Pub Date : 2022-04-12DOI: 10.29011/amco-130.000137
Li Zhang, X. Xie, Pei-Jun Xie, Yan An Wang, L. Su, Feng Wang
High-Grade Gliomas (HGGs) are the most frequently diagnosed Central Nervous System (CNS) tumors in children. Maximal safe surgical resection is the cornerstone of management of pediatric HGGs. Radiation therapy is the standard of care after surgical resection and significantly improves survival of children older than 3 years-old with HGGs, but the recurrence rate of pediatric HGGs remains very high. Currently, there are no effective treatments for pediatric patients with recurrent HGGs, but inhibition of Vascular Endothelial Growth Factor (VEGF) pathway has shown promising clinical benefit in several clinical studies as it can reduce brain edema, lead to symptomatic relief. Temozolomide (TMZ) is a standard chemotherapeutic modality in treating adult patients with HGGs. In this case, we described a 3-year-old boy who received repeated surgery and proton beam radiation therapy due to severe clinical symptoms. He experienced recurrence 6 months after first surgical resection. Finally, he received Apatinib combined with temozolomide (TMZ) as salvage therapy and obtained a durable response with manageable adverse events. Though the effect of Apatinib combined with TMZ has been confirmed in adult patients with recurrent HGGs, the clinical benefit in pediatric patients with recurrent HGGs has not been investigated. We hope our case could provide a reference for clinicians in this region.
{"title":"Durable Response from Temozolomide Combined with Apatinib in a Pediatric Patient with Recurrent High-Grade Glioma: A Case Report","authors":"Li Zhang, X. Xie, Pei-Jun Xie, Yan An Wang, L. Su, Feng Wang","doi":"10.29011/amco-130.000137","DOIUrl":"https://doi.org/10.29011/amco-130.000137","url":null,"abstract":"High-Grade Gliomas (HGGs) are the most frequently diagnosed Central Nervous System (CNS) tumors in children. Maximal safe surgical resection is the cornerstone of management of pediatric HGGs. Radiation therapy is the standard of care after surgical resection and significantly improves survival of children older than 3 years-old with HGGs, but the recurrence rate of pediatric HGGs remains very high. Currently, there are no effective treatments for pediatric patients with recurrent HGGs, but inhibition of Vascular Endothelial Growth Factor (VEGF) pathway has shown promising clinical benefit in several clinical studies as it can reduce brain edema, lead to symptomatic relief. Temozolomide (TMZ) is a standard chemotherapeutic modality in treating adult patients with HGGs. In this case, we described a 3-year-old boy who received repeated surgery and proton beam radiation therapy due to severe clinical symptoms. He experienced recurrence 6 months after first surgical resection. Finally, he received Apatinib combined with temozolomide (TMZ) as salvage therapy and obtained a durable response with manageable adverse events. Though the effect of Apatinib combined with TMZ has been confirmed in adult patients with recurrent HGGs, the clinical benefit in pediatric patients with recurrent HGGs has not been investigated. We hope our case could provide a reference for clinicians in this region.","PeriodicalId":254574,"journal":{"name":"Annals of Medical and Clinical Oncology","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130736333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-29DOI: 10.29011/amco-133.000133
Ligia Ríos, Liliana Vásquez, I. Maza, Mónica Oscanoa, G. Paredes, Fanny Tarrillo, Jenny Gerónimo
The Febrile Neutropenia (FN) in children with cancer may be the only indication of a serious underlying infection, which can lead to sepsis and be fatal; it is recommend start antibiotics as soon as possible. We realized a retrospective analysis of all patients under 14 years of age with cancer, who attended the Pediatric Emergency of Rebagliati Hospital (Lima-Peru), between July 2016 and February 2017, due to fever, neutropenia and history to received chemotherapy in the last 15 days. Of 36079 emergency attentions, 31 were episodes of FN. The median of time from arrival to emergency to the first dose of antibiotic or Time To Antibiotics (TTA) was 206 minutes (Interquartile range [IQR], 137-390). Patients with leukemia had a lower TTA than patients with solid tumors (p = 0.037). The TTA after 120 minutes was not associated with longer hospital stay, transfer to the PICU or mortality. In the cases evaluated, the TTA exceeded the international standards. Patients with solid tumors have higher TTA than patients with leukemia. It is necessary to create a multidisciplinary program to improve this time.
