Pub Date : 2020-11-28DOI: 10.5772/intechopen.94243
Rajesha K. Nairy, N. Bhat, K. Anjaria, U. Yadav, R. Chaurasia, K. Shirsath, Utkarsha N. Desai, Sanjay Gupta, B. K. Sapra, Narayana Yerol
Proton being the easiest light ion to accelerate and achieve desired beam profile, has been pursued as a popular particulate radiation for therapy applications. In the present study, Saccharomyces cerevisiae D7 strain was used to estimate the RBE values of the 3 MeV proton beam, and an attempt was made to derive mathematical formula for calculating RBE value with respect to the dose. Dosimetry studies were carried out using Fricke dosimetry and Semiconductor Surface Barrier detector to calibrate the absorbed doses of Gamma chamber-1200 and Folded Tandem Ion Accelerator respectively. Gold standard cell survival assay and gene conversion assay were used to compare gamma and proton radiation induced cell death and genetic endpoint. Multi target single hit model was used to derive mathematical formula for RBE estimation. The results show a linear survival-dose response after proton radiation and sigmoid survival-dose response after gamma radiation treatment. The calculated RBE value from the survival and gene conversion studies was 1.60 and 3.93, respectively. The derived mathematical formula is very useful in calculating RBE value, which varies from 3.61 to 1.80 with increasing dose. The estimated RBE value from the mathematical formula is comparable with the experimental values. With the help of the present mathematical formulation, RBE value at any dose can be calculated in the exponential and sigmoidal regions of the survival curve without actually extending the experiment in that dose region, which is not possible using conventional methods.
{"title":"Relative Biological Effectiveness Studies Using 3 MeV Proton Beam from Folded Tandem Ion Accelerator: An Experimental and Theoretical Approach","authors":"Rajesha K. Nairy, N. Bhat, K. Anjaria, U. Yadav, R. Chaurasia, K. Shirsath, Utkarsha N. Desai, Sanjay Gupta, B. K. Sapra, Narayana Yerol","doi":"10.5772/intechopen.94243","DOIUrl":"https://doi.org/10.5772/intechopen.94243","url":null,"abstract":"Proton being the easiest light ion to accelerate and achieve desired beam profile, has been pursued as a popular particulate radiation for therapy applications. In the present study, Saccharomyces cerevisiae D7 strain was used to estimate the RBE values of the 3 MeV proton beam, and an attempt was made to derive mathematical formula for calculating RBE value with respect to the dose. Dosimetry studies were carried out using Fricke dosimetry and Semiconductor Surface Barrier detector to calibrate the absorbed doses of Gamma chamber-1200 and Folded Tandem Ion Accelerator respectively. Gold standard cell survival assay and gene conversion assay were used to compare gamma and proton radiation induced cell death and genetic endpoint. Multi target single hit model was used to derive mathematical formula for RBE estimation. The results show a linear survival-dose response after proton radiation and sigmoid survival-dose response after gamma radiation treatment. The calculated RBE value from the survival and gene conversion studies was 1.60 and 3.93, respectively. The derived mathematical formula is very useful in calculating RBE value, which varies from 3.61 to 1.80 with increasing dose. The estimated RBE value from the mathematical formula is comparable with the experimental values. With the help of the present mathematical formulation, RBE value at any dose can be calculated in the exponential and sigmoidal regions of the survival curve without actually extending the experiment in that dose region, which is not possible using conventional methods.","PeriodicalId":250970,"journal":{"name":"Recent Techniques and Applications in Ionizing Radiation Research","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114600836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-20DOI: 10.5772/intechopen.92029
T. Frometa-Castillo, A. Pyakuryal, A. Wals-Zurita, A. Mesbahi
The current radiosensitive studies are described with linear-quadratic (LQ) cell survival (S) model for one fraction with a dose d. As result of assuming all sublethally damaged cells (SLDCs) are completely repaired during the interfractions, that is, no presence of SLDCs, the survived cells are calculated for a n-fractionated regimen with the LQ S(n,D) model. A mathematically processed subpart of LQS(n,D) is the biologically effective dose (BED) that is used for evaluating a so-called “biological dose.” The interactions of ionizing radiation with a living tissue can produce partial death or sublethal damage from healthy or sublethally damaged cells. The proportions of the killed and sub-lethally damaged cells define the radiation biological effects (RBEfs). Computational simulations using RBEFs for fractionated regimens let calculating tumor control probability. While the derivation of the LQ S(n,D) considers a 100% cell repair, that is, 0% of sublethally damaged cells (SLDCs), the radiobiological simulators take into account the presence of SLDCs, as well as a cell repair <100% during the interfractions and interruption. Given “biological dose” does not exist, but RBEf, there was need for creating the BED. It is shown how some uses of BED, like the derivation of EQ2D expression, can be done directly with the LQ S(n,D).
