首页 > 最新文献

World Journal for Pediatric and Congenital Heart Surgery最新文献

英文 中文
Does Secondary Antibiotic Prophylaxis Improve Clinical Outcomes in Adult Rheumatic Heart Disease Patients Post-Valve Replacement? 二级抗生素预防是否能改善成人风湿性心脏病患者瓣膜置换术后的临床结果?
IF 0.9 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2023-03-01 DOI: 10.1177/21501351221139834
Abdulrazaq S Al-Jazairi, Ahlam M Althobaiti, Josef Marek, Edward B Devol, Zohair Al Halees, Dania Mohty, Bahaa M Fadel

Background: Secondary prevention of recurrent rheumatic fever in individuals with rheumatic heart disease (RHD) requires continuous antibiotic prophylaxis. However, the impact of antibiotic prophylaxis on the outcome of patients with severe RHD who underwent heart valve replacement is unknown. The objective of the study was to assess the relationship between the use of antibiotics as secondary prophylaxis in RHD patients who underwent valve replacement and clinical outcomes including mortality, reoperation, and valve-related hospitalization.

Methods: We retrospectively compared outcomes of adult patients who underwent heart valve replacement for RHD at our institution from 1990 through 2014 and who received secondary antibiotic prophylaxis (prophylaxis group) with those who did not receive prophylaxis (nonprophylaxis group) using propensity score matching analysis.

Results: A total of 1094 patients (56% females, median age 40 years, range 31-53 years) were included with a median follow-up of 9.6 years (range 2.9-12.6 years). Antibiotic prophylaxis was prescribed in 201 patients (18%). Propensity score matching analysis demonstrated no significant difference in overall survival (95% [92%-98%] vs 97% [95%-99%], respectively; P = .7), valve-related hospitalization-independent survival (72% [range 65%-78%] vs 81% [range 76%-88%]; P = .25), and redo valve surgery-independent survival [76% [range 70%-83%] vs 75% [range 72%-79%]; P = .41) at 10-year follow-up in the nonantibiotic prophylaxis versus the antibiotic prophylaxis group.

Conclusion: Secondary antibiotic prophylaxis among adult RHD patients following valve replacement is not associated with improved clinical outcomes.

背景:风湿性心脏病(RHD)患者复发性风湿热的二级预防需要持续的抗生素预防。然而,抗生素预防对接受心脏瓣膜置换术的严重RHD患者预后的影响尚不清楚。本研究的目的是评估接受瓣膜置换术的RHD患者使用抗生素作为二级预防与临床结果(包括死亡率、再手术和瓣膜相关住院)之间的关系。方法:我们回顾性比较1990年至2014年在我院接受心脏瓣膜置换术治疗RHD的成人患者的结局,这些患者接受了二级抗生素预防(预防组)和未接受预防(非预防组)的患者使用倾向评分匹配分析。结果:共纳入1094例患者(56%为女性,中位年龄40岁,范围31-53岁),中位随访时间9.6年(范围2.9-12.6年)。201例患者(18%)开了抗生素预防处方。倾向评分匹配分析显示,总生存率无显著差异(分别为95%[92%-98%]和97% [95%-99%];P = .7),与瓣膜相关的非住院生存率(72%[范围65%-78%]vs 81%[范围76%-88%];P = 0.25),重做瓣膜手术独立生存率[76%[范围70%-83%]对75%[范围72%-79%];P = 0.41),非抗生素预防组与抗生素预防组的10年随访结果。结论:成人RHD患者瓣膜置换术后的二次抗生素预防与改善临床结果无关。
{"title":"Does Secondary Antibiotic Prophylaxis Improve Clinical Outcomes in Adult Rheumatic Heart Disease Patients Post-Valve Replacement?","authors":"Abdulrazaq S Al-Jazairi,&nbsp;Ahlam M Althobaiti,&nbsp;Josef Marek,&nbsp;Edward B Devol,&nbsp;Zohair Al Halees,&nbsp;Dania Mohty,&nbsp;Bahaa M Fadel","doi":"10.1177/21501351221139834","DOIUrl":"https://doi.org/10.1177/21501351221139834","url":null,"abstract":"<p><strong>Background: </strong>Secondary prevention of recurrent rheumatic fever in individuals with rheumatic heart disease (RHD) requires continuous antibiotic prophylaxis. However, the impact of antibiotic prophylaxis on the outcome of patients with severe RHD who underwent heart valve replacement is unknown. The objective of the study was to assess the relationship between the use of antibiotics as secondary prophylaxis in RHD patients who underwent valve replacement and clinical outcomes including mortality, reoperation, and valve-related hospitalization.</p><p><strong>Methods: </strong>We retrospectively compared outcomes of adult patients who underwent heart valve replacement for RHD at our institution from 1990 through 2014 and who received secondary antibiotic prophylaxis (prophylaxis group) with those who did not receive prophylaxis (nonprophylaxis group) using propensity score matching analysis.</p><p><strong>Results: </strong>A total of 1094 patients (56% females, median age 40 years, range 31-53 years) were included with a median follow-up of 9.6 years (range 2.9-12.6 years). Antibiotic prophylaxis was prescribed in 201 patients (18%). Propensity score matching analysis demonstrated no significant difference in overall survival (95% [92%-98%] vs 97% [95%-99%], respectively; <i>P</i> = .7), valve-related hospitalization-independent survival (72% [range 65%-78%] vs 81% [range 76%-88%]; <i>P</i> = .25), and redo valve surgery-independent survival [76% [range 70%-83%] vs 75% [range 72%-79%]; <i>P</i> = .41) at 10-year follow-up in the nonantibiotic prophylaxis versus the antibiotic prophylaxis group.</p><p><strong>Conclusion: </strong>Secondary antibiotic prophylaxis among adult RHD patients following valve replacement is not associated with improved clinical outcomes.</p>","PeriodicalId":23974,"journal":{"name":"World Journal for Pediatric and Congenital Heart Surgery","volume":"14 2","pages":"161-167"},"PeriodicalIF":0.9,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9325045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Normothermic Versus Hypothermic Norwood Procedure. 常温与低温诺伍德手术。
IF 0.9 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2023-03-01 DOI: 10.1177/21501351221140330
Eitan Keizman, David Mishaly, Eilon Ram, Soslan Urtaev, Shai Tejman-Yarden, Tal Tirosh Wagner, Alain E Serraf

