Pub Date : 2023-03-18DOI: 10.13052/JSAME2245-4551.7.002
A. Mendes, I. Chronakis
Functional phospholipid nano-microfibers and nano-microparticles developedusing electrohydrodynamic processing methods are reviewed. Depending onthe phospholipid concentration the solvent used and the processing conditions,fibers and particles with a range of morphologies, mechanical properties andfunctionalities were observed. The efficacy of electrospun phospholipid fibersas antioxidant, encapsulation, and delivery matrices for bioactive compoundsis also presented.
{"title":"Functional Phospholipid Nano-Microfibers and Nano-Microparticles by Electrohydrodynamic Processing: A Review","authors":"A. Mendes, I. Chronakis","doi":"10.13052/JSAME2245-4551.7.002","DOIUrl":"https://doi.org/10.13052/JSAME2245-4551.7.002","url":null,"abstract":"Functional phospholipid nano-microfibers and nano-microparticles developedusing electrohydrodynamic processing methods are reviewed. Depending onthe phospholipid concentration the solvent used and the processing conditions,fibers and particles with a range of morphologies, mechanical properties andfunctionalities were observed. The efficacy of electrospun phospholipid fibersas antioxidant, encapsulation, and delivery matrices for bioactive compoundsis also presented.","PeriodicalId":250057,"journal":{"name":"Journal of Self Assembly and Molecular Electronics","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130603513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-03DOI: 10.13052/jsame2245-8824.2022.001
B. N. Jensen, T. Pedersen, P. Fojan
Emulsion electrospinning is a promising method for creating fibrous vehicles for delivery of drugs and bioactive compounds for the medical and food industries. Droplet microfluidics is a potent way of continuously generating controllable emulsion droplets. The incorporation of a droplet generator in an electrospinning setup for continuous electrospinning of emulsion fibers has been investigated. The influence of a droplet generator on the morphology of emulsion fibers has been established through electrospinning of emulsions of grapeseed oil in PVA and gelatine. The droplet generator was found to have no influence on the morphology of fibers. Conventional emulsification methods and droplet generator emulsification has been used to investigate the influence of emulsion droplet sizes on the morphology of emulsion fibers. Increasing the emulsion droplet size was found to create in-fiber droplets with diameters larger than the fiber diameter. The size of the in-fiber droplets was found to be dependent on both material and emulsion size.
{"title":"Electrospinning with Droplet Generators: A Method for Continuous Electrospinning of Emulsion Fibers","authors":"B. N. Jensen, T. Pedersen, P. Fojan","doi":"10.13052/jsame2245-8824.2022.001","DOIUrl":"https://doi.org/10.13052/jsame2245-8824.2022.001","url":null,"abstract":"Emulsion electrospinning is a promising method for creating fibrous vehicles for delivery of drugs and bioactive compounds for the medical and food industries. Droplet microfluidics is a potent way of continuously generating controllable emulsion droplets. The incorporation of a droplet generator in an electrospinning setup for continuous electrospinning of emulsion fibers has been investigated. The influence of a droplet generator on the morphology of emulsion fibers has been established through electrospinning of emulsions of grapeseed oil in PVA and gelatine. The droplet generator was found to have no influence on the morphology of fibers. Conventional emulsification methods and droplet generator emulsification has been used to investigate the influence of emulsion droplet sizes on the morphology of emulsion fibers. Increasing the emulsion droplet size was found to create in-fiber droplets with diameters larger than the fiber diameter. The size of the in-fiber droplets was found to be dependent on both material and emulsion size.","PeriodicalId":250057,"journal":{"name":"Journal of Self Assembly and Molecular Electronics","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125556021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-03DOI: 10.13052/jsame2245-8824.2022.002
