Pub Date : 2022-07-25DOI: 10.47960/2744-2470.2022.1.1.56
Josip Volarić, I. Rudež, Ante Bošnjak
Background. The main part of the study was to determine the lower frequency of postoperative complications and fewer days spent in hospital and in the intensive care unit postoperatively, among patients operated on using the OPCAB method, as opposed to those operated on using the CABG method.Methods: In a cross-sectional, epidemiological study, data were collected and processed from the medical database. The parameters taken into consideration were: the incidence of postoperative complications, the number of days spent in the intensive care unit postoperatively and the number of days spent in the hospital postoperatively. Main findings: From a total of 60 patients operated on at the Department of Cardiac Surgery, 8.33% of patients had postoperative complications. Half of the patients underwent CABG surgery and 13.3% had postoperative complications. The other half who underwent OPCAB surgery had 3.3% postoperative complications. CABG patients spent an average of 2.57 days in the intensive care unit, whereas OPCAB patients spent 2.17 days there.Principal conclusion: There is no statistically significant difference in the number of days spent in the intensive care unit and the incidence of postoperative complications between patients operated by on using the CABG or the OPCAB method.Key words: CABG method, OPCAB method, postoperativecomplication, intensive care unit
{"title":"Differences in Recovery After Coronary Artery Bypass Grafting or Off-pump Coronary Artery Bypass","authors":"Josip Volarić, I. Rudež, Ante Bošnjak","doi":"10.47960/2744-2470.2022.1.1.56","DOIUrl":"https://doi.org/10.47960/2744-2470.2022.1.1.56","url":null,"abstract":"Background. The main part of the study was to determine the lower frequency of postoperative complications and fewer days spent in hospital and in the intensive care unit postoperatively, among patients operated on using the OPCAB method, as opposed to those operated on using the CABG method.Methods: In a cross-sectional, epidemiological study, data were collected and processed from the medical database. The parameters taken into consideration were: the incidence of postoperative complications, the number of days spent in the intensive care unit postoperatively and the number of days spent in the hospital postoperatively. Main findings: From a total of 60 patients operated on at the Department of Cardiac Surgery, 8.33% of patients had postoperative complications. Half of the patients underwent CABG surgery and 13.3% had postoperative complications. The other half who underwent OPCAB surgery had 3.3% postoperative complications. CABG patients spent an average of 2.57 days in the intensive care unit, whereas OPCAB patients spent 2.17 days there.Principal conclusion: There is no statistically significant difference in the number of days spent in the intensive care unit and the incidence of postoperative complications between patients operated by on using the CABG or the OPCAB method.Key words: CABG method, OPCAB method, postoperativecomplication, intensive care unit","PeriodicalId":252537,"journal":{"name":"Annals of Biomedical and Clinical Research","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124459766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-25DOI: 10.47960/2744-2470.2022.1.1.34
Gordana Kraljević, Ivona Čarapina Zovko, B. Jelavic
Background: In many countries today, there is an increase in the share of women practicing medicine. This trend has been called the''feminization'' of medicine. The aim of this study was to determine whether there is a trend towards the feminization of medicine within the School of Medicine in Mostar.Methods: The examinees were medical students who graduated from the School of Medicine from 2003 to 2019. Male:female ratios were calculated for each year and for the entire study period. The entire study period was divided into 3-time intervals: 2003-2007, 2008-2013 and 2014-2019. These time intervals were compared according to the male:female ratio.Results: During the studied time periods there were 67.30% female graduates and 32.70% male graduates with a male:female ratio of 0.49:1. There were statistically significantly more females than males in all examined periods. There was a trend towards an increased share of females since the percentages of females in 2003-2007, 2008-2013 and 2014-2019 were 64%, 65% and 71%, respectively. However, the differences in sex shares between these periods were not statistically significant.Conclusions: The results of this cross-sectional study showed a significantly greater share of females than males among graduates and a trend towards a statistically non-significant increase in the share of females from the first to the last generation of graduates,which is in line with global trends.Key words: women, feminization, sex ratio, medical profession, school of medicine
