Pub Date : 2026-01-15DOI: 10.1186/s12957-026-04195-9
Nattaya Raykateeraroj, Fabien Chu, Je Min Suh, Luca Petterlin, Ella Francis, Junyan Zhao, Prabhashi Ratnayakemudiyanselage, Fawaz Ahmed Prem Navaz, Chin Jin Ker, Sepideh Roshanaei, Harry Botta, Jacques Elias, Evina Ling, Ronald Ma, Stephen A Barnett, Simon Knight, Dong-Kyu Lee, Laurence Weinberg
{"title":"Textbook outcome and long-term survival after pulmonary resection for non-small cell lung cancer: a retrospective cohort study.","authors":"Nattaya Raykateeraroj, Fabien Chu, Je Min Suh, Luca Petterlin, Ella Francis, Junyan Zhao, Prabhashi Ratnayakemudiyanselage, Fawaz Ahmed Prem Navaz, Chin Jin Ker, Sepideh Roshanaei, Harry Botta, Jacques Elias, Evina Ling, Ronald Ma, Stephen A Barnett, Simon Knight, Dong-Kyu Lee, Laurence Weinberg","doi":"10.1186/s12957-026-04195-9","DOIUrl":"10.1186/s12957-026-04195-9","url":null,"abstract":"","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":" ","pages":"73"},"PeriodicalIF":2.5,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12892612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145991108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-13DOI: 10.1186/s12957-025-04166-6
Atef A Hassan, Mohamed Hamouda Elkasaby, Hazem A Megahed, Abdorabih Alemam, Mohamed Naroz, Ahmed M Kandel, Ahmed Fayez Othman, Mohammed Eid Abdelrahman, Mohammed Ali Abdelaty, Boshra Ali El-Houseiny, Khaled Mohamed Salamh, Rasha Mohamed Motawea, Hassan Elsayed Younes, Ashraf Ali Abdel Aziz, Ahmed Ali Eldin Taki-Eldin
Background: Gastric outlet obstruction (GOO) complicates unresectable gastric and pancreatic cancers. Conventional gastrojejunostomy (CGJ) is standard but frequently leads to delayed gastric emptying. Stomach-partitioning gastrojejunostomy (SPGJ) mitigates this problem and improves outcomes.
Methods: We conducted a meta-analysis of SPGJ versus CGJ for GOO, searching databases through 25 November 2025. Outcomes were delayed gastric emptying (DGE), major complications, reintervention, 30-day mortality, operative time, Gastric Outlet Obstruction Scoring System (GOOS) scores, length of stay, chemotherapy adherence, and survival. Continuous variables were pooled as mean differences (MD) with 95% CIs; dichotomous variables as relative risks (RR) with 95% CIs. Survival was analyzed using individual patient data reconstructed from Kaplan-Meier curves.
Results: A total of 11 studies comprising 456 patients were included. SPGJ was associated with significantly reduced DGE (RR = 0.24, 95% CI: 0.12-0.47) and postoperative major complications (RR = 0.26, 95% CI: 0.12-0.54) compared to CGJ. No significant differences were found in the need for reintervention (RR = 0.59, 95% CI: 0.21-1.64), short-term mortality (RR = 0.99, 95% CI: 0.42-2.33), or LOS (MD = -1.47 days, 95% CI: -3.10 to 0.16). GOOS scores were comparable between groups. Overall survival was also similar between SPGJ and CGJ (HR = 1.06, 95% CI: 0.66-1.70).
Conclusions: Our meta-analysis shows that SPGJ offers important clinical advantages over CGJ by significantly reducing delayed gastric emptying and postoperative major complications, while demonstrating comparable GOOS scores, length of stay, reintervention rates, and short- and long-term survival. These findings support SPGJ as a viable and potentially preferable option for managing malignant GOO, although high-quality randomized trials are still needed.
