Pub Date : 2018-12-21DOI: 10.1002/9781119072980.CH12
L. Pal, Shefali R Pathy
Rationale: Polycystic ovarian syndrome (PCOS) affects a percentage of 5–10% of women of reproductive age worldwide and has a prevalence of 6.6% (95% CI: 2.3–10.9%) in Mexican women and most common cause of infertility in developed countries. Treatment with insulin sensitizing drugs (metformin and pioglitazone) has been shown to improve menstrual cyclicity and fertility in the metabolic profile with polycystic ovarian patients. Incretins and DPP-4 inhibitors have been shown to enhance pancreatic β cell activity, increasing weight loss by its anorexic effect and resulting in an adequate weight control and improved fertility. Previous evidence has compared the effect of exenatide and alone or in combination with metformin in the treatment of PCOS, in this article we will compare sitagliptin and metformin alone or in combination. Study design: Blind, controlled and randomized clinical trial.
{"title":"Polycystic ovarian syndrome","authors":"L. Pal, Shefali R Pathy","doi":"10.1002/9781119072980.CH12","DOIUrl":"https://doi.org/10.1002/9781119072980.CH12","url":null,"abstract":"Rationale: Polycystic ovarian syndrome (PCOS) affects a percentage of 5–10% of women of reproductive age worldwide and has a prevalence of 6.6% (95% CI: 2.3–10.9%) in Mexican women and most common cause of infertility in developed countries. Treatment with insulin sensitizing drugs (metformin and pioglitazone) has been shown to improve menstrual cyclicity and fertility in the metabolic profile with polycystic ovarian patients. Incretins and DPP-4 inhibitors have been shown to enhance pancreatic β cell activity, increasing weight loss by its anorexic effect and resulting in an adequate weight control and improved fertility. Previous evidence has compared the effect of exenatide and alone or in combination with metformin in the treatment of PCOS, in this article we will compare sitagliptin and metformin alone or in combination. Study design: Blind, controlled and randomized clinical trial.","PeriodicalId":250776,"journal":{"name":"Evidence-based Obstetrics and Gynecology","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123064457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-12-21DOI: 10.1002/9781119072980.CH15
J. Friedenthal, F. Naftolin, L. Nachtigall, S. Goldstein
{"title":"Menopause and HRT","authors":"J. Friedenthal, F. Naftolin, L. Nachtigall, S. Goldstein","doi":"10.1002/9781119072980.CH15","DOIUrl":"https://doi.org/10.1002/9781119072980.CH15","url":null,"abstract":"","PeriodicalId":250776,"journal":{"name":"Evidence-based Obstetrics and Gynecology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130716572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-12-21DOI: 10.1002/9781119072980.CH31
C. Heuser, W. Branch
{"title":"Diagnosis and management of antiphospholipid syndrome","authors":"C. Heuser, W. Branch","doi":"10.1002/9781119072980.CH31","DOIUrl":"https://doi.org/10.1002/9781119072980.CH31","url":null,"abstract":"","PeriodicalId":250776,"journal":{"name":"Evidence-based Obstetrics and Gynecology","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115456454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-12-21DOI: 10.1002/9781119072980.CH17
Jessica Lee, J. Curtin
{"title":"Vulval/vaginal cancer","authors":"Jessica Lee, J. Curtin","doi":"10.1002/9781119072980.CH17","DOIUrl":"https://doi.org/10.1002/9781119072980.CH17","url":null,"abstract":"","PeriodicalId":250776,"journal":{"name":"Evidence-based Obstetrics and Gynecology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129243296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-12-21DOI: 10.1002/9781119072980.CH53
C. Johnson
{"title":"Methods for spontaneous delivery","authors":"C. Johnson","doi":"10.1002/9781119072980.CH53","DOIUrl":"https://doi.org/10.1002/9781119072980.CH53","url":null,"abstract":"","PeriodicalId":250776,"journal":{"name":"Evidence-based Obstetrics and Gynecology","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116213697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-12-21DOI: 10.1002/9781119072980.CH42
M. Beall, M. Ross
{"title":"Disorders of amniotic fluid volume","authors":"M. Beall, M. Ross","doi":"10.1002/9781119072980.CH42","DOIUrl":"https://doi.org/10.1002/9781119072980.CH42","url":null,"abstract":"","PeriodicalId":250776,"journal":{"name":"Evidence-based Obstetrics and Gynecology","volume":"111 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122881522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-12-21DOI: 10.1002/9781119072980.CH19
M. Salcedo, K. Schmeler
{"title":"Cervical dysplasia and HPV","authors":"M. Salcedo, K. Schmeler","doi":"10.1002/9781119072980.CH19","DOIUrl":"https://doi.org/10.1002/9781119072980.CH19","url":null,"abstract":"","PeriodicalId":250776,"journal":{"name":"Evidence-based Obstetrics and Gynecology","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126394601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-12-21DOI: 10.1002/9781119072980.CH43
K. Goetzinger, A. Odibo
{"title":"Disorders of fetal growth","authors":"K. Goetzinger, A. Odibo","doi":"10.1002/9781119072980.CH43","DOIUrl":"https://doi.org/10.1002/9781119072980.CH43","url":null,"abstract":"","PeriodicalId":250776,"journal":{"name":"Evidence-based Obstetrics and Gynecology","volume":"114 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123391151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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