{"title":"Time to First Dose of Antibiotics in Children with Cancer and Febrile Neutropenia. A Report from a Peruvian Hospital","authors":"Ligia Ríos, Liliana Vásquez, I. Maza, Mónica Oscanoa, G. Paredes, Fanny Tarrillo, Jenny Gerónimo","doi":"10.29011/amco-133.000133","DOIUrl":"https://doi.org/10.29011/amco-133.000133","url":null,"abstract":"The Febrile Neutropenia (FN) in children with cancer may be the only indication of a serious underlying infection, which can lead to sepsis and be fatal; it is recommend start antibiotics as soon as possible. We realized a retrospective analysis of all patients under 14 years of age with cancer, who attended the Pediatric Emergency of Rebagliati Hospital (Lima-Peru), between July 2016 and February 2017, due to fever, neutropenia and history to received chemotherapy in the last 15 days. Of 36079 emergency attentions, 31 were episodes of FN. The median of time from arrival to emergency to the first dose of antibiotic or Time To Antibiotics (TTA) was 206 minutes (Interquartile range [IQR], 137-390). Patients with leukemia had a lower TTA than patients with solid tumors (p = 0.037). The TTA after 120 minutes was not associated with longer hospital stay, transfer to the PICU or mortality. In the cases evaluated, the TTA exceeded the international standards. Patients with solid tumors have higher TTA than patients with leukemia. It is necessary to create a multidisciplinary program to improve this time.","PeriodicalId":254574,"journal":{"name":"Annals of Medical and Clinical Oncology","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132012966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.29011/amco-125.000125
{"title":"Commentary Referring to Pericyte FAK Negatively Regulates Gas6/ Axl Signalling To Suppress Tumour Angiogenesis and Tumour Growth","authors":"","doi":"10.29011/amco-125.000125","DOIUrl":"https://doi.org/10.29011/amco-125.000125","url":null,"abstract":"","PeriodicalId":254574,"journal":{"name":"Annals of Medical and Clinical Oncology","volume":"499 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116085612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.29011/amco-130.000130
{"title":"Quantitative Morphometry of the Breast Cancer Vascularity","authors":"","doi":"10.29011/amco-130.000130","DOIUrl":"https://doi.org/10.29011/amco-130.000130","url":null,"abstract":"","PeriodicalId":254574,"journal":{"name":"Annals of Medical and Clinical Oncology","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125541269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.29011/amco-121.000121
A. Puzikov
The goal is to identify motor disorders of the Gastrointestinal Tract and Biliary tract (GIT and RVC) in tumors of the pancreas. Material and methods: There were 8 patients with pancreatic adenoma under observation: 75% of women aged 67.2 ± 3.5 years and 25% of men aged 57.3 ± 5.9 years. The diagnosis of a pancreatic tumor was made on the basis of abdominal sonography, aiming at the pancreas. The motor function of the gastrointestinal tract and GI departments was studied Electromyographically (EMG) by applying silver bipolar electrodes to the projection area of the registered organ on the anterior abdominal wall. The analysis of electromyograms was performed using the Conan-M hardware and software complex with a bandwidth of 1-10 Hz. Results: In pancreatic tumors, hypermotor dyskinesia of the longitudinal and oblique muscle layers of the stomach, hypermotor dyskinesia of the duodenum were observed. Hypermotor dyskinesia of the jejunum, hypomotor dyskinesia of the right parts of the colon, hypomotor dyskinesia of the proximal part of the descending colon due to a pronounced spasm of the circular muscle layer.
