World Journal of Pediatrics最新文献

Background: Ultrasound and serum matrix metalloproteinase-7 (MMP-7) hold great value in distinguishing biliary atresia (BA) from other cholestatic diseases. This study aims to assess the accuracy of an artificial intelligence (AI) based diagnostic model of ultrasound combined with serum MMP-7 in discriminative diagnosis of BA.

Methods: This is a multicenter diagnostic study involving six medical centers in China. Patients with obstructive jaundice were enrolled. A set of morphological operators were employed to extract features of the ultrasound images to construct an AI algorithm. Logistic regression model was established with validation.

Results: Two cohorts with a total of 348 children with obstructive jaundice were recruited from January 2020 to April 2023. A retrospective cohort of 187 infants served as a training cohort; this included 56 BA and 131 non-BA patients. Serum MMP-7 testing model yielded an area under the receiver-operating characteristic curve (AUROC) of 0.916 [95% confidence interval (CI) = 0.876-0.956], sensitivity of 94.6% (95% CI = 85.1%-98.9%), specificity of 88.6% (95% CI = 81.8%-93.5%), and accuracy of 90.4% (95% CI = 85.2%-94.2%). Values for ultrasound testing model were 0.945 (95% CI = 0.902-0.987), 98.2% (95% CI = 90.5%-99.9%), 91.6% (95% CI = 85.5%-95.7%), and 93.6% (95% CI = 89.1%-96.6%), respectively. The combined AI model obtained an AUROC of 0.985 (95% CI = 0.971-0.999), sensitivity of 98.2% (95% CI = 90.5%-99.9%), specificity of 93.1% (95% CI = 84.4%-96.4%), and accuracy of 94.7% (95% CI = 90.4%-97.4%), respectively. Performance was confirmed using a multicenter prospective validation cohort of 161 patients that included 100 BA cases.

Conclusion: An AI model combining ultrasound and serum MMP-7 demonstrated robust high sensitivity and specificity in the differential diagnosis of BA.

Background: Childhood cancer survivors (CCSs) are at increased risk of long-term treatment-related complications. Although international guidelines support risk-based long-term follow-up (LTFU) care, its standardized implementation in China has been limited. To address this gap, the National Children's Medical Center-Shanghai convened a multidisciplinary expert panel to develop disease-based LTFU care plans tailored to the Chinese healthcare context.

Methods: Guided by established international frameworks (Children's Oncology Group, International Guideline Harmonization Group, and PanCareFollowUp), an expert group representing 25 institutions across China developed consensus-based LTFU care plans for common pediatric cancer patients and post-hematopoietic cell transplant survivors. Each care plan includes core components: a treatment summary, risk stratification for late effects, recommended surveillance, psychosocial evaluation, and lifestyle guidance. The panel also developed a consensus on the specific roles of oncologists, primary care providers, and subspecialists.

Results: Finalized care plans provide structured, risk-adapted follow-up pathways for CCSs. The model emphasizes multidisciplinary collaboration, clinical feasibility, and scalability across diverse settings. As part of the care process, a centralized survivorship database has been integrated to facilitate clinical use and data collection. This system supports the generation of standardized treatment summaries and longitudinal documentation of late effects across the continuum of survivorship care. Tools, such as clinician checklists and survivor education templates, were also developed to support clinical use and promote consistency across institutions. A list of outcome metrics was proposed to evaluate the implementation outcomes of this initiative.

Conclusions: This expert consensus establishes an innovative, nationally coordinated, disease-specific LTFU care framework for CCSs in China. This study provides a practical foundation for improving survivorship care quality and guiding clinical practice nationwide. This model can serve as a blueprint for other low- and middle-income countries seeking to strengthen LTFU care for CCSs.

Background: Posterior drooling and saliva aspiration are hidden threats to progressive respiratory morbidity in patients with cerebral palsy (CP). This study aimed to identify and synthesize current evidence on the definitions, prevalence, pathophysiology, diagnosis and treatment of posterior drooling and saliva aspiration in children with CP.

Methods: This was a scoping review. The inclusion criteria were articles focused on the objectives of the study; published between January 2000 and June 2025; written in English, Portuguese, Spanish, French or Italian; and whose full texts were available. The PubMed, Virtual Health Library, Scielo, Cochrane Library, Scopus and EMBASE databases were searched.

Results: A total of 1195 citations were identified by our search strategy, with 637 remaining after the removal of 558 duplicates. After screening titles and abstracts, 304 citations progressed to full-text review. A total of 86 articles met the eligibility criteria and were included in the review. While 28 articles were excluded because they lacked access to full texts and/or were not written in the selected languages, only 114 (9.5%) studies involved posterior drooling/saliva aspiration.

Conclusions: A large discrepancy was evident, with a much larger volume of studies on anterior drooling than on posterior drooling/saliva aspiration. This article highlights the need for more research and greater emphasis on these conditions in pediatric clinical practice. Early and reliable diagnosis and proactive interventions are essential to prevent progressive lung injury, lower respiratory tract infections, hospitalizations, impaired quality of life, and premature death.

Background: Spinal cord injury is a catastrophic medical condition and a growing global public health priority, with divergent etiologies, risk factors, and epidemiology. Comprehensive analyses of trends in pediatric spinal cord injury burden both in China and globally are lacking.

