV after laparoscopic rectal extirpation and adjuvant FOLFIRI + Cetuximab polychemotherapy. Following a thorough examination of the patient, a decision was made to treat by transplanting a liver lobe graft donated by a living related donor (son).\u0000On April 12, 2022, the patient underwent orthotopic living related donor transplantation of the liver right lobe. In the early postoperative period, the patient developed an acute perforated ulcer of the small intestine, and he therefore was reoperated. The postoperative period was severe, but the condition stabilization was achieved with conservative treatment, and on the 38th postoperative day, the recipient was discharged from the hospital in a satisfactory condition.\u0000According to the control abdominal MRI during follow-up examinations, no signs of recurrence or progression were detected, however, 2 isolated metastatic foci in the lung parenchyma were detected bilaterally on the control CT scan of the chest 11 months after the liver lobe transplantation from the living related donor. Resection of metastatic foci was performed and systemic polychemotherapy was prescribed in that regard. Based on the control laboratory and instrumental examinations from 05.05.2023 (CT scan, MRI), there were no signs of the disease recurrence, the level of carcinoembryonic antigen was 1.5 ng/ml.\u0000Conclusions. Liver transplantation is an effective and radical method of treatment for patients with unresectable liver metastases from colorectal cancer. Transplantation using liver lobe from a living related donor in unresectable isolated liver metastases from colorectal cancer has advantages over all other methods and is safe for donors in highly specialized centers with sufficient experience in living related liver transplantation.","PeriodicalId":23832,"journal":{"name":"Zaporozhye Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85357417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-31DOI: 10.14739/2310-1210.2023.3.273664
O. B. Teslenko, S. V. Fedorov, M. Bielinskyi, N. M. Serediuk
The prevalence of nonalcoholic fatty liver disease (NAFLD) and atrial fibrillation (AF) has increased globally in recent years. According to recent studies, NAFLD and AF affect approximately 32 % and 0.51 % of the general population, respectively. Aim. To examine the association between NAFLD and AF by using the FibroTest-4 (FIB-4) and the NAFLD Fibrosis score (NFS) and measuring periostin levels. Materials and methods. In this study, we enrolled 96 patients diagnosed with NAFLD and divided them in two groups, the main group – 35 patients with NAFLD + AF and the control group – 61 patients with NAFLD alone. NFS and FIB-4 indices were calculated and serum periostin level was measured. Results. The NAFLD + AF group had higher levels of periostin (10.80 ± 1.60 ng/ml vs. 9.80 ± 1.75 ng/ml, p < 0.001) and higher NFS (-1.05 ± 1.46 vs. -2.65 ± 1.63, p < 0.001) and FIB-4 scores (1.34 ± 0.86 vs 1.07 ± 0.60, p = 0.048). Periostin has been found to be associated with the risk of NAFLD + AF with an OR of 2.079 (95 % CI: 1.418–3.048, p < 0.001). Similar results were with NFS (OR = 3.233, 95 % CI: 1.970–5.303, p < 0.001) and FIB-4 (OR = 2.498, 95 % CI: 1.109–5.627, p = 0.027). The receiver operating characteristic (ROC) analysis was performed using three variables, NFS, FIB-4 and periostin, to determine their ability to distinguish between patients with NAFLD + AF and NAFLD alone. The results have shown that the NFS had the highest area under the curve (AUC) with a value of 0.868 (95 % CI: 0.792–0.943, p < 0.001), indicating excellent discriminatory ability. FIB-4 had an AUC of 0.651 (95 % CI: 0.537–0.765, p = 0.014), while periostin had an AUC of 0.759 (95 % CI: 0.660–0.858, p < 0.001). Conclusions. These findings have suggested a strong association between NAFLD and AF and highlighted the importance of considering AF as a potential complication in patients with NAFLD. Both the use of the FIB-4 and NFS indices and measurement of periostin levels have been proved to be effective in detecting this association.