{"title":"Motor Function of the Gastrointestinal Tract and Biliary Tract in Pancreatic Tumors","authors":"A. Puzikov","doi":"10.29011/amco-121.000121","DOIUrl":"https://doi.org/10.29011/amco-121.000121","url":null,"abstract":"The goal is to identify motor disorders of the Gastrointestinal Tract and Biliary tract (GIT and RVC) in tumors of the pancreas. Material and methods: There were 8 patients with pancreatic adenoma under observation: 75% of women aged 67.2 ± 3.5 years and 25% of men aged 57.3 ± 5.9 years. The diagnosis of a pancreatic tumor was made on the basis of abdominal sonography, aiming at the pancreas. The motor function of the gastrointestinal tract and GI departments was studied Electromyographically (EMG) by applying silver bipolar electrodes to the projection area of the registered organ on the anterior abdominal wall. The analysis of electromyograms was performed using the Conan-M hardware and software complex with a bandwidth of 1-10 Hz. Results: In pancreatic tumors, hypermotor dyskinesia of the longitudinal and oblique muscle layers of the stomach, hypermotor dyskinesia of the duodenum were observed. Hypermotor dyskinesia of the jejunum, hypomotor dyskinesia of the right parts of the colon, hypomotor dyskinesia of the proximal part of the descending colon due to a pronounced spasm of the circular muscle layer.","PeriodicalId":254574,"journal":{"name":"Annals of Medical and Clinical Oncology","volume":"69 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122240914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.29011/amco-123.000123
R. Mosquera
Gastric Cancer (GC) is the 5th most common cancer in the world, accounting for 5.7% of all new cancers, affecting one million people annually [1]. It is the third leading cause of death by cancer (DC), accounting for 8.2% (DC), or 782,000 deaths in 2018. The cumulative risk of death from GC, from birth to 74 years, is 1.36 % for males and 0.57% for females. Its incidence and mortality are highly variable, and will depend on the region in the world analyzed and its culture [2]. GC have been associated with diet and / or infection with Helicobacter pylori bacteria. It’s more prevalent in men, and is more common in developed nations. The incidence of the GC is higher in Central and East Asia, and Latino America, but has been declining for the past 50 years, possibly due to the prevention and eradication of Helicobacter pylori bacteria. Ninety five percent of GC are adenocarcinomas, followed by primary gastric lymphomas. Survival of patients with GC at 5 years of diagnosis is 31% in the United States, this is because they are usually diagnosed at advanced stages. The majority of GC’s, are sporadic, but there is a hereditary tendency, as has been identified in several groups of families with GC (10%), and in about 1 to 3% of the families with Hereditary Diffuse Gastric Cancer Syndrome (HDGCS).
{"title":"Hereditary Diffuse Gastric Cancer","authors":"R. Mosquera","doi":"10.29011/amco-123.000123","DOIUrl":"https://doi.org/10.29011/amco-123.000123","url":null,"abstract":"Gastric Cancer (GC) is the 5th most common cancer in the world, accounting for 5.7% of all new cancers, affecting one million people annually [1]. It is the third leading cause of death by cancer (DC), accounting for 8.2% (DC), or 782,000 deaths in 2018. The cumulative risk of death from GC, from birth to 74 years, is 1.36 % for males and 0.57% for females. Its incidence and mortality are highly variable, and will depend on the region in the world analyzed and its culture [2]. GC have been associated with diet and / or infection with Helicobacter pylori bacteria. It’s more prevalent in men, and is more common in developed nations. The incidence of the GC is higher in Central and East Asia, and Latino America, but has been declining for the past 50 years, possibly due to the prevention and eradication of Helicobacter pylori bacteria. Ninety five percent of GC are adenocarcinomas, followed by primary gastric lymphomas. Survival of patients with GC at 5 years of diagnosis is 31% in the United States, this is because they are usually diagnosed at advanced stages. The majority of GC’s, are sporadic, but there is a hereditary tendency, as has been identified in several groups of families with GC (10%), and in about 1 to 3% of the families with Hereditary Diffuse Gastric Cancer Syndrome (HDGCS).","PeriodicalId":254574,"journal":{"name":"Annals of Medical and Clinical Oncology","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115348095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.29011/amco-128.000128
{"title":"A Rare Case of a Minor Salivary Gland Carcinoma with a Voluminous Cardiac Metastasis","authors":"","doi":"10.29011/amco-128.000128","DOIUrl":"https://doi.org/10.29011/amco-128.000128","url":null,"abstract":"","PeriodicalId":254574,"journal":{"name":"Annals of Medical and Clinical Oncology","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124806527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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