Background: Either deep hypothermia with circulatory arrest or hypothermic perfusion with antegrade selective cerebral perfusion is used during the Norwood procedure for hypoplastic left heart syndrome. Normothermic perfusion has been described for pediatric patients. The aim of this study was to compare the early outcomes of patients undergoing the Norwood procedure with antegrade selective cerebral perfusion under hypothermia with the procedure under normothermia.

Methods: From 2005 to 2020, 117 consecutive patients with hypoplastic left heart syndrome underwent the Norwood procedure: 68 (58.2%) under hypothermia and 49 (41.8%) under normothermia. Antegrade selective cerebral perfusion flow was adjusted to maintain right radial arterial pressure above 50 mm Hg, and a flow rate of 40 to 50 mL kg-1 min-1. Baseline characteristics, operative data, and postoperative outcomes including lactate recovery time were compared.

Results: The baseline characteristics and cardiovascular diagnosis were similar in both groups. The normothermic group had a significantly shorter bypass time (in minutes) of 90.31 (±31.60) versus 123.63 (±25.33), a cross-clamp time of 45.24 (±16.35) versus 81.93 (±16.34), and an antegrade selective cerebral perfusion time of 25.61 (±13.84) versus 47.30 (±14.35) (P < .001). There were no statistically significant differences in the immediate postoperative course, or in terms of in-hospital mortality, which totaled 9 (18.4%) in the normothermic group, and 10 (14.9%) in the hypothermic group (P = .81).

Conclusion: The normothermic Norwood procedure with selective cerebral perfusion is feasible and safe in terms of in-hospital mortality and short-term outcomes. It is comparable to the standard hypothermic Norwood with selective cerebral perfusion.

背景:在诺伍德手术治疗左心发育不全综合征时,要么采用深度低温伴循环停止,要么采用低温灌注伴顺行选择性脑灌注。正常灌注已被描述用于儿科患者。本研究的目的是比较接受诺伍德手术的患者在低温下顺行选择性脑灌注与常温下手术的早期结果。方法:2005 - 2020年,117例左心发育不全综合征患者连续行诺伍德手术,其中低温68例(58.2%),常温49例(41.8%)。调整顺行选择性脑灌注流量,使右桡动脉压维持在50 mm Hg以上,血流速率维持在40 ~ 50 mL kg-1 min-1。比较基线特征、手术数据和术后结果,包括乳酸恢复时间。结果:两组患者的基线特征和心血管诊断相似。常温组旁路时间(分钟)为90.31(±31.60)比123.63(±25.33),交叉夹持时间为45.24(±16.35)比81.93(±16.34),顺行选择性脑灌注时间为25.61(±13.84)比47.30(±14.35)(P < 0.001)。两组术后即时病程及住院死亡率均无统计学差异,常温组为9例(18.4%),低温组为10例(14.9%)(P = 0.81)。结论:从住院死亡率和短期预后来看,常温诺伍德手术加选择性脑灌注是可行和安全的。它与标准的低低温诺伍德选择性脑灌注相当。
{"title":"Normothermic Versus Hypothermic Norwood Procedure.","authors":"Eitan Keizman,&nbsp;David Mishaly,&nbsp;Eilon Ram,&nbsp;Soslan Urtaev,&nbsp;Shai Tejman-Yarden,&nbsp;Tal Tirosh Wagner,&nbsp;Alain E Serraf","doi":"10.1177/21501351221140330","DOIUrl":"https://doi.org/10.1177/21501351221140330","url":null,"abstract":"<p><strong>Background: </strong>Either deep hypothermia with circulatory arrest or hypothermic perfusion with antegrade selective cerebral perfusion is used during the Norwood procedure for hypoplastic left heart syndrome. Normothermic perfusion has been described for pediatric patients. The aim of this study was to compare the early outcomes of patients undergoing the Norwood procedure with antegrade selective cerebral perfusion under hypothermia with the procedure under normothermia.</p><p><strong>Methods: </strong>From 2005 to 2020, 117 consecutive patients with hypoplastic left heart syndrome underwent the Norwood procedure: 68 (58.2%) under hypothermia and 49 (41.8%) under normothermia. Antegrade selective cerebral perfusion flow was adjusted to maintain right radial arterial pressure above 50 mm Hg, and a flow rate of 40 to 50 mL kg<sup>-1</sup> min<sup>-1</sup>. Baseline characteristics, operative data, and postoperative outcomes including lactate recovery time were compared.</p><p><strong>Results: </strong>The baseline characteristics and cardiovascular diagnosis were similar in both groups. The normothermic group had a significantly shorter bypass time (in minutes) of 90.31 (±31.60) versus 123.63 (±25.33), a cross-clamp time of 45.24 (±16.35) versus 81.93 (±16.34), and an antegrade selective cerebral perfusion time of 25.61 (±13.84) versus 47.30 (±14.35) (<i>P</i> < .001). There were no statistically significant differences in the immediate postoperative course, or in terms of in-hospital mortality, which totaled 9 (18.4%) in the normothermic group, and 10 (14.9%) in the hypothermic group (<i>P</i> = .81).</p><p><strong>Conclusion: </strong>The normothermic Norwood procedure with selective cerebral perfusion is feasible and safe in terms of in-hospital mortality and short-term outcomes. It is comparable to the standard hypothermic Norwood with selective cerebral perfusion.</p>","PeriodicalId":23974,"journal":{"name":"World Journal for Pediatric and Congenital Heart Surgery","volume":"14 2","pages":"125-132"},"PeriodicalIF":0.9,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9329672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Noninvasive Monitoring to Demonstrate Postoperative Differences in Regional Hemodynamics in Newborn Infants With d-Transposition of the Great Arteries and Hypoplastic Left Heart Syndrome. 无创监测显示新生儿d-大动脉转位和左心发育不全综合征术后局部血流动力学差异。
IF 0.9 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2023-03-01 DOI: 10.1177/21501351221141425
Prateek V Sahni, Ganga Krishnamurthy, Rakesh Sahni