近年来，非酒精性脂肪性肝病(NAFLD)和心房颤动(AF)的患病率在全球范围内有所增加。根据最近的研究，NAFLD和AF分别影响大约32%和0.51%的普通人群。通过使用FibroTest-4 (FIB-4)和NAFLD纤维化评分(NFS)以及测量骨膜蛋白水平来检查NAFLD与房颤之间的关系。材料和方法。在这项研究中，我们招募了96名确诊为NAFLD的患者，并将他们分为两组，主要组(35名NAFLD + AF患者)和对照组(61名单纯NAFLD患者)。计算NFS、FIB-4指标，测定血清骨膜素水平。NAFLD + AF组患者骨膜蛋白水平较高(10.80±1.60 ng/ml vs. 9.80±1.75 ng/ml, p < 0.001)， NFS(-1.05±1.46 vs. -2.65±1.63,p < 0.001)， FIB-4评分较高(1.34±0.86 vs. 1.07±0.60,p = 0.048)。研究发现，Periostin与NAFLD + AF的风险相关，OR为2.079 (95% CI: 1.418-3.048, p < 0.001)。NFS (OR = 3.233, 95% CI: 1.970-5.303, p < 0.001)和FIB-4 (OR = 2.498, 95% CI: 1.109-5.627, p = 0.027)的结果相似。使用NFS、FIB-4和periostin三个变量进行受试者工作特征(ROC)分析，以确定它们区分NAFLD + AF和单纯NAFLD患者的能力。结果表明，NFS的曲线下面积(AUC)最高，为0.868 (95% CI: 0.792 ~ 0.943, p < 0.001)，具有较好的鉴别能力。FIB-4的AUC为0.651 (95% CI: 0.537 ~ 0.765, p = 0.014)，而periostin的AUC为0.759 (95% CI: 0.660 ~ 0.858, p < 0.001)。这些发现提示了NAFLD和房颤之间的强烈关联，并强调了将房颤视为NAFLD患者潜在并发症的重要性。FIB-4和NFS指数的使用以及骨膜蛋白水平的测量已被证明是检测这种关联的有效方法。
{"title":"Nonalcoholic fatty liver disease and atrial fibrillation: the main markers of this association","authors":"O. B. Teslenko, S. V. Fedorov, M. Bielinskyi, N. M. Serediuk","doi":"10.14739/2310-1210.2023.3.273664","DOIUrl":"https://doi.org/10.14739/2310-1210.2023.3.273664","url":null,"abstract":"The prevalence of nonalcoholic fatty liver disease (NAFLD) and atrial fibrillation (AF) has increased globally in recent years. According to recent studies, NAFLD and AF affect approximately 32 % and 0.51 % of the general population, respectively.\u0000Aim. To examine the association between NAFLD and AF by using the FibroTest-4 (FIB-4) and the NAFLD Fibrosis score (NFS) and measuring periostin levels.\u0000Materials and methods. In this study, we enrolled 96 patients diagnosed with NAFLD and divided them in two groups, the main group – 35 patients with NAFLD + AF and the control group – 61 patients with NAFLD alone. NFS and FIB-4 indices were calculated and serum periostin level was measured.\u0000Results. The NAFLD + AF group had higher levels of periostin (10.80 ± 1.60 ng/ml vs. 9.80 ± 1.75 ng/ml, p < 0.001) and higher NFS (-1.05 ± 1.46 vs. -2.65 ± 1.63, p < 0.001) and FIB-4 scores (1.34 ± 0.86 vs 1.07 ± 0.60, p = 0.048). Periostin has been found to be associated with the risk of NAFLD + AF with an OR of 2.079 (95 % CI: 1.418–3.048, p < 0.001). Similar results were with NFS (OR = 3.233, 95 % CI: 1.970–5.303, p < 0.001) and FIB-4 (OR = 2.498, 95 % CI: 1.109–5.627, p = 0.027). The receiver operating characteristic (ROC) analysis was performed using three variables, NFS, FIB-4 and periostin, to determine their ability to distinguish between patients with NAFLD + AF and NAFLD alone. The results have shown that the NFS had the highest area under the curve (AUC) with a value of 0.868 (95 % CI: 0.792–0.943, p < 0.001), indicating excellent discriminatory ability. FIB-4 had an AUC of 0.651 (95 % CI: 0.537–0.765, p = 0.014), while periostin had an AUC of 0.759 (95 % CI: 0.660–0.858, p < 0.001).\u0000Conclusions. These findings have suggested a strong association between NAFLD and AF and highlighted the importance of considering AF as a potential complication in patients with NAFLD. Both the use of the FIB-4 and NFS indices and measurement of periostin levels have been proved to be effective in detecting this association.","PeriodicalId":23832,"journal":{"name":"Zaporozhye Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82905398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-31DOI: 10.14739/2310-1210.2023.3.274844
І. Vlasenko, L. Davtian, V. V. Hladyshev
There are barriers to initiation, use or intensification of insulin therapy for patients with diabetes. A non-invasive therapeutic approach in insulin therapy should overcome these barriers. The development of alternative methods of insulin delivery is a complex task of fundamental medicine and pharmacy. The availability of oral / nasal insulin helps millions of people with diabetes avoid daily burden of subcutaneous insulin injections. The aim of the work was to study the current state of the latest developments in alternative routes of insulin delivery, their technology, and clinical trials. Materials and methods. The latest publications of scientific research on non-invasive insulin delivery systems were the study objects. Content