{"title":"Sex Ratio of Graduated Medical Students of the School of Medicine in Mostar for the Period 2003-2020","authors":"Gordana Kraljević, Ivona Čarapina Zovko, B. Jelavic","doi":"10.47960/2744-2470.2022.1.1.34","DOIUrl":"https://doi.org/10.47960/2744-2470.2022.1.1.34","url":null,"abstract":"Background: In many countries today, there is an increase in the share of women practicing medicine. This trend has been called the''feminization'' of medicine. The aim of this study was to determine whether there is a trend towards the feminization of medicine within the School of Medicine in Mostar.Methods: The examinees were medical students who graduated from the School of Medicine from 2003 to 2019. Male:female ratios were calculated for each year and for the entire study period. The entire study period was divided into 3-time intervals: 2003-2007, 2008-2013 and 2014-2019. These time intervals were compared according to the male:female ratio.Results: During the studied time periods there were 67.30% female graduates and 32.70% male graduates with a male:female ratio of 0.49:1. There were statistically significantly more females than males in all examined periods. There was a trend towards an increased share of females since the percentages of females in 2003-2007, 2008-2013 and 2014-2019 were 64%, 65% and 71%, respectively. However, the differences in sex shares between these periods were not statistically significant.Conclusions: The results of this cross-sectional study showed a significantly greater share of females than males among graduates and a trend towards a statistically non-significant increase in the share of females from the first to the last generation of graduates,which is in line with global trends.Key words: women, feminization, sex ratio, medical profession, school of medicine","PeriodicalId":252537,"journal":{"name":"Annals of Biomedical and Clinical Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125871623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-25DOI: 10.47960/2744-2470.2022.1.1.19
Jelena Faletar, K. Vukojević
Background. Diabetic nephropathy is the leading cause of end-stage renal disease (ESRD) in most developed countries. A number of specific factors may contribute to the onset and progression of diabetic nephropathy. One of those specific factors is vascular endothelial growth factor (VEGF). We studied the expression of VEGF in the kidneys of diabetic rats during aging. Methods. Male Sprague-Dawley rats were injected with 55mg/kg streptozotocin (STZ) (DM group) or with citrate buffer (control group). Kidneys were collected after 2 weeks, 2 months, 6 months and 12 months, and were analyzed in three different kidney structures: glomeruli, proximal (PCT) and distal convoluted tubules (DCT). Sections were stained immunohistochemically, using VEGF.Results. Significant differences in marker expression were observed after 2 months, with higher VEGF expression in diabetic rats. Positive VEGF cells were detected exclusively in the glomeruli of diabetic rats after 2 months. After 2 weeks of DM onset, high VEGF expression was demonstrated in the distal tubules of diabetic rats, as well as a complete absence of VEGF expression in the distal tubules of the control group. Conclusions. The major change in expression of VEGF occurs after 2 months of DM onset, particularly in the DTC, implying an early onset of pathophysiological changes in diabetic kidneys, which would usually occur with aging. These findings help to contribute to our understanding of changes associated with DN and guide towards potentially appropriate treatment modalities.Key words: diabetes mellitus, kidneys, nephropathy, VEGF
{"title":"Changes in Expression of the Vascular Endothelial Growth Factor in the Kidneys of Diabetic Rats During Aging","authors":"Jelena Faletar, K. Vukojević","doi":"10.47960/2744-2470.2022.1.1.19","DOIUrl":"https://doi.org/10.47960/2744-2470.2022.1.1.19","url":null,"abstract":"Background. Diabetic nephropathy is the leading cause of end-stage renal disease (ESRD) in most developed countries. A number of specific factors may contribute to the onset and progression of diabetic nephropathy. One of those specific factors is vascular endothelial growth factor (VEGF). We studied the expression of VEGF in the kidneys of diabetic rats during aging. Methods. Male Sprague-Dawley rats were injected with 55mg/kg streptozotocin (STZ) (DM group) or with citrate buffer (control group). Kidneys were collected after 2 weeks, 2 months, 6 months and 12 months, and were analyzed in three different kidney structures: glomeruli, proximal (PCT) and distal