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Pathogenetic and Clinical Relationships between Chronic Obstructive Pulmonary Disease, Sarcopenia and Frailty 慢性阻塞性肺病、肌肉疏松症和虚弱之间的病因和临床关系
Pub Date : 2024-04-09 DOI: 10.37586/2686-8636-1-2024-40-48
V. A. Sergeeva, N. Runikhina
The  impact  of  aging and geriatric syndromes on  chronic obstructive pulmonary disease, a  complex, chronic inflammatory condition, is a subject of significant interest in aging medicine. Understanding the key pathogenic mechanisms that combine the aging process and chronic obstructive pulmonary disease can help rethink therapeutic concepts in patients with the described comorbidity and be considered the basis of new directions for preventive measures.The purpose of the review is to update data from open access scientific sources on the pathogenetic mechanisms and clinical relationships of chronic obstructive pulmonary disease, sarcopenia, and frailty.Methods. Foreign and domestic scientific publications on this topic over the past 15 years were analyzed using electronic libraries PubMed/MedLine, Elsevier, elibrary.Conclusion. An  extensive examination  of  current scientific data  was carried out to  determine the pathogenetic connections between chronic obstructive pulmonary disease and the aging process, along with the prominent geriatric conditions of sarcopenia and frailty. A significant amount of information has been accumulated indicating deterioration in the clinical manifestations and prognosis of older patients with a combination of the described pathologies; therefore, the relevance of further study of these comorbidities remains. The cause-and-effect relationship of these clinical manifestations remains not entirely clear: chronic obstructive pulmonary disease leads to  the development of  sarcopenia and frailty, or  these geriatric syndromes only accompany chronic obstructive pulmonary disease, as  a disease that manifests itself most frequently in advanced age. There is significant interest in developing therapeutic strategies to improve the clinical outcomes of older patients with a combination of chronic obstructive pulmonary disease, frailty and sarcopenia.
慢性阻塞性肺病是一种复杂的慢性炎症性疾病,老龄化和老年综合征对慢性阻塞性肺病的影响是老龄医学界非常关注的一个课题。了解衰老过程与慢性阻塞性肺病结合的关键致病机制有助于重新思考对患有上述合并症的患者的治疗理念,并被认为是预防措施新方向的基础。本综述旨在更新开放获取的科学来源中有关慢性阻塞性肺病、肌肉疏松症和虚弱的致病机制和临床关系的数据。使用电子图书馆 PubMed/MedLine、Elsevier 和 elibrary 分析了过去 15 年中有关该主题的国内外科学出版物。对当前科学数据进行了广泛研究,以确定慢性阻塞性肺疾病与衰老过程之间的病理联系,以及肌肉疏松症和虚弱等突出的老年病。已积累的大量信息表明,合并上述病症的老年患者的临床表现和预后都会恶化;因此,对这些合并症进行进一步研究仍然具有现实意义。这些临床表现的因果关系仍不完全清楚:是慢性阻塞性肺病导致肌肉疏松症和虚弱症的发生,还是这些老年综合症仅伴随慢性阻塞性肺病,因为慢性阻塞性肺病是一种在高龄时表现最为频繁的疾病。人们对制定治疗策略以改善合并慢性阻塞性肺病、虚弱和肌肉疏松症的老年患者的临床疗效非常感兴趣。
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引用次数: 0
Comprehensive Geriatric Assessment of Older and Oldest-Old Patients in the Perioperative Period. Russian Gerontology Research and Clinical Centre Experience 围手术期老年病人和高龄病人的老年病综合评估。俄罗斯老年学研究与临床中心的经验
Pub Date : 2024-01-17 DOI: 10.37586/2686-8636-4-2023-233-238
A. V. Luzina, A. Y. Mozgovykh, N. Runikhina, O. N. Tkacheva
