首页 > 最新文献

Zhonghua nei ke za zhi最新文献

英文 中文
[Expert consensus on technical strategies for interventional treatment of acute large vessel occlusive stroke in China]. 【中国急性大血管闭塞性脑卒中介入治疗技术策略专家共识】。
Pub Date : 2023-08-01 DOI: 10.3760/cma.j.cn112138-20220819-00608

Ischemic stroke caused by acute large vessel occlusion is associated with high rates of disability and mortality. Endovascular interventional therapy is evidently an effective treatment for occlusion of large cerebral vessels within the relevant time window, but there is no established methodological standard for recanalization interventional therapy. The Professional Committee of Interventional Neurology in Chinese Research Hospital Association organized cerebrovascular disease experts in China and developed the expert consensus described herein, to provide a reference for clinicians to formulate technical strategies for recanalization of acute cerebral vascular occlusion.

急性大血管闭塞引起的缺血性中风与高致残率和死亡率相关。血管内介入治疗显然是在相关时间窗内治疗大脑血管闭塞的有效方法,但介入再通治疗尚无既定的方法标准。中国研究型医院协会介入神经病学专业委员会组织全国脑血管病专家,形成本文所述专家共识,为临床医生制定急性脑血管闭塞再通技术策略提供参考。
{"title":"[Expert consensus on technical strategies for interventional treatment of acute large vessel occlusive stroke in China].","authors":"","doi":"10.3760/cma.j.cn112138-20220819-00608","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20220819-00608","url":null,"abstract":"<p><p>Ischemic stroke caused by acute large vessel occlusion is associated with high rates of disability and mortality. Endovascular interventional therapy is evidently an effective treatment for occlusion of large cerebral vessels within the relevant time window, but there is no established methodological standard for recanalization interventional therapy. The Professional Committee of Interventional Neurology in Chinese Research Hospital Association organized cerebrovascular disease experts in China and developed the expert consensus described herein, to provide a reference for clinicians to formulate technical strategies for recanalization of acute cerebral vascular occlusion.</p>","PeriodicalId":24000,"journal":{"name":"Zhonghua nei ke za zhi","volume":"62 8","pages":"931-938"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10300847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Paget's disease of bone with SQSTM1 and HNRNPA2B1 gene mutations: report of 2 cases]. [伴有SQSTM1和HNRNPA2B1基因突变的骨Paget病:附2例报告]。
Pub Date : 2023-08-01 DOI: 10.3760/cma.j.cn112138-20220901-00648
X H Tao, T Xu, Q Lu, W D Yang, Y Q Hu, W Z Fu, H Yue, Z L Zhang
畸形性骨炎是一种临床罕见的慢性进展性代谢性骨病,目前病因不明,其主要特征为骨吸收增加,随之代偿性新骨形成增加,临床表现为碱性磷酸酶升高、骨痛、骨骼畸形,易出现病理性骨折。本文报道2例罕见的畸形性骨炎分别由SQSTM1基因及HNRNPA2B1基因突变所致,分析2例患者的临床表现并复习相关文献,以期提高临床医生对该病的认识和诊治水平,并为后续开展分子诊断和基因筛查提供依据。.
{"title":"[Paget's disease of bone with SQSTM1 and HNRNPA2B1 gene mutations: report of 2 cases].","authors":"X H Tao,&nbsp;T Xu,&nbsp;Q Lu,&nbsp;W D Yang,&nbsp;Y Q Hu,&nbsp;W Z Fu,&nbsp;H Yue,&nbsp;Z L Zhang","doi":"10.3760/cma.j.cn112138-20220901-00648","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20220901-00648","url":null,"abstract":"畸形性骨炎是一种临床罕见的慢性进展性代谢性骨病,目前病因不明,其主要特征为骨吸收增加,随之代偿性新骨形成增加,临床表现为碱性磷酸酶升高、骨痛、骨骼畸形,易出现病理性骨折。本文报道2例罕见的畸形性骨炎分别由SQSTM1基因及HNRNPA2B1基因突变所致,分析2例患者的临床表现并复习相关文献,以期提高临床医生对该病的认识和诊治水平,并为后续开展分子诊断和基因筛查提供依据。.","PeriodicalId":24000,"journal":{"name":"Zhonghua nei ke za zhi","volume":"62 8","pages":"1021-1025"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9980093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Effects of biologics on psychological status and quality of life in patients with inflammatory bowel disease: a multicenter study]. [生物制剂对炎症性肠病患者心理状态和生活质量的影响:一项多中心研究]。
Pub Date : 2023-08-01 DOI: 10.3760/cma.j.cn112138-20220818-00603
S C Wei, C Liu, M Chen, Y H Cai, X H Wu, M L Chen, J X Zhang, D Xiang, Z C Liu, C Q Jiang, J Shi, K C Wu, W G Dong

Objective: To investigate the effects of biologics on psychological status and quality of life in patients with inflammatory bowel disease (IBD). Methods: A cross-sectional survey was conducted in 42 hospitals in 22 provinces (autonomous regions and municipalities directly under the central government) from September 2021 to May 2022. General clinical information and the use of biologics were obtained from adult patients diagnosed with IBD who voluntarily participated in the study. Psychological status was evaluated using the Generalized Anxiety Disorder (GAD-7), Patient Health Questionnaire-9 (PHQ-9), Pittsburgh Sleep Quality Index (PSQI), and Inflammatory Bowel Disease Questionnaire (IBDQ) assessment tools. Counts were analyzed via the Chi-square test, and datasets that were not normally distributed were analyzed via nonparametric tests. P<0.05 was considered statistically significant. Results: A total of 2 478 valid questionnaires were collected. The GAD-7 score of the biologics group was significantly lower than that of the non-use group [6 (2, 9) vs. 7 (3, 10), Z=-3.49, P<0.001]. IBDQ scores [183 (158, 204) vs. 178 (152, 198), Z=-4.11, P<0.001], intestinal symptom scores [61 (52, 67) vs. 58 (49, 65), Z=-5.41, P<0.001], systemic symptom scores [28 (24, 32) vs. 27 (23, 31), Z=-2.37, P=0.018], emotional ability scores [69 (58, 77) vs. 67 (56, 75), Z=-3.58, P<0.001] and social ability scores [26 (22, 29) vs. 25 (22, 29), Z=-2.52, P=0.012] in the biologics group were significantly higher than in the non-use group. GAD-7 scores [5 (2, 9) vs. 6 (3, 10), Z=-3.50, P<0.001] and PSQI scores [6 (4, 9) vs. 6 (4, 9), Z=-2.55, P=0.011] were significantly lower in the group using infliximab than in the group not using it. IBDQ scores were significantly higher in patients using vedolizumab than in those not using it [186 (159, 205) vs. 181 (155, 201), Z=-2.32, P=0.021] and were also significantly higher in the group treated with adalimumab than in the group not treated with adalimumab [187 (159, 209) vs. 181 (155, 201), Z=-2.16, P=0.030]. However, ustekinumab had no significant effect on any of the scores. Conclusion: The use of biologics is strongly associated with improvements in anxiety status and quality of life in IBD patients.