convoluted tubules (DCT). Sections were stained immunohistochemically, using VEGF.Results. Significant differences in marker expression were observed after 2 months, with higher VEGF expression in diabetic rats. Positive VEGF cells were detected exclusively in the glomeruli of diabetic rats after 2 months. After 2 weeks of DM onset, high VEGF expression was demonstrated in the distal tubules of diabetic rats, as well as a complete absence of VEGF expression in the distal tubules of the control group. Conclusions. The major change in expression of VEGF occurs after 2 months of DM onset, particularly in the DTC, implying an early onset of pathophysiological changes in diabetic kidneys, which would usually occur with aging. These findings help to contribute to our understanding of changes associated with DN and guide towards potentially appropriate treatment modalities.Key words: diabetes mellitus, kidneys, nephropathy, VEGF","PeriodicalId":252537,"journal":{"name":"Annals of Biomedical and Clinical Research","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127010624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-25DOI: 10.47960/2744-2470.2022.1.1.44
Romana Romić, Inge Klupka Sarić, Davor Batinić
Background: The aim of this study was to compare the quality of life of patients with multiple sclerosis and the healthy population. Another aim of this study was to determine the impact of pathological fatigue, the number of relapses and the effect of immunotherapy on the level of satisfaction with thequality of life among the sick population.Methods: The study included 30 patients diagnosed with relapsing-remitting multiple sclerosis and 30 healthy subjects. Basic data were taken from the archives of the clinic for neurology, and patients were examined according to the Modified Fatigue Impact Scale and SF36-v2 questionnaires. Results: This study showed that patients with multiple sclerosis have a poorer quality of life compared to the healthy population (p=0.002), Among the patients, the level of satisfaction with thequality of life differed significantly depending on fatigue, the number of relapses in the last year and immunotherapy. It was found that patients with more relapses in the last year were more dissatisfied with the quality of life compared to patients with one or no relapses (p=0.048). Moreover, research has shown that patients who suffer from increased fatigue have a poorer quality of life, in contrast to patients with a normal level of fatigue (p=0.007). Finally, patients receiving immunotherapy have a better quality of life compared with patients not receiving it (p=0.033). Conclusion: Those with multiple sclerosis have a significantly lower level of satisfaction with the quality of life. Patients with more relapses in the last year, those who suffer from increased fatigue and those who do not receive immunotherapy have a poorer quality of life.Key words: relapsing-remitting multiple sclerosis; quality of life; fatigue; MFIS; SF36-v2
{"title":"Comparison of the Quality of Life of Patients with Multiple Sclerosis and the Healthy Population with Special Reference to the Impact of Fatigue, the Frequency of Relapses and the Use of Immunotherapy","authors":"Romana Romić, Inge Klupka Sarić, Davor Batinić","doi":"10.47960/2744-2470.2022.1.1.44","DOIUrl":"https://doi.org/10.47960/2744-2470.2022.1.1.44","url":null,"abstract":"Background: The aim of this study was to compare the quality of life of patients with multiple sclerosis and the healthy population. Another aim of this study was to determine the impact of pathological fatigue, the number of relapses and the effect of immunotherapy on the level of satisfaction with thequality of life among the sick population.Methods: The study included 30 patients diagnosed with relapsing-remitting multiple sclerosis and 30 healthy subjects. Basic data were taken from the archives of the clinic for neurology, and patients were examined according to the Modified Fatigue Impact Scale and SF36-v2 questionnaires. Results: This study showed that patients with multiple sclerosis have a poorer quality of life compared to the healthy population (p=0.002), Among the patients, the level of satisfaction with thequality of life differed significantly depending on fatigue, the number of relapses in the last year and immunotherapy. It was found that patients with more relapses in the last year were more dissatisfied with the quality of life compared to patients with one or no relapses (p=0.048). Moreover, research has shown that patients who suffer from increased fatigue have a poorer quality of life, in contrast to patients with a normal level of fatigue (p=0.007). Finally, patients receiving immunotherapy have a better quality of life compared with patients not receiving it (p=0.033). Conclusion: Those with multiple sclerosis have a significantly lower level of satisfaction with the quality of life. Patients with more relapses in the last year, those who suffer from increased fatigue and those who do not receive immunotherapy have a poorer quality of life.Key words: relapsing-remitting multiple sclerosis; quality of life; fatigue; MFIS; SF36-v2","PeriodicalId":252537,"journal":{"name":"Annals of Biomedical and Clinical Research","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128706187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-25DOI: 10.47960/2744-2470.2022.1.1.50