Background: The adequacy of tissue O2 delivery in infants receiving intensive care is difficult to measure directly. Regional O2 (rSO2) and fractional tissue O2 extraction (FTOE), the ratio of O2 consumption to O2 delivery, obtained from newer noninvasive tools, such as near-infrared spectroscopy (INVOS) and microvascular tissue oximetry (T-Stat) can provide important information on the adequacy of tissue oxygenation and aid in managing critically ill infants.

Methods: We prospectively evaluated differences in rSO2 and FTOE in 26 infants with hypoplastic left heart syndrome (HLHS) (n = 12) or d-transposition of the great arteries (d-TGA) (n = 14). Continuous noninvasive monitoring of SpO2, heart rate, and perfusion index with pulse oximetry, cerebral-rSO2 and renal-rSO2 with INVOS, and buccal tissue oxygenation using T-Stat were performed during immediate postoperative period for 24 hours.

Results: The SpO2 and rSO2 in infants with d-TGA were higher compared with the infants with HLHS at all measured sites (buccal mucosa, cerebral, and renal). Significant regional differences were also observed in FTOE across all infants with the highest at the buccal mucosa tissue level, followed by cerebral and renal measurement sites. As compared with infants with d-TGA, infants with HLHS had higher regional FTOE and heart rate, with a lower arterial O2 content and perfusion index.

Conclusions: Our study demonstrates the utility of noninvasive hemodynamic monitoring to assess regional oxygenation and perfusion, as evidenced by significant differences in infants with HLHS and d-TGA, conditions with different circulation physiologies. Such comprehensive monitoring can potentially aid in evaluating treatment strategies aimed at preventing organ damage from O2 insufficiency.

