Pub Date : 2023-04-01DOI: 10.4103/srmjrds.srmjrds_5_23
Yatishkumar Joshi, S. Vagha, Sweta G Pisulkar, Gaurav Mishra
Background: With the need to strengthen conative domain competencies, the medical council has introduced the attitude, ethics, and communication (AETCOM) module in the new competency-based medical education. Similar competencies exist in the curriculum prescribed by the Dental Council of India (DCI). Aim: This study aimed to collect the data regarding the perception of dental interns and their awareness of the existing curriculum. Materials and Methods: Eighty-six interns of a single batch participated in the survey. The survey included declaration, voluntary consent, basic knowledge regarding curriculum, their perception regarding DCI and AETCOM competency, and their assessment. Collected data were presented descriptively in figures and scores of perception were analyzed using the single sample Student's t-test. Results: Out of the 78 competency statements, only two DCI competency statements and nine AETCOM competency statements had P values higher than 0.05. Conclusion: Students perceive the increased emphasis on preclinical work and minimal emphasis on interpersonal skills in the curriculum. Students lack confidence in research projects and practice management competency and need additional training after BDS for setting up a practice.
{"title":"Attitude, bio-ethics, and communication skills in undergraduate dental education: Perspective of dental interns from a dental school in Maharashtra – A cross-sectional survey","authors":"Yatishkumar Joshi, S. Vagha, Sweta G Pisulkar, Gaurav Mishra","doi":"10.4103/srmjrds.srmjrds_5_23","DOIUrl":"https://doi.org/10.4103/srmjrds.srmjrds_5_23","url":null,"abstract":"Background: With the need to strengthen conative domain competencies, the medical council has introduced the attitude, ethics, and communication (AETCOM) module in the new competency-based medical education. Similar competencies exist in the curriculum prescribed by the Dental Council of India (DCI). Aim: This study aimed to collect the data regarding the perception of dental interns and their awareness of the existing curriculum. Materials and Methods: Eighty-six interns of a single batch participated in the survey. The survey included declaration, voluntary consent, basic knowledge regarding curriculum, their perception regarding DCI and AETCOM competency, and their assessment. Collected data were presented descriptively in figures and scores of perception were analyzed using the single sample Student's t-test. Results: Out of the 78 competency statements, only two DCI competency statements and nine AETCOM competency statements had P values higher than 0.05. Conclusion: Students perceive the increased emphasis on preclinical work and minimal emphasis on interpersonal skills in the curriculum. Students lack confidence in research projects and practice management competency and need additional training after BDS for setting up a practice.","PeriodicalId":252088,"journal":{"name":"SRM Journal of Research in Dental Sciences","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121541459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.4103/srmjrds.srmjrds_33_23
Abubakar M. Kaura, A. Shehu, B. Mujtaba, Bawa Anas, Rufai Jaafaru, Sani Balarabe, B. Bamgbose
Background: The loss of teeth can impose a huge burden on both the patient and the health system as it requires gigantic effort, technical know-how, and on most occasions out-of-pocket expenditure to reestablish the lost functions and esthetics. Aim: The aim of this study was to highlight the indications and patterns of tooth extractions in the Dental Surgery Department, Federal Medical Centre, Gusau, Zamfara State, Nigeria. Materials and Methods: Retrospective study design was used by retrieving case folders of patients who had extractions within the study period and analyzing for age, gender, and type of tooth/teeth extracted as well as the indications for tooth extraction. Data were analyzed using SPSS software version 25 and <0.005 of the P value was considered statistically significant. Results: A total of 2992 extractions were carried out within the 4-year time frame with 53.8% of males and 46.2% of females. The mean age was 30.66 (±16.9) years. The indication for tooth extraction was dental caries and its sequelae 75.9%, followed by periodontal disease 9.1% and recurrent pericoronitis 7.3%, respectively. There was a statistically significant difference between gender and indication for extraction (P < 0.001, df = 5). Conclusion: Dental caries and periodontal disease were the principal indications for tooth extraction, whereas molar teeth extractions were the most common in the studied population irrespective of age and gender.