Methods: We investigated temporal trends in pediatric spinal cord injury burden [incidence, prevalence, and years lived with disability (YLDs)] from 1990 to 2021 and projected future burden to 2045 using Global Burden of Disease (GBD) 2021 data. The year with the most significant changes in trends was identified via joinpoint regression analysis. Age-standardized rates, average annual percentage changes (AAPC), and subgroup analyses by injury location, sex, age, and sociodemographic index were calculated. To project burden data to 2045, we employed a Bayesian age‒period‒cohort model.

Results: Our analyses revealed that global pediatric spinal cord injury incidence [AAPC: - 1.13; 95% confidence interval (CI): - 1.49 to - 0.76], prevalence (AAPC: - 1.13; 95% CI: - 1.16 to - 1.11), and YLDs rates (AAPC: - 1.37; 95% CI: - 1.41 to - 1.35) decreased significantly from 1990 to 2021. The highest burden was observed in males, adolescents (15-19 years), and high-sociodemographic index regions; falls were the leading cause. China exhibited similar declining trends (e.g., incidence AAPC: - 1.33; 95% CI: - 1.71 to - 0.83). It is predicted that by 2045, the global trend of pediatric spinal cord injury will decline; China will exhibit an upward trend.

Conclusions: Persistent disparities in pediatric spinal cord injury disease burden and causes necessitate targeted prevention strategies, optimized rehabilitation services, and equitable resource allocation. This is particularly important in high-risk groups and regions with rising burdens.

Background: Major depressive disorder is a major cause of disability and health-related burden globally. Repetitive transcranial magnetic stimulation (rTMS) has emerged as a promising alternative therapy for major depressive disorder in adults, but its efficacy and safety in 10-25 years (youth) with depression remains inconclusive. We aim to evaluate the efficacy and safety of rTMS in youth with depression in randomized sham-controlled trials.

Methods: A comprehensive search of nine databases was conducted from inception to April 30, 2025. Trials using random assignment with a sham control group were selected. Heterogeneity among studies was assessed using the I² and Cochran Q test. A random-effects model was employed when I² > 50%. Standard mean deviation (SMD) for depression rating scale scores and risk difference (RD) with corresponding 95% confidence intervals (CIs) of adverse event were used to evaluate efficacy and safety, respectively.

Results: Sixteen studies with 1295 patients aged 10-25 years were included. Meta-analysis showed that active rTMS significantly reduced depression scale scores (SMD = - 0.93, 95% CI = - 1.31 to - 0.55). Subgroup analysis revealed significant relief of depressive symptoms at the second week (SMD =  - 0.66, 95% CI = - 1.25 to - 0.07) and persisting at the fourth week (SMD =  - 1.28, 95% CI = - 1.82 to - 0.75) when compared to sham stimulation. Pooled RR was 1.24 (95% CI = 1.06-1.45) for response rate and 1.63 (95% CI = 1.11-2.39) for remission rate (with an associated number needed to treat of 10).

Conclusions: Evidence indicates that rTMS is effective, safe and exhibits a relatively rapid onset of action for treating youth depression. Larger-scale studies with longer treatment durations and extended follow-up periods are essential to understand and characterize the short- and long-term neuromodulatory effects within this vulnerable population. The effect of rTMS in treatment-resistant depression and its use across diverse populations also need further investigation.

Background: Epilepsy affects millions of patients worldwide, and approximately one-third of patients are resistant to antiepileptic drugs. Dietary therapies, such as ketogenic diet (KD), modified Atkins diet (MAD), and low glycemic index treatment, have shown potential in seizure control. This review aims to evaluate the effectiveness and safety of these dietary interventions in reducing seizure frequency and improving related outcomes in individuals with drug-resistant epilepsy.

Methods: A comprehensive search of PubMed, Scopus, the Cochrane Library, and Web of Science was conducted up to December 2024 and updated in May 2025. Eligible studies were randomized controlled trials and prospective cohort studies evaluating KDs in patients with drug-resistant epilepsy. The primary outcomes included seizure reduction (≥ 50%, ≥ 90%, or complete cessation), whereas the secondary outcomes included cognitive function, quality of life, and adverse events. The risk of bias was assessed via the Cochrane Risk of Bias 2 tool. Meta-analyses were performed via R (version 4.3.2), with odds ratios (ORs) and 95% confidence intervals (CIs) calculated. Fixed- or random-effects models were applied on the basis of heterogeneity levels.

Results: Dietary interventions significantly increased ≥ 50% seizure reduction [odds ratio (OR) = 3.46, 95% CI = 1.83-6.56] compared with standard care, with stronger effects in pediatric patients (OR = 10.93 vs. 2.54 in adults, P = 0.007). MAD outperformed standard care (OR = 4.04), whereas KD did not (OR = 1.83). For a ≥ 90% reduction, KD had greater efficacy (OR = 6.23) than MAD did (OR = 1.98). No significant difference was found for complete seizure resolution (OR = 1.19). Adverse events varied: constipation was most common with MAD (30.97%), whereas KD had higher rates of respiratory infections (42.77%, P < 0.0001 vs. MAD) and diarrhea (13.75% vs. 8.11%, P = 0.0017). Heterogeneity was substantial in most analyses (I² > 75%).

Conclusions: KDs and MADs are effective in reducing seizures in patients with drug-resistant epilepsy, especially in children. However, claims of seizure freedom remain uncertain. Further high-quality trials are needed to compare diets and assess long-term safety.