{"title":"Biologically Effective Dose (BED) or Radiation Biological Effect (RBEf)?","authors":"T. Frometa-Castillo, A. Pyakuryal, A. Wals-Zurita, A. Mesbahi","doi":"10.5772/intechopen.92029","DOIUrl":"https://doi.org/10.5772/intechopen.92029","url":null,"abstract":"The current radiosensitive studies are described with linear-quadratic (LQ) cell survival (S) model for one fraction with a dose d. As result of assuming all sublethally damaged cells (SLDCs) are completely repaired during the interfractions, that is, no presence of SLDCs, the survived cells are calculated for a n-fractionated regimen with the LQ S(n,D) model. A mathematically processed subpart of LQS(n,D) is the biologically effective dose (BED) that is used for evaluating a so-called “biological dose.” The interactions of ionizing radiation with a living tissue can produce partial death or sublethal damage from healthy or sublethally damaged cells. The proportions of the killed and sub-lethally damaged cells define the radiation biological effects (RBEfs). Computational simulations using RBEFs for fractionated regimens let calculating tumor control probability. While the derivation of the LQ S(n,D) considers a 100% cell repair, that is, 0% of sublethally damaged cells (SLDCs), the radiobiological simulators take into account the presence of SLDCs, as well as a cell repair <100% during the interfractions and interruption. Given “biological dose” does not exist, but RBEf, there was need for creating the BED. It is shown how some uses of BED, like the derivation of EQ2D expression, can be done directly with the LQ S(n,D).","PeriodicalId":250970,"journal":{"name":"Recent Techniques and Applications in Ionizing Radiation Research","volume":"101 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124613173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-15DOI: 10.5772/intechopen.92457
P. Saidi, M. Sadeghi
This study will briefly explain the production of 103Pd via cyclotron for brachytherapy use. The excitation functions of 103Rh(p,n)103Pd and 103Rh(d,2n)103Pd reactions were calculated using ALICE/91, ALICE/ASH, and TALYS-1.2 codes and compared with published data. Production of 103Pd was done via 103Rh(p,n)103Pd nuclear reaction. The target was bombarded with 18 MeV protons at 200 μA beam current for 15 h. After irradiation and radiochemical separation of the electroplated rhodium target, at the optimum condition, 103Pd was absorbed into Amberlite®IR-93 resin. The preparation of the brachytherapy seed, which is loaded by the resin beads, has also been presented. At least, the method to determine the dosimetric parameters for the seed by experimental measurement has been presented.
{"title":"Production of the 103Pd via Cyclotron and Preparation of the Brachytherapy Seed","authors":"P. Saidi, M. Sadeghi","doi":"10.5772/intechopen.92457","DOIUrl":"https://doi.org/10.5772/intechopen.92457","url":null,"abstract":"This study will briefly explain the production of 103Pd via cyclotron for brachytherapy use. The excitation functions of 103Rh(p,n)103Pd and 103Rh(d,2n)103Pd reactions were calculated using ALICE/91, ALICE/ASH, and TALYS-1.2 codes and compared with published data. Production of 103Pd was done via 103Rh(p,n)103Pd nuclear reaction. The target was bombarded with 18 MeV protons at 200 μA beam current for 15 h. After irradiation and radiochemical separation of the electroplated rhodium target, at the optimum condition, 103Pd was absorbed into Amberlite®IR-93 resin. The preparation of the brachytherapy seed, which is loaded by the resin beads, has also been presented. At least, the method to determine the dosimetric parameters for the seed by experimental measurement has been presented.","PeriodicalId":250970,"journal":{"name":"Recent Techniques and Applications in Ionizing Radiation Research","volume":"282 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132972802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-29DOI: 10.5772/intechopen.92317
E. Malchukova
Effects of ionizing irradiation on defect creation processes have been studied in rare earth (RE)-doped (RE = Sm, Gd, Eu, Ce, Nd) aluminoborosilicate glass with use of the electron paramagnetic resonance (EPR) and optical spectroscopy. As a function of RE ion nature, we observe that doping significantly influences the nature of the defects produced during irradiation and more specifically the relative proportions between hole and electron defect centers. Strong decrease of defect production efficiency under ionizing radiation independence on both the RE doping content and on the relative stability of the RE different oxidation states is also clearly revealed. The results could be explained by dynamical reversible trapping of the electron-hole pairs produced during irradiation on the different RE charge states as well as by RE segregation and pre-existing defects speciation in ABS glass structure.