Ivona Šušak, Vedran Bjelanović, Dejan Tirić, V. Tomić
Background: The aim of this study was to determine and analyze the frequency and obstetric features of preterm birth and neonatal outcomes of infants born before 37 completed weeks of pregnancy. Methods: The retrospective study included 470 premature births. The following data on preterm births were collected from hospital records and analyzed: gestational age, type of preterm birth, multiple pregnancy and maternal parity. The parameters of preterm infants were: Apgar score, intrauterine growth restriction (IUGR), perinatal asphyxia, respiratory distress syndrome (RDS), sepsis, necrotizing enterocolitis, intracranial hemorrhage, neonatal convulsions, hypoglycemia, blood transfusion, the need for surfactant, the need for mechanical ventilation, the length of stay in an Intensive Care Unit and early and late neonatal mortality.Main findings: The frequency of preterm births was 6.48%. The most common type of premature birth was spontaneous premature birth. Most complications occurred in neonates with a gestational age of 28-34 weeks. The most common respiratory complication was RDS (8.1%). Early neonatal mortality was 1.49% and late neonatal mortality was 0.85%.Principal conclusion: Neonatal outcomes of premature infants are directly proportional to their gestational age. The neonatal mortality rate of premature infants at Clinical Hospital Center Mostar (CHC) Mostar is comparable to other developing countries.Key words: preterm birth, gestational age neonatal outcome, perinatal care, neonatal mortality
{"title":"Preterm Births: Obstetric Features and Neonatal Outcomes at University Hospital Mostar","authors":"Ivona Šušak, Vedran Bjelanović, Dejan Tirić, V. Tomić","doi":"10.47960/2744-2470.2022.1.1.50","DOIUrl":"https://doi.org/10.47960/2744-2470.2022.1.1.50","url":null,"abstract":"Background: The aim of this study was to determine and analyze the frequency and obstetric features of preterm birth and neonatal outcomes of infants born before 37 completed weeks of pregnancy. Methods: The retrospective study included 470 premature births. The following data on preterm births were collected from hospital records and analyzed: gestational age, type of preterm birth, multiple pregnancy and maternal parity. The parameters of preterm infants were: Apgar score, intrauterine growth restriction (IUGR), perinatal asphyxia, respiratory distress syndrome (RDS), sepsis, necrotizing enterocolitis, intracranial hemorrhage, neonatal convulsions, hypoglycemia, blood transfusion, the need for surfactant, the need for mechanical ventilation, the length of stay in an Intensive Care Unit and early and late neonatal mortality.Main findings: The frequency of preterm births was 6.48%. The most common type of premature birth was spontaneous premature birth. Most complications occurred in neonates with a gestational age of 28-34 weeks. The most common respiratory complication was RDS (8.1%). Early neonatal mortality was 1.49% and late neonatal mortality was 0.85%.Principal conclusion: Neonatal outcomes of premature infants are directly proportional to their gestational age. The neonatal mortality rate of premature infants at Clinical Hospital Center Mostar (CHC) Mostar is comparable to other developing countries.Key words: preterm birth, gestational age neonatal outcome, perinatal care, neonatal mortality","PeriodicalId":252537,"journal":{"name":"Annals of Biomedical and Clinical Research","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130926295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-25DOI: 10.47960/2744-2470.2022.1.1.4
Leonora Bedeković, K. Vukojević
