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The psychosocial effects of Female Genital Mutilation in sub-Saharan Africa: A scoping review. 撒哈拉以南非洲女性生殖器切割的社会心理影响:范围审查。
IF 1.4 4区 医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-08-01 Epub Date: 2025-09-01 DOI: 10.1080/03630242.2025.2547608
Daniel Lesiba Letsoalo, Mahlatsi Venolia Semenya

Female Genital Mutilation (FGM) is a deeply ingrained cultural practice in many regions of sub-Saharan Africa, involving the partial or complete removal of external genitalia for non-medical purposes. It is estimated that millions of women are affected by this. Despite global attempts to eradicate this behavior, it continues to be prevalent, causing severe psychological and social repercussions for those affected. Noteworthy effects encompass anxiety, depression, post-traumatic stress disorder (PTSD), chronic pain, infections, and complications related to childbirth. The purpose of this scoping review, conducted against this background, was to comprehensively examine and synthesize the available research on the psychosocial effects of FGM in sub-Saharan Africa, while also identifying key themes and gaps in the literature. To incorporate the latest research, the review encompassed a ten-year period from 2014 to 2024. The study adopted the Arksey and O'Malley methodology and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guidelines for comprehensive analysis and reporting. Medical Subject Headings (MeSH) terms, Boolean keywords, and truncations were utilized to search relevant studies in selected databases. The consulted databases included Academic Search Ultimate, APA PsycArticles, APA PsycInfo, Global Health, CINAHL Plus with Full Text, MEDLINE, and Taylor and Francis Online. The identified studies were crosschecked by conducting a manual search on Google Scholar and Google. The results showed that victims of FGM experience numerous negative psychosocial consequences. Community-based education programs, support groups for victims, increased resources, sensitively trained healthcare professionals, and strict enforcement of FGM laws are all essential in addressing this conundrum. Conducting longitudinal studies is suggested to track victims' long-term psychosocial effects.

切割女性生殖器官是撒哈拉以南非洲许多地区根深蒂固的文化习俗,涉及为非医疗目的部分或完全切除外部生殖器。据估计,数百万妇女受到这一问题的影响。尽管全球都在努力根除这种行为,但它仍然普遍存在,给受影响的人造成严重的心理和社会影响。值得注意的影响包括焦虑、抑郁、创伤后应激障碍(PTSD)、慢性疼痛、感染和与分娩有关的并发症。在此背景下进行的这一范围审查的目的是全面审查和综合撒哈拉以南非洲地区关于女性生殖器切割的社会心理影响的现有研究,同时确定文献中的关键主题和空白。为了纳入最新的研究,该审查涵盖了从2014年到2024年的十年时间。本研究采用了Arksey和O'Malley方法,以及用于系统评价和元分析扩展范围评价的首选报告项目(PRISMA-ScR)指南进行综合分析和报告。使用医学主题词(MeSH)术语、布尔关键词和截断在选定的数据库中搜索相关研究。咨询的数据库包括Academic Search Ultimate、APA PsycArticles、APA PsycInfo、Global Health、CINAHL Plus with Full Text、MEDLINE和Taylor and Francis Online。通过在谷歌Scholar和谷歌上进行人工搜索,对已确定的研究进行交叉检查。结果表明,女性生殖器切割的受害者经历了许多负面的社会心理后果。以社区为基础的教育方案、受害者支持小组、增加资源、训练有素的保健专业人员以及严格执行切割女性生殖器官的法律,都是解决这一难题的关键。建议进行纵向研究,以跟踪受害者的长期心理社会影响。
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引用次数: 0
The effect of positive birth story videos on women's fear of birth, childbirth self- efficacy and birth preference: A randomized controlled study. 积极分娩故事影片对女性分娩恐惧、分娩自我效能感和生育偏好的影响:一项随机对照研究。
IF 1.4 4区 医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-08-01 Epub Date: 2025-07-23 DOI: 10.1080/03630242.2025.2537659
Feyza Aktaş Reyhan, Elif Dağli