{"title":"Influence of the Doping Ion Nature and Content on Defect Creation Processes under the Effect of Ionizing Radiation in Aluminoborosilicate Glasses","authors":"E. Malchukova","doi":"10.5772/intechopen.92317","DOIUrl":"https://doi.org/10.5772/intechopen.92317","url":null,"abstract":"Effects of ionizing irradiation on defect creation processes have been studied in rare earth (RE)-doped (RE = Sm, Gd, Eu, Ce, Nd) aluminoborosilicate glass with use of the electron paramagnetic resonance (EPR) and optical spectroscopy. As a function of RE ion nature, we observe that doping significantly influences the nature of the defects produced during irradiation and more specifically the relative proportions between hole and electron defect centers. Strong decrease of defect production efficiency under ionizing radiation independence on both the RE doping content and on the relative stability of the RE different oxidation states is also clearly revealed. The results could be explained by dynamical reversible trapping of the electron-hole pairs produced during irradiation on the different RE charge states as well as by RE segregation and pre-existing defects speciation in ABS glass structure.","PeriodicalId":250970,"journal":{"name":"Recent Techniques and Applications in Ionizing Radiation Research","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128005047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-14DOI: 10.5772/intechopen.91899
Entesar H. Elaraby
This chapter is primarily concerned with natural radioactive decay. Generally speaking, there are two types of natural radioactive decays: alpha decays “which contain two neutrons and two protons” emitted from radon gas; additionally, nuclear decay by emission of photons (γ-decay). This chapter aims to describe γ and alpha loss of nuclei and demonstrates how to measure the radioactive material naturally using solid-state nuclear track detector (SSNTD) and high purity Germanium detector (HPGD). Also, methods of measuring the different characteristics of the alpha particle using the track profile technique (TPT) will be presented. Finally, results will be presented in the alpha and radon measurements. The concentration of aerosols has attracted much attention by many researchers in the past decade. Research has shown that aerosols are responsible for harmful chemical reactions that lead to the physical degradation of the stratospheric ozone layer. Moreover, aerosols increase the risk of developing cancer in humans when inhaled in large proportions. Therefore, neutron activation analysis (NAA) is a very important application to measure these concentrations.
{"title":"Natural Radioactive Decay","authors":"Entesar H. Elaraby","doi":"10.5772/intechopen.91899","DOIUrl":"https://doi.org/10.5772/intechopen.91899","url":null,"abstract":"This chapter is primarily concerned with natural radioactive decay. Generally speaking, there are two types of natural radioactive decays: alpha decays “which contain two neutrons and two protons” emitted from radon gas; additionally, nuclear decay by emission of photons (γ-decay). This chapter aims to describe γ and alpha loss of nuclei and demonstrates how to measure the radioactive material naturally using solid-state nuclear track detector (SSNTD) and high purity Germanium detector (HPGD). Also, methods of measuring the different characteristics of the alpha particle using the track profile technique (TPT) will be presented. Finally, results will be presented in the alpha and radon measurements. The concentration of aerosols has attracted much attention by many researchers in the past decade. Research has shown that aerosols are responsible for harmful chemical reactions that lead to the physical degradation of the stratospheric ozone layer. Moreover, aerosols increase the risk of developing cancer in humans when inhaled in large proportions. Therefore, neutron activation analysis (NAA) is a very important application to measure these concentrations.","PeriodicalId":250970,"journal":{"name":"Recent Techniques and Applications in Ionizing Radiation Research","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123663659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：