Background: Diabetic nephropathy (DN) is the most common cause of chronic renal failure in the world. There appears to be different pathogenetic, hemodynamic and metabolic processes leading to the pathologic mechanisms in DN. We studied the expression of connective tissue growth factor (CTGF) in the kidneys of diabetic rats over time.Methods: Male Sprague-Dawley rats were injected with 55mg/kg streptozotocin (STZ) (diabetes mellitus (DM) group) or with citrate buffer (control group). The rat kidneys were harvested 2 weeks, 2 months, 6 months and 12 months following the STZ challenge, and sectioned into three different kidney structures: glomeruli, proximal convoluted tubule (PCT) and distal convoluted tubule (DCT). Sections were immunohistochemically stained to monitor the expression of CTGF. Results:Significant differences in CTGF expression were observed 2 weeks and 2 months after the STZ challenge, with higher CTGF expression in diabetic rats. Two weeks post DM onset, high CTGF expression was demonstrated in the distal tubules of the diabetic rats. The expression of CTGF in the glomeruli of diabetic rats washighest 12 months after diabetes induction, with a complete absence of CTGF expression in the control groups throughout the study.Conclusions:The major change in expression of CTGF occurs within the first 2 months of DM, particularly in the DTC, implying an early onset of pathophysiological changes in diabetic kidneys, which would normally occur with aging. These findings help to contribute to our understanding of changes associated with DN and guide towards potentially appropriate treatment modalities.Key words: diabetes mellitus (DM), nephropathy, chronic renal failure, connective tissue growth factor (CTGF)
{"title":"Changes in Expression of the Connective Tissue Growth Factor in the Kidneys of Diabetic Rats During Aging","authors":"Leonora Bedeković, K. Vukojević","doi":"10.47960/2744-2470.2022.1.1.4","DOIUrl":"https://doi.org/10.47960/2744-2470.2022.1.1.4","url":null,"abstract":"Background: Diabetic nephropathy (DN) is the most common cause of chronic renal failure in the world. There appears to be different pathogenetic, hemodynamic and metabolic processes leading to the pathologic mechanisms in DN. We studied the expression of connective tissue growth factor (CTGF) in the kidneys of diabetic rats over time.Methods: Male Sprague-Dawley rats were injected with 55mg/kg streptozotocin (STZ) (diabetes mellitus (DM) group) or with citrate buffer (control group). The rat kidneys were harvested 2 weeks, 2 months, 6 months and 12 months following the STZ challenge, and sectioned into three different kidney structures: glomeruli, proximal convoluted tubule (PCT) and distal convoluted tubule (DCT). Sections were immunohistochemically stained to monitor the expression of CTGF. Results:Significant differences in CTGF expression were observed 2 weeks and 2 months after the STZ challenge, with higher CTGF expression in diabetic rats. Two weeks post DM onset, high CTGF expression was demonstrated in the distal tubules of the diabetic rats. The expression of CTGF in the glomeruli of diabetic rats washighest 12 months after diabetes induction, with a complete absence of CTGF expression in the control groups throughout the study.Conclusions:The major change in expression of CTGF occurs within the first 2 months of DM, particularly in the DTC, implying an early onset of pathophysiological changes in diabetic kidneys, which would normally occur with aging. These findings help to contribute to our understanding of changes associated with DN and guide towards potentially appropriate treatment modalities.Key words: diabetes mellitus (DM), nephropathy, chronic renal failure, connective tissue growth factor (CTGF)","PeriodicalId":252537,"journal":{"name":"Annals of Biomedical and Clinical Research","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126141000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-25DOI: 10.47960/2744-2470.2022.1.1.39
Džejla Mahmutović, Ivica Brizić
Arterial Hypertension in Patients with Acute Coronary Syndrome
急性冠脉综合征患者的动脉高血压
{"title":"Arterial Hypertension in Patients with Acute Coronary Syndrome","authors":"Džejla Mahmutović, Ivica Brizić","doi":"10.47960/2744-2470.2022.1.1.39","DOIUrl":"https://doi.org/10.47960/2744-2470.2022.1.1.39","url":null,"abstract":"Arterial Hypertension in Patients with Acute Coronary Syndrome","PeriodicalId":252537,"journal":{"name":"Annals of Biomedical and Clinical Research","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131026910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-25DOI: 10.47960/2744-2470.2022.1.1.28
Katarina Knezović, A. Sesar, Anita Pušić Sesar, Irena Sesar, I. Čavar, Ivan Merdžo