Fear of childbirth is a common concern among primiparous women and may negatively affect their confidence and birth preferences. This randomized controlled trial examined the effects of positive birth story videos on childbirth fear, self-efficacy, and birth beliefs. A total of 120 primiparous women between 24 and 28 weeks of gestation were randomly assigned to an intervention group (n = 60), which attended four weekly digital storytelling workshops featuring positive birth videos, or a control group (n = 60), which received routine antenatal education. Measures were taken at baseline, four weeks post-intervention, and within 24 hours postpartum. At baseline, both groups had similar scores in fear of childbirth, childbirth self-efficacy, and birth beliefs (p > .05). After the intervention, the intervention group had significantly lower mean scores for fear of childbirth (18.17 ± 3.51) compared to the control group (55.12 ± 7.23). Their beliefs in a medicalized birth process were also lower (22.12 ± 4.19 vs. 24.87 ± 2.91), while childbirth self-efficacy (288.77 ± 13.49 vs. 248.13 ± 15.30) and beliefs in a natural birth process (24.73 ± 3.46 vs. 18.27 ± 2.73) were significantly higher (p < .001 for all). These findings suggest that integrating digital storytelling with positive birth narratives into antenatal education may effectively reduce fear of childbirth and enhance women's self-efficacy and preference for physiological birth.

对分娩的恐惧是初产妇女普遍关心的问题,并可能对她们的信心和生育偏好产生负面影响。这个随机对照试验检验了积极的分娩故事视频对分娩恐惧、自我效能和分娩信念的影响。共有120名怀孕24至28周的初产妇被随机分配到干预组(n = 60)和对照组(n = 60),干预组每周参加四次以积极分娩视频为特色的数字讲故事讲习班,对照组接受常规产前教育。在基线、干预后4周和产后24小时内采取措施。在基线时,两组在分娩恐惧、分娩自我效能和分娩信念方面得分相似(p < 0.05)。干预后,干预组分娩恐惧平均得分(18.17±3.51)明显低于对照组(55.12±7.23)。分娩自我效能感(288.77±13.49比248.13±15.30)和自然分娩自我效能感(24.73±3.46比18.27±2.73)显著高于分娩自我效能感(p < 0.05)
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引用次数: 0
Benign gynecological diseases and women's health burden: time to remove the invisibility cloak. 良性妇科疾病与女性健康负担:是时候脱掉隐形斗篷了。
IF 1.4 4区 医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-08-01 Epub Date: 2025-09-04 DOI: 10.1080/03630242.2025.2557044
Márcia Mendonça Carneiro
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引用次数: 0
Effect of zinc supplementation on premenstrual symptoms: A systematic review and meta-analysis. 锌补充剂对经前症状的影响:一项系统回顾和荟萃分析。
IF 1.4 4区 医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-08-01 Epub Date: 2025-07-30 DOI: 10.1080/03630242.2025.2539815
Young Man Kim, Jihyun Baek

This systematic review and meta-analysis aimed to evaluate the efficacy of zinc supplementation for alleviating premenstrual symptoms (PMS) in women of reproductive age. A literature search was conducted across six electronic databases. Five randomized controlled trials were included in the qualitative synthesis and four were eligible for meta-analysis. All studies had some concerns for risk of bias. The certainty of the evidence was evaluated using the Grading of Recommendations, Assessment, Development, and Evaluation framework. Zinc supplementation reduced total PMS scores and emotional symptoms with moderate certainty of evidence, while physical symptoms were supported by low certainty of evidence. Meta-analyses revealed that zinc supplementation significantly reduced total PMS scores (Hedges's g =  -0.384), emotional symptoms (g =  -0.347), and physical symptoms (g =  -0.512), all favoring the intervention. Sensitivity analyses confirmed the robustness of results for the total and emotional domains, but the effect sizes for physical symptoms were moderately influenced by individual studies. In conclusion, zinc supplementation shows promise as a non-pharmacological intervention for reducing PMS. However, its generalizability is limited by the small number of trials and methodological heterogeneity. Further, multicenter RCTs with standardized protocols are warranted to establish clinical utility and explore dose - response relationships.

