Zentralblatt fur allgemeine Pathologie u. pathologische Anatomie最新文献

Reported in this paper are two autopsy cases in which metastases were recorded from oat-cell carcinomas of the lung to other tumors. In one case, formation of metastases was extended into a hamartochondroma of the other lung, while an adenocarcinoma of the pancreas was affected in the other. Different possible explanations for the phenomenon observed are discussed, and particular reference is made to the important role played by autopsy in accurate investigation of interrelations between coexisting tumors.

An unusual variant of immunocytoma of low grade malignancy, cytologically resembling follicular cleaved-cell malignant lymphoma is described. Presence of heavy deposits of amyloid, intracytoplasmic monoclonal IgM-kappa immunoglobulin, cells with Dutcher inclusions, electron-microscopic features and negativity of T-cell markers led to diagnosis of immunocytoma. After cytostatic chemotherapy the lymphoma changed its morphology into typical lymphoplasmacytoid immunocytoma.

Described in this paper is a new artificial chamber model to enable in vivo investigation of nerve fiber regeneration. Transection of the sciatic nerve of a rat was followed by analysis of axonal regeneration and revascularisation in the tissue chamber. Vascularisation of the endoneurium via the newly formed epineurium and perineurium was almost physiological in the cavity formed. The latter was found to be suitable for application of drugs and neurotrophic substances.

An unusual case is described of Bartholin's gland carcinoma which developed 28 years after radiotherapy for a cervical carcinoma. The tumor showed three-directional differentiation with predominance of the papillary non-invasive transitional cell pattern.

Electron microscopy is an important supplementary tool in bioptic diagnosis of bone marrow lesions. The hematologically specialised clinical pathologist should better resort to it for all bone marrow investigations. The routine pathologist can focus attention at least on certain diagnostic cases, such as children, or on sequential biopsies with specific diagnostic problems. It will be necessary, in such cases, to use proper fixation and, before further processing to cut the bone marrow sample into small pieces without delay. Electron microscopy has worked well, in the context of our own material, for differential diagnosis between various forms of myelogenous leukemia, hypereosinophilia of bone marrow and lymphocytic leukemia as well as between immature multiple myeloma and malignant lymphoma, centrocytic/centroblastic malignant lymphoma and nodular sclerosis of Hodgkin's disease and in the diagnosis of megakaryocytic leukemia.

A man to whom sudden cardiac death occurred after he had lived to the age of 25 years in perfect condition is reported in this paper. Fibromuscular dysplasia of the coronary arteries was established as the cause of death by postmortem examination.

Epimyoepithelial carcinoma (EMC) of salivary gland origin, primarily in the parotid gland, is a tumor in its own right and of low malignancy, usually occurring in women. Our patient is alive with her second recurrence, 16 years after the first surgical intervention. Immunohistochemical results suggest active involvement of myoepithelial and epithelial components of intercalated ducts in the histogenesis of this particular tumor.

Mucopolysaccharidoses are autosomal recessive or X-linked hereditary lysosomal storage diseases occurring to one in 10,000 to 16,000 births. The definitive diagnosis is based on the biochemical verification of the enzyme defect in cultured fibroblasts of amniotic fluid cells, in amniotic fluid, in chorionic biopsies and by determination of the urinary excretion of glycosaminoglycans. Morphological studies are of utmost importance both for genetic counselling and enlightenment of the pathogenesis. In recent years, numerous reports appeared dealing with morphological changes in different types of mucopolysaccharidoses. Based on own studies in pre- and postnatal cases, the present paper gives an update review on light and electron microscopic peculiarities of the different types and subtypes of mucopolysaccharidoses according to the classification of MCKUSICK and NEUFELD (1983). Lysosomal storage is found in practically all organs. However, there are quantitative and qualitative differences which are responsible for variations in clinical symptomatology. The purpose of this paper is to describe these differences with particular emphasis on changes in various tissues, on the pathogenetic mechanism of the storage as well as on pre- and postnatal morphological diagnostics.

A brief account is given in this paper of latest knowledge on regeneration in peripheral nerve following axotomy. Structural changes are discussed together with metabolic peculiarities associated with such restoration. Separate reference is made to neurotrophic growth factors and their effects.

Intramural stomach innervation was investigated in DBA mice after 1 week, 6 weeks and 3 months of intragastric ethanol treatment (1 cm3 daily by plastic tube). The results indicated that the intramural nervous system of the stomach underwent ultrastructural and histological changes in relation to ethanol. Alterations were noticeable after 3 weeks of treatment. They were more strongly pronounced after 6 weeks and were maximally advanced in the group with 3 months of ethanol treatment. Mitochondria seemed to be first affected, especially in the axonal processes and nerve endings (higher density, hypertrophy, inverted pattern of cristae). Dense bodies with double membrane as well as altered fibrocytes and myocytes were noticed after longer periods of intoxication. Ischemic disease of neurons developed after 3 months of ethanol administration, probably against the background of severe mitochondrial damage. Some features suggested reconstruction of the cell population in intramural ganglia.