背景:重症监护婴儿组织氧输送的充分性难以直接测量。近红外光谱(INVOS)和微血管组织血氧仪(T-Stat)等较新的无创工具可获得区域氧(rSO2)和组织氧提取分数(FTOE),即氧气消耗与氧气输送的比率,可提供关于组织氧合充分性的重要信息,并有助于危重婴儿的管理。方法:我们前瞻性评估26例左心发育不全综合征(HLHS) (n = 12)或大动脉d-转位(d-TGA) (n = 14)患儿rSO2和FTOE的差异。术后即刻24小时用脉搏血氧仪连续无创监测SpO2、心率和灌注指数,用INVOS连续监测脑rso2和肾rso2,用T-Stat连续监测颊组织氧合。结果:d-TGA患儿的SpO2和rSO2在所有测量部位(口腔黏膜、大脑和肾脏)均高于HLHS患儿。在所有婴儿的FTOE中也观察到显著的区域差异,口腔黏膜组织水平最高,其次是大脑和肾脏测量部位。与d-TGA婴儿相比,HLHS婴儿的局部FTOE和心率更高,动脉O2含量和灌注指数更低。结论:我们的研究证明了无创血流动力学监测在评估区域氧合和灌注方面的实用性,证明了HLHS和d-TGA婴儿在不同循环生理条件下的显著差异。这种全面的监测可以潜在地帮助评估旨在防止器官损伤的治疗策略。
{"title":"Noninvasive Monitoring to Demonstrate Postoperative Differences in Regional Hemodynamics in Newborn Infants With d-Transposition of the Great Arteries and Hypoplastic Left Heart Syndrome.","authors":"Prateek V Sahni,&nbsp;Ganga Krishnamurthy,&nbsp;Rakesh Sahni","doi":"10.1177/21501351221141425","DOIUrl":"https://doi.org/10.1177/21501351221141425","url":null,"abstract":"<p><strong>Background: </strong>The adequacy of tissue O<sub>2</sub> delivery in infants receiving intensive care is difficult to measure directly. Regional O<sub>2</sub> (rSO<sub>2</sub>) and fractional tissue O<sub>2</sub> extraction (FTOE), the ratio of O<sub>2</sub> consumption to O<sub>2</sub> delivery, obtained from newer noninvasive tools, such as near-infrared spectroscopy (INVOS) and microvascular tissue oximetry (T-Stat) can provide important information on the adequacy of tissue oxygenation and aid in managing critically ill infants.</p><p><strong>Methods: </strong>We prospectively evaluated differences in rSO<sub>2</sub> and FTOE in 26 infants with hypoplastic left heart syndrome (HLHS) (n = 12) or d-transposition of the great arteries (d-TGA) (n = 14). Continuous noninvasive monitoring of SpO<sub>2</sub>, heart rate, and perfusion index with pulse oximetry, cerebral-rSO<sub>2</sub> and renal-rSO<sub>2</sub> with INVOS, and buccal tissue oxygenation using T-Stat were performed during immediate postoperative period for 24 hours.</p><p><strong>Results: </strong>The SpO<sub>2</sub> and rSO<sub>2</sub> in infants with d-TGA were higher compared with the infants with HLHS at all measured sites (buccal mucosa, cerebral, and renal). Significant regional differences were also observed in FTOE across all infants with the highest at the buccal mucosa tissue level, followed by cerebral and renal measurement sites. As compared with infants with d-TGA, infants with HLHS had higher regional FTOE and heart rate, with a lower arterial O<sub>2</sub> content and perfusion index.</p><p><strong>Conclusions: </strong>Our study demonstrates the utility of noninvasive hemodynamic monitoring to assess regional oxygenation and perfusion, as evidenced by significant differences in infants with HLHS and d-TGA, conditions with different circulation physiologies. Such comprehensive monitoring can potentially aid in evaluating treatment strategies aimed at preventing organ damage from O<sub>2</sub> insufficiency.</p>","PeriodicalId":23974,"journal":{"name":"World Journal for Pediatric and Congenital Heart Surgery","volume":"14 2","pages":"194-200"},"PeriodicalIF":0.9,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9380552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surgical Experience With Crossed and Anomalous Origin of the Pulmonary Arteries From the Pulmonary Trunk: A Single Center Report of 24 Cases. 肺动脉起源于肺动脉干交叉和异常的手术经验:附24例单中心报告。
IF 0.9 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2023-03-01 DOI: 10.1177/21501351221139833
Sameh M Said, Eric Hoggard, Shanti Narasimhan

Background: Anomalies of the pulmonary origin of the pulmonary arteries are uncommon; however, the true incidence is unknown and may be underestimated. We sought to review our experience with this unusual pathology and examine its surgical implications.

Methods: We reviewed medical records between 2011 and 2022.

Results: A total of 24 patients were identified. Genetic syndromes were present in 12 patients (50%). The patients were divided into two main groups. Those with septal defects (14 patients,58.3%), and those without (10 patients, 41.7%). Aortic arch hypoplasia with/without coarctation was present in nine patients (37.5%). Pulmonary arterial branch hypoplasia and/or obstruction was present in six patients (25%) with resultant preoperative systemic or suprasystemic right ventricular pressure. Four patients (16.7%) underwent pulmonary artery branch and/or right ventricular outflow tract interventions prior to surgery. All patients underwent surgical interventions for their associated cardiac defects. The crossed pulmonary arteries were uncrossed for those four patients (16.7%) who required concomitant pulmonary arterioplasties and pulmonary arterial branch rehabilitation and who had elevated right ventricular pressures preoperatively. No early or late mortalities. One Alagille's syndrome underwent liver transplant prior to discharge. Late transcatheter interventions were needed in four (16.7%) during the follow-up period, while four patients required repeat aortic arch augmentation for recurrent arch obstruction.

Conclusions: Anomalous origin of the pulmonary arteries from the pulmonary trunk including crossed pulmonary arteries is an uncommon anomaly that may be underrecognized. It can occur in isolation or in association with other heart defects. Recognition of this malpositional anomaly is important as it has specific surgical and/or transcatheter implications.