本系统综述和荟萃分析旨在评估补充锌对缓解育龄妇女经前症状(PMS)的疗效。在六个电子数据库中进行了文献检索。定性综合纳入5个随机对照试验,其中4个符合meta分析条件。所有的研究都存在一定的偏倚风险。采用建议分级、评估、发展和评估框架评估证据的确定性。补充锌可以降低经前综合症的总评分和情绪症状,证据的确定性中等,而身体症状的证据确定性较低。荟萃分析显示,补锌显著降低经前综合症总分(Hedges’s g = -0.384)、情绪症状(g = -0.347)和身体症状(g = -0.512),均有利于干预。敏感性分析证实了总体和情绪领域结果的稳健性,但身体症状的效应大小受到个别研究的适度影响。总之,锌补充剂有望作为一种非药物干预减少经前综合症。然而,其普遍性受到试验数量少和方法异质性的限制。此外,标准化方案的多中心随机对照试验有必要建立临床效用并探索剂量-反应关系。
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引用次数: 0
HPV vaccine reporting in Taiwan: media and politics, 2005-2018. 台湾HPV疫苗报告:2005-2018年媒体与政治。
IF 1.4 4区 医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-08-01 Epub Date: 2025-07-31 DOI: 10.1080/03630242.2025.2539818
Chia-Fang Chang, Darren Liu, Chiung-Ying Kuan, Yao-Mao Chang, Tung-Liang Chiang

This study analyzes the media coverage of HPV vaccines in Taiwan from 2005 to 2018, with a focus on adherence to World Health Organization (WHO) media guidelines and the influence of election cycles on reporting patterns. A content analysis of 911 articles from four major newspapers revealed peaks in 2008, 2014, and 2018 election years, coinciding with vaccines policy rollouts. Most articles (78 percent) appeared in national news sections, with medical professionals cited in 36.3 percent of cases. Coverage primarily emphasized vaccine policy (36.3 percent) and health education (36.4 percent), with 83 percent of articles portraying HPV vaccination positively and 88 percent explicitly endorsing it. However, only 42 percent adhered to WHO's media communication guidelines, and headlines often misaligned with article content. These findings highlight the media's advocacy role during key political and public health events, while underscoring the need for improved journalistic practices to ensure accurate, guideline-consistent vaccine communication.

本研究分析了2005年至2018年台湾HPV疫苗的媒体报道,重点关注遵守世界卫生组织(WHO)媒体指南以及选举周期对报道模式的影响。对四家主要报纸的911篇文章的内容分析显示,2008年、2014年和2018年的选举年出现了高峰,恰逢疫苗政策推出。大多数文章(78%)出现在国家新闻板块,其中36.3%的案例引用了医疗专业人士。覆盖率主要强调疫苗政策(36.3%)和健康教育(36.4%),83%的文章积极描述HPV疫苗接种,88%的文章明确支持HPV疫苗接种。然而,只有42%的人遵守了世卫组织的媒体传播准则,标题往往与文章内容不一致。这些发现突出了媒体在重大政治和公共卫生事件中的宣传作用,同时强调需要改进新闻实践,以确保准确、符合指南的疫苗传播。
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引用次数: 0
Perceived barriers and physical activity levels in women with endometriosis: The role of symptoms. 子宫内膜异位症患者的感知障碍和身体活动水平:症状的作用
IF 1.4 4区 医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-08-01 Epub Date: 2025-08-29 DOI: 10.1080/03630242.2025.2549986
Nerea Blanco-Martínez, Silvia Varela, Carlos Ayán-Pérez, José Carlos Diz-Gómez

