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Management of Cyanide Intoxication with Extracorporeal Membrane Oxygenation and Continuous Renal Replacement Therapy 体外膜氧合和持续肾替代治疗氰化物中毒的治疗
Pub Date : 2015-08-01 DOI: 10.4266/KJCCM.2015.30.3.218
Jin Park, Seung Yeob Lee, H. Choi, Y. Choi, Young Joo Lee
Cyanide intoxication results in severe metabolic acidosis and catastrophic prognosis with conventional treatment. Indications of extracorporeal membrane oxygenation (ECMO) and continuous renal replacement therapy (CRRT) are expanding to poisoning cases. A 50-year-old male patient arrived in the emergency room due to mental change after ingestion of cyanide as a suicide attempt 30 minutes prior. He was comatose, and brain stem reflexes were absent. Initial laboratory analysis demonstrated severe metabolic acidosis with increased lactic acid of 25 mM/L. Shock and acidosis were not corrected despite a large amount of fluid resuscitation with highdose norepinephrine and continuous renal replacement therapy. We decided to apply ECMO and CRRT to allow time for stabilization of hemodynamic status. After administration of antidote infusion, although the patient had the potential to progress to brain death status, vital signs were improved with correction of acidosis. We considered the evaluation for organ donation. We report a male patient who showed typical cyanide intoxication as lethal metabolic acidosis and cardiac impairment, and the patient recovered after antidote administration during vital organ support through ECMO and CRRT.
氰化物中毒可导致严重的代谢性酸中毒,常规治疗预后极差。体外膜氧合(ECMO)和持续肾替代治疗(CRRT)的适应症正在扩大到中毒病例。一名50岁的男性患者在30分钟前试图自杀而摄入氰化物后,因精神变化而被送往急诊室。他处于昏迷状态,脑干没有反射。最初的实验室分析显示严重的代谢性酸中毒,乳酸增加25 mM/L。尽管给予大剂量去甲肾上腺素和持续肾脏替代治疗的大量液体复苏,但休克和酸中毒仍未得到纠正。我们决定应用ECMO和CRRT,以便有时间稳定血流动力学状态。在给予解毒剂输注后,尽管患者有可能发展为脑死亡状态,但随着酸中毒的纠正,生命体征得到改善。我们考虑了器官捐赠的评估。我们报告一位男性患者表现为典型的氰化物中毒为致死性代谢性酸中毒和心脏损害,患者在通过ECMO和CRRT进行重要器官支持时给予解毒剂后恢复。
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引用次数: 2
Early Extracorporeal Membrane Oxygenation for Massive Aspiration during Anesthesia Induction 麻醉诱导中大量误吸的早期体外膜氧合
Pub Date : 2015-05-31 DOI: 10.4266/KJCCM.2015.30.2.109
Namo Kim, Kwan Hyung Kim, Jeongmin Kim, S. Choi, S. Na
Although the incidence is not high in the general surgical population, pulmonary aspiration of gastric contents can result in serious long-term morbidity and mortality. We report a case of early use of extracorporeal membrane oxygenation (ECMO) to correct severe hypoxemia refractory to conventional mechanical ventilation in a patient with massive aspiration of gastric contents immediately followed by acute lung injury during general anesthesia induction. A 64-year-old woman diagnosed with stomach cancer was scheduled for elective diagnostic laparoscopy. Although there was no sign of gastrointestinal tract obstruction and midnight Nil per Os (NPO) was performed before the operation, pulmonary aspiration occurred during the induction of anesthesia. Despite the endotracheal intubation with mechanical ventilation, severe hypoxemia with hypercapnea persisted. Medical team agreed with applying veno-venous (VV) ECMO, and her blood gas analysis results became stable. ECMO was weaned successfully 9 days after the first aspiration event had occurred. Based on this case, early application of extracorporeal life support can have survival benefits.