analysis, bibliosemantic, analytical, summarizing analyzes were used. Results. The smart insulin delivery systems and pain-reducing technologies have been developed over the years. For this, research was conducted on numerous materials and technologies, including nanoparticles, hydrogels, liposomes, ionic liquids or special devices. Several alternative delivery technologies have been identified to reduce pain (pain-reducing technologies): oral, inhaled, intranasal, buccal, transdermal, and long-acting injectable insulins, but with low frequency of use. Various modern technological approaches are applying, namely, chemical modification of insulin; mucoadhesion system; protease inhibitors; increased absorption; particle delivery systems. Smart insulin delivery technologies are based on different strategies, materials, and glucose-responsive synthesis and conversion, but a common “diffuse-type” insulin release mechanism is used. Innovations in insulin chemistry and formulations have shown improved clinical outcomes when used. Conclusions. Innovations in alternative insulin delivery systems include algorithms for continuous glucose monitoring systems, glucose-sensitive polymer matrices and biological structures with insulin. The introduction of non-invasive systems would contribute to an earlier start of insulin therapy on medical advice, ensuring better glycemic control and reducing the risk of complications, which are the main burden on the health care system. The use of insulin in the form of alternative delivery systems may also be promising in the prevention of type 1 diabetes and other diseases.
{"title":"Modern strategies of alternative insulin delivery systems","authors":"І. Vlasenko, L. Davtian, V. V. Hladyshev","doi":"10.14739/2310-1210.2023.3.274844","DOIUrl":"https://doi.org/10.14739/2310-1210.2023.3.274844","url":null,"abstract":"There are barriers to initiation, use or intensification of insulin therapy for patients with diabetes. A non-invasive therapeutic approach in insulin therapy should overcome these barriers. The development of alternative methods of insulin delivery is a complex task of fundamental medicine and pharmacy. The availability of oral / nasal insulin helps millions of people with diabetes avoid daily burden of subcutaneous insulin injections.\u0000The aim of the work was to study the current state of the latest developments in alternative routes of insulin delivery, their technology, and clinical trials.\u0000Materials and methods. The latest publications of scientific research on non-invasive insulin delivery systems were the study objects. Content analysis, bibliosemantic, analytical, summarizing analyzes were used.\u0000Results. The smart insulin delivery systems and pain-reducing technologies have been developed over the years. For this, research was conducted on numerous materials and technologies, including nanoparticles, hydrogels, liposomes, ionic liquids or special devices.\u0000Several alternative delivery technologies have been identified to reduce pain (pain-reducing technologies): oral, inhaled, intranasal, buccal, transdermal, and long-acting injectable insulins, but with low frequency of use. Various modern technological approaches are applying, namely, chemical modification of insulin; mucoadhesion system; protease inhibitors; increased absorption; particle delivery systems. Smart insulin delivery technologies are based on different strategies, materials, and glucose-responsive synthesis and conversion, but a common “diffuse-type” insulin release mechanism is used. Innovations in insulin chemistry and formulations have shown improved clinical outcomes when used.\u0000Conclusions. Innovations in alternative insulin delivery systems include algorithms for continuous glucose monitoring systems, glucose-sensitive polymer matrices and biological structures with insulin. The introduction of non-invasive systems would contribute to an earlier start of insulin therapy on medical advice, ensuring better glycemic control and reducing the risk of complications, which are the main burden on the health care system. The use of insulin in the form of alternative delivery systems may also be promising in the prevention of type 1 diabetes and other diseases.","PeriodicalId":23832,"journal":{"name":"Zaporozhye Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73419117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-31DOI: 10.14739/2310-1210.2023.3.276190