{"title":"Gastric partitioning compared to conventional gastrojejunostomy as palliative surgeries in patients with gastric outlet obstruction: a pairwise and individual patient data meta-analysis.","authors":"Atef A Hassan, Mohamed Hamouda Elkasaby, Hazem A Megahed, Abdorabih Alemam, Mohamed Naroz, Ahmed M Kandel, Ahmed Fayez Othman, Mohammed Eid Abdelrahman, Mohammed Ali Abdelaty, Boshra Ali El-Houseiny, Khaled Mohamed Salamh, Rasha Mohamed Motawea, Hassan Elsayed Younes, Ashraf Ali Abdel Aziz, Ahmed Ali Eldin Taki-Eldin","doi":"10.1186/s12957-025-04166-6","DOIUrl":"10.1186/s12957-025-04166-6","url":null,"abstract":"<p><strong>Background: </strong>Gastric outlet obstruction (GOO) complicates unresectable gastric and pancreatic cancers. Conventional gastrojejunostomy (CGJ) is standard but frequently leads to delayed gastric emptying. Stomach-partitioning gastrojejunostomy (SPGJ) mitigates this problem and improves outcomes.</p><p><strong>Methods: </strong>We conducted a meta-analysis of SPGJ versus CGJ for GOO, searching databases through 25 November 2025. Outcomes were delayed gastric emptying (DGE), major complications, reintervention, 30-day mortality, operative time, Gastric Outlet Obstruction Scoring System (GOOS) scores, length of stay, chemotherapy adherence, and survival. Continuous variables were pooled as mean differences (MD) with 95% CIs; dichotomous variables as relative risks (RR) with 95% CIs. Survival was analyzed using individual patient data reconstructed from Kaplan-Meier curves.</p><p><strong>Results: </strong>A total of 11 studies comprising 456 patients were included. SPGJ was associated with significantly reduced DGE (RR = 0.24, 95% CI: 0.12-0.47) and postoperative major complications (RR = 0.26, 95% CI: 0.12-0.54) compared to CGJ. No significant differences were found in the need for reintervention (RR = 0.59, 95% CI: 0.21-1.64), short-term mortality (RR = 0.99, 95% CI: 0.42-2.33), or LOS (MD = -1.47 days, 95% CI: -3.10 to 0.16). GOOS scores were comparable between groups. Overall survival was also similar between SPGJ and CGJ (HR = 1.06, 95% CI: 0.66-1.70).</p><p><strong>Conclusions: </strong>Our meta-analysis shows that SPGJ offers important clinical advantages over CGJ by significantly reducing delayed gastric emptying and postoperative major complications, while demonstrating comparable GOOS scores, length of stay, reintervention rates, and short- and long-term survival. These findings support SPGJ as a viable and potentially preferable option for managing malignant GOO, although high-quality randomized trials are still needed.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":" ","pages":"56"},"PeriodicalIF":2.5,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145966678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-09DOI: 10.1186/s12957-025-04189-z
Cai Gao, Xuebing Li, Xinwei Liu, Sha Yan, Xiaodan Ran, Jingxian Han
<p><strong>Objective: </strong>This study aimed to identify novel circulating protein biomarkers for hepatocellular carcinoma (HCC) superior to alpha-fetoprotein (AFP) by integrating tumor stemness index and secreted protein screening, and to explore their roles in prognosis, immune microenvironment, and tumor mechanisms.</p><p><strong>Methods: </strong>Stemness-associated differentially expressed genes were identified from TCGA (The Cancer Genome Atlas) and GEO (Gene Expression Omnibus) databases after applying ComBat batch effect correction and quantile normalization to harmonize the datasets. WGCNA (weighted gene co-expression network analysis), secreted protein databases, and plasma sequencing were used to select candidate genes. Functional and immune infiltration analyses were performed, alongside multivariable Cox regression modeling and inverse variance weighted (IVW) MendelianRandomization (MR) for prognostic and causal validation.</p><p><strong>Results: </strong>A total of 19 genes significantly associated with tumor stemness and detectable in circulation were identified. After filtering based on clinicopathological features and survival analysis, 10 key genes were selected. The receiver operating characteristic (ROC) curve analysis revealed that, aside from FCN3 (ficolin 3), the diagnostic sensitivity and specificity of CRHBP (corticotropin-releasing hormone binding protein), CLEC3B (C-type lectin domain family 3 member B), TEK (TEK receptor tyrosine kinase), SOGA1 (SOGA family member 1), IL33 (interleukin 33), CXCL12 (C-X-C motif chemokine ligand 12), NENF (neudesin neurotrophic factor), and ITM2B (integral membrane protein 2B) (AUCs [area under the curves] ranging from 0.67 to 0.99) surpassed those of AFP (AUC = 0.64). Cibersort analysis indicated significant associations of CRHBP, CLEC3B, TEK, IL33, NENF, CXCL12, and AFP with various