虽然在普通外科人群中发病率不高,但肺误吸胃内容物可导致严重的长期发病率和死亡率。我们报告一例早期使用体外膜氧合(ECMO)来纠正常规机械通气难治性严重低氧血症的病例,该患者在全麻诱导期间因胃内容物大量误吸而立即发生急性肺损伤。一位64岁的女性被诊断为胃癌,计划进行选择性诊断腹腔镜检查。术前虽未见胃肠道梗阻,且行夜间零氧检查(NPO),但在麻醉诱导过程中发生肺误吸。尽管气管插管和机械通气,严重的低氧血症和高呼吸持续存在。团队同意应用静脉-静脉(VV) ECMO,患者血气分析结果稳定。首次误吸事件发生后9天成功脱离ECMO。基于这种情况,早期应用体外生命支持可以获得生存益处。
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引用次数: 2
Evaluation of Informed Consent for Withholding and Withdrawal of Life Support in Korean Intensive Care Units 韩国重症监护病房中保留和撤回生命支持的知情同意评估
Pub Date : 2015-05-31 DOI: 10.4266/KJCCM.2015.30.2.73
J. Park, S. Koh, J. Cho, S. Na
Background: The goal of this study was to analyze the process and characteristics of withholding or withdrawal of life support (WLS) in Korean intensive care units (ICUs). Methods: This was a single-centered retrospective analysis of patients who died in the ICUs of a tertiary hospital in Korea from January to December 2012. WLS informed consents and clinical data were analyzed. Results: Of 285 deaths during the study period, informed consents for WLS were obtained from 228 patients (80.0%). All WLS decisions were made by family members after the patient’s loss of decision-making capacity. Decisions were made most frequently by the patient’s son (50.6%). Patients in the WLS group were older than those in the non-WLS group, and older age was associated with the WLS decision. Thirty-seven patients (16.2%) died within one hour of WLS approval, and 182 patients (79.8%) died on the day of WLS approval. The most frequently withheld life support modality was chest compression (100%), followed by defibrillation (95.9%) and pacemaker insertion (63.3%). Conclusions: Aggressive and invasive life support measures were those most frequently withheld or withdrawn by decision-makers in Korean ICUs. The most common proxy was the son, rather than the spouse.
背景:本研究的目的是分析韩国重症监护病房(icu)患者停止或撤回生命支持(WLS)的过程和特点。方法:对2012年1月至12月在韩国某三级医院icu死亡的患者进行单中心回顾性分析。分析WLS知情同意书和临床数据。结果:在研究期间的285例死亡中,228例(80.0%)患者获得了WLS的知情同意。所有WLS的决定都是在患者丧失决策能力后由家属做出的。做决定最多的是患者的儿子(50.6%)。WLS组患者比非WLS组患者年龄大,年龄大与WLS的决定相关。37例患者(16.2%)在WLS批准后1小时内死亡,182例患者(79.8%)在WLS批准当天死亡。最常见的生命支持方式是胸按压(100%),其次是除颤(95.9%)和起搏器插入(63.3%)。结论:积极和有创生命支持措施是韩国icu决策者最常拒绝或撤销的措施。最常见的代理人是儿子,而不是配偶。
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引用次数: 3
A Critical Case of Wernicke's Encephalopathy Induced by Hyperemesis Gravidarum 妊娠剧吐致韦尼克脑病1例危重症
Pub Date : 2015-05-31 DOI: 10.4266/KJCCM.2015.30.2.128
B. Kang, Min Gu Kim, Jwa Hoon Kim, Mingee Lee, Sang-beom Jeon, Ha Il Kim, J. Huh
Wernicke’s encephalopathy is a reversible but potentially critical disease caused by thiamine deficiency. Most patients complain of symptoms such as ophthalmoplegia, ataxia and confusion. Heavy alcohol drinking is commonly associated with the disease, but other clinical conditions also can provoke it. In pregnant women, hyperemesis gravidarum can lead to the depletion of body thiamine due to poor oral intake and a high metabolic demand. We report a case of Wernicke’s encephalopathy following hyperemesis gravidarum in a 36-year-old female at 20 weeks of pregnancy, who visited our hospital because of shock with vaginal bleeding. This case suggests that although the initial presentation may include atypical symptoms (e.g., shock or bleeding), Wernicke’s encephalopathy should be considered, and thiamine replacement should be performed in pregnant women with neurologic symptoms and poor oral intake.