Background: The aim of this study was to evaluate the efficacy of aflibercept by comparison with bevacizumab in the treatment of diabetic macular edema.Methods: The study included 159 patients; the first group consisted of 58 patients who underwent intravitreal application of aflibercept, and the second group of 101 patients underwent intravitreal application of bevacizumab.Main Findings: There was a statistically significant decrease in edema during the optical coherence tomography (OCT) scans after the application of bevacizumab (533±152 μm vs. 384±104 μm, p<0.001) and aflibercept (500±110 μm vs. 354±80 μm, p<0.001). Moreover, a significant increase in central visual acuity was observed both for bevacizumab (0.29±0.20 μm vs. 0.36±0.22 μm, p<0.001) and aflibercept (0.40±0.30 μm vs. 0.48±0.31 μm, p<0.001). Principal Conclusion: Anintravitreal application of either aflibercept or bevacizumab resulted in a significant reduction in macular edema and a significant increase in central visual acuity. Although statistically more efficient, aflibercept use can hardly be justified, due to the high cost associated with its use. Bevacizumab achieved a higher cost-effectiveness compared with aflibercept. Therefore, its use should be considered depending on various healthcare systems, as well as socio-economic factors. Key words: diabetic retinopathy, diabetic macular edema, bevacizumab, aflibercept, optical coherence tomography, visual acuity
背景:本研究的目的是通过与贝伐单抗的比较来评价阿非利西普治疗糖尿病性黄斑水肿的疗效。方法:纳入159例患者;第一组有58名患者接受玻璃体腔内应用阿非利塞普，第二组有101名患者接受玻璃体腔内应用贝伐单抗。主要发现:应用贝伐单抗(533±152 μm vs. 384±104 μm, p<0.001)和阿非利赛普(500±110 μm vs. 354±80 μm, p<0.001)后，光学相干断层扫描(OCT)期间水肿减少具有统计学意义。此外，贝伐单抗组(0.29±0.20 μm vs. 0.36±0.22 μm, p<0.001)和阿非利西普组(0.40±0.30 μm vs. 0.48±0.31 μm, p<0.001)的中心视力均显著提高。主要结论:非玻璃体内应用阿非利塞普或贝伐单抗可显著减少黄斑水肿并显著增加中央视力。虽然统计上更有效，但由于与使用相关的高成本，使用阿伯西普几乎是不合理的。贝伐单抗与阿非利西普相比具有更高的成本效益。因此，应根据各种医疗保健系统以及社会经济因素来考虑其使用。关键词:糖尿病视网膜病变，糖尿病性黄斑水肿，贝伐单抗，阿非利塞普，光学相干断层扫描，视力
{"title":"Use of Bevacizumab and Aflibercept in the Treatment of Diabetic Macular Edema: Cost-effectiveness Analysis","authors":"Katarina Knezović, A. Sesar, Anita Pušić Sesar, Irena Sesar, I. Čavar, Ivan Merdžo","doi":"10.47960/2744-2470.2022.1.1.28","DOIUrl":"https://doi.org/10.47960/2744-2470.2022.1.1.28","url":null,"abstract":"Background: The aim of this study was to evaluate the efficacy of aflibercept by comparison with bevacizumab in the treatment of diabetic macular edema.Methods: The study included 159 patients; the first group consisted of 58 patients who underwent intravitreal application of aflibercept, and the second group of 101 patients underwent intravitreal application of bevacizumab.Main Findings: There was a statistically significant decrease in edema during the optical coherence tomography (OCT) scans after the application of bevacizumab (533±152 μm vs. 384±104 μm, p<0.001) and aflibercept (500±110 μm vs. 354±80 μm, p<0.001). Moreover, a significant increase in central visual acuity was observed both for bevacizumab (0.29±0.20 μm vs. 0.36±0.22 μm, p<0.001) and aflibercept (0.40±0.30 μm vs. 0.48±0.31 μm, p<0.001). Principal Conclusion: Anintravitreal application of either aflibercept or bevacizumab resulted in a significant reduction in macular edema and a significant increase in central visual acuity. Although statistically more efficient, aflibercept use can hardly be justified, due to the high cost associated with its use. Bevacizumab achieved a higher cost-effectiveness compared with aflibercept. Therefore, its use should be considered depending on various healthcare systems, as well as socio-economic factors. Key words: diabetic retinopathy, diabetic macular edema, bevacizumab, aflibercept, optical coherence tomography, visual acuity","PeriodicalId":252537,"journal":{"name":"Annals of Biomedical and Clinical Research","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126501298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-25DOI: 10.47960/2744-2470.2022.1.1.12
J. Curcic, Anita Racetin, Nela Kelam, K. Vukojević
Background. The aim of our study is to provide an insight into the genetic expression landscape of Dab1 and Reelin, which are important in human genitourinary tract development and could help elucidate the critical stages of the onset of bladder anomalies.Methods. Yotari, heterozygote and wild type mice were sacrificed on the 4th, 11th and 14th postnatal day. Morphological parameters were analyzed using immunohistochemistry on mice bladder samples.Results. Significant expression of Dab1 was observed in the bladder epithelium during the 4th postnatal day and in the wt -wild type, but also in the yot -/- mouse. Reelin expression was significant in bladder epithelium during the 4th postnatal day in the wild-type and mutant mouse type. A significant expression of Dab1 positive cells in lamina propria was observed on the 4th postnatal day in yot -/- and in wt. The percentage of Reelin positive cells in lamina propria was significant on the 4th postnatal day in mutated and wild-type mice.Conclusions. An increase in the expression of Dab1 and Reelin proteins in the bladder of a yotari mouse may indicate bladder damage, due to congenital renal abnormalities and caused by a mutation in the Dab1 gene.Key words: Dab1; Reelin, CAKUT, bladder development, yotari mice
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