背景:肺动脉起源于肺的异常并不常见;然而,真正的发病率是未知的,可能被低估了。我们试图回顾我们的经验与这种不寻常的病理和检查其手术意义。方法:回顾2011年至2022年的医疗记录。结果:共鉴定出24例患者。12例(50%)患者存在遗传综合征。患者被分为两组。有间隔缺损的14例(58.3%),无间隔缺损的10例(41.7%)。主动脉弓发育不全伴/不伴缩窄9例(37.5%)。6例(25%)患者出现肺动脉分支发育不全和/或梗阻,导致术前全身或全身上右心室压力升高。4例(16.7%)患者在手术前接受了肺动脉分支和/或右心室流出道干预。所有患者均因其相关心脏缺陷而接受手术干预。4例(16.7%)需要合并肺动脉成形术和肺动脉分支康复且术前右心室压力升高的患者,交叉肺动脉未交叉。没有早期或晚期死亡。一名阿拉格氏综合征患者在出院前接受了肝移植。在随访期间,4例(16.7%)患者需要后期经导管介入治疗,4例患者因复发性主动脉弓阻塞需要重复主动脉弓增强。结论:肺动脉异常起源于肺动脉干,包括肺动脉交叉是一种罕见的异常,可能被低估。它可以单独发生,也可以与其他心脏缺陷一起发生。这种错位异常的识别是重要的,因为它具有特定的手术和/或经导管影响。
{"title":"Surgical Experience With Crossed and Anomalous Origin of the Pulmonary Arteries From the Pulmonary Trunk: A Single Center Report of 24 Cases.","authors":"Sameh M Said,&nbsp;Eric Hoggard,&nbsp;Shanti Narasimhan","doi":"10.1177/21501351221139833","DOIUrl":"https://doi.org/10.1177/21501351221139833","url":null,"abstract":"<p><strong>Background: </strong>Anomalies of the pulmonary origin of the pulmonary arteries are uncommon; however, the true incidence is unknown and may be underestimated. We sought to review our experience with this unusual pathology and examine its surgical implications.</p><p><strong>Methods: </strong>We reviewed medical records between 2011 and 2022.</p><p><strong>Results: </strong>A total of 24 patients were identified. Genetic syndromes were present in 12 patients (50%). The patients were divided into two main groups. Those with septal defects (14 patients,58.3%), and those without (10 patients, 41.7%). Aortic arch hypoplasia with/without coarctation was present in nine patients (37.5%). Pulmonary arterial branch hypoplasia and/or obstruction was present in six patients (25%) with resultant preoperative systemic or suprasystemic right ventricular pressure. Four patients (16.7%) underwent pulmonary artery branch and/or right ventricular outflow tract interventions prior to surgery. All patients underwent surgical interventions for their associated cardiac defects. The crossed pulmonary arteries were uncrossed for those four patients (16.7%) who required concomitant pulmonary arterioplasties and pulmonary arterial branch rehabilitation and who had elevated right ventricular pressures preoperatively. No early or late mortalities. One Alagille's syndrome underwent liver transplant prior to discharge. Late transcatheter interventions were needed in four (16.7%) during the follow-up period, while four patients required repeat aortic arch augmentation for recurrent arch obstruction.</p><p><strong>Conclusions: </strong>Anomalous origin of the pulmonary arteries from the pulmonary trunk including crossed pulmonary arteries is an uncommon anomaly that may be underrecognized. It can occur in isolation or in association with other heart defects. Recognition of this malpositional anomaly is important as it has specific surgical and/or transcatheter implications.</p>","PeriodicalId":23974,"journal":{"name":"World Journal for Pediatric and Congenital Heart Surgery","volume":"14 2","pages":"185-193"},"PeriodicalIF":0.9,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9380554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Performance of CardioCel in Cardiac Surgery: A Systematic Review. 心脏细胞在心脏外科中的应用:系统综述。
IF 0.9 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2023-03-01 DOI: 10.1177/21501351221149416
Aditya A Patukale, Jessica Suna, Abhishek Anand, Kim S Betts, Tom R Karl, Prem Venugopal, Supreet P Marathe, Nelson Alphonso

A systematic review was performed for evaluation of the performance of CardioCel® in cardiac surgery. The review included all studies published from January 2013 to December 2020. We conclude that CardioCel is a strong, flexible tissue substitute with good handling characteristics and a low incidence of thrombosis, aneurysm formation, infection, or structural degeneration. It can be used for a variety of intracardiac and extracardiac repairs of congenital heart defects in all age groups with good durability at mid-term follow-up. However, the use of CardioCel in certain positions requires caution. Information on the long-term performance of CardioCel is lacking.

对CardioCel®在心脏外科手术中的表现进行了系统评价。该综述包括2013年1月至2020年12月发表的所有研究。我们的结论是,CardioCel是一种坚固、灵活的组织替代品,具有良好的处理特性,血栓形成、动脉瘤形成、感染或结构变性的发生率低。在中期随访中,可用于各种年龄段先天性心脏缺损的心内、心外修复,具有良好的耐久性。然而,在某些位置使用CardioCel需要谨慎。关于CardioCel的长期性能的信息是缺乏的。
{"title":"Performance of CardioCel in Cardiac Surgery: A Systematic Review.","authors":"Aditya A Patukale,&nbsp;Jessica Suna,&nbsp;Abhishek Anand,&nbsp;Kim S Betts,&nbsp;Tom R Karl,&nbsp;Prem Venugopal,&nbsp;Supreet P Marathe,&nbsp;Nelson Alphonso","doi":"10.1177/21501351221149416","DOIUrl":"https://doi.org/10.1177/21501351221149416","url":null,"abstract":"<p><p>A systematic review was performed for evaluation of the performance of CardioCel<sup>®</sup> in cardiac surgery. The review included all studies published from January 2013 to December 2020. We conclude that CardioCel is a strong, flexible tissue substitute with good handling characteristics and a low incidence of thrombosis, aneurysm formation, infection, or structural degeneration. It can be used for a variety of intracardiac and extracardiac repairs of congenital heart defects in all age groups with good durability at mid-term follow-up. However, the use of CardioCel in certain positions requires caution. Information on the long-term performance of CardioCel is lacking.</p>","PeriodicalId":23974,"journal":{"name":"World Journal for Pediatric and Congenital Heart Surgery","volume":"14 2","pages":"211-219"},"PeriodicalIF":0.9,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9318244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Norwood Aneurysm: Report of a Rare Phenomenon. 诺伍德动脉瘤:一罕见现象报告。
IF 0.9 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2023-03-01 DOI: 10.1177/21501351221137288
Othman A Aljohani, Ahmad Hasan, Francesca Byrne, John Lamberti, Raghav Murthy