目的:探讨生物制剂对炎症性肠病(IBD)患者心理状态和生活质量的影响。方法:于2021年9月至2022年5月对22个省(区、市)的42家医院进行横断面调查。从自愿参加研究的IBD成年患者中获得一般临床信息和生物制剂的使用情况。采用广泛性焦虑障碍(GAD-7)、患者健康问卷-9 (PHQ-9)、匹兹堡睡眠质量指数(PSQI)和炎症性肠病问卷(IBDQ)评估工具评估心理状态。计数通过卡方检验分析,非正态分布的数据集通过非参数检验分析。结果:共回收有效问卷2 478份。生物制剂组的GAD-7得分显著低于非使用组[6(2,9)比7 (3,10),Z=-3.49, PZ=-4.11, PZ=-5.41, PZ=-2.37, P=0.018],情绪能力得分[69(58,77)比67 (56,75),Z=-3.58, PZ=-2.52, P=0.012],生物制剂组显著高于非使用组。使用英夫利昔单抗组的GAD-7评分[5 (2,9)vs. 6 (3,10), Z=-3.50, PZ=-2.55, P=0.011]显著低于未使用英夫利昔单抗组。使用维多单抗的患者IBDQ评分显著高于未使用维多单抗的患者[186(159,205)比181 (155,201),Z=-2.32, P=0.021],阿达木单抗治疗组的IBDQ评分也显著高于未使用阿达木单抗治疗组[187(159,209)比181 (155,201),Z=-2.16, P=0.030]。然而,ustekinumab对任何评分都没有显著影响。结论:生物制剂的使用与IBD患者焦虑状态和生活质量的改善密切相关。
{"title":"[Effects of biologics on psychological status and quality of life in patients with inflammatory bowel disease: a multicenter study].","authors":"S C Wei,&nbsp;C Liu,&nbsp;M Chen,&nbsp;Y H Cai,&nbsp;X H Wu,&nbsp;M L Chen,&nbsp;J X Zhang,&nbsp;D Xiang,&nbsp;Z C Liu,&nbsp;C Q Jiang,&nbsp;J Shi,&nbsp;K C Wu,&nbsp;W G Dong","doi":"10.3760/cma.j.cn112138-20220818-00603","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20220818-00603","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the effects of biologics on psychological status and quality of life in patients with inflammatory bowel disease (IBD). <b>Methods:</b> A cross-sectional survey was conducted in 42 hospitals in 22 provinces (autonomous regions and municipalities directly under the central government) from September 2021 to May 2022. General clinical information and the use of biologics were obtained from adult patients diagnosed with IBD who voluntarily participated in the study. Psychological status was evaluated using the Generalized Anxiety Disorder (GAD-7), Patient Health Questionnaire-9 (PHQ-9), Pittsburgh Sleep Quality Index (PSQI), and Inflammatory Bowel Disease Questionnaire (IBDQ) assessment tools. Counts were analyzed via the Chi-square test, and datasets that were not normally distributed were analyzed via nonparametric tests. <i>P</i><0.05 was considered statistically significant. <b>Results:</b> A total of 2 478 valid questionnaires were collected. The GAD-7 score of the biologics group was significantly lower than that of the non-use group [6 (2, 9) vs. 7 (3, 10), <i>Z</i>=-3.49, <i>P</i><0.001]. IBDQ scores [183 (158, 204) vs. 178 (152, 198), <i>Z</i>=-4.11, <i>P</i><0.001], intestinal symptom scores [61 (52, 67) vs. 58 (49, 65), <i>Z</i>=-5.41, <i>P</i><0.001], systemic symptom scores [28 (24, 32) vs. 27 (23, 31), <i>Z</i>=-2.37, <i>P</i>=0.018], emotional ability scores [69 (58, 77) vs. 67 (56, 75), <i>Z</i>=-3.58, <i>P</i><0.001] and social ability scores [26 (22, 29) vs. 25 (22, 29), <i>Z</i>=-2.52, <i>P</i>=0.012] in the biologics group were significantly higher than in the non-use group. GAD-7 scores [5 (2, 9) vs. 6 (3, 10), <i>Z</i>=-3.50, <i>P</i><0.001] and PSQI scores [6 (4, 9) vs. 6 (4, 9), <i>Z</i>=-2.55, <i>P</i>=0.011] were significantly lower in the group using infliximab than in the group not using it. IBDQ scores were significantly higher in patients using vedolizumab than in those not using it [186 (159, 205) vs. 181 (155, 201), <i>Z</i>=-2.32, <i>P</i>=0.021] and were also significantly higher in the group treated with adalimumab than in the group not treated with adalimumab [187 (159, 209) vs. 181 (155, 201), <i>Z</i>=-2.16, <i>P</i>=0.030]. However, ustekinumab had no significant effect on any of the scores. <b>Conclusion:</b> The use of biologics is strongly associated with improvements in anxiety status and quality of life in IBD patients.</p>","PeriodicalId":24000,"journal":{"name":"Zhonghua nei ke za zhi","volume":"62 8","pages":"1000-1006"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10300848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Application and prospect of telehealth in the management of cardiovascular disease]. 远程医疗在心血管疾病管理中的应用与展望
Pub Date : 2023-08-01 DOI: 10.3760/cma.j.cn112138-20220913-00676
L Zhou, C S Ma, Y Kong, L He, C Jiang
心血管疾病发病率致死率高,位居我国疾病负担首位。互联网医疗有利于实现对心血管病患者的全病程管理,可缓解实体医疗资源不足、地域分布不均衡等问题。本文主要综述了互联网医疗应用于心血管慢性病管理的基础、应用现状和未来发展。.