Endometriosis affects approximately 10 percent of women of reproductive age. Although physical activity has shown beneficial effects for managing endometriosis-related symptoms, women with this condition often engage in lower levels of activity. This study aimed to assess physical activity levels and identify perceived barriers to exercise among women diagnosed with endometriosis. A cross-sectional study was conducted using online questionnaires distributed through endometriosis associations in Spain. Participants (n = 154, mean age: 39 ± 7 years) completed the Barriers to Being Active Quiz (BBAQ) and the International Physical Activity Questionnaire - Short Form (IPAQ-SF). Sociodemographic and clinical data were also collected to explore potential associations between symptoms and activity patterns. The most prevalent barriers were lack of energy (68.2 percent) and lack of willpower (50.0 percent). Lack of energy was significantly associated with pain, dysmenorrhea, fatigue, and depression, and emerged as the primary limiting factor. Despite reporting moderate-to-high levels of physical activity, as defined by IPAQ criteria - moderate (≥600 MET-min/week) or high (≥1,500 MET-min/week with vigorous activity ≥ 3 days/week, or ≥ 3,000 MET-min/week with activity on ≥ 7 days/week) - symptoms such as pain (79.2 percent) and fatigue (79.9 percent) remained prevalent. Psychological and physical symptoms, especially fatigue and depression, significantly influence exercise participation among women with endometriosis. These findings underscore the need for tailored strategies to address perceived barriers and promote sustained physical activity in this population. Integrating psychological support and individualized exercise guidance, and pain management interventions, may enhance adherence and long-term outcomes.

子宫内膜异位症影响了大约10%的育龄妇女。尽管体育锻炼对控制子宫内膜异位症相关症状有有益作用,但患有这种疾病的女性通常运动量较低。这项研究旨在评估被诊断为子宫内膜异位症的女性的身体活动水平,并确定运动的感知障碍。一项横断面研究是通过西班牙子宫内膜异位症协会分发的在线问卷进行的。参与者(n = 154,平均年龄:39±7岁)完成了运动障碍测验(BBAQ)和国际体育活动问卷-简短形式(IPAQ-SF)。还收集了社会人口学和临床数据,以探索症状和活动模式之间的潜在关联。最普遍的障碍是缺乏精力(68.2%)和缺乏意志力(50.0%)。缺乏能量与疼痛、痛经、疲劳和抑郁显著相关,并成为主要的限制因素。尽管报告中至高水平的身体活动,根据IPAQ标准定义-中度(≥600 MET-min/周)或高(≥1,500 MET-min/周,剧烈活动≥3天/周,或≥3,000 MET-min/周,活动≥7天/周)-疼痛(79.2%)和疲劳(79.9%)等症状仍然普遍存在。心理和生理症状,特别是疲劳和抑郁,显著影响子宫内膜异位症妇女的运动参与。这些发现强调有必要制定量身定制的策略,以解决这些人群的感知障碍并促进持续的身体活动。整合心理支持和个体化运动指导,以及疼痛管理干预,可以提高依从性和长期结果。
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引用次数: 0
Accessing information on menopause transition and the role of digital health technologies: A narrative review. 获取关于更年期过渡的信息和数字卫生技术的作用:叙述性审查。
IF 1.4 4区 医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-07-01 Epub Date: 2025-06-26 DOI: 10.1080/03630242.2025.2523258
Alison K Osborne, Elizabeth Sillence

Digital health resources can provide an effective way for women to seek advice and share information. The aim of the current review is to understand the role of digital technologies in accessing digital menopause information. Six databases were examined for papers considering the use of digital technology in accessing digital information on menopause, published before March 2025. From 1970 papers identified, 14 papers were included in the review. Digital technologies are used to seek further information on the menopause, whether in addition to information provided by healthcare professionals, or to track symptoms or to normalize personal experiences. Trust in the source of the digital menopause information impacts whether it is accessed and how the information received is appraised. The impact of using digital technologies for menopause information was positive, including increased feelings of empowerment, decision making satisfaction, and the facilitation of conversations with others around menopause. However, representation of those who experience menopause was imperative. Overall, women find using digital technologies for menopause to be a positive experience. Future research should address the unique and complementary value of different types of digital technology to support menopause and understand how technologies can be better integrated into discussions with healthcare professionals.