An 18-year-old male with complex single-ventricle physiology status post-3-stage palliation developed a large Norwood aneurysm (77 × 67 mm). The patient underwent a successful surgical reconstruction. Care providers must be aware of this rare complication and provide appropriate surveillance.

患者为18岁男性,单脑室生理状况复杂,经3期姑息治疗后发现巨大的诺伍德动脉瘤(77 × 67 mm)。病人接受了成功的手术重建。护理人员必须意识到这种罕见的并发症,并提供适当的监测。
{"title":"Norwood Aneurysm: Report of a Rare Phenomenon.","authors":"Othman A Aljohani,&nbsp;Ahmad Hasan,&nbsp;Francesca Byrne,&nbsp;John Lamberti,&nbsp;Raghav Murthy","doi":"10.1177/21501351221137288","DOIUrl":"https://doi.org/10.1177/21501351221137288","url":null,"abstract":"<p><p>An 18-year-old male with complex single-ventricle physiology status post-3-stage palliation developed a large Norwood aneurysm (77 × 67 mm). The patient underwent a successful surgical reconstruction. Care providers must be aware of this rare complication and provide appropriate surveillance.</p>","PeriodicalId":23974,"journal":{"name":"World Journal for Pediatric and Congenital Heart Surgery","volume":"14 2","pages":"243-246"},"PeriodicalIF":0.9,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9329669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Invited Commentary: Norwood Procedure Using Regional Cerebral Perfusion at Normothermia: Are We There Yet? 特邀评论:诺伍德手术在正常体温下使用局部脑灌注:我们还在那里吗?
IF 0.9 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2023-03-01 DOI: 10.1177/21501351231155811
Christian Pizarro
Over the last few decades, significant advances in the field of congenital heart surgery have allowed the successful management of most forms of congenital heart disease even in the smallest patients. The two most significant challenges are the protection of the brain and the myocardium. Interventions on the aortic arch require a perturbation of the cerebral blood flow that, therefore, requires a specific protective strategy. Since the initial report by Bigelow, it was recognized that deep hypothermic circulatory arrest (DHCA) permitted a precise repair and was associated with improved surgical outcomes. This was largely due to the advantage of a “quiet and bloodless operative field” as well as organ protection from ischemia due to a significant reduction of oxygen consumption. Nevertheless, extended periods of DHCA have been associated with neurologic injury leading to adverse neurodevelopmental (ND) outcomes. The search for an optimal strategy led to the Boston Circulatory Arrest Study, which based on a subanalysis of a small subgroup of patients created the perception that low-flow hypothermic bypass was a superior strategy, when in fact the message was that each strategy had its own ND imprint. Based on this notion, when it comes to the reconstruction of the aortic arch, regional cerebral perfusion (RCP) has been widely embraced as a “superior” strategy, because it minimizes the exposure to DHCA. Nevertheless, several studies, including a large prospective randomized trial, have failed to provide such evidence.4–6 Moreover, despite the intuitive notion that antegrade or RCP is protective, Gunn and colleagues reported a 33% incidence of perioperative seizures in a cohort of patients undergoing arch reconstruction while utilizing RCP between 18 °C and 25 °C. Seizures were commonly leftsided and usually present during the period of antegrade cerebral perfusion. In addition, the reduction in left-hemispheric cerebral oxygenation reported by near-infrared spectroscopy during RCP brings into question the safety and effectiveness of this approach in its current form to ameliorate the morbidity associated with DHCA exposure. Keizman and colleagues describe their experience with patients with hypoplastic left heart syndrome comparing a strategy of arch reconstruction with antegrade cerebral perfusion at normothermia (>34 °C) versus hypothermia (<34 °C). This work is courageous and potentially promising. However, it lacks the necessary assurances that normothermic RCP is not detrimental to ND outcomes. The retrospective nature of the study and the lack of universal ND evaluation preand postintervention are serious limitations of this study. As demonstrated by the recent survey of preferences and attitudes toward perfusion techniques during neonatal arch reconstruction, there is a paucity of robust and conclusive data to inform this decision. The choice of DHCA, antegrade or RCP, or DHCA with intermittent perfusion remains largely based on personal expe
{"title":"Invited Commentary: Norwood Procedure Using Regional Cerebral Perfusion at Normothermia: Are We There Yet?","authors":"Christian Pizarro","doi":"10.1177/21501351231155811","DOIUrl":"https://doi.org/10.1177/21501351231155811","url":null,"abstract":"Over the last few decades, significant advances in the field of congenital heart surgery have allowed the successful management of most forms of congenital heart disease even in the smallest patients. The two most significant challenges are the protection of the brain and the myocardium. Interventions on the aortic arch require a perturbation of the cerebral blood flow that, therefore, requires a specific protective strategy. Since the initial report by Bigelow, it was recognized that deep hypothermic circulatory arrest (DHCA) permitted a precise repair and was associated with improved surgical outcomes. This was largely due to the advantage of a “quiet and bloodless operative field” as well as organ protection from ischemia due to a significant reduction of oxygen consumption. Nevertheless, extended periods of DHCA have been associated with neurologic injury leading to adverse neurodevelopmental (ND) outcomes. The search for an optimal strategy led to the Boston Circulatory Arrest Study, which based on a subanalysis of a small subgroup of patients created the perception that low-flow hypothermic bypass was a superior strategy, when in fact the message was that each strategy had its own ND imprint. Based on this notion, when it comes to the reconstruction of the aortic arch, regional cerebral perfusion (RCP) has been widely embraced as a “superior” strategy, because it minimizes the exposure to DHCA. Nevertheless, several studies, including a large prospective randomized trial, have failed to provide such evidence.4–6 Moreover, despite the intuitive notion that antegrade or RCP is protective, Gunn and colleagues reported a 33% incidence of perioperative seizures in a cohort of patients undergoing arch reconstruction while utilizing RCP between 18 °C and 25 °C. Seizures were commonly leftsided and usually present during the period of antegrade cerebral perfusion. In addition, the reduction in left-hemispheric cerebral oxygenation reported by near-infrared spectroscopy during RCP brings into question the safety and effectiveness of this approach in its current form to ameliorate the morbidity associated with DHCA exposure. Keizman and colleagues describe their experience with patients with hypoplastic left heart syndrome comparing a strategy of arch reconstruction with antegrade cerebral perfusion at normothermia (&gt;34 °C) versus hypothermia (&lt;34 °C). This work is courageous and potentially promising. However, it lacks the necessary assurances that normothermic RCP is not detrimental to ND outcomes. The retrospective nature of the study and the lack of universal ND evaluation preand postintervention are serious limitations of this study. As demonstrated by the recent survey of preferences and attitudes toward perfusion techniques during neonatal arch reconstruction, there is a paucity of robust and conclusive data to inform this decision. The choice of DHCA, antegrade or RCP, or DHCA with intermittent perfusion remains largely based on personal expe","PeriodicalId":23974,"journal":{"name":"World Journal for Pediatric and Congenital Heart Surgery","volume":"14 2","pages":"133"},"PeriodicalIF":0.9,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9380597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Multidisciplinary Surgical Approach to Mediastinal Masses in Children. 儿童纵隔肿块的多学科手术方法。
IF 0.9 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2023-03-01 Epub Date: 2023-02-19 DOI: 10.1177/21501351221133753
Vanessa M Miller, Mitchell Disharoon, Luz A Padilla, Elizabeth A Beierle, Robert J Dabal