O. Kiosov, B. A, EF S. M. Hulevskyi C, M. V. Korobov, О. М. Кіосов, В. С. Ткачов, С. М. Гулевський, М. В. Коробов
The combination of esophageal achalasia with epiphrenic diverticulum is extremely rare and mostly treated surgically. Several cases of successful endoscopic treatment were presented in the literature, but treatment strategy has not yet been defined. Aim. To present a case of the rare combination as achalasia and giant esophageal epiphrenic diverticulum successfully treated endoscopically. Case report. We present to your attention a case report of a 75-year-old woman with complete dysphagia, significant weight loss, who was diagnosed with symptomatic epiphrenic diverticulum secondary to achalasia. Upper gastrointestinal endoscopy showed signs of severe fibrosis in the submucosal layer of the diverticulum. She received peroral endoscopic myotomy combined with diverticuloseptotomy made from the same submucosal tunnel. The regression of symptoms from 10 to 2 points according to the Eckardt symptom score clinically showed the treatment success. Conclusions. The presented endoscopic one-tunnel technique could be an effective miniinvasive option for large symptomatic epiphrenic diverticula associated with achalasia.
{"title":"A case report of achalasia and large epiphrenic diverticulum treated by peroral endoscopic myotomy combined with diverticuloseptotomy","authors":"O. Kiosov, B. A, EF S. M. Hulevskyi C, M. V. Korobov, О. М. Кіосов, В. С. Ткачов, С. М. Гулевський, М. В. Коробов","doi":"10.14739/2310-1210.2023.3.276190","DOIUrl":"https://doi.org/10.14739/2310-1210.2023.3.276190","url":null,"abstract":"The combination of esophageal achalasia with epiphrenic diverticulum is extremely rare and mostly treated surgically. Several cases of successful endoscopic treatment were presented in the literature, but treatment strategy has not yet been defined.\u0000Aim. To present a case of the rare combination as achalasia and giant esophageal epiphrenic diverticulum successfully treated endoscopically.\u0000Case report. We present to your attention a case report of a 75-year-old woman with complete dysphagia, significant weight loss, who was diagnosed with symptomatic epiphrenic diverticulum secondary to achalasia. Upper gastrointestinal endoscopy showed signs of severe fibrosis in the submucosal layer of the diverticulum. She received peroral endoscopic myotomy combined with diverticuloseptotomy made from the same submucosal tunnel. The regression of symptoms from 10 to 2 points according to the Eckardt symptom score clinically showed the treatment success.\u0000Conclusions. The presented endoscopic one-tunnel technique could be an effective miniinvasive option for large symptomatic epiphrenic diverticula associated with achalasia.","PeriodicalId":23832,"journal":{"name":"Zaporozhye Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75277772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-31DOI: 10.14739/2310-1210.2023.3.276000
I. O. Shkil, V. Smolanka, K. Y. Deinichenko
Aim. To analyze and determine the optimal indications for microsurgical operative interventions in the shortest possible time from the subarachnoid hemorrhage onset to prevent anterior communicating artery (AcomA) aneurysm re-rupture and bleeding. Materials and methods. 280 patients with brain aneurysms were examined at the Uzhhorod Regional Center of Neurosurgery and Neurology and the City Hospital of Urgent and Emergency Medical Care under Zaporizhzhia City Council. Among them, 98 patients (48 males and 50 females) were diagnosed with AcomA aneurysms. The age of patients with AcomA aneurysms was from 20 to 72 years (mean age 47.8 ± 11.0 years). Aneurysms were verified using head and neck computed tomography angiography (a Toshiba Astelion scanner, 2016, No. 4СС162106), selective cerebral angiography (an angiography system General Energy Optima IGS 330, 2019, No. 80071260314), and brain magnetic resonance angiography (an i_Open 0,36 T magnetic resonance tomograph, 2005, No. Toc102633006). Cerebral hemodynamics was assessed using