韦尼克脑病是由硫胺素缺乏引起的一种可逆但潜在的严重疾病。多数患者主诉有眼麻痹、共济失调和精神错乱等症状。大量饮酒通常与该病有关,但其他临床条件也可引起该病。在孕妇中,由于口服摄入不足和高代谢需求,妊娠剧吐可导致体内硫胺素的消耗。我们报告一例妊娠20周的36岁女性妊娠剧吐后出现韦尼克脑病,因阴道出血休克而来我院就诊。本病例提示,虽然最初的表现可能包括非典型症状(如休克或出血),但应考虑韦尼克脑病,对有神经系统症状和口服摄入不良的孕妇应进行硫胺素替代。
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引用次数: 5
Transfusion Associated Hyperkalemia and Cardiac Arrest in an Infant after Extracorporeal Membrane Oxygenation 婴儿体外膜氧合后输血相关性高钾血症和心脏骤停
Pub Date : 2015-05-31 DOI: 10.4266/KJCCM.2015.30.2.132
Do Wan Kim, Kyeong Ryeol Cheon, D. Cho, K. Lee, H. Cho, I. Jeong
Cardiac arrest associated with hyperkalemia during red blood cell transfusion is a rare but fatal complication. Herein, we report a case of transfusion-associated cardiac arrest following the initiation of extracorporeal membrane oxygenation support in a 9-month old infant. Her serum potas sium level was increased to 9.0 mEq/L, soon after the newly primed circuit with pre-stored red blood cell (RBC) was started and followed by sudden cardiac arrest. Eventually, circulation was restored and the potassium level decreased to 5.1 mEq/L after 5 min. Extracorporeal membrane oxygenation (ECMO) priming is a relatively massive transfusion into a pediatric patient. Thus, to prevent cardiac arrest during blood-primed ECMO in neonates and infants, freshly irradi ated and washed RBCs should be used when priming the ECMO circuit, to minimize the potassium concentration. Also, physicians should be aware of all possible complica tions associated with transfusions during ECMO.
在红细胞输注过程中,心脏骤停伴随高钾血症是一种罕见但致命的并发症。在此,我们报告一例9个月大的婴儿在开始体外膜氧合支持后输血相关的心脏骤停。在新启动的预存红细胞(RBC)启动后不久,患者血清钾水平升高至9.0 mEq/L,随后发生心脏骤停。最终,血液循环恢复,5min后钾水平降至5.1 mEq/L。体外膜氧合(ECMO)启动是儿科患者相对大量的输血。因此,为了防止新生儿和婴儿在血液启动ECMO期间心脏骤停,在启动ECMO回路时应使用新鲜照射和洗涤的红细胞,以尽量减少钾浓度。此外,医生应该意识到ECMO期间输血相关的所有可能的并发症。
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引用次数: 7
Resuscitative Endovascular Balloon Occlusion of the Aorta in a Trauma Patient with Hypovolemic Shock 低血容量性休克创伤患者的复苏性血管内球囊阻塞主动脉
Pub Date : 2015-05-31 DOI: 10.4266/KJCCM.2015.30.2.115
H. Shin, Ho-Seong Han, Taeseung Lee, D. Park, K. Jung, Kyuseok Kim
Hemorrhagic shock is one of the most common causes of death in patients with multiple trauma and therefore rapid control of bleeding is the main strategy to save these patients. Resuscitative balloon occlusion of the aorta (REBOA) has been applied in several trauma cases and because of the effectiveness of this procedure it has been adopted in the trauma field. Herein, we report the first successful case of REBOA in Korea performed on a 46-year-old man with hemorrhagic shock after a fall from a height of 14-stories. The patient visited our hospital emergency room with hypovolemic shock, we performed Resuscitative Endovascular Balloon Occlusion of the Aorta under bed side blind technique. His vital sign was stabilized after procedure, then we could performed endovascular bleeding control. The patient was discharged on his 33rd in-hospital day without invasive procedure and major scar.
失血性休克是多发创伤患者最常见的死亡原因之一,因此快速控制出血是挽救这些患者的主要策略。复苏主动脉球囊闭塞术(REBOA)已被应用于几例创伤病例,由于该手术的有效性,它已被应用于创伤领域。在此,我们报告了韩国首例成功的REBOA病例,患者为一名46岁的失血性休克男子,他从14层楼的高度坠落。患者因低血容量性休克来到我院急诊,我们在床侧盲下实施了复苏血管内球囊阻断主动脉术。术后生命体征稳定,可进行血管内出血控制。患者住院第33天出院,无侵入性手术,无大疤痕。
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引用次数: 3
Successful Management of Airway Emergency in a Patient with Esophageal Cancer 食管癌患者气道急症的成功处理
Pub Date : 2015-05-31 DOI: 10.4266/KJCCM.2015.30.2.135
Samina Park, Hyun Joo Lee, C. Kang, Y. T. Kim
A 60-year-old man with advanced esophageal cancer was admitted for surgical placement of a feeding jejunostomy tube before commencement of chemoradiotherapy. His esophageal cancer had directly invaded the posterior tracheal wall, inducing a nearly total obstruction of the distal trachea. On the day before the surgery, respiratory failure developed due to tumor progression and tracheal edema. Tracheal intubation and mechanical ventilation were attempted without success. Application of veno-venous extracorporeal membrane oxygenation (ECMO) corrected the patient’s respiratory acidosis and relieved his dyspnea. With full ECMO support, he underwent tracheal stent insertion. Two hours later, he was weaned from ECMO support uneventfully. This was a successful case of tracheal stenting for airway obstruction under rescue veno-venous ECMO.