The aim of this study is to demonstrate the safety and advantages of a multidisciplinary approach to surgical resection of mediastinal masses in children. Eight patients underwent resection of a mediastinal mass by a team involving both a pediatric general surgeon and pediatric cardiothoracic surgeon. One patient required rapid initiation of cardiopulmonary bypass to complete the tumor resection and repair an aortic injury that occurred when removing adherent tumor from the structure. Perioperative outcomes were excellent for all patients. This series shows that a multidisciplinary surgical approach can be potentially life saving.

本研究的目的是证明采用多学科方法对儿童纵隔肿块进行手术切除的安全性和优势。八名患者接受了由小儿普外科医生和小儿心胸外科医生组成的团队进行的纵隔肿块切除术。其中一名患者需要快速启动心肺旁路术,以完成肿瘤切除,并修复在切除粘连肿瘤时造成的主动脉损伤。所有患者的围手术期效果都非常好。该系列手术表明,多学科手术方法有可能挽救患者的生命。
{"title":"A Multidisciplinary Surgical Approach to Mediastinal Masses in Children.","authors":"Vanessa M Miller, Mitchell Disharoon, Luz A Padilla, Elizabeth A Beierle, Robert J Dabal","doi":"10.1177/21501351221133753","DOIUrl":"10.1177/21501351221133753","url":null,"abstract":"<p><p>The aim of this study is to demonstrate the safety and advantages of a multidisciplinary approach to surgical resection of mediastinal masses in children. Eight patients underwent resection of a mediastinal mass by a team involving both a pediatric general surgeon and pediatric cardiothoracic surgeon. One patient required rapid initiation of cardiopulmonary bypass to complete the tumor resection and repair an aortic injury that occurred when removing adherent tumor from the structure. Perioperative outcomes were excellent for all patients. This series shows that a multidisciplinary surgical approach can be potentially life saving.</p>","PeriodicalId":23974,"journal":{"name":"World Journal for Pediatric and Congenital Heart Surgery","volume":"14 2","pages":"180-184"},"PeriodicalIF":0.9,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9680047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Genetic Disorders in the Surgical Management of Congenital Heart Disease. 遗传性疾病对先天性心脏病手术治疗的影响。
IF 0.9 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2023-03-01 DOI: 10.1177/21501351221139837
Elizabeth H Stephens, Joseph A Dearani, Heidi M Connolly, Stephen J Gleich, David R Deyle, Jonathan N Johnson