数字卫生资源可为妇女提供寻求咨询和分享信息的有效途径。本综述的目的是了解数字技术在获取数字更年期信息中的作用。对六个数据库进行了审查,以获取2025年3月以前发表的考虑使用数字技术获取关于更年期的数字信息的论文。从鉴定的1970篇论文中,有14篇论文被纳入综述。数字技术被用于寻找关于更年期的进一步信息,无论是在医疗保健专业人员提供的信息之外,还是用于跟踪症状或使个人经历正常化。对数字更年期信息来源的信任影响是否访问以及如何评估接收到的信息。使用数字技术获取更年期信息的影响是积极的,包括增强了赋权感、决策满意度,以及促进了更年期与他人的对话。然而,代表那些经历更年期的人是必要的。总的来说,女性发现在更年期使用数字技术是一种积极的体验。未来的研究应该解决不同类型的数字技术的独特和互补价值,以支持更年期,并了解如何更好地将技术整合到医疗保健专业人员的讨论中。
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引用次数: 0
Academic surgery: Faculty gender and racial trends through an intersectional lens. 学术外科:通过交叉镜头的教师性别和种族趋势。
IF 1.4 4区 医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-07-01 Epub Date: 2025-07-04 DOI: 10.1080/03630242.2025.2523256
Mah I Kan Changez, Syed Ali Farhan, Jeffrey Ding, Ahmer Azhar Karimuddin, Javed Siddiqi, Sabeen Tiwana, Faisal Khosa

The healthcare workforce in the United States (US) has an inequitable representation of women and Underrepresented in Medicine (URIM) groups, including Black or African Americans, American Indians, Alaska Natives, Pacific Islanders, Hispanic or Latinos, and Asians. Despite almost three decades of equal representation of women students in medical school, the gender disparity persists throughout leadership ranks. Studies have shown that residency recruitment is a limiting factor in diversity in surgery, and systemic changes are needed to increase the representation of minorities and women in the medical and surgical disciplines.Our study used data from the AAMC (Association of American Medical Colleges) to analyze the demographic distribution of surgical faculty at medical schools from 1971 to 2021. Data was analyzed using Microsoft Excel and JupyterLab programs, and a t-test was used to determine significant changes over time. The categories with significant changes were reported, and proportion bar graphs were created. Data was classified into multiple categories.URIM Surgeons have seen an increased representation in Surgical faculty during our study over the past five decades. Still, these trends have not brought them in line with their proportion among the US population. Significant trends in surgical chair positions included a 21% decrease in Whites, a 15% increase in Asians, a 2.4% increase in Blacks, and a 3.8% increase in Hispanics. There were no significant trends for Natives. Significant trends in the academic rank of Professor included a 14% increase in Asians, a 1.1% increase in Blacks, a 1.5% increase in Hispanics, and an 18.4% decrease in Whites. A slight increase among URIM Surgeons is concerning when considering that these trends span from 1971 to 2021.The data showed that White and Asian Surgeons were overrepresented in surgical discipline compared to their proportions among the US population, while Black, Hispanic, and Native Surgeons were underrepresented. This was especially true in higher academic ranks and chair positions. Women were also underrepresented in surgery, with the slowest growth in higher academic ranks and leadership positions.Al.

在美国的医疗保健工作人员中,妇女的代表性不公平,在医学(URIM)群体中的代表性不足,包括黑人或非裔美国人、美洲印第安人、阿拉斯加原住民、太平洋岛民、西班牙裔或拉丁裔以及亚洲人。尽管近三十年来女学生在医学院的比例是平等的,但在整个领导阶层中,性别差距仍然存在。研究表明,住院医师招聘是外科多样化的一个限制因素,需要进行系统性改革,以增加少数民族和妇女在医学和外科学科中的代表性。我们的研究使用了美国医学院协会(AAMC)的数据来分析1971年至2021年医学院外科教师的人口分布。使用Microsoft Excel和JupyterLab程序分析数据,并使用t检验来确定随时间的显著变化。报告有显著变化的类别,并制作比例条形图。数据被分成多个类别。在过去五十年的研究中,URIM外科医生在外科教师中的代表性有所增加。然而,这些趋势并没有使他们与他们在美国人口中的比例保持一致。手术椅位的显著趋势包括白人减少21%,亚洲人增加15%,黑人增加2.4%,西班牙裔增加3.8%。土著人没有明显的趋势。教授学术排名的显著趋势包括亚洲人增加14%,黑人增加1.1%,西班牙裔增加1.5%,白人减少18.4%。考虑到这些趋势从1971年到2021年,URIM外科医生的轻微增长令人担忧。数据显示,与美国人口比例相比,白人和亚洲外科医生在外科学科中的比例过高,而黑人、西班牙裔和本土外科医生的比例偏低。在较高的学术职位和主席职位上尤其如此。女性在外科领域的比例也偏低,在高级学术职位和领导职位上的增长最慢。
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引用次数: 0
Associations of body shape dissatisfaction before and during pregnancy with perinatal depressive symptoms among Japanese women. 日本妇女孕前和孕期体型不满意与围产期抑郁症状的关系
IF 1.4 4区 医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-07-01 Epub Date: 2025-05-23 DOI: 10.1080/03630242.2025.2509624
Mie Shiraishi, Yuki Kurashima, Rio Harada, Hijiri Ito