{"title":"Pattern and indications for tooth extraction among patients attending dental clinic at federal medical center Gusau, Zamfara state, Nigeria: A retrospective study","authors":"Abubakar M. Kaura, A. Shehu, B. Mujtaba, Bawa Anas, Rufai Jaafaru, Sani Balarabe, B. Bamgbose","doi":"10.4103/srmjrds.srmjrds_33_23","DOIUrl":"https://doi.org/10.4103/srmjrds.srmjrds_33_23","url":null,"abstract":"Background: The loss of teeth can impose a huge burden on both the patient and the health system as it requires gigantic effort, technical know-how, and on most occasions out-of-pocket expenditure to reestablish the lost functions and esthetics. Aim: The aim of this study was to highlight the indications and patterns of tooth extractions in the Dental Surgery Department, Federal Medical Centre, Gusau, Zamfara State, Nigeria. Materials and Methods: Retrospective study design was used by retrieving case folders of patients who had extractions within the study period and analyzing for age, gender, and type of tooth/teeth extracted as well as the indications for tooth extraction. Data were analyzed using SPSS software version 25 and <0.005 of the P value was considered statistically significant. Results: A total of 2992 extractions were carried out within the 4-year time frame with 53.8% of males and 46.2% of females. The mean age was 30.66 (±16.9) years. The indication for tooth extraction was dental caries and its sequelae 75.9%, followed by periodontal disease 9.1% and recurrent pericoronitis 7.3%, respectively. There was a statistically significant difference between gender and indication for extraction (P < 0.001, df = 5). Conclusion: Dental caries and periodontal disease were the principal indications for tooth extraction, whereas molar teeth extractions were the most common in the studied population irrespective of age and gender.","PeriodicalId":252088,"journal":{"name":"SRM Journal of Research in Dental Sciences","volume":"87 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123112507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.4103/srmjrds.srmjrds_54_23
R. Govindaraju, Sheema Ali, M. Baig, Siri N. Shetty, S. Reddy, V. Jain
Rationale: Atraumatic myositis ossificans circumscripta is a benign condition characterized by the aberrant formation of bone in extraskeletal soft tissues without a usual connection to trauma. Patient Concern: A female patient of around 17 years of age reported with the main complaint of pain and swelling over the chin area for 6 months with no history of trauma. Diagnosis: Clinical, radiographic, and histopathological examinations were performed and all signs and symptoms pointed to a diagnosis of Atraumatic Myositis Ossificans in the Mentalis muscle. Intervention: Surgical exploration of the area concerned was done under (L.A) local anesthesia with adrenaline (1:1,00,000), where the nodes were extracted from the lower surface of the Mentalis muscle. The wound was sutured back to its normal physiologic anatomy, and the patient then was advised of postoperative instructions. Results: The patient recovered with a good prognosis and returned to a normal routine with good functional capacity. Lessons Learned: The practitioner must consider Atraumatic Myositis ossificans as a viable diagnosis for painful soft tissue calcification when a history of trauma is not present.
{"title":"Atraumatic myositis ossificans of mentalis muscle: A rare case report","authors":"R. Govindaraju, Sheema Ali, M. Baig, Siri N. Shetty, S. Reddy, V. Jain","doi":"10.4103/srmjrds.srmjrds_54_23","DOIUrl":"https://doi.org/10.4103/srmjrds.srmjrds_54_23","url":null,"abstract":"Rationale: Atraumatic myositis ossificans circumscripta is a benign condition characterized by the aberrant formation of bone in extraskeletal soft tissues without a usual connection to trauma. Patient Concern: A female patient of around 17 years of age reported with the main complaint of pain and swelling over the chin area for 6 months with no history of trauma. Diagnosis: Clinical, radiographic, and histopathological examinations were performed and all signs and symptoms pointed to a diagnosis of Atraumatic Myositis Ossificans in the Mentalis muscle. Intervention: Surgical exploration of the area concerned was done under (L.A) local anesthesia with adrenaline (1:1,00,000), where the nodes were extracted from the lower surface of the Mentalis muscle. The wound was sutured back to its normal physiologic anatomy, and the patient then was advised of postoperative instructions. Results: The patient recovered with a good prognosis and returned to a normal routine with good functional capacity. Lessons Learned: The practitioner must consider Atraumatic Myositis ossificans as a viable diagnosis for painful soft tissue calcification when a history of trauma is not present.","PeriodicalId":252088,"journal":{"name":"SRM Journal of Research in Dental Sciences","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130127018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.4103/srmjrds.srmjrds_42_23
N. Umamaheswari, Saranyan Ravi, J. John, Muthu G. Mohan
Background: Dental anxiety is significantly influenced by the fear and annoyance brought on by the sound of a dental drill. As a result, the welcoming atmosphere at pediatric dental offices is likely to entice young children to come in for examination and treatment. Aim: The aim of this study was to compare the masking effect of dental drill noise with the sound maskers on the annoyance rate of pediatric dental patients. Materials and Methods: To evaluate the stimuli in the annoyance experiment, 40 children (20 boys and 20 girls) were enlisted. As masker sounds, dragonfly and whistle sounds were chosen, and the functioning dental drill noise was blended with the original sound level. The participants rated each audio stimulus signal delivered to them in a random order, with the level of annoyance indicated by a color scale corresponding to the intensity of their psychological sense. The mean comparison between the acoustic stimuli was made using the Friedman's test. Based on gender, the mean comparison between acoustic stimuli was made using the Mann–Whitney U-test. Results: The mean annoyance rate of dental drill noise dragonfly sound and whistle sound was 4.83, 1.15, and 3.82, respectively. Gender has a significant effect on masking effect in nonacoustic factor outcomes. Conclusion: The dragonfly sound had the best impact and the most significant reduction in annoyance compared to the sound of the drill. Typically, girls felt more at ease around the dragonfly sound than boys did.