The congenital heart surgeon frequently encounters patients with various genetic disorders requiring surgical intervention. Although the specifics of the genetics for these patients and their families lie in the purview of specialists in genetics, the surgeon is well-served to be familiar with aspects of specific syndromes that impact surgical management and perioperative care. This aids in counseling families in expectations for the hospital course and recovery as well as can impact intraoperative and surgical management. This review article summarizes key characteristics for the congenital heart surgeon to be familiar with for common genetic disorders as they help coordinate care.

先天性心脏外科医生经常遇到需要手术干预的各种遗传疾病患者。虽然这些患者及其家庭的遗传学细节属于遗传学专家的范围,但外科医生应该熟悉影响手术管理和围手术期护理的特定综合征的各个方面。这有助于咨询家庭对住院过程和康复的期望,以及可以影响术中和手术管理。这篇综述文章总结了先天性心脏外科医生熟悉的常见遗传疾病的关键特征,因为它们有助于协调护理。
{"title":"Impact of Genetic Disorders in the Surgical Management of Congenital Heart Disease.","authors":"Elizabeth H Stephens,&nbsp;Joseph A Dearani,&nbsp;Heidi M Connolly,&nbsp;Stephen J Gleich,&nbsp;David R Deyle,&nbsp;Jonathan N Johnson","doi":"10.1177/21501351221139837","DOIUrl":"https://doi.org/10.1177/21501351221139837","url":null,"abstract":"<p><p>The congenital heart surgeon frequently encounters patients with various genetic disorders requiring surgical intervention. Although the specifics of the genetics for these patients and their families lie in the purview of specialists in genetics, the surgeon is well-served to be familiar with aspects of specific syndromes that impact surgical management and perioperative care. This aids in counseling families in expectations for the hospital course and recovery as well as can impact intraoperative and surgical management. This review article summarizes key characteristics for the congenital heart surgeon to be familiar with for common genetic disorders as they help coordinate care.</p>","PeriodicalId":23974,"journal":{"name":"World Journal for Pediatric and Congenital Heart Surgery","volume":"14 2","pages":"201-210"},"PeriodicalIF":0.9,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9680062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biventricular Repair for Aortic Atresia, Ventricular Septal Defect, and Type C Interrupted Aortic Arch. 主动脉闭锁、室间隔缺损和C型主动脉弓中断的双室修复。
IF 0.9 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2023-03-01 DOI: 10.1177/21501351221145162
Yi-Chia Wang, Heng-Wen Chou, Yih-Sharng Chen, Shu-Chien Huang

Interrupted aortic arch is a rare congenital heart defect. Among patients with interrupted aortic arch, an interruption between the innominate artery and left common carotid artery (type C) is the rarest. Herein, we report the case of a neonate with aortic atresia, ventricular septal defect, type C interrupted aortic arch, and aberrant right subclavian artery who underwent Norwood stage I operation and staged biventricular repair. Due to aortic atresia, coronary artery perfusion was retrograde from the right common carotid artery. The surgical technique and special considerations for cardiopulmonary bypass are presented.

主动脉弓中断是一种罕见的先天性心脏缺陷。在主动脉弓中断的患者中,无名动脉和左颈总动脉(C型)之间的中断是最罕见的。在此,我们报告一例新生儿主动脉闭锁,室间隔缺损,C型主动脉弓中断,右锁骨下动脉异常,接受诺伍德I期手术和分阶段双心室修复。由于主动脉闭锁,冠状动脉灌注从右颈总动脉逆行。本文介绍了体外循环的手术技术和特殊注意事项。
{"title":"Biventricular Repair for Aortic Atresia, Ventricular Septal Defect, and Type C Interrupted Aortic Arch.","authors":"Yi-Chia Wang,&nbsp;Heng-Wen Chou,&nbsp;Yih-Sharng Chen,&nbsp;Shu-Chien Huang","doi":"10.1177/21501351221145162","DOIUrl":"https://doi.org/10.1177/21501351221145162","url":null,"abstract":"<p><p>Interrupted aortic arch is a rare congenital heart defect. Among patients with interrupted aortic arch, an interruption between the innominate artery and left common carotid artery (type C) is the rarest. Herein, we report the case of a neonate with aortic atresia, ventricular septal defect, type C interrupted aortic arch, and aberrant right subclavian artery who underwent Norwood stage I operation and staged biventricular repair. Due to aortic atresia, coronary artery perfusion was retrograde from the right common carotid artery. The surgical technique and special considerations for cardiopulmonary bypass are presented.</p>","PeriodicalId":23974,"journal":{"name":"World Journal for Pediatric and Congenital Heart Surgery","volume":"14 2","pages":"248-250"},"PeriodicalIF":0.9,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9318241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
World Journal for Pediatric and Congenital Heart Surgery
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1