With the aging population, the significance of preoperative diagnostics and optimizing the treatment of surgical patients with frailty syndrome is gaining momentum. For such patients a comprehensive geriatric assessment (CGA) is carried out to clarify the severity of frailty and the individual characteristics of the geriatric status [1]. The results of this assessment are used to stratify the risk in the postoperative period and to determine targeted interventions for the correction of geriatric syndromes [2]. The introduction of new geriatric technologies during hip and knee replacement in weakened older patients needs scientific justification and confirmation of effectiveness.Objective: to test the method of complex geriatric management of older and oldest-old patients before and after surgical interventions in the provision of planned inpatient orthopedic care (knee and hip arthroplasty).Materials and methods: the study involved two groups of older and oldest-old patients with frailty: 50 patients, average age 69.2 ± 6.0 years [60 to 87 years] with gonarthrosis and 50 patients, average age 67.6 ± 5.5 years [60 to 81 years] with coxarthrosis. At the prehospital stage, patients were diagnosed with frailty, in accordance with the clinical recommendations of «Senile asthenia» [3]. Upon admission to surgical treatment, a CGA was performed, including indicators of basic (Barthel Activities of daily living Index, Barthel scale [4]) and instrumental activity (The Instrumental Activities of Daily Living Scale, IADL scale [5]), nutrition assessment (Mini Nutritional assessment, MNA scale [6]), cognitive functions (The Montreal Cognitive Assessment, MOCA test [7]), depression (Geriatric Depression Scale, GDS-15 scale [8]), as well as quality of life (A Visual Analogue Scale, EQ-VAS scale [9]), multimorbidity and polypragmasia. An  individual plan of  perioperative management was drawn up.Results. A  comparative analysis demonstrated statistically significant improvements in  functional status (based on  the Barthel scale), cognitive status (based on the MOCA test), nutritional status (based on the MNA scale) and quality of life (based on the EQ-VAS scale) 12 months after surgical intervention in groups of patients after knee and hip replacement. In the group of patients after hip replacement, there was also an improvement in the quality of life of patients 12 months after surgery. The assessment and dynamics of indicators in functional and cognitive status within the control group were not carried out, which makes it difficult to compare the results. However, there was a reduction in hospital stay for patients using geriatric approaches compared with previously used surgical care in the control group.Conclusion: the management of  patients with frailty in  the perioperative period with the use of  CGA allows for preventive measures aimed at  maintaining functional, psycho-emotional status. Individual characteristics of  the state of psychoemotional and f
