Zhong xi yi jie he za zhi = Chinese journal of modern developments in traditional medicine最新文献

Desensitive treatment of 102 cases of allergic rhinitis caused by allergens has been carried out using acupuncture endermic points of the head with the extract of positive allergen (or allergens). After two courses of the treatment, the extract of allergens was taken again to make intradermal injection. Diameter of redness and swelling on the skin was significantly reduced in comparison with that before the treatment (P less than 0.01). Cell mediated and humoral immunity of the patients tended to be normal. These cases were followed up for 2 years. 72.18% of the cases had significantly curative effect; 23.56% turned better. Comparison of curative difference of this group with the other two control groups was significant (P less than 0.01). Therefore, this method is of considerable clinical value and worth popularizing in treatment of allergic rhinitis.

By using ELISA and RIA to measure the levels of Beta-thromboglobulin (beta-TG), platelet factor 4(PF4), thromboxane B2 (TXB2) and 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha) in plasma of patients with acute cerebral infarction, the authors found that the levels of beta-TG, PF4 and TXB2 in plasma had significantly increased (P less than 0.01), but the level of 6-keto-PGF1 alpha in plasma showed no change (P greater than 0.05). The results of the Ligusticum wallichii (Ligusticum) treatment to the test-group showed that the levels of beta-TG, PF4 and TXB2 in plasma had significantly decreased (P less than 0.01), and the level of 6-keto-PGF1 alpha in plasma had significantly increased (P less than 0.05). This suggested that the Ligusticum treatment could effectively inhibit the platelet activation in vivo and correct the TXA2-PGI2 imbalance in blood of the patients. In this study, some new approaches were explored to explain the mechanisms of Ligusticum for preventing and treating cerebral ischemia.

In the present experiment, the hemodynamic effect of Salvia miltiorrhizae composite injection (SMCI) on pulmonary and systemic circulation during hypoxic pulmonary arterial hypertension was observed. The results showed that the pulmonary arterial pressure increased at first in both group, then decreased gradually, but in SMCI group decreased much more than in the control group. The pulmonary vascular resistance increased very significantly in the control group, but in SMCI group considerably decreased after administration, then keeping at a level little more than the normal. Difference between groups was very significant. The stroke volume increased slightly at first and then decreased persistently in the control group, but increased significantly and kept at a higher level in SMCI group. The protective effects of SMCI on hypoxic myocardium was studied by observing ST-segment on ECG. It was found that the ST-segment fell in both groups, but the degree of fall in SMCI was much less than in the control group. It was found that the PaO2 was 35.1 +/- 2.6 in the control group, 38.1 +/- 2.4 in SMCI group. Difference between groups was significant (P less than 0.05.) The above results suggest that SMCI can diminish hypoxic pulmonary vasoconstriction, improve PaO2 in hypoxic animal and protect hypoxic myocardium. Hence, SMCI can be used to prevent and treat hypoxic pulmonary arterial hypertension.

The role of da cheng qi decoction co. (DCQDC) in preventing endotoxemia in obstructive jaundice has been investigated. A prospective study was performed on 43 consecutive patients with obstructive jaundice undergoing surgery. 24 patients were given oral DCQDC before operation and were compared with 19 jaundiced control patients and 17 non-jaundiced control patients. The incidence of endotoxemia was reduced in perioperative portal (P less than 0.05) and postoperative systemic (P less than 0.01) blood samples in the DCQDC treated group, and a significant fall of the postoperative 24h creatinine clearance (P less than 0.01) and the plasma fibronectin level (P less than 0.01) occurred in jaundiced controls compared with the DCQDC treated group. DCQDC may reduce endotoxin absorption by a reduction or alteration of gut flora thereby reducing the endotoxin pool available for absorption as well as by a direct effect on endotoxin. Result of this study indicated that DCQDC had a beneficial effect on endotoxemia or outcome in obstructive jaundice.

In this paper, comparative studies on main pharmacological activities and toxilogical activities of water extracts from cultivated Saposhnikovia divaricata (SD) and wild SD in Qixia county of Shandong province were performed. The results showed that the febrifugal analgesic and anticonvulsived activities of water extracts from cultivated SD and wild SD were primary same. Estimative results of LD50 showed that order of toxicity were such as firstly direct cultivated SD, secondly cuttage SD and finally wild SD. Therefore it was recognized that cultivated SD completely can replaced wild one in medical use.

The malondialdehyde generation by platelets and TXB2 in poor platelet plasma were examined in 36 patients with stroke during acute stage. By CT examination 19 cases were diagnosed hemorrhagic, 17 cases ischemic; while by syndrome differentiation of TCM 16 cases belonged to Zhongzangfu(middle internal organs), 20 cases Zhongjingluo (middle channels). Results showed that the malondialdehyde generation by platelets was reduced, TXB2 in poor platelet plasma increased in patients, compared with those in the healthy controls. This finding was common in stroke during acute stage and was not related to diagnostic classes by either CT examination or syndrome differentiation of TCM. This study indicates that maintenance of normal platelet function may have significant implication in the prevention and treatment of cerebrovascular disease.

The therapeutic effect of Ligustrazine was studied in patients with benign paroxysmal positional vertigo (BPPV). 11 cases were given Ligustrazine 100 mg daily (iv. or im.), another 11 cases were given Valium and Diphenidol as the control group. The results were as follows: In Ligustrazine group, the average curative time was 37 days. In the control group, the average curative time was 72 days. This result suggests that Ligustrazine is a useful drug in the treatment of BPPV. It is believed that the cause of BPPV is due to the occlusion of the anterior vestibular artery. Ligustrazine has the effect of improving microcirculation of the cochlea.

According to the multiple pharmacological functions of Chinese herbs for treating burns, the authors selected some traditional herbs to cure the burning wound, which had not only the function of improving the local microcirculation of the burned surface and their bactericidal action, but also the function of changing the bacterial growth milieu action. Coptis chinensis 40%, Herba Taraxaci 40%, Fructus Mume 10% and Salvia miltiorrhizae 10% were boiled, infiltrated and disinfected. The mixture thus made was called as Burn II, which were applied on the burned surface daily, 97.1% of 103 patients were cured. Through the experiment of 60 rabbits burned by irons, which were divided into 6 groups (n = 10 in each group) and each 2 groups infected respectively with Bacillus pyocyaneus, Bacillus Coli and Staphylococcus Aureus, took one of each infected group as control group. After 14 days, the infected burned surfaces which were applied with Burn II daily. The results showed that the effect of Burn II was not only significant, but also its usage was not highly restricted by the medical condition.