{"title":"[Application and prospect of telehealth in the management of cardiovascular disease].","authors":"L Zhou,&nbsp;C S Ma,&nbsp;Y Kong,&nbsp;L He,&nbsp;C Jiang","doi":"10.3760/cma.j.cn112138-20220913-00676","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20220913-00676","url":null,"abstract":"心血管疾病发病率致死率高,位居我国疾病负担首位。互联网医疗有利于实现对心血管病患者的全病程管理,可缓解实体医疗资源不足、地域分布不均衡等问题。本文主要综述了互联网医疗应用于心血管慢性病管理的基础、应用现状和未来发展。.","PeriodicalId":24000,"journal":{"name":"Zhonghua nei ke za zhi","volume":"62 8","pages":"1034-1038"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9980095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Associations between serum GDF15 and glycolipid metabolism disorder in metabolic associated fatty liver patients]. [代谢性脂肪肝患者血清GDF15与糖脂代谢紊乱的关系]。
Pub Date : 2023-08-01 DOI: 10.3760/cma.j.cn112138-20220822-00614
X Li, X M Yu, E H Li, P H Chen, L M Zheng, S Zhang

Objective: To investigate relationships between serum growth differentiation factor 15 (GDF15) and glycolipid metabolism in patients with metabolic associated fatty liver disease (MAFLD). Methods: The current investigation was a cross-sectional study. A total of 333 patients from the Fengxian District Central Hospital were recruited into the study after physical examination from February 2020 to February 2021. There were 107 patients with MAFLD and type 2 diabetes mellitus (T2DM), including 54 males and 53 females with a mean age of (57±11) years. There were 65 patients with simple MAFLD only, including 32 men and 33 women with a mean age of (49±5) years. There were 105 patients with T2DM only, including 53 men and 52 women, with a mean age of (56±10) years. A control group of 56 people without MAFLD or diabetes,28 male, 28 female, mean age (48±6) years, was also included in the study. Serum GDF15 was measured via enzyme-linked immunosorbent assays. IBM SPSS 26.0 was used for statistical analysis. Logistic regression was used to evaluate relationships between GDF15 and metabolic abnormalities in MAFLD patients. Results: GDF15 progressively increased in the control [385 (296, 484) ng/L], nonobese MAFLD [388 (319, 435) ng/L], obese MAFLD [426 (354, 527) ng/L], T2DM [664 (483, 900) ng/L], and MAFLD+T2DM groups [770 (560, 1 074) ng/L](H=113.82, P=0.001). There was no significant difference in serum GDF15 between the simple MAFLD [406 (339, 524) ng/L] and control group (U=1 505.50, P=0.132). GDF15 was significantly higher in the MAFLD+T2DM group than in the T2DM-only group (U=4 573.50, P=0.019). In logistic regression analysis increased GDF15 was associated with increased risks of simple MAFLD [odds ratio (OR)=2.202], T2DM (OR=29.656), and MAFLD+T2DM(OR=58.197). In patients with MAFLD, serum GDF15 was higher in the FIB4 index>1.45 group [773 (534, 1 162) ng/L] than in the FIB4 index<1.45 group [527 (389, 787) ng/L] (U=1 709.50, P<0.001). Increased GDF15 was associated with an increased risk of advanced liver fibrosis (OR=2.388). Conclusion: In patients with simple MAFLD, GDF15 level was not significantly higher than in the control group. In the T2DM-only group and the MAFLD+T2DM group GDF15 was significantly higher than in the control group. Increased serum GDF15 was associated with increased risk and severity of MAFLD complicated with abnormal glucose and lipid metabolism. High GDF15 increased the risk of advanced fibrosis in MAFLD patients.