Body image may play a significant role in the development of perinatal depression; however, its relevance remains controversial. This study aimed to elucidate the association between body shape dissatisfaction before and during pregnancy and depressive symptoms during the perinatal period among Japanese women. This study used secondary data. Women with singleton pregnancies were recruited from March to December 2020 in Osaka, Japan. Depressive symptoms were assessed using the Edinburgh Postnatal Depression Scale. Participants were classified into three groups according to their body shape satisfaction before and during pregnancy; satisfied, dissatisfied, and neither. Multivariate logistic regression analysis was performed. Of the 230 participants, 33 (14.3 percent) had depressive symptoms during pregnancy. Of the 221 participants assessed at 1 month postpartum, 20 (9.0 percent) had depressive symptoms. Women with body shape dissatisfaction during pregnancy had a significantly higher risk of depressive symptoms during pregnancy and at 1 month postpartum than those with body shape satisfaction. Furthermore, women who were body shape dissatisfied both before and during pregnancy had a significantly higher risk of depressive symptoms than those whose satisfaction improved during pregnancy. These findings suggest the importance of focusing on body dissatisfaction before and during pregnancy in relation to perinatal depressive symptoms.

身体形象可能在围产期抑郁症的发展中起重要作用;然而,其相关性仍然存在争议。本研究旨在探讨日本女性孕前及孕期体型不满意与围产期抑郁症状之间的关系。本研究使用的是二手数据。该研究于2020年3月至12月在日本大阪招募了单胎妊娠妇女。使用爱丁堡产后抑郁量表评估抑郁症状。参与者根据怀孕前和怀孕期间的体型满意度分为三组;满意,不满意,两者都不是。进行多因素logistic回归分析。在230名参与者中,33名(14.3%)在怀孕期间有抑郁症状。在产后1个月评估的221名参与者中,20名(9.0%)有抑郁症状。怀孕期间对身材不满意的妇女在怀孕期间和产后1个月出现抑郁症状的风险明显高于身材满意的妇女。此外,在怀孕前和怀孕期间对身材不满意的女性比那些在怀孕期间对身材满意的女性患抑郁症状的风险要高得多。这些发现表明,在怀孕前和怀孕期间关注与围产期抑郁症状有关的身体不满是很重要的。
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引用次数: 0
Gene polymorphisms associated with immunosuppression and their implications in the onset of cervical cancer. 与免疫抑制相关的基因多态性及其在宫颈癌发病中的意义。
IF 1.4 4区 医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-07-01 Epub Date: 2025-07-03 DOI: 10.1080/03630242.2025.2525282
Adriano M F Aranome, Ana P L Pereira, Nádia C M Okuyama, Kleber P Trugilo, Michelle M Sena, Rodolfo S Ferreira, Fernando Cezar-Dos-Santos, José O Couto-Filho, Janaina N Oliveira, Eliza P Castilha, Rafaela R J Curti, Sara Mataroli de Godoy, Wilson Frantine-Silva, Roberta L Guembarovski, Karen B de Oliveira

The immune system plays a crucial role in determining the resolution or development of cervical pre-malignant lesions that culminate in cervical cancer (CC). A microenvironment with low inflammatory patterns is often associated with a worse prognosis.

Aim: To evaluate polymorphisms rs3087465 in the TGFBR2 and rs3761548 in the FOXP3 genes, as well as sociodemographic, reproductive, and sexual behavior data which may be associated with CC development.