一位60岁晚期食管癌患者在开始放化疗前接受了空肠造瘘管的手术安置。他的食管癌直接侵犯气管后壁,导致远端气管几乎完全阻塞。手术前一天,由于肿瘤进展和气管水肿,患者出现呼吸衰竭。气管插管和机械通气均未成功。应用静脉-静脉体外膜氧合(ECMO)纠正了患者的呼吸性酸中毒,缓解了患者的呼吸困难。在全ECMO支持下,他接受了气管支架置入。两小时后,他平静地从ECMO支持下断奶。这是一例静脉-静脉ECMO下气管支架置入术治疗气道阻塞的成功案例。
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引用次数: 1
Lung Transplantation in a Patient with Pre-transplant Colonization of Extensively Drug-resistant Acinetobacter baumannii 移植前广泛耐药鲍曼不动杆菌定植患者的肺移植
Pub Date : 2015-05-31 DOI: 10.4266/KJCCM.2015.30.2.103
Hwa Young Lee, Hea Yon Lee, S. Shin, K. S. Shin, B. Lee, H. Kim, S. Lee, S. Kim
Colonization of the pre-transplant lung by multidrug-resistant bacteria affects shortand long-term outcomes of lung transplantation. However, there are no case reports on the colonization of a pre-transplant lung by drug-resistant Acinetobacter baumannii. We report a case of extensively drug resistant (XDR) A. baumannii colonization in the tracheobronchial tree that caused severe infectious complications after bilateral lung transplantation. A 23-year-old man diagnosed with bronchiolitis obliterans syndrome (BOS) 4 years earlier with a history of allogenic bone marrow transplantation for acute lymphoblastic leukemia was admitted to the hospital with dyspnea. Due to progressive hypercapnic respiratory failure, long-term mechanical ventilation was started after a tracheostomy was performed, and the patient underwent a bilateral lung transplantation to treat end-stage BOS. After the transplantation, the colonization of XDR A. baumannii caused severe bacterial pneumonia in the early postoperative period. Combined treatment with colistin and meropenem led to recovery from the pneumonia but caused drug-induced renal failure. Because many centers are willing to transplant candidates who are on mechanical ventilation or extracorporeal life support, the incidence of XDR A. baumannii colonization of pretransplant lungs is expected to increase. Further studies are needed to examine pre-transplant management strategies in patients colonized with XDR A. baumannii.
多药耐药菌在移植前肺部的定植影响肺移植的短期和长期预后。然而,目前还没有关于耐药鲍曼不动杆菌在移植前肺部定植的病例报告。我们报告一例广泛耐药(XDR)鲍曼不动杆菌在气管支气管树定植,导致双侧肺移植后严重的感染并发症。一名23岁男性,4年前诊断为闭塞性细支气管炎综合征(BOS),有急性淋巴细胞白血病同种异体骨髓移植史,因呼吸困难入院。由于进行性高碳酸血症性呼吸衰竭,患者在气管切开术后开始长期机械通气,并行双侧肺移植治疗终末期BOS。移植后,XDR鲍曼芽胞杆菌的定植引起术后早期严重的细菌性肺炎。联合应用粘菌素和美罗培南可使肺炎恢复,但引起药物性肾衰竭。由于许多中心都愿意移植需要机械通气或体外生命支持的候选人,移植前肺部XDR鲍曼杆菌定植的发生率预计会增加。需要进一步的研究来检查XDR鲍曼杆菌定殖患者的移植前管理策略。
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引用次数: 0
Subclavian Artery Laceration Caused by Pigtail Catheter Removal in a Patient with Pneumothorax 气管导管拔除致锁骨下动脉撕裂1例
Pub Date : 2015-05-31 DOI: 10.4266/KJCCM.2015.30.2.119
Hyo Jin Kim, Y. Cho, G. Suh, Jeong Hoon Yang, K. Jeon
We report a case of subclavian artery laceration caused by the removal of a pigtail pleural drainage catheter in a patient with a pneumothorax. The patient was successfully resuscitated through diagnostic angiography with subsequent balloon occlusion and primary repair of the injured subclavian artery. Although pigtail drainage of a pneumothorax is known to be safe and effective, proper insertion and removal techniques should be emphasized to reduce the risk of complications.