目的:探讨代谢相关性脂肪肝(MAFLD)患者血清生长分化因子15 (GDF15)与糖脂代谢的关系。方法:本研究为横断面研究。在2020年2月至2021年2月期间,来自奉贤区中心医院的333名患者在体检后被招募到研究中。合并2型糖尿病(T2DM)患者107例,其中男性54例,女性53例,平均年龄(57±11)岁。单纯性MAFLD患者65例,其中男性32例,女性33例,平均年龄(49±5)岁。仅T2DM患者105例,其中男性53例,女性52例,平均年龄(56±10)岁。对照组56例无MAFLD或糖尿病患者,男28例,女28例,平均年龄(48±6)岁。采用酶联免疫吸附法测定血清GDF15。采用IBM SPSS 26.0进行统计分析。采用Logistic回归评估GDF15与MAFLD患者代谢异常之间的关系。结果:GDF15在对照组[385 (296,484)ng/L]、非肥胖MAFLD [388 (319, 435) ng/L]、肥胖MAFLD [426 (354,527) ng/L]、T2DM组[664 (483,900)ng/L]、MAFLD+T2DM组[770 (560,1 074)ng/L]中逐渐升高(H=113.82, P=0.001)。单纯性MAFLD患者血清GDF15 [406 (339, 524) ng/L]与对照组比较差异无统计学意义(U=1 505.50, P=0.132)。MAFLD+T2DM组GDF15明显高于T2DM组(U=4 573.50, P=0.019)。在logistic回归分析中,GDF15升高与单纯性MAFLD[比值比(OR)=2.202]、T2DM(OR= 29.656)和MAFLD+T2DM(OR=58.197)的风险增加相关。在MAFLD患者中,血清GDF15在FIB4指数>1.45组[773 (534,1 162)ng/L]高于FIB4指数组(1 709.50,POR=2.388)。结论:单纯性MAFLD患者GDF15水平不显著高于对照组。T2DM组和MAFLD+T2DM组GDF15明显高于对照组。血清GDF15升高与MAFLD并发糖脂代谢异常的风险和严重程度增加相关。高GDF15增加了MAFLD患者晚期纤维化的风险。
{"title":"[Associations between serum GDF15 and glycolipid metabolism disorder in metabolic associated fatty liver patients].","authors":"X Li,&nbsp;X M Yu,&nbsp;E H Li,&nbsp;P H Chen,&nbsp;L M Zheng,&nbsp;S Zhang","doi":"10.3760/cma.j.cn112138-20220822-00614","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20220822-00614","url":null,"abstract":"<p><p><b>Objective:</b> To investigate relationships between serum growth differentiation factor 15 (GDF15) and glycolipid metabolism in patients with metabolic associated fatty liver disease (MAFLD). <b>Methods:</b> The current investigation was a cross-sectional study. A total of 333 patients from the Fengxian District Central Hospital were recruited into the study after physical examination from February 2020 to February 2021. There were 107 patients with MAFLD and type 2 diabetes mellitus (T2DM), including 54 males and 53 females with a mean age of (57±11) years. There were 65 patients with simple MAFLD only, including 32 men and 33 women with a mean age of (49±5) years. There were 105 patients with T2DM only, including 53 men and 52 women, with a mean age of (56±10) years. A control group of 56 people without MAFLD or diabetes,28 male, 28 female, mean age (48±6) years, was also included in the study. Serum GDF15 was measured via enzyme-linked immunosorbent assays. IBM SPSS 26.0 was used for statistical analysis. Logistic regression was used to evaluate relationships between GDF15 and metabolic abnormalities in MAFLD patients. <b>Results:</b> GDF15 progressively increased in the control [385 (296, 484) ng/L], nonobese MAFLD [388 (319, 435) ng/L], obese MAFLD [426 (354, 527) ng/L], T2DM [664 (483, 900) ng/L], and MAFLD+T2DM groups [770 (560, 1 074) ng/L](<i>H</i>=113.82, <i>P</i>=0.001). There was no significant difference in serum GDF15 between the simple MAFLD [406 (339, 524) ng/L] and control group (<i>U</i>=1 505.50, <i>P</i>=0.132). GDF15 was significantly higher in the MAFLD+T2DM group than in the T2DM-only group (<i>U</i>=4 573.50, <i>P</i>=0.019). In logistic regression analysis increased GDF15 was associated with increased risks of simple MAFLD [odds ratio (<i>OR</i>)=2.202], T2DM (<i>OR</i>=29.656), and MAFLD+T2DM(<i>OR</i>=58.197). In patients with MAFLD, serum GDF15 was higher in the FIB4 index>1.45 group [773 (534, 1 162) ng/L] than in the FIB4 index<1.45 group [527 (389, 787) ng/L] (<i>U</i>=1 709.50, <i>P</i><0.001). Increased GDF15 was associated with an increased risk of advanced liver fibrosis (<i>OR</i>=2.388). <b>Conclusion:</b> In patients with simple MAFLD, GDF15 level was not significantly higher than in the control group. In the T2DM-only group and the MAFLD+T2DM group GDF15 was significantly higher than in the control group. Increased serum GDF15 was associated with increased risk and severity of MAFLD complicated with abnormal glucose and lipid metabolism. High GDF15 increased the risk of advanced fibrosis in MAFLD patients.</p>","PeriodicalId":24000,"journal":{"name":"Zhonghua nei ke za zhi","volume":"62 8","pages":"987-992"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10282725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Correlation analysis of anterior pituitary hormone and tumor size in patients with pituitary adenomas]. [垂体腺瘤患者垂体前叶激素与肿瘤大小的相关性分析]。
Pub Date : 2023-08-01 DOI: 10.3760/cma.j.cn112138-20221019-00765
Y P Wang, Y J Li, B Li, L Zang, K Chen, J Du, J T Dou, Z H Lyu, W J Gu, Y M Mu

Objective: To summarize the correlation between anterior pituitary function and tumor size in patients with different hormone-secreting pituitary adenomas. Methods: This was a retrospective case series study. The clinical data of 1 946 patients with pituitary adenoma hospitalized in the First Medical Center of Chinese PLA General Hospital from January 1, 2005, to December 31, 2020, were collected. The correlation between tumor size and anterior pituitary hormone levels was analyzed using Spearman rank correlation analysis in different types of pituitary adenomas. Results: The median age of the 1 946 patients was 45.1 years, of which 857 (44.0%) were men. The maximum tumor diameter of the patients [M (Q1, Q3)] was 22 (14, 30) mm. Tumor size in nonfunctioning adenomas (n=1 191) was negatively correlated with adrenocorticotropic hormone (ACTH) (r=-0.11, P<0.001), growth hormone (r=-0.13, P<0.001), and luteinizing hormone (men: r=-0.26, P<0.001, women: r=-0.31, all P<0.001). The tumor size of somatotropic adenomas (n=297) was positively correlated with growth hormone (r=0.46, P<0.001), but negatively correlated with male testosterone (r=-0.41, P<0.001). The tumor size of ACTH-secreting pituitary adenomas (n=155) was positively correlated with the ACTH level at 8∶00 AM (r=0.25, P<0.001); however, no correlation was found with cortisol at 8∶00 AM (P>0.05). The tumor size of prolactinomas (n=303) was positively correlated with the prolactin level (men: r=0.34, P=0.001; women: r=0.13, P=0.070). Conclusions: The correlation between the function of the anterior pituitary and size of the tumor depends on the cellular origin of the pituitary adenoma and specific type of hormone secretion. In somatotroph adenomas, ACTH-secreting pituitary adenomas, and prolactinomas, there is a positive correlation between tumor size and level of hormones secreted by the corresponding tumors. In patients with nonfunctioning adenomas, the tumor size was negatively correlated with the hormone levels of the pituitary-adrenal and pituitary-growth hormone axes.