{"title":"Effect of sound masking using child-friendly masker sounds on the perception of the dental drill noise in pediatric dental practice: An interventional study","authors":"N. Umamaheswari, Saranyan Ravi, J. John, Muthu G. Mohan","doi":"10.4103/srmjrds.srmjrds_42_23","DOIUrl":"https://doi.org/10.4103/srmjrds.srmjrds_42_23","url":null,"abstract":"Background: Dental anxiety is significantly influenced by the fear and annoyance brought on by the sound of a dental drill. As a result, the welcoming atmosphere at pediatric dental offices is likely to entice young children to come in for examination and treatment. Aim: The aim of this study was to compare the masking effect of dental drill noise with the sound maskers on the annoyance rate of pediatric dental patients. Materials and Methods: To evaluate the stimuli in the annoyance experiment, 40 children (20 boys and 20 girls) were enlisted. As masker sounds, dragonfly and whistle sounds were chosen, and the functioning dental drill noise was blended with the original sound level. The participants rated each audio stimulus signal delivered to them in a random order, with the level of annoyance indicated by a color scale corresponding to the intensity of their psychological sense. The mean comparison between the acoustic stimuli was made using the Friedman's test. Based on gender, the mean comparison between acoustic stimuli was made using the Mann–Whitney U-test. Results: The mean annoyance rate of dental drill noise dragonfly sound and whistle sound was 4.83, 1.15, and 3.82, respectively. Gender has a significant effect on masking effect in nonacoustic factor outcomes. Conclusion: The dragonfly sound had the best impact and the most significant reduction in annoyance compared to the sound of the drill. Typically, girls felt more at ease around the dragonfly sound than boys did.","PeriodicalId":252088,"journal":{"name":"SRM Journal of Research in Dental Sciences","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131551861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.4103/srmjrds.srmjrds_35_23
N. Kalavathy, Nikhil Anantharaj, Karthiban Ragunath, Mitha M Shetty, P. Kumar, Netra Patil
Rationale: This article describes step by step procedure for the rehabilitation of a completely edentulous patient with 12 endosseous implants followed by the fabrication of the Malo bridge with CAD-CAM fabricated titanium framework. Patient Concerns: The patient with a chief complaint of ill-fitting conventional complete denture reported to the hospital and wanted a fixed rehabilitation. Diagnosis: The patient was diagnosed with completely edentulous maxillary and mandibular arches without any systemic illness. Interventions: Twelve implants (Neobio tech) were placed in maxillary and mandibular arches (6 in each arch). After osseointegration, healing abutments were placed during the second stage of surgery. A final impression was made using the open tray technique. The accuracy of the impression was verified using jig trial and OPG. This was followed by jaw relation and try-in. A titanium metallic framework was positioned on the implants to check the fit. A Malo bridge with individual cementable zirconium crowns was fabricated. The metallic framework was torqued to 35N and crowns were cemented using Implant Premier cement. The screw holes were packed with Teflon tape and restored using composite. Outcomes: The patient was satisfied with the treatment outcome. Follow up were done after 10 years with no significant complications. Lessons: Fixed implant prosthesis with titanium framework was found to be a successful treatment protocol for the rehabilitation of the completely edentulous patient.