transcranial dopplerography (“Philips HD7” ultrasound diagnostic system, 2014, No. 69935). Results. In the first three days after the onset of subarachnoid hemorrhage, 18 (18 %) patients were admitted with ruptured aneurysms of this location, 62 (62 %) within 4–8 days, 12 (12 %) patients within 9–14 days, later than 14 days – 6 (6 %). All 98 patients underwent microsurgical clipping of AcomA aneurysms. Due to severe cerebral edema, decompressive craniectomy was performed in two patients. The results of surgical treatment were evaluated according to the modified Rankin scale at the time of hospital discharge and were as follows: in 65 (65 %) patients – good; in 18 (18 %) – moderate disability; in 4 (4 %) – serious disability. 11 (11 %) patients died. Conclusions. The treatment outcomes in patients with ruptured AcomA aneurysms were significantly dependent on factors related to increased risk of re-rupture: the presence of large-sized intracerebral hematoma, the aneurysm index exceeding 2, and multi-chamber aneurysm.
{"title":"Determination of indications for early surgical treatment in patients with ruptured anterior communicating artery aneurysms","authors":"I. O. Shkil, V. Smolanka, K. Y. Deinichenko","doi":"10.14739/2310-1210.2023.3.276000","DOIUrl":"https://doi.org/10.14739/2310-1210.2023.3.276000","url":null,"abstract":"Aim. To analyze and determine the optimal indications for microsurgical operative interventions in the shortest possible time from the subarachnoid hemorrhage onset to prevent anterior communicating artery (AcomA) aneurysm re-rupture and bleeding.\u0000Materials and methods. 280 patients with brain aneurysms were examined at the Uzhhorod Regional Center of Neurosurgery and Neurology and the City Hospital of Urgent and Emergency Medical Care under Zaporizhzhia City Council. Among them, 98 patients (48 males and 50 females) were diagnosed with AcomA aneurysms. The age of patients with AcomA aneurysms was from 20 to 72 years (mean age 47.8 ± 11.0 years). Aneurysms were verified using head and neck computed tomography angiography (a Toshiba Astelion scanner, 2016, No. 4СС162106), selective cerebral angiography (an angiography system General Energy Optima IGS 330, 2019, No. 80071260314), and brain magnetic resonance angiography (an i_Open 0,36 T magnetic resonance tomograph, 2005, No. Toc102633006). Cerebral hemodynamics was assessed using transcranial dopplerography (“Philips HD7” ultrasound diagnostic system, 2014, No. 69935).\u0000Results. In the first three days after the onset of subarachnoid hemorrhage, 18 (18 %) patients were admitted with ruptured aneurysms of this location, 62 (62 %) within 4–8 days, 12 (12 %) patients within 9–14 days, later than 14 days – 6 (6 %). All 98 patients underwent microsurgical clipping of AcomA aneurysms. Due to severe cerebral edema, decompressive craniectomy was performed in two patients. The results of surgical treatment were evaluated according to the modified Rankin scale at the time of hospital discharge and were as follows: in 65 (65 %) patients – good; in 18 (18 %) – moderate disability; in 4 (4 %) – serious disability. 11 (11 %) patients died.\u0000Conclusions. The treatment outcomes in patients with ruptured AcomA aneurysms were significantly dependent on factors related to increased risk of re-rupture: the presence of large-sized intracerebral hematoma, the aneurysm index exceeding 2, and multi-chamber aneurysm.","PeriodicalId":23832,"journal":{"name":"Zaporozhye Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72980711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-31DOI: 10.14739/2310-1210.2023.3.269374
K. I. Davydenko, D. Maltsev, L. Natrus