目的:总结不同激素分泌型垂体腺瘤患者垂体前叶功能与肿瘤大小的关系。方法:回顾性病例系列研究。收集2005年1月1日至2020年12月31日在中国人民解放军总医院第一医疗中心住院的1946例垂体腺瘤患者的临床资料。采用Spearman秩相关分析分析不同类型垂体腺瘤肿瘤大小与垂体前叶激素水平的相关性。结果:1946例患者中位年龄为45.1岁,其中男性857例(44.0%)。无功能腺瘤(n=1 191)的肿瘤大小与促肾上腺皮质激素(ACTH)呈负相关(r=-0.11, Pr=-0.13, Pr=-0.26, Pr=-0.31,均Pn=297);与生长激素(r=0.46, Pr=-0.41, Pn=155)呈正相关(r=0.25, PP>0.05);催乳素瘤的肿瘤大小(n=303)与催乳素水平呈正相关(男性:r=0.34, P=0.001;女性:r=0.13, P=0.070)。结论:垂体前叶功能与肿瘤大小的关系取决于垂体腺瘤的细胞来源和分泌激素的具体类型。在生长滋长性腺瘤、垂体acth分泌腺瘤和泌乳素瘤中,肿瘤大小与相应肿瘤分泌的激素水平呈正相关。在无功能腺瘤患者中,肿瘤大小与垂体-肾上腺和垂体-生长激素轴的激素水平呈负相关。
{"title":"[Correlation analysis of anterior pituitary hormone and tumor size in patients with pituitary adenomas].","authors":"Y P Wang,&nbsp;Y J Li,&nbsp;B Li,&nbsp;L Zang,&nbsp;K Chen,&nbsp;J Du,&nbsp;J T Dou,&nbsp;Z H Lyu,&nbsp;W J Gu,&nbsp;Y M Mu","doi":"10.3760/cma.j.cn112138-20221019-00765","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20221019-00765","url":null,"abstract":"<p><p><b>Objective:</b> To summarize the correlation between anterior pituitary function and tumor size in patients with different hormone-secreting pituitary adenomas. <b>Methods:</b> This was a retrospective case series study. The clinical data of 1 946 patients with pituitary adenoma hospitalized in the First Medical Center of Chinese PLA General Hospital from January 1, 2005, to December 31, 2020, were collected. The correlation between tumor size and anterior pituitary hormone levels was analyzed using Spearman rank correlation analysis in different types of pituitary adenomas. <b>Results:</b> The median age of the 1 946 patients was 45.1 years, of which 857 (44.0%) were men. The maximum tumor diameter of the patients [<i>M</i> (<i>Q</i><sub>1</sub>, <i>Q</i><sub>3</sub>)] was 22 (14, 30) mm. Tumor size in nonfunctioning adenomas (<i>n</i>=1 191) was negatively correlated with adrenocorticotropic hormone (ACTH) (<i>r</i>=-0.11, <i>P</i><0.001), growth hormone (<i>r</i>=-0.13, <i>P</i><0.001), and luteinizing hormone (men: <i>r</i>=-0.26, <i>P</i><0.001, women: <i>r</i>=-0.31, all <i>P</i><0.001). The tumor size of somatotropic adenomas (<i>n</i>=297) was positively correlated with growth hormone (<i>r</i>=0.46, <i>P</i><0.001), but negatively correlated with male testosterone (<i>r</i>=-0.41, <i>P</i><0.001). The tumor size of ACTH-secreting pituitary adenomas (<i>n</i>=155) was positively correlated with the ACTH level at 8∶00 AM (<i>r</i>=0.25, <i>P</i><0.001); however, no correlation was found with cortisol at 8∶00 AM (<i>P</i>>0.05). The tumor size of prolactinomas (<i>n</i>=303) was positively correlated with the prolactin level (men: <i>r</i>=0.34, <i>P</i>=0.001; women: <i>r</i>=0.13, <i>P</i>=0.070). <b>Conclusions:</b> The correlation between the function of the anterior pituitary and size of the tumor depends on the cellular origin of the pituitary adenoma and specific type of hormone secretion. In somatotroph adenomas, ACTH-secreting pituitary adenomas, and prolactinomas, there is a positive correlation between tumor size and level of hormones secreted by the corresponding tumors. In patients with nonfunctioning adenomas, the tumor size was negatively correlated with the hormone levels of the pituitary-adrenal and pituitary-growth hormone axes.</p>","PeriodicalId":24000,"journal":{"name":"Zhonghua nei ke za zhi","volume":"62 8","pages":"979-986"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10282729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Research progress of renal-targeted nanopharmaceuticals in the treatment of acute kidney injury]. 【肾靶向纳米药物治疗急性肾损伤的研究进展】。
Pub Date : 2023-08-01 DOI: 10.3760/cma.j.cn112138-20221003-00726
X W He, Y Liu, Q G Ao, Q L Cheng
急性肾损伤(AKI)具有发病率高、致死率高等特点,目前临床上缺乏有效的治疗方法。现应用的肾脏保护药物由于其生物利用度不高而难以有效治疗AKI。纳米药物载体(nanosized drug carriers,NDCs)的应用,可提高肾脏保护药物的生物利用度和靶向递送效率,以持续、受控的方式有效地将治疗剂靶向至所需组织,可延长肾脏保护剂的生物半衰期和血液循环时间,并减少其在健康组织中的脱靶毒性。本文综述了用于AKI治疗的肾脏纳米药物的研究现状,特别关注NDCs递送肾脏保护剂的肾组织靶向选择性机制、影响因素及其改善药物特性的作用,并对NDCs如何更好地治疗AKI 所面对的挑战及未来前景进行展望。.