{"title":"Rehabilitation of a completely edentulous patient with fixed implant prosthesis on titanium framework: A case report","authors":"N. Kalavathy, Nikhil Anantharaj, Karthiban Ragunath, Mitha M Shetty, P. Kumar, Netra Patil","doi":"10.4103/srmjrds.srmjrds_35_23","DOIUrl":"https://doi.org/10.4103/srmjrds.srmjrds_35_23","url":null,"abstract":"Rationale: This article describes step by step procedure for the rehabilitation of a completely edentulous patient with 12 endosseous implants followed by the fabrication of the Malo bridge with CAD-CAM fabricated titanium framework. Patient Concerns: The patient with a chief complaint of ill-fitting conventional complete denture reported to the hospital and wanted a fixed rehabilitation. Diagnosis: The patient was diagnosed with completely edentulous maxillary and mandibular arches without any systemic illness. Interventions: Twelve implants (Neobio tech) were placed in maxillary and mandibular arches (6 in each arch). After osseointegration, healing abutments were placed during the second stage of surgery. A final impression was made using the open tray technique. The accuracy of the impression was verified using jig trial and OPG. This was followed by jaw relation and try-in. A titanium metallic framework was positioned on the implants to check the fit. A Malo bridge with individual cementable zirconium crowns was fabricated. The metallic framework was torqued to 35N and crowns were cemented using Implant Premier cement. The screw holes were packed with Teflon tape and restored using composite. Outcomes: The patient was satisfied with the treatment outcome. Follow up were done after 10 years with no significant complications. Lessons: Fixed implant prosthesis with titanium framework was found to be a successful treatment protocol for the rehabilitation of the completely edentulous patient.","PeriodicalId":252088,"journal":{"name":"SRM Journal of Research in Dental Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128782529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.4103/srmjrds.srmjrds_32_23
A. Mishra, S. Roy Choudhury, S. Bhandari, Satyanarayan Pandey
Background: The temporomandibular joint (TMJ) ankylosis management incorporates various modalities. Total alloplastic temporomandibular joint replacement (TJR) has opened a new avenue in TMJ reconstruction. Costochondral grafts (CCGs) are the gold standard treatment option. Aim: This study was designed to compare the clinical outcome between total alloplastic TJR and CCG in TMJ ankylosis cases. Materials and Methods: The retrospective data of patients were collected between 2017 and 2020. A total of 12 TJR cases and 8 cases of CCG were included in the study. Maximum mouth opening was recorded in mm and pain score/diet score was recorded on a Visual Analog Score system where 0 was no pain/normal diet and 10 was worse pain/liquid diet. The data were statistically analyzed using the “two-sample t-test (Welch's t-test).” Results: The mean interincisal opening in the TJR group was 32.67 (±2.19) and in the CCG group was 33.71 (±4.77). The pain reduction score was better in the TJR group with 0.5 (±0.90) and the diet score was better in the CCG group with 0.714 (±0.95). Conclusion: The stock TJR devices have a predictable outcome with a good pain reduction score and an acceptable diet score; however, the autogenous CCG is still better in terms of maximum mouth opening. Although failed CCG cases can be taken up for further correction with the TJR.