我们报告一例锁骨下动脉撕裂引起的去除辫子胸膜引流导管的病人气胸。通过诊断性血管造影,随后的球囊闭塞和受伤的锁骨下动脉的初步修复,患者成功复苏。虽然猪尾引流术是安全有效的,但应强调正确的插入和取出技术,以减少并发症的风险。
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引用次数: 3
Is Body Mass Index a Useful Prognostic Factor for Critically Ill Patients 体重指数对危重病人的预后有用吗
Pub Date : 2015-05-31 DOI: 10.4266/KJCCM.2015.30.2.61
Seongtae Jeong
Body mass index (BMI) is a measure of body fat calculated by dividing weight by the square of height. Since the index was devised by Adolphe Quetelet and is defined by dividing one’s body mass by the square of one’s height (kg/m), BMI has been commonly used as proxy measure of excess body fat. According to the literature, higher BMI was strongly associated with higher mortality in the general population.[1-4] However, critically ill patients’ relative mortality risks associated with overweight or obesity are still subject to debate although underweight has been established as a strong predictor of their deaths.[5-8] Several large-scale prospective studies have assessed the association between BMI and mortality in critically ill patients using (identical) cut off values. However, most of these studies were conducted on western populations.[9,10] The results of these studies cannot be generalized to Asian populations because of variations in body compositions and body fat distribution. Indeed, Asians have lower BMI but higher levels of body fat than Caucasians.[11] In the local research context, Lim SY et al claimed that BMI was not significantly associated with mortality in critically ill patients and that mortality risk in critically ill patients was more associated with failed extubation and severity of illness.[8] In their retrospective study, BMI values were classified into three categories: underweight 30.0 kg/m). Their findings showed that the Cox-proportional hazard ratios with exact partial likelihood to handle tied failures for hospital mortality comparing the BMI caretories with the reference category were 1.13 (0.88 to 1.44), 1.03 (0.84 to 1.26), 0.96 (0.76 to 1.22), and 0.68 (0.43 to 1.08) respectively, none of which were statistically significant. Nonetheless, a graded inverse association between BMI and mortality rate was evident. In other words, the lowest mortality rate was observed in the highest BMI group when surgical patients were excluded, and their findings were further explained by experimental evidence that adipocyte-secreted hormones such as
身体质量指数(BMI)是衡量身体脂肪的指标,计算方法是体重除以身高的平方。由于该指数是由Adolphe Quetelet设计的,并通过将一个人的体重除以一个人的身高的平方(kg/m)来定义,因此BMI通常被用作衡量身体多余脂肪的替代指标。根据文献,在一般人群中,较高的BMI与较高的死亡率密切相关。[1-4]然而,尽管体重过轻已被确定为重症患者死亡的有力预测因素,但与超重或肥胖相关的相对死亡风险仍存在争议。[5-8]几项大规模前瞻性研究使用(相同的)截断值评估了危重患者BMI与死亡率之间的关系。然而,这些研究大多是在西方人群中进行的。[9,10]由于身体组成和体脂分布的差异,这些研究的结果不能推广到亚洲人群。确实,亚洲人的身体质量指数比白种人低,但体脂水平比白种人高。[11]在本地研究中,Lim SY等人认为BMI与危重症患者的死亡率无显著相关性,危重症患者的死亡风险与拔管失败和病情严重程度的相关性更大。[8]在他们的回顾性研究中,BMI值被分为三类:体重不足(30.0 kg/m)。他们的研究结果显示,与参考类别相比,BMI类别与参考类别处理相关失败的确切部分似然风险比分别为1.13(0.88至1.44)、1.03(0.84至1.26)、0.96(0.76至1.22)和0.68(0.43至1.08),这些风险比均无统计学意义。尽管如此,BMI和死亡率之间明显呈负相关。换句话说,在排除手术患者后,BMI最高组的死亡率最低,实验证据进一步解释了他们的发现,脂肪细胞分泌的激素如
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引用次数: 0
期刊
The Korean Journal of Critical Care Medicine
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