{"title":"[Research progress of renal-targeted nanopharmaceuticals in the treatment of acute kidney injury].","authors":"X W He,&nbsp;Y Liu,&nbsp;Q G Ao,&nbsp;Q L Cheng","doi":"10.3760/cma.j.cn112138-20221003-00726","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20221003-00726","url":null,"abstract":"急性肾损伤(AKI)具有发病率高、致死率高等特点,目前临床上缺乏有效的治疗方法。现应用的肾脏保护药物由于其生物利用度不高而难以有效治疗AKI。纳米药物载体(nanosized drug carriers,NDCs)的应用,可提高肾脏保护药物的生物利用度和靶向递送效率,以持续、受控的方式有效地将治疗剂靶向至所需组织,可延长肾脏保护剂的生物半衰期和血液循环时间,并减少其在健康组织中的脱靶毒性。本文综述了用于AKI治疗的肾脏纳米药物的研究现状,特别关注NDCs递送肾脏保护剂的肾组织靶向选择性机制、影响因素及其改善药物特性的作用,并对NDCs如何更好地治疗AKI 所面对的挑战及未来前景进行展望。.","PeriodicalId":24000,"journal":{"name":"Zhonghua nei ke za zhi","volume":"62 8","pages":"1029-1033"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9980094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Progress in the application of uric acid-lowering treatments in amyotrophic lateral sclerosis]. 降尿酸疗法在肌萎缩性侧索硬化症中的应用进展
Pub Date : 2023-07-01 DOI: 10.3760/cma.j.cn112138-20220708-00498
Y N Zhao, J Y Fu, J He, D S Fan
尿酸是人体内嘌呤代谢的终产物,主要通过影响能量代谢、氧化应激、炎症反应等通路来影响肌萎缩侧索硬化症(ALS)的发生发展,但目前尿酸对于ALS的作用仍然存在争议。动物实验显示降尿酸药物黄嘌呤氧化酶抑制剂可以延缓动物模型发病、延长生存期、减缓体重下降、延缓运动能力下降,提示降尿酸药物,尤其是黄嘌呤酶抑制剂在ALS中应用的潜在可能性。.
{"title":"[Progress in the application of uric acid-lowering treatments in amyotrophic lateral sclerosis].","authors":"Y N Zhao,&nbsp;J Y Fu,&nbsp;J He,&nbsp;D S Fan","doi":"10.3760/cma.j.cn112138-20220708-00498","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20220708-00498","url":null,"abstract":"尿酸是人体内嘌呤代谢的终产物,主要通过影响能量代谢、氧化应激、炎症反应等通路来影响肌萎缩侧索硬化症(ALS)的发生发展,但目前尿酸对于ALS的作用仍然存在争议。动物实验显示降尿酸药物黄嘌呤氧化酶抑制剂可以延缓动物模型发病、延长生存期、减缓体重下降、延缓运动能力下降,提示降尿酸药物,尤其是黄嘌呤酶抑制剂在ALS中应用的潜在可能性。.","PeriodicalId":24000,"journal":{"name":"Zhonghua nei ke za zhi","volume":"62 7","pages":"885-890"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9800301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Clinical analysis of the usefulness of letermovir for prevention of cytomegalovirus infection after haploidentical hematopoietic stem cell transplantation]. [利特莫韦预防单倍体造血干细胞移植后巨细胞病毒感染的临床分析]。
Pub Date : 2023-07-01 DOI: 10.3760/cma.j.cn112138-20221204-00904
R Ma, Y He, H F Wang, L Bai, W Han, Y F Cheng, K Y Liu, L P Xu, X H Zhang, Y Wang, Y Y Zhang, F R Wang, X D Mo, C H Yan, X J Huang, Y Q Sun

Objective: To analyze the efficacy and safety of letermovir in primary prophylaxis of cytomegalovirus (CMV) reactivation in patients receiving haploidentical hematopoietic stem cell transplantation. Methods: This retrospective, cohort study was conducted using data of patients who underwent haploidentical transplantation at Peking University Institute of Hematology and received letermovir for primary prophylaxis between May 1, 2022 and August 30, 2022. The inclusion criteria of the letermovir group were as follows: letermovir initiation within 30 days after transplantation and continuation for≥90 days after transplantation. Patients who underwent haploidentical transplantation within the same time period but did not receive letermovir prophylaxis were selected in a 1∶4 ratio as controls. The main outcomes were the incidence of CMV infection and CMV disease after transplantation as well as the possible effects of letermovir on acute graft versus host disease (aGVHD), non-relapse mortality (NRM), and bone marrow suppression. Categorical variables were analyzed by chi-square test, and continuous variables were analyzed by Mann-Whitney U test. The Kaplan-Meier method was used for evaluating incidence differences. Results: Seventeen patients were included in the letermovir prophylaxis group. The median patient age in the letermovir group was significantly greater than that in the control group (43 yr vs. 15 yr; Z=-4.28, P<0.001). The two groups showed no significant difference in sex distribution and primary diseases, etc. (all P>0.05). The proportion of CMV-seronegative donors was significantly higher in the letermovir prophylaxis group in comparison with the control group (8/17 vs. 0/68, χ2=35.32, P<0.001). Three out of the 17 patients in the letermovir group experienced CMV reactivation, which was significantly lower than the incidence of CMV reactivation in the control group (3/17 vs. 40/68, χ2=9.23, P=0.002), and no CMV disease development observed in the letermovir group. Letermovir showed no significant effects on platelet engraftment (P=0.105), aGVHD (P=0.348), and 100-day NRM (P=0.474). Conclusions: Preliminary data suggest that letermovir may effectively reduce the incidence of CMV infection after haploidentical transplantation without influencing aGVHD, NRM, and bone marrow suppression. Prospective randomized controlled studies are required to further verify these findings.