随着人口老龄化的加剧,对患有虚弱综合征的外科手术患者进行术前诊断和优化治疗的重要性日益凸显。对这类患者要进行全面的老年评估(CGA),以明确虚弱的严重程度和老年状态的个体特征[1]。评估结果用于对术后风险进行分层,并确定有针对性的干预措施,以纠正老年综合症[2]。在对体质较弱的老年患者进行髋关节和膝关节置换术时引入新的老年病学技术需要科学的论证和有效性的确认。目的:在提供有计划的住院骨科护理(膝关节和髋关节置换术)时,测试在手术干预前后对老年患者和高龄患者进行复杂老年病学管理的方法。材料和方法:研究涉及两组年老体弱的高龄患者:50 名平均年龄为 69.2±6.0 岁[60-87 岁]的权关节患者和 50 名平均年龄为 67.6±5.5 岁[60-81 岁]的髋关节患者。在入院前阶段,根据 "老年性虚弱 "的临床建议[3],患者被诊断为虚弱。在入院接受手术治疗时,对患者进行了CGA检查,包括基本活动指标(巴特尔日常生活活动指数,巴特尔量表[4])和器质性活动指标(器质性日常生活活动量表,IADL量表[5])、营养评估(迷你营养评估,MNA量表[6])、营养状况评估(Mini Nutritional assessment、6])、认知功能(蒙特利尔认知评估,MOCA 测试[7])、抑郁(老年抑郁量表,GDS-15 量表[8])以及生活质量(视觉模拟量表,EQ-VAS 量表[9])、多病和多瘫。制定了个性化的围手术期管理计划。对比分析表明,膝关节和髋关节置换术后 12 个月后,各组患者的功能状况(根据 Barthel 量表)、认知状况(根据 MOCA 测试)、营养状况(根据 MNA 量表)和生活质量(根据 EQ-VAS 量表)均有显著改善。在髋关节置换术后患者组中,术后 12 个月患者的生活质量也有所改善。对照组的功能和认知状况指标没有进行评估和动态分析,因此很难对结果进行比较。然而,与对照组之前使用的手术护理相比,使用老年医学方法的患者住院时间缩短了。结论:在围手术期使用 CGA 对体弱患者进行管理,可以采取旨在维持功能和心理情感状态的预防措施。在传统的术前风险分层中,老年患者和高龄患者的心理情感和功能状态的个体特征可能未被考虑在内,这增加了手术治疗的不良后果、住院时间和反复住院的风险。
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引用次数: 0
Uroselective α1A-Adrenoceptor Antagonist Tamsulosin in Treatment Lower Urinary Tract Symptoms in Men with Benign Prostatic Hyperplasia 尿选择性α1A-肾上腺素受体拮抗剂坦索罗辛治疗良性前列腺增生症男性的下尿路症状
Pub Date : 2024-01-17 DOI: 10.37586/2686-8636-4-2023-295-300
G. Krivoborodov, N. S. Efremov, D. A. Shirin, A. A. Gontar, O. N. Tkacheva
Lower urinary tract symptoms suggestive of benign prostatic hyperplasia (LUTS/BPH) is a common condition in older man. Uroselective a1a-adrenoceptor (AR) antagonists tamsulosin and tamsulosin modified release (OCAS) are the most frequently prescribed medications for the men with LUTS due to BPH. Both tamsulosin and tamsulosin OCAS improve the patients disease-specific quality of life, reduce IPSS by approximately 30–40% and increase Qmax by approximately 20– 25%. The high selectivity of tamsulosin to α1А-adrenoceptor and slow release system OCAS provide a minimal vasodilating effect and correspondingly low risks of falls. These benefits are important in the treatment of LUTS in older men.
提示良性前列腺增生的下尿路症状(LUTS/BPH)是老年人的常见病。尿选择性a1a肾上腺素受体(AR)拮抗剂坦索罗辛和坦索罗辛缓释剂(OCAS)是治疗良性前列腺增生引起的下尿路症状的最常用处方药。坦索罗辛和坦索罗辛缓释剂(OCAS)都能改善患者与疾病相关的生活质量,使 IPSS 降低约 30-40%,Qmax 提高约 20-25%。坦索罗辛对α1А-肾上腺素受体的高选择性和缓释系统 OCAS 提供了最小的血管扩张效果,相应地降低了跌倒的风险。这些优点对于治疗老年男性尿失禁非常重要。
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引用次数: 0
The Role of Modern Cardiac-Specific Biomarkers in Assessing the Risk of Developing Complications of Cardiovascular Diseases During Surgical Operations Not Related to Cardiac Intervention 现代心脏特异性生物标记物在评估与心脏介入无关的外科手术期间心血管疾病并发症风险中的作用
Pub Date : 2024-01-17 DOI: 10.37586/2686-8636-4-2023-254-260
E. Alimova, S. Gilyarevsky, K. Eruslanova, Yulia V. Kotovskaya
Despite significant tactic’s improvements of perioperative management of patients undergoing non-cardiac surgery, there is still a high incidence of postoperative complications. So more accurate risk stratification is necessary before surgery in order to possibly reduce such risk. In addition to assessing the risk associated with surgery, the risk associated with the patient, which may be due to the presence of certain diseases, primarily cardiovascular, is also assessed. There are currently evidences of the validity of determining the level of biomarkers in the blood in certain groups of patients during operations not related to cardiac intervention, which makes it possible to clarify the scope of necessary diagnostic interventions in preparation for surgery, as well as to diagnose complications of heart disease in the postoperative period.