{"title":"An evaluation of clinical outcome of total alloplastic temporomandibular joint replacement and costochondral graft in temporomandibular joint ankylosis cases – A retrospective study","authors":"A. Mishra, S. Roy Choudhury, S. Bhandari, Satyanarayan Pandey","doi":"10.4103/srmjrds.srmjrds_32_23","DOIUrl":"https://doi.org/10.4103/srmjrds.srmjrds_32_23","url":null,"abstract":"Background: The temporomandibular joint (TMJ) ankylosis management incorporates various modalities. Total alloplastic temporomandibular joint replacement (TJR) has opened a new avenue in TMJ reconstruction. Costochondral grafts (CCGs) are the gold standard treatment option. Aim: This study was designed to compare the clinical outcome between total alloplastic TJR and CCG in TMJ ankylosis cases. Materials and Methods: The retrospective data of patients were collected between 2017 and 2020. A total of 12 TJR cases and 8 cases of CCG were included in the study. Maximum mouth opening was recorded in mm and pain score/diet score was recorded on a Visual Analog Score system where 0 was no pain/normal diet and 10 was worse pain/liquid diet. The data were statistically analyzed using the “two-sample t-test (Welch's t-test).” Results: The mean interincisal opening in the TJR group was 32.67 (±2.19) and in the CCG group was 33.71 (±4.77). The pain reduction score was better in the TJR group with 0.5 (±0.90) and the diet score was better in the CCG group with 0.714 (±0.95). Conclusion: The stock TJR devices have a predictable outcome with a good pain reduction score and an acceptable diet score; however, the autogenous CCG is still better in terms of maximum mouth opening. Although failed CCG cases can be taken up for further correction with the TJR.","PeriodicalId":252088,"journal":{"name":"SRM Journal of Research in Dental Sciences","volume":"160 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134041331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.4103/srmjrds.srmjrds_55_23
A. Saravanan, D. Kumar, R. Arthi
In the modern era, intelligent systems are playing a vital role in day-to-day human life-related applications. It is not only giving solutions to handling health-care applications for dental treatments. In this context, artificial intelligence-based machine learning (ML) algorithms are used for experimenting with the trained data sets that progress the relevances in decision-making. A specific practice The “Internet of Dental Things” is a ground-breaking method to accomplish the avoidance and supervision of periodontal diseases, dental caries, oral cancers, and other dental diseases. Various ML algorithms such as convolutional neural network, K-nearest neighbor, and random Forest are used for anticipating nodal status and tumor grade in oropharyngeal and oral cavity squamous cell carcinoma. The ML algorithms help with diagnosis, assistive systems, and monitoring toward decision-making and contribute to the pursuit of suggesting an exact dental treatment. It is helpful in diagnosing tooth loss, cracked teeth, periodontitis, dental fluorosis, dental caries, dental calculus, dental plaque, and periodontal disease. The suggestions given by the intelligent system render accuracy, precision, specificity, sensitivity, confusion matrix, recall, and F1-Score to strengthen the decision-making and contribute to the pursuit of offering an exact treatment.
{"title":"A state-of-the-art approach for dental diagnosis using machine learning assessment: A short communication","authors":"A. Saravanan, D. Kumar, R. Arthi","doi":"10.4103/srmjrds.srmjrds_55_23","DOIUrl":"https://doi.org/10.4103/srmjrds.srmjrds_55_23","url":null,"abstract":"In the modern era, intelligent systems are playing a vital role in day-to-day human life-related applications. It is not only giving solutions to handling health-care applications for dental treatments. In this context, artificial intelligence-based machine learning (ML) algorithms are used for experimenting with the trained data sets that progress the relevances in decision-making. A specific practice The “Internet of Dental Things” is a ground-breaking method to accomplish the avoidance and supervision of periodontal diseases, dental caries, oral cancers, and other dental diseases. Various ML algorithms such as convolutional neural network, K-nearest neighbor, and random Forest are used for anticipating nodal status and tumor grade in oropharyngeal and oral cavity squamous cell carcinoma. The ML algorithms help with diagnosis, assistive systems, and monitoring toward decision-making and contribute to the pursuit of suggesting an exact dental treatment. It is helpful in diagnosing tooth loss, cracked teeth, periodontitis, dental fluorosis, dental caries, dental calculus, dental plaque, and periodontal disease. The suggestions given by the intelligent system render accuracy, precision, specificity, sensitivity, confusion matrix, recall, and F1-Score to strengthen the decision-making and contribute to the pursuit of offering an exact treatment.","PeriodicalId":252088,"journal":{"name":"SRM Journal of Research in Dental Sciences","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129675154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.4103/srmjrds.srmjrds_31_23
K. Sai Charan, M. Kumari, K. Nivedha, M. Aishwariya
Background: Various experimental studies have proved that histone methyltransferases (HMTs) are responsible for tumor progression, and the use of inhibitors for the same opens new therapeutic approaches in the treatment of cancer. Aim: The purpose of this review was to appraise the basics of histones, HMTs, the classification of the HMT, and the mechanism of HMT in tumor progression and their inhibitors. Materials and Methods: This narrative review was carried out using an electronic search of the data for articles related to the basics of histone, classification of HMTs, their role in tumor progression, and the molecular inhibitors of HMTs from the following databases such as PubMed, Scopus, and Web of science. Results: On the basis of our literary search, we were able to locate 11 articles that fulfilled our criteria. Conclusion: The advancement in the invention of small molecular inhibitors of HMTs is becoming a cutting-edge area of drug development. Soon, the drugs in preclinical and phase I trials will be approved by the Food and Drug Administration for clinical use.