Chemical analysis of metalized DNA has made it quite clear that traditional models of DNA thermodynamics are insufficient to predict and control self-assembly in the context of orthogonally-paired nucleotides. Recently, there has been an increase in reports of Watson-Crick assembly of DNA wires and nanostructures [1–4]. The ability to add or remove pairing rules between nucleobases toward non-Watson-Crick, or orthogonal, self-assembly alters the fundamental language of DNA assembly: this change in behavior necessitates an accompanying shift in computational design. We begin by exploring the state-of-the-art in DNA modeling, and include both sequence analysis and sequence design practices. We then start from first principles and establish a mathematical basis for heterostructure and ‘nmer’ analysis in connected DNA networks that operates without assumptions about nucleobase parity. A generalized search algorithm is then constructed in Matlab and implemented using evolutionary techniques. We then discuss DNA nanostructure design criteria, operation efficiency in differentially-connected networks, and the application of computationally-aided sequence design for nanotechnological applications. We design a double crossover DNA motif with a silver base pair modification as a test case, and demonstrate successful model implementation. In sum, we present a novel computational framework for geometry-informed optimization of DNA networks. This tool is meant to enable design of both linear and nonlinear polynucleotide assemblies with inherent modularity for base parity, metalation, or more exotic nucleotide substitutions that may arise from advances in synthetic biology, nanomaterials and nanomedicine.
{"title":"DNA by Design: De novo Computational Framework for DNA Sequence Design and Nanotechnology","authors":"","doi":"10.13052/jsame2245-8824.2022.002","DOIUrl":"https://doi.org/10.13052/jsame2245-8824.2022.002","url":null,"abstract":"Chemical analysis of metalized DNA has made it quite clear that traditional models of DNA thermodynamics are insufficient to predict and control self-assembly in the context of orthogonally-paired nucleotides. Recently, there has been an increase in reports of Watson-Crick assembly of DNA wires and nanostructures [1–4]. The ability to add or remove pairing rules between nucleobases toward non-Watson-Crick, or orthogonal, self-assembly alters the fundamental language of DNA assembly: this change in behavior necessitates an accompanying shift in computational design. We begin by exploring the state-of-the-art in DNA modeling, and include both sequence analysis and sequence design practices. We then start from first principles and establish a mathematical basis for heterostructure and ‘nmer’ analysis in connected DNA networks that operates without assumptions about nucleobase parity. A generalized search algorithm is then constructed in Matlab and implemented using evolutionary techniques. We then discuss DNA nanostructure design criteria, operation efficiency in differentially-connected networks, and the application of computationally-aided sequence design for nanotechnological applications. We design a double crossover DNA motif with a silver base pair modification as a test case, and demonstrate successful model implementation. In sum, we present a novel computational framework for geometry-informed optimization of DNA networks. This tool is meant to enable design of both linear and nonlinear polynucleotide assemblies with inherent modularity for base parity, metalation, or more exotic nucleotide substitutions that may arise from advances in synthetic biology, nanomaterials and nanomedicine.","PeriodicalId":250057,"journal":{"name":"Journal of Self Assembly and Molecular Electronics","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124353699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-04-30DOI: 10.13052/JSAME2245-4551.5.001
S. Mohan, Manoranjan P. Singh, M. Joshi
The influence of film morphology on the broadening of the time-of-flighttransient photo-current pulse is investigated using Monte Carlo simulation.Simulation of the time-of-flight transient photo-current pulse shape is carriedout for homogeneous and inhomogeneous organic thin films by varying theoverall energetic disorder. In homogeneous system, the value of the tailbroadening parameter (W) of the photocurrent pulse is found to decrease upondecreasing the energetic disorder, which can be attributed to the variation inthe non-thermal field assisted diffusion. Interestingly, in the case of inhomo-geneous system, upon decreasing the overall energetic disorder of the systemthe value of W initially attains a maximum value before it starts decreasing.This observation is explained in terms of the morphology dependent carrierdiffusion. This study asserts the importance of the influence of the morphologydependent carrier diffusion on the charge transport in disordered systems andthe related experimental measurements.