Non-specific inflammatory diseases of the female genital organs (NIDFGO) are an important problem of modern gynecology due to their high frequency in the population, the tendency to frequent recurrences, and many cases of resistance to recommended antimicrobial and anti-inflammatory drugs. Aim: to study indicators of immune status in women with different recurrence rates of NIDFGO and biomarkers of recurrences to improve potential therapeutic approaches and prevent recurrences in the further. Materials and methods. A prospective single-center controlled non-randomized clinical study was conducted with the participation of 98 adult women. Out of them, 80 patients with NIDFGO had one-year recurrence rate of 1, 2–3, 4 or more events, and 18 age-matched women without NIDFGO were assigned to the control group. Immunogram and hemogram were performed for all study participants using standardized methods. Statistical analysis of the results was performed using IBM SPSS 23 statistical package software. Results. The mean serum concentration of IgE in patients with frequent relapses was 3 times (p < 0.05) lower than that in women with only one recurrence, 2.6 times (p < 0.05) lower than that in patients with medium recurrence rate, and 3.4 times (p < 0.05) less than in the control. In women with frequent recurrences, the mean relative number of blood NKT cells was 3.5 times (p < 0.05) less than that in patients with only one recurrence, 2.3 times (p < 0.05) less than that in persons with medium recurrence rate, and 3 times (p < 0.05) less as compared to women of the control group. Conclusions. Selective deficiencies of IgE and NKT cells in women with NIDFGO are factors that lead to a higher frequency of disease exacerbations per year. T he development and clinical approval of immunotherapeutic approaches to compensate for deficiencies of IgE and NKT cells in women with NIDFGO will contribute to the imposition of immune control over the inflammatory process, increase the effectiveness of antimicrobial treatment, resulting in a decrease in the recurrence rate.
{"title":"Indicators of immune status in women with different recurrence rates of nonspecific inflammatory diseases of the genital organs","authors":"K. I. Davydenko, D. Maltsev, L. Natrus","doi":"10.14739/2310-1210.2023.3.269374","DOIUrl":"https://doi.org/10.14739/2310-1210.2023.3.269374","url":null,"abstract":"Non-specific inflammatory diseases of the female genital organs (NIDFGO) are an important problem of modern gynecology due to their high frequency in the population, the tendency to frequent recurrences, and many cases of resistance to recommended antimicrobial and anti-inflammatory drugs.\u0000Aim: to study indicators of immune status in women with different recurrence rates of NIDFGO and biomarkers of recurrences to improve potential therapeutic approaches and prevent recurrences in the further.\u0000Materials and methods. A prospective single-center controlled non-randomized clinical study was conducted with the participation of 98 adult women. Out of them, 80 patients with NIDFGO had one-year recurrence rate of 1, 2–3, 4 or more events, and 18 age-matched women without NIDFGO were assigned to the control group. Immunogram and hemogram were performed for all study participants using standardized methods. Statistical analysis of the results was performed using IBM SPSS 23 statistical package software.\u0000Results. The mean serum concentration of IgE in patients with frequent relapses was 3 times (p < 0.05) lower than that in women with only one recurrence, 2.6 times (p < 0.05) lower than that in patients with medium recurrence rate, and 3.4 times (p < 0.05) less than in the control. In women with frequent recurrences, the mean relative number of blood NKT cells was 3.5 times (p < 0.05) less than that in patients with only one recurrence, 2.3 times (p < 0.05) less than that in persons with medium recurrence rate, and 3 times (p < 0.05) less as compared to women of the control group.\u0000Conclusions. Selective deficiencies of IgE and NKT cells in women with NIDFGO are factors that lead to a higher frequency of disease exacerbations per year. T he development and clinical approval of immunotherapeutic approaches to compensate for deficiencies of IgE and NKT cells in women with NIDFGO will contribute to the imposition of immune control over the inflammatory process, increase the effectiveness of antimicrobial treatment, resulting in a decrease in the recurrence rate.","PeriodicalId":23832,"journal":{"name":"Zaporozhye Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81086475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-31DOI: 10.14739/2310-1210.2023.3.274743
V. Melnyk