背景:各种实验研究已经证明，组蛋白甲基转移酶(hmt)与肿瘤进展有关，使用相同的抑制剂为癌症的治疗开辟了新的治疗途径。目的:本综述的目的是评估组蛋白、HMT的基础知识，HMT的分类，以及HMT在肿瘤进展中的机制及其抑制剂。材料和方法:本叙述性综述通过电子检索与组蛋白基础知识、hmt分类、hmt在肿瘤进展中的作用以及hmt分子抑制剂相关的文章数据进行，这些文章来自PubMed、Scopus和Web of science等数据库。结果:在文献检索的基础上，我们找到了11篇符合我们标准的文章。结论:hmt小分子抑制剂的发明正在成为药物开发的前沿领域。很快，处于临床前和I期试验的药物将被美国食品和药物管理局批准临床使用。
{"title":"Cancer drug resistance can be combated by targeting histone methyltransferases – A novel therapeutic approach: A narrative review","authors":"K. Sai Charan, M. Kumari, K. Nivedha, M. Aishwariya","doi":"10.4103/srmjrds.srmjrds_31_23","DOIUrl":"https://doi.org/10.4103/srmjrds.srmjrds_31_23","url":null,"abstract":"Background: Various experimental studies have proved that histone methyltransferases (HMTs) are responsible for tumor progression, and the use of inhibitors for the same opens new therapeutic approaches in the treatment of cancer. Aim: The purpose of this review was to appraise the basics of histones, HMTs, the classification of the HMT, and the mechanism of HMT in tumor progression and their inhibitors. Materials and Methods: This narrative review was carried out using an electronic search of the data for articles related to the basics of histone, classification of HMTs, their role in tumor progression, and the molecular inhibitors of HMTs from the following databases such as PubMed, Scopus, and Web of science. Results: On the basis of our literary search, we were able to locate 11 articles that fulfilled our criteria. Conclusion: The advancement in the invention of small molecular inhibitors of HMTs is becoming a cutting-edge area of drug development. Soon, the drugs in preclinical and phase I trials will be approved by the Food and Drug Administration for clinical use.","PeriodicalId":252088,"journal":{"name":"SRM Journal of Research in Dental Sciences","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124313479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.4103/srmjrds.srmjrds_37_23
Reetika Singh, V. Nikhil, Sonalee Sahu
Introduction: Persistent idiopathic dentoalveolar pain (PIDP) is a type of chronic pain that affects the teeth and surrounding tissue, and it is a condition that has been puzzling dental practitioners for many years. Aim: To clarify some misconceptions about persistent idiopathic dentoalveolar pain and provides insight into its possible diagnoses. Methods: The electronic literature search was conducted between June 2003 and December 2022 in PubMed and Google Scholar using Mesh terms: pain, idiopathic pain, phantom pain, and dentoalveolar pain in the English language. Later, relevant articles were screened and read thoroughly. Results: After reviewing the various articles, it was found that PIDP is a disease of exclusion that is confined to the dentoalveolar region with profound, dull, and pressure-like sensations. Discussion: Most of the research on PIDP has centered on its occurrence rates, symptoms, and ways to treat it, as well as the possible causes behind it. Various studies have also investigated different forms of treatment, such as medication, nerve blocks, and psychological interventions, in an effort to manage PIDP.