immune cell infiltrates. The gene set enrichment analysis (GSEA) suggested that CRHBP, CLEC3B, TEK, NENF, and AFP were primarily enriched in cell cycle-related pathways, whereas IL33, CXCL12, SOGA1, and ITM2B were involved in MAPK, GNRH, and NOTCH signaling. A multivariable Cox regression model identified CLEC3B, TEK, and NENF for constructing a prognostic signature, which demonstrated strong predictive performance in the TCGA cohort, as evidenced by the concordance index (C-index), time-dependent ROC analysis (1-/3-/5-year AUCs: 0.74/0.72/0.70), and decision curve analysis. IVW MR analysis further confirmed a causal relationship between cis-expression quantitative trait loci (cis-eQTLs) of the NENF gene and HCC risk (P = 0.024), with no significant pleiotropy or heterogeneity detected. Elevated NENF protein expression, validated by proteomic and immunohistochemical analyses of public databases and a tissue microarray cohort, was significantly associated with HCC progression and reduced overall survival (hazard ratio [HR], 2.456; 95% CI, 1.271-4.960; P = 0.012).</p><p><strong>Conclusion: </strong>This mu
{"title":"Identification of novel circulating protein biomarkers for hepatocellular carcinoma superior to alpha-fetoprotein through a stemness index and secretome analysis.","authors":"Cai Gao, Xuebing Li, Xinwei Liu, Sha Yan, Xiaodan Ran, Jingxian Han","doi":"10.1186/s12957-025-04189-z","DOIUrl":"https://doi.org/10.1186/s12957-025-04189-z","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to identify novel circulating protein biomarkers for hepatocellular carcinoma (HCC) superior to alpha-fetoprotein (AFP) by integrating tumor stemness index and secreted protein screening, and to explore their roles in prognosis, immune microenvironment, and tumor mechanisms.</p><p><strong>Methods: </strong>Stemness-associated differentially expressed genes were identified from TCGA (The Cancer Genome Atlas) and GEO (Gene Expression Omnibus) databases after applying ComBat batch effect correction and quantile normalization to harmonize the datasets. WGCNA (weighted gene co-expression network analysis), secreted protein databases, and plasma sequencing were used to select candidate genes. Functional and immune infiltration analyses were performed, alongside multivariable Cox regression modeling and inverse variance weighted (IVW) MendelianRandomization (MR) for prognostic and causal validation.</p><p><strong>Results: </strong>A total of 19 genes significantly associated with tumor stemness and detectable in circulation were identified. After filtering based on clinicopathological features and survival analysis, 10 key genes were selected. The receiver operating characteristic (ROC) curve analysis revealed that, aside from FCN3 (ficolin 3), the diagnostic sensitivity and specificity of CRHBP (corticotropin-releasing hormone binding protein), CLEC3B (C-type lectin domain family 3 member B), TEK (TEK receptor tyrosine kinase), SOGA1 (SOGA family member 1), IL33 (interleukin 33), CXCL12 (C-X-C motif chemokine ligand 12), NENF (neudesin neurotrophic factor), and ITM2B (integral membrane protein 2B) (AUCs [area under the curves] ranging from 0.67 to 0.99) surpassed those of AFP (AUC = 0.64). Cibersort analysis indicated significant associations of CRHBP, CLEC3B, TEK, IL33, NENF, CXCL12, and AFP with various immune cell infiltrates. The gene set enrichment analysis (GSEA) suggested that CRHBP, CLEC3B, TEK, NENF, and AFP were primarily enriched in cell cycle-related pathways, whereas IL33, CXCL12, SOGA1, and ITM2B were involved in MAPK, GNRH, and NOTCH signaling. A multivariable Cox regression model identified CLEC3B, TEK, and NENF for constructing a prognostic signature, which demonstrated strong predictive performance in the TCGA cohort, as evidenced by the concordance index (C-index), time-dependent ROC analysis (1-/3-/5-year AUCs: 0.74/0.72/0.70), and decision curve analysis. IVW MR analysis further confirmed a causal relationship between cis-expression quantitative trait loci (cis-eQTLs) of the NENF gene and HCC risk (P = 0.024), with no significant pleiotropy or heterogeneity detected. Elevated NENF protein expression, validated by proteomic and immunohistochemical analyses of public databases and a tissue microarray cohort, was significantly associated with HCC progression and reduced overall survival (hazard ratio [HR], 2.456; 95% CI, 1.271-4.960; P = 0.012).</p><p><strong>Conclusion: </strong>This mu","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145935276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-06DOI: 10.1186/s12957-025-04161-x
Baoji Xing, Meini Cen, Yin Yu, Feng Feng, Zhao Wang
Aims: To investigate the expression and potential mechanism of action of miR-146b-5p in prostate cancer (PCa).