目的:分析莱特莫韦在单倍体造血干细胞移植患者巨细胞病毒(CMV)再激活一级预防中的疗效和安全性。方法:这项回顾性队列研究使用了2022年5月1日至2022年8月30日期间在北京大学血液研究所接受单倍体移植并接受莱替韦一级预防治疗的患者数据。letermovir组纳入标准为:移植后30天内开始使用letermovir,移植后持续治疗≥90天。选择同期行单倍体移植但未接受莱替韦预防治疗的患者,按1∶4的比例作为对照。主要结局是移植后巨细胞病毒感染和巨细胞病毒疾病的发生率,以及利特莫韦对急性移植物抗宿主病(aGVHD)、非复发死亡率(NRM)和骨髓抑制的可能影响。分类变量分析采用卡方检验,连续变量分析采用Mann-Whitney U检验。采用Kaplan-Meier法评价发生率差异。结果:17例患者纳入雷替韦预防组。letermovir组患者的中位年龄显著大于对照组(43岁vs 15岁;Z = -4.28,页> 0.05)。利特莫韦预防组CMV血清阴性供者比例显著高于对照组(8/17 vs. 0/68, χ2=35.32, Pχ2=9.23, P=0.002),利特莫韦预防组未见CMV疾病发生。Letermovir对血小板植入(P=0.105)、aGVHD (P=0.348)、100天NRM (P=0.474)无显著影响。结论:初步资料提示,letermovir可有效降低单倍体移植后CMV感染的发生率,且不影响aGVHD、NRM和骨髓抑制。需要前瞻性随机对照研究来进一步验证这些发现。
{"title":"[Clinical analysis of the usefulness of letermovir for prevention of cytomegalovirus infection after haploidentical hematopoietic stem cell transplantation].","authors":"R Ma,&nbsp;Y He,&nbsp;H F Wang,&nbsp;L Bai,&nbsp;W Han,&nbsp;Y F Cheng,&nbsp;K Y Liu,&nbsp;L P Xu,&nbsp;X H Zhang,&nbsp;Y Wang,&nbsp;Y Y Zhang,&nbsp;F R Wang,&nbsp;X D Mo,&nbsp;C H Yan,&nbsp;X J Huang,&nbsp;Y Q Sun","doi":"10.3760/cma.j.cn112138-20221204-00904","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20221204-00904","url":null,"abstract":"<p><p><b>Objective:</b> To analyze the efficacy and safety of letermovir in primary prophylaxis of cytomegalovirus (CMV) reactivation in patients receiving haploidentical hematopoietic stem cell transplantation. <b>Methods:</b> This retrospective, cohort study was conducted using data of patients who underwent haploidentical transplantation at Peking University Institute of Hematology and received letermovir for primary prophylaxis between May 1, 2022 and August 30, 2022. The inclusion criteria of the letermovir group were as follows: letermovir initiation within 30 days after transplantation and continuation for≥90 days after transplantation. Patients who underwent haploidentical transplantation within the same time period but did not receive letermovir prophylaxis were selected in a 1∶4 ratio as controls. The main outcomes were the incidence of CMV infection and CMV disease after transplantation as well as the possible effects of letermovir on acute graft versus host disease (aGVHD), non-relapse mortality (NRM), and bone marrow suppression. Categorical variables were analyzed by chi-square test, and continuous variables were analyzed by Mann-Whitney <i>U</i> test. The Kaplan-Meier method was used for evaluating incidence differences. <b>Results:</b> Seventeen patients were included in the letermovir prophylaxis group. The median patient age in the letermovir group was significantly greater than that in the control group (43 yr vs. 15 yr; <i>Z=-</i>4.28, <i>P</i><0.001). The two groups showed no significant difference in sex distribution and primary diseases, etc. (all <i>P</i>>0.05). The proportion of CMV-seronegative donors was significantly higher in the letermovir prophylaxis group in comparison with the control group (8/17 vs. 0/68, <i>χ</i><sup>2</sup>=35.32, <i>P</i><0.001). Three out of the 17 patients in the letermovir group experienced CMV reactivation, which was significantly lower than the incidence of CMV reactivation in the control group (3/17 vs. 40/68, <i>χ</i><sup>2</sup>=9.23, <i>P</i>=0.002), and no CMV disease development observed in the letermovir group. Letermovir showed no significant effects on platelet engraftment (<i>P</i>=0.105), aGVHD (<i>P</i>=0.348), and 100-day NRM (<i>P</i>=0.474). <b>Conclusions:</b> Preliminary data suggest that letermovir may effectively reduce the incidence of CMV infection after haploidentical transplantation without influencing aGVHD, NRM, and bone marrow suppression. Prospective randomized controlled studies are required to further verify these findings.</p>","PeriodicalId":24000,"journal":{"name":"Zhonghua nei ke za zhi","volume":"62 7","pages":"826-832"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10104051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A comparative analysis of the clinical symptoms of benign paroxysmal positional vertigo between older and young and middle-aged patients]. 【良性阵发性体位性眩晕中老年与中青年患者临床症状比较分析】。
Pub Date : 2023-07-01 DOI: 10.3760/cma.j.cn112138-20221225-00956
R L Fang, Q Leng, Y Wang, M M Chen, Y Cui, X L Wu, Y Ju

Objective: To compare the differences in clinical symptoms and the time required for diagnosis of benign paroxysmal positional vertigo (BPPV) between older patients and young and middle-aged patients in the structured inquiry of dizziness history. Methods: The medical records of 6 807 patients diagnosed with BPPV from the Vertigo Database of Vertigo Clinical Diagnosis, Treatment, and Research Center of Beijing Tiantan Hospital, Capital Medical University, between January 2019 and October 2021 were retrospectively analyzed. The data included basic demographic information, clinical symptoms in a structured medical history questionnaire, and the time interval from the appearance of BPPV symptoms to diagnosis consultation. The patients were divided into the young and middle-aged group (<65 years old) and the older group (≥65 years old). The differences in clinical symptoms and consultation time were compared between these two groups. Categorical variables were represented by numbers (%), and compared using Chi-squared tests or Fisher's exact probability test for analysis; whereas, continuous variables conforming to normal distribution were represented by mean±standard deviation. Both data groups were compared and analyzed by Student's t-test. Results: The mean age of the older group was 65-92 (71±5) years, while the mean age of the middle-aged group was 18-64 (49±12) years. The incidence of vertigo (42.5% vs. 49.1%, χ2=23.69, P<0.001); vertigo triggered by changes in position of the head or body (52.4% vs. 58.7%, χ2=22.31, P<0.001); and autonomic symptoms (10.1% vs. 12.4%, χ2=7.09, P=0.008) were lower, but hearing loss (11.8% vs. 7.8%, χ2=27.36, P<0.001) and sleep disorders (18.5% vs. 15.2%, χ2=11.13, P=0.001) were higher in the older group than in the young and middle-aged group. The time from the appearance of dizziness to diagnosis was commonly longer in the older patient group than the other group (55.0% vs. 38.5%, χ2=55.95, P<0.001). Conclusions: Older patients with BPPV have more atypical symptoms and complex concomitant symptoms than young and middle-aged patients. For older patients with dizziness, positional testing is needed to confirm the possibility of BPPV even if the clinical symptoms are atypical.