{"title":"Clinical diagnosis and management of persistent idiopathic dentoalveolar pain: A narrative review","authors":"Reetika Singh, V. Nikhil, Sonalee Sahu","doi":"10.4103/srmjrds.srmjrds_37_23","DOIUrl":"https://doi.org/10.4103/srmjrds.srmjrds_37_23","url":null,"abstract":"Introduction: Persistent idiopathic dentoalveolar pain (PIDP) is a type of chronic pain that affects the teeth and surrounding tissue, and it is a condition that has been puzzling dental practitioners for many years. Aim: To clarify some misconceptions about persistent idiopathic dentoalveolar pain and provides insight into its possible diagnoses. Methods: The electronic literature search was conducted between June 2003 and December 2022 in PubMed and Google Scholar using Mesh terms: pain, idiopathic pain, phantom pain, and dentoalveolar pain in the English language. Later, relevant articles were screened and read thoroughly. Results: After reviewing the various articles, it was found that PIDP is a disease of exclusion that is confined to the dentoalveolar region with profound, dull, and pressure-like sensations. Discussion: Most of the research on PIDP has centered on its occurrence rates, symptoms, and ways to treat it, as well as the possible causes behind it. Various studies have also investigated different forms of treatment, such as medication, nerve blocks, and psychological interventions, in an effort to manage PIDP.","PeriodicalId":252088,"journal":{"name":"SRM Journal of Research in Dental Sciences","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130916315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.4103/srmjrds.srmjrds_28_23
S. Fenn, Suganya Ravi, K. Mohan, R. Thangavelu
Background: Oral breath can be used as a chairside investigation method in the detection of volatile sulfur compounds (VSCs), which can serve as a potential biomarker in the early detection of underlying systemic diseases. Aim: The primary aim was to study the hydrogen sulfide levels in oral breath of patients with chronic obstructive pulmonary disease (COPD), chronic renal failure (CRF), and peptic ulcer disease. Materials and Methods: The study included 100 patients divided into four groups with 25 patients in each group of CRF, COPD, peptic ulcer, and control. The oral breath sample collected from each participant was passed through a sensor in the hydrogen sulfide detector (Tanita, Japan), which registers the level of sulfides. The maximum level attained was determined in parts per billion sulfide equivalents using direct readings from the monitor's digital display. The values obtained were statistically analyzed using statistical tests: Shapiro–Wilk test, analysis of variance, and post hoc analysis. Results: The mean values for the age and hydrogen sulfide scores were as follows: control group (35.16 ± 14.12 and 0.44 ± 1.00), CRF (49.16 ± 13.93 and 2.32 ± 0.98), COPD (48.16 ± 15.58 and 2.40 ± 0.95), and the peptic ulcer (42.36 ± 15.44 and 1.68 ± 1.02). The post hoc analysis for intergroup comparison of mean values reveals that statistically significant (P = 0.001*) differences exist between the control group and the CRF group, the control group and the COPD group, and the control group and the peptic ulcer group. Conclusion: The CRF group had slightly higher hydrogen sulfide measurements among the four groups, indicating the release of more VSCs.
{"title":"Evaluation of halitosis in patients with chronic obstructive pulmonary disease, chronic renal failure, and peptic ulcer: A comparative study","authors":"S. Fenn, Suganya Ravi, K. Mohan, R. Thangavelu","doi":"10.4103/srmjrds.srmjrds_28_23","DOIUrl":"https://doi.org/10.4103/srmjrds.srmjrds_28_23","url":null,"abstract":"Background: Oral breath can be used as a chairside investigation method in the detection of volatile sulfur compounds (VSCs), which can serve as a potential biomarker in the early detection of underlying systemic diseases. Aim: The primary aim was to study the hydrogen sulfide levels in oral breath of patients with chronic obstructive pulmonary disease (COPD), chronic renal failure (CRF), and peptic ulcer disease. Materials and Methods: The study included 100 patients divided into four groups with 25 patients in each group of CRF, COPD, peptic ulcer, and control. The oral breath sample collected from each participant was passed through a sensor in the hydrogen sulfide detector (Tanita, Japan), which registers the level of sulfides. The maximum level attained was determined in parts per billion sulfide equivalents using direct readings from the monitor's digital display. The values obtained were statistically analyzed using statistical tests: Shapiro–Wilk test, analysis of variance, and post hoc analysis. Results: The mean values for the age and hydrogen sulfide scores were as follows: control group (35.16 ± 14.12 and 0.44 ± 1.00), CRF (49.16 ± 13.93 and 2.32 ± 0.98), COPD (48.16 ± 15.58 and 2.40 ± 0.95), and the peptic ulcer (42.36 ± 15.44 and 1.68 ± 1.02). The post hoc analysis for intergroup comparison of mean values reveals that statistically significant (P = 0.001*) differences exist between the control group and the CRF group, the control group and the COPD group, and the control group and the peptic ulcer group. Conclusion: The CRF group had slightly higher hydrogen sulfide measurements among the four groups, indicating the release of more VSCs.","PeriodicalId":252088,"journal":{"name":"SRM Journal of Research in Dental Sciences","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134356101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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