Aim. To improve the results of surgical treatment for patients with non-neoplastic colonic diseases by optimizing the choice of radical surgery extent. Materials and methods. The study material was the analysis of radical surgical interventions performed in 87 patients with non-neoplastic colonic diseases: ulcerative colitis, Crohn’s disease, familial adenomatous polyposis, chronic colonic and coloproctogenic stasis, diverticular colon disease. The age of the operated patients was 20–72 years. There were 49 (56.3 %) men and 38 (43.7 %) women. The criteria for choosing the radical surgery extent for these diseases were defined and substantiated. Results. There were 3 postoperative mortalities (3.4 %) among patients operated on absolute indications for acute complications of ulcerative colitis and Crohn’s disease. Recurrences of ulcerative colitis, Crohn’s disease and familial adenomatous polyposis occurred in 16 (18.4 %) operated patients in the area of the retained rectal stump and terminal ileum. Malignant transformation of the rectal stump occurred in 5 (5.7 %) patients with these recurrences. The extent of radical surgery in non-neoplastic colonic diseases depended on the diagnosis of the underlying disease, the presence of complications, the depth of wall lesions and the extent of the pathological process, the risk of recurrence in the anatomical parts of the small and large intestine. Conclusions. Deciding on the extent of the radical stage of surgical intervention depended on the diagnosis, features of the clinical course of non-neoplastic colorectal diseases, recurrences, the general condition of a patient, the pathological process extent and severity. Performing the optimal extent of radical surgery for non-neoplastic colonic diseases helped reduce the number of recurrences in the terminal part of the small intestine to 4 (4.6 %), in the area of the rectal stump to 7 (8.1 %), improved functional outcomes and quality of life in 76 (87.3 %) operated patients.
{"title":"Radical surgery for non-neoplastic colonic diseases","authors":"V. Melnyk","doi":"10.14739/2310-1210.2023.3.274743","DOIUrl":"https://doi.org/10.14739/2310-1210.2023.3.274743","url":null,"abstract":"Aim. To improve the results of surgical treatment for patients with non-neoplastic colonic diseases by optimizing the choice of radical surgery extent.\u0000Materials and methods. The study material was the analysis of radical surgical interventions performed in 87 patients with non-neoplastic colonic diseases: ulcerative colitis, Crohn’s disease, familial adenomatous polyposis, chronic colonic and coloproctogenic stasis, diverticular colon disease. The age of the operated patients was 20–72 years. There were 49 (56.3 %) men and 38 (43.7 %) women. The criteria for choosing the radical surgery extent for these diseases were defined and substantiated.\u0000Results. There were 3 postoperative mortalities (3.4 %) among patients operated on absolute indications for acute complications of ulcerative colitis and Crohn’s disease. Recurrences of ulcerative colitis, Crohn’s disease and familial adenomatous polyposis occurred in 16 (18.4 %) operated patients in the area of the retained rectal stump and terminal ileum. Malignant transformation of the rectal stump occurred in 5 (5.7 %) patients with these recurrences. The extent of radical surgery in non-neoplastic colonic diseases depended on the diagnosis of the underlying disease, the presence of complications, the depth of wall lesions and the extent of the pathological process, the risk of recurrence in the anatomical parts of the small and large intestine.\u0000Conclusions. Deciding on the extent of the radical stage of surgical intervention depended on the diagnosis, features of the clinical course of non-neoplastic colorectal diseases, recurrences, the general condition of a patient, the pathological process extent and severity. Performing the optimal extent of radical surgery for non-neoplastic colonic diseases helped reduce the number of recurrences in the terminal part of the small intestine to 4 (4.6 %), in the area of the rectal stump to 7 (8.1 %), improved functional outcomes and quality of life in 76 (87.3 %) operated patients.","PeriodicalId":23832,"journal":{"name":"Zaporozhye Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85826098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-31DOI: 10.14739/2310-1210.2023.3.272785