目的:比较老年患者与中青年患者在良性阵发性体位性眩晕(BPPV)的临床症状及诊断所需时间的差异。方法:回顾性分析首都医科大学附属北京天坛医院眩晕临床诊疗研究中心眩晕数据库中2019年1月至2021年10月诊断为BPPV的6 807例患者的病历。数据包括基本人口统计信息、结构化病史问卷中的临床症状以及从BPPV症状出现到诊断会诊的时间间隔。将患者分为青壮年组和中年组(t检验)。结果:老年组平均年龄65 ~ 92(71±5)岁,中老年组平均年龄18 ~ 64(49±12)岁。眩晕发生率(42.5%比49.1%,χ2=23.69, Pχ2=22.31, Pχ2=7.09, P=0.008)低于中青年组,而听力损失发生率(11.8%比7.8%,χ2=27.36, Pχ2=11.13, P=0.001)高于中青年组。老年BPPV患者出现头晕症状至确诊时间明显长于其他组(55.0% vs. 38.5%, χ2=55.95, p < 0.05)。结论:老年BPPV患者比中青年患者有更多的不典型症状和复杂的伴随症状。对于老年头晕患者,即使临床症状不典型,也需要体位检查来确认BPPV的可能性。
{"title":"[A comparative analysis of the clinical symptoms of benign paroxysmal positional vertigo between older and young and middle-aged patients].","authors":"R L Fang,&nbsp;Q Leng,&nbsp;Y Wang,&nbsp;M M Chen,&nbsp;Y Cui,&nbsp;X L Wu,&nbsp;Y Ju","doi":"10.3760/cma.j.cn112138-20221225-00956","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20221225-00956","url":null,"abstract":"<p><p><b>Objective:</b> To compare the differences in clinical symptoms and the time required for diagnosis of benign paroxysmal positional vertigo (BPPV) between older patients and young and middle-aged patients in the structured inquiry of dizziness history. <b>Methods:</b> The medical records of 6 807 patients diagnosed with BPPV from the Vertigo Database of Vertigo Clinical Diagnosis, Treatment, and Research Center of Beijing Tiantan Hospital, Capital Medical University, between January 2019 and October 2021 were retrospectively analyzed. The data included basic demographic information, clinical symptoms in a structured medical history questionnaire, and the time interval from the appearance of BPPV symptoms to diagnosis consultation. The patients were divided into the young and middle-aged group (<65 years old) and the older group (≥65 years old). The differences in clinical symptoms and consultation time were compared between these two groups. Categorical variables were represented by numbers (%), and compared using Chi-squared tests or Fisher's exact probability test for analysis; whereas, continuous variables conforming to normal distribution were represented by mean±standard deviation. Both data groups were compared and analyzed by Student's <i>t</i>-test. <b>Results:</b> The mean age of the older group was 65-92 (71±5) years, while the mean age of the middle-aged group was 18-64 (49±12) years. The incidence of vertigo (42.5% vs. 49.1%, <i>χ</i><sup>2</sup>=23.69, <i>P</i><0.001); vertigo triggered by changes in position of the head or body (52.4% vs. 58.7%, <i>χ</i><sup>2</sup>=22.31, <i>P</i><0.001); and autonomic symptoms (10.1% vs. 12.4%, <i>χ</i><sup>2</sup>=7.09, <i>P</i>=0.008) were lower, but hearing loss (11.8% vs. 7.8%, <i>χ</i><sup>2</sup>=27.36, <i>P</i><0.001) and sleep disorders (18.5% vs. 15.2%, <i>χ</i><sup>2</sup>=11.13, <i>P</i>=0.001) were higher in the older group than in the young and middle-aged group. The time from the appearance of dizziness to diagnosis was commonly longer in the older patient group than the other group (55.0% vs. 38.5%, <i>χ</i><sup>2</sup>=55.95, <i>P</i><0.001). <b>Conclusions:</b> Older patients with BPPV have more atypical symptoms and complex concomitant symptoms than young and middle-aged patients. For older patients with dizziness, positional testing is needed to confirm the possibility of BPPV even if the clinical symptoms are atypical.</p>","PeriodicalId":24000,"journal":{"name":"Zhonghua nei ke za zhi","volume":"62 7","pages":"802-807"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10104052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Zhonghua nei ke za zhi
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1