Methods: Quantification of miR-146b-5p and FOXO3 expression by RT-qPCR was performed on 140 paired PCa and normal adjacent tissues. Kaplan-Meier curves and Cox regression models were used to analyze the relationship between miR-146b-5p expression and 5-year survival outcomes. In vitro experiments were performed in PC-3 and 22RV1 cells to explore the regulatory relationship between miR-146b-5p and FOXO3.
Results: miR-146b-5p is markedly upregulated in PCa tissues and cell lines, exhibiting a significant correlation with tumor stage, Gleason score, lymph node metastasis, and unfavorable prognosis. miR-146b-5p overexpression promoted PCa cell proliferation, migration, and invasion, while inhibition exerted opposite effects. Bioinformatics prediction and dual-luciferase assay confirmed that miR-146b-5p directly targeted the 3'UTR of FOXO3, negatively regulating its expression. Rescue experiments demonstrated that silencing FOXO3 reversed the inhibitory effects of miR-146b-5p inhibitor on PCa cell malignancy.
Conclusions: miR-146b-5p drives PCa progression through the targeted downregulation of FOXO3, implicating it as a promising prognostic marker and therapeutic target.
{"title":"miR-146b-5p promotes prostate cancer progression by targeting and negatively regulating FOXO3 and its mechanism.","authors":"Baoji Xing, Meini Cen, Yin Yu, Feng Feng, Zhao Wang","doi":"10.1186/s12957-025-04161-x","DOIUrl":"10.1186/s12957-025-04161-x","url":null,"abstract":"<p><strong>Aims: </strong>To investigate the expression and potential mechanism of action of miR-146b-5p in prostate cancer (PCa).</p><p><strong>Methods: </strong>Quantification of miR-146b-5p and FOXO3 expression by RT-qPCR was performed on 140 paired PCa and normal adjacent tissues. Kaplan-Meier curves and Cox regression models were used to analyze the relationship between miR-146b-5p expression and 5-year survival outcomes. In vitro experiments were performed in PC-3 and 22RV1 cells to explore the regulatory relationship between miR-146b-5p and FOXO3.</p><p><strong>Results: </strong>miR-146b-5p is markedly upregulated in PCa tissues and cell lines, exhibiting a significant correlation with tumor stage, Gleason score, lymph node metastasis, and unfavorable prognosis. miR-146b-5p overexpression promoted PCa cell proliferation, migration, and invasion, while inhibition exerted opposite effects. Bioinformatics prediction and dual-luciferase assay confirmed that miR-146b-5p directly targeted the 3'UTR of FOXO3, negatively regulating its expression. Rescue experiments demonstrated that silencing FOXO3 reversed the inhibitory effects of miR-146b-5p inhibitor on PCa cell malignancy.</p><p><strong>Conclusions: </strong>miR-146b-5p drives PCa progression through the targeted downregulation of FOXO3, implicating it as a promising prognostic marker and therapeutic target.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":" ","pages":"66"},"PeriodicalIF":2.5,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12870093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145913119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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