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To Those Who Don The White Coat 给那些穿白大褂的人
Pub Date : 1900-01-01 DOI: 10.29046/TMF.020.1.020
C. Choudhary
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引用次数: 0
New-Onset Rheumatologic Disease in an Elderly Patient Initially Presenting as Worsening Sequelae of Longstanding Peripheral Vascular Disease 新发风湿病的老年患者最初表现为长期周围血管疾病的恶化后遗症
Pub Date : 1900-01-01 DOI: 10.29046/tmf.022.1.010
P. Levey, Lauren Lally, MD, Xuejun Alice Wang, MD, Vivek Batra, MD
Systemic lupus erythematosus (SLE) is an autoimmune disease that is believed to activate and attack nuclear antigens in genetically susceptible individuals after exposure to environmental factors causing cell damage. Although it is most common in females of child-bearing age, initial presentation is not strictly limited to this population, as onset over the age of 50 years is reported in 3-18% of cases. The common manifestations of SLE affect nearly every system of the body and may include arthralgia, myalgia, fever, rash, hepatosplenomegaly, lymphadenopathy, pleuritis, glomerulonephritis, pericarditis and neuropsychiatric manifestations. Common laboratory findings in SLE with varying degrees of sensitivity and specificity include anti-nuclear antibodies (ANA), anti-doublestranded DNA antibodies (anti-dsDNA), anti-histone antibodies, elevated inflammatory markers, and decreased levels of complements C3 and C4. 1 Treatment is typically aimed toward symptom management and prevention of organ damage; thus, treatment regimens are typically dictated by the organ systems involved and symptoms experienced.
系统性红斑狼疮(SLE)是一种自身免疫性疾病,被认为是在暴露于环境因素导致细胞损伤后,激活和攻击遗传易感个体的核抗原。虽然它最常见于育龄女性,但最初的表现并不严格限于这一人群,因为据报道,3-18%的病例发病年龄超过50岁。SLE的常见表现几乎影响到身体的每一个系统,可能包括关节痛、肌痛、发烧、皮疹、肝脾肿大、淋巴结病、胸膜炎、肾小球肾炎、心包炎和神经精神表现。SLE常见的实验室检查结果具有不同程度的敏感性和特异性,包括抗核抗体(ANA)、抗双链DNA抗体(抗dsdna)、抗组蛋白抗体、炎症标志物升高、补体C3和C4水平降低。治疗通常以症状管理和预防器官损害为目标;因此,治疗方案通常取决于所涉及的器官系统和所经历的症状。
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引用次数: 0
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The Medicine Forum
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