{"title":"Influence of Film Morphology on Transient Photocurrent Pulse Shape in Organic Thin Films: A Monte Carlo Study","authors":"S. Mohan, Manoranjan P. Singh, M. Joshi","doi":"10.13052/JSAME2245-4551.5.001","DOIUrl":"https://doi.org/10.13052/JSAME2245-4551.5.001","url":null,"abstract":"The influence of film morphology on the broadening of the time-of-flighttransient photo-current pulse is investigated using Monte Carlo simulation.Simulation of the time-of-flight transient photo-current pulse shape is carriedout for homogeneous and inhomogeneous organic thin films by varying theoverall energetic disorder. In homogeneous system, the value of the tailbroadening parameter (W) of the photocurrent pulse is found to decrease upondecreasing the energetic disorder, which can be attributed to the variation inthe non-thermal field assisted diffusion. Interestingly, in the case of inhomo-geneous system, upon decreasing the overall energetic disorder of the systemthe value of W initially attains a maximum value before it starts decreasing.This observation is explained in terms of the morphology dependent carrierdiffusion. This study asserts the importance of the influence of the morphologydependent carrier diffusion on the charge transport in disordered systems andthe related experimental measurements.","PeriodicalId":250057,"journal":{"name":"Journal of Self Assembly and Molecular Electronics","volume":"74 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121175014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-04-30DOI: 10.13052/JSAME2245-4551.2016.001
Liguo Tao, Yunpeng Cao, Cuixia Ma, Jie Wang, Lin Lin, Lei Liu, M. Dong
The aggregation of amyloid peptides is closely related to the pathogenesisof degenerative diseases. More and more evidence implies that the protofibrillar intermediates rather than the mature amyloid fibrils are the toxicspecies related to the membrane disruption. In this work we found that theself-assembling intermediates of Aβ33-42 during early aggregation are ableto break down the liposome. During the process of amyloid peptide (Aβ33-42)intermediate binding to liposome, the β-sheet secondary structure of peptidetook change on the molecular level which was characterized by circulardichroism (CD) spectra. The small micelles were formed due to the disruptionof amyloid peptide, and further to grow into big irregular complexes withfurther incubation, which is characterized by the assay of disrupting liposomemembrane and atomic force microscopy (AFM). This founding paved the wayto understand the interactions between the amyloid peptide and membranes,and support the amyloid peptide nanostructure formed in the early stage ofaggregation has good affinity with membrane.
{"title":"Probing the Amyloid Peptide-Membrane Interaction Using a Liposome Model System","authors":"Liguo Tao, Yunpeng Cao, Cuixia Ma, Jie Wang, Lin Lin, Lei Liu, M. Dong","doi":"10.13052/JSAME2245-4551.2016.001","DOIUrl":"https://doi.org/10.13052/JSAME2245-4551.2016.001","url":null,"abstract":"The aggregation of amyloid peptides is closely related to the pathogenesisof degenerative diseases. More and more evidence implies that the protofibrillar intermediates rather than the mature amyloid fibrils are the toxicspecies related to the membrane disruption. In this work we found that theself-assembling intermediates of Aβ33-42 during early aggregation are ableto break down the liposome. During the process of amyloid peptide (Aβ33-42)intermediate binding to liposome, the β-sheet secondary structure of peptidetook change on the molecular level which was characterized by circulardichroism (CD) spectra. The small micelles were formed due to the disruptionof amyloid peptide, and further to grow into big irregular complexes withfurther incubation, which is characterized by the assay of disrupting liposomemembrane and atomic force microscopy (AFM). This founding paved the wayto understand the interactions between the amyloid peptide and membranes,and support the amyloid peptide nanostructure formed in the early stage ofaggregation has good affinity with membrane.","PeriodicalId":250057,"journal":{"name":"Journal of Self Assembly and Molecular Electronics","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128980211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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