Methods: In this cross-sectional case-control study conducted in the northern region of Paraná, Brazil, 134 women (41 cervical cancer patients and 93 controls) were recruited from public health services. DNA samples were extracted from cervical cells, peripheral blood, and tumor tissues and subjected to PCR for confirmation of HPV presence and subsequent genotyping of TGFBR2 (rs3087465) and FOXP3 (rs3761548) polymorphisms.

Results: Women with limited HPV knowledge, low income, and infrequent preventive exams were at higher risk of CC. Smoking and high parity were also associated with increased risk. Notably, TGFBR2 rs3087465 AG/GG genotypes were initially associated with increased risk of CC development. However, these associations were attenuated after adjusting for confounding variables.

Conclusions: These findings suggest that understanding genetic, environmental, and behavioral factors is essential for the prevention and effective treatment of CC.

免疫系统在决定最终导致宫颈癌(CC)的宫颈癌前病变的消退或发展中起着至关重要的作用。低炎症模式的微环境通常与较差的预后相关。目的:评估TGFBR2基因rs3087465多态性和FOXP3基因rs3761548多态性,以及可能与CC发生相关的社会人口学、生殖和性行为数据。方法:本横断面病例对照研究在巴西帕拉纳北部地区进行,从公共卫生服务部门招募134名妇女(41名宫颈癌患者和93名对照组)。从宫颈细胞、外周血和肿瘤组织中提取DNA样本,进行PCR确认HPV的存在,并随后进行TGFBR2 (rs3087465)和FOXP3 (rs3761548)多态性的基因分型。结果:HPV知识有限、收入低、不经常进行预防性检查的妇女患CC的风险较高,吸烟和高胎次也与风险增加有关。值得注意的是,TGFBR2 rs3087465 AG/GG基因型最初与CC发展风险增加相关。然而,在调整混杂变量后,这些关联减弱了。结论:研究结果表明,了解遗传、环境和行为因素对预防和有效治疗CC至关重要。
{"title":"Gene polymorphisms associated with immunosuppression and their implications in the onset of cervical cancer.","authors":"Adriano M F Aranome, Ana P L Pereira, Nádia C M Okuyama, Kleber P Trugilo, Michelle M Sena, Rodolfo S Ferreira, Fernando Cezar-Dos-Santos, José O Couto-Filho, Janaina N Oliveira, Eliza P Castilha, Rafaela R J Curti, Sara Mataroli de Godoy, Wilson Frantine-Silva, Roberta L Guembarovski, Karen B de Oliveira","doi":"10.1080/03630242.2025.2525282","DOIUrl":"10.1080/03630242.2025.2525282","url":null,"abstract":"<p><p>The immune system plays a crucial role in determining the resolution or development of cervical pre-malignant lesions that culminate in cervical cancer (CC). A microenvironment with low inflammatory patterns is often associated with a worse prognosis.</p><p><strong>Aim: </strong>To evaluate polymorphisms rs3087465 in the <i>TGFBR2</i> and rs3761548 in the <i>FOXP3</i> genes, as well as sociodemographic, reproductive, and sexual behavior data which may be associated with CC development.</p><p><strong>Methods: </strong>In this cross-sectional case-control study conducted in the northern region of Paraná, Brazil, 134 women (41 cervical cancer patients and 93 controls) were recruited from public health services. DNA samples were extracted from cervical cells, peripheral blood, and tumor tissues and subjected to PCR for confirmation of HPV presence and subsequent genotyping of <i>TGFBR2</i> (rs3087465) and <i>FOXP3</i> (rs3761548) polymorphisms.</p><p><strong>Results: </strong>Women with limited HPV knowledge, low income, and infrequent preventive exams were at higher risk of CC. Smoking and high parity were also associated with increased risk. Notably, <i>TGFBR2</i> rs3087465 AG/GG genotypes were initially associated with increased risk of CC development. However, these associations were attenuated after adjusting for confounding variables.</p><p><strong>Conclusions: </strong>These findings suggest that understanding genetic, environmental, and behavioral factors is essential for the prevention and effective treatment of CC.</p>","PeriodicalId":23972,"journal":{"name":"Women & Health","volume":" ","pages":"522-532"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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Women & Health
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