T. Sorokman, E. C.
Despite the success of the treatment of infected individuals, Helicobacter pylori infection remains the most common human bacterial pathogen, infecting half of the world’s population. In a large part of people, H. pylori causes gastroduodenal diseases, in particular, chronic antral gastritis and ulcer disease. The possible role of selenium in the course of chronic inflammatory H. pylori-associated pathology of the upper gastrointestinal tract in children has not yet been fully investigated and understood. The aim is to determine selenium plasma levels in children with Helicobacter pylori-associated diseases of the upper gastrointestinal tract. Materials and methods. The study included 135 school-age children with Helicobacter pylori-associated diseases of the upper gastrointestinal tract, who made up the main study group (55 children with chronic gastritis (CG), 57 children with chronic gastroduodenitis (CGD), 23 children with duodenal ulcer (DU), and 20 practically healthy age-matched children were the comparison group. Quantitative measurements of plasma selenium were performed using inductively coupled plasma mass spectrometry (MS-ICP) on an Optima 2000 DV spectrometer (Perkin Elmer, USA). Results. The lowest level of plasma selenium was registered in children with H. pylori-negative DU (67.81 ± 2.67 μg/l), while in children with H. pylori-associated DU, its level was higher – 73.56 ± 2.34 μg/l (p < 0.05), however, it did not reach the level in children of the comparison group. A similar direction of changes in the selenium plasma concentration was observed in children with CGD: higher levels of selenium were detected in children with H. pylori-positive CGD compared to H. pylori-negative CGD (75.61 ± 2.48 μg/l and 70.99 ± 2.31 μg/l, respectively, p < 0.05). Conclusions. Significantly lower levels of plasma selenium in children with chronic destructive-inflammatory diseases of the upper gastrointestinal tract were found, which could be explained by the acute phase of inflammation in the mucous membrane of the stomach and duodenum resulting in a decrease in selenium absorption. In H. pylori-positive children, the level of selenium was significantly higher compared to H. pylori-negative children indicating a possible role of selenium in the pathogenesis and further progression of H. pylori-associated diseases.
{"title":"Selenium plasma levels in children with Helicobacter pylori-associated diseases of the upper gastrointestinal tract","authors":"T. Sorokman, E. C.","doi":"10.14739/2310-1210.2023.3.272785","DOIUrl":"https://doi.org/10.14739/2310-1210.2023.3.272785","url":null,"abstract":"Despite the success of the treatment of infected individuals, Helicobacter pylori infection remains the most common human bacterial pathogen, infecting half of the world’s population. In a large part of people, H. pylori causes gastroduodenal diseases, in particular, chronic antral gastritis and ulcer disease. The possible role of selenium in the course of chronic inflammatory H. pylori-associated pathology of the upper gastrointestinal tract in children has not yet been fully investigated and understood.\u0000The aim is to determine selenium plasma levels in children with Helicobacter pylori-associated diseases of the upper gastrointestinal tract.\u0000Materials and methods. The study included 135 school-age children with Helicobacter pylori-associated diseases of the upper gastrointestinal tract, who made up the main study group (55 children with chronic gastritis (CG), 57 children with chronic gastroduodenitis (CGD), 23 children with duodenal ulcer (DU), and 20 practically healthy age-matched children were the comparison group. Quantitative measurements of plasma selenium were performed using inductively coupled plasma mass spectrometry (MS-ICP) on an Optima 2000 DV spectrometer (Perkin Elmer, USA).\u0000Results. The lowest level of plasma selenium was registered in children with H. pylori-negative DU (67.81 ± 2.67 μg/l), while in children with H. pylori-associated DU, its level was higher – 73.56 ± 2.34 μg/l (p < 0.05), however, it did not reach the level in children of the comparison group. A similar direction of changes in the selenium plasma concentration was observed in children with CGD: higher levels of selenium were detected in children with H. pylori-positive CGD compared to H. pylori-negative CGD (75.61 ± 2.48 μg/l and 70.99 ± 2.31 μg/l, respectively, p < 0.05).\u0000Conclusions. Significantly lower levels of plasma selenium in children with chronic destructive-inflammatory diseases of the upper gastrointestinal tract were found, which could be explained by the acute phase of inflammation in the mucous membrane of the stomach and duodenum resulting in a decrease in selenium absorption. In H. pylori-positive children, the level of selenium was significantly higher compared to H. pylori-negative children indicating a possible role of selenium in the pathogenesis and further progression of H. pylori-associated diseases.","PeriodicalId":23832,"journal":{"name":"Zaporozhye Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89088435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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