尽管对非心脏手术患者的围手术期管理在战术上有了重大改进,但术后并发症的发生率仍然很高。因此,有必要在手术前进行更准确的风险分层,以降低风险。除了评估与手术相关的风险外,还要评估与患者相关的风险,这可能是由于患者患有某些疾病,主要是心血管疾病。目前有证据表明,在进行与心脏介入无关的手术时,测定某些组别患者血液中的生物标志物水平是有效的,这样就有可能明确手术准备过程中必要的诊断干预范围,以及诊断术后心脏病并发症。
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引用次数: 0
Nursing Protocol: Management of Older and Oldest-Old Patients Living with Frailty Syndrome in the Perioperative Period 护理协议:围手术期对患有虚弱综合征的高龄和高龄患者的管理
Pub Date : 2024-01-17 DOI: 10.37586/2686-8636-4-2023-301-304
O. N. Tkacheva, N. V. Sharashkina, M. M. Balaeva, K. Eruslanova, N. Runikhina, Yulia V. Kotovskaya
In this article, the authors discuss the principles of perioperative management of patients in the older age group with frailty syndrome. Most patients with frailty syndrome have several chronic diseases; associations of  frailty with cardiovascular diseases are known — arterial hypertension, coronary heart disease, chronic heart failure, as well as with diabetes mellitus, chronic kidney disease, diseases of the joints and lower respiratory tract, oncological diseases, which causes a higher risk of  complications in  the postoperative period and requires a  special approach in  the perioperative period. This protocol addresses the issues of preventing complications and preserving the patient’s autonomy after surgical treatment.
在本文中,作者讨论了对患有虚弱综合征的老年患者进行围手术期管理的原则。大多数体弱综合征患者都患有多种慢性疾病;众所周知,体弱与心血管疾病--动脉高血压、冠心病、慢性心力衰竭以及糖尿病、慢性肾病、关节和下呼吸道疾病、肿瘤疾病--有关,这导致术后出现并发症的风险更高,因此需要在围手术期采取特殊方法。该方案解决了手术治疗后预防并发症和保护患者自主权的问题。
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引用次数: 0
Enhanced STOPP/START Criteria: A Tool for Managing Polypharmacy in Older Population 增强型 STOPP/START 标准:管理老年人群多种药物治疗的工具
Pub Date : 2024-01-17 DOI: 10.37586/2686-8636-4-2023-273-288
Yulia V. Kotovskaya, O. N. Tkacheva, N. Runikhina, M. Cherniaeva, I. Malaya, O. Maslennikova, L. A. Egorova, A. A. Dotsenko
Polypharmacy in geriatric patients is associated with an increased risk of adverse outcomes. Therefore, several instruments for prescription analysis and optimization can be used to enhance the safety and efficacy of pharmacotherapy in old age population. STOPP/START criteria is one of the most popular screening tools in the Russian Federation and abroad that list potentially inappropriate drugs for use in older patients (STOPP criteria) and potentially prescribed for certain clinical cases (START criteria). Two previous versions of the STOPP/START criteria were published in 2008 and 2015. Released in 2023, the newest (third version) demonstrates the evolution of evidence-based pharmacotherapy for older and oldestold patients, featuring 133 STOPP and 57 START criteria. Expanding the base of STOPP/START criteria should support optimization of prescriptions and reducing ADRs risk in older patients. This article introduces translation of STOPP/START criteria, version 3.
老年病人使用多种药物会增加不良后果的风险。因此,可以使用多种处方分析和优化工具来提高老年人群药物治疗的安全性和有效性。STOPP/START 标准是俄罗斯联邦和国外最流行的筛查工具之一,它列出了可能不适合老年患者使用的药物(STOPP 标准)和可能用于某些临床病例的处方药(START 标准)。STOPP/START 标准的前两个版本分别于 2008 年和 2015 年发布。最新版本(第三版)于 2023 年发布,展示了老年患者和高龄患者循证药物治疗的演变,包含 133 项 STOPP 标准和 57 项 START 标准。扩大 STOPP/START 标准的基础应有助于优化处方和降低老年患者的 ADRs 风险。本文介绍 STOPP/START 标准第 3 版的翻译。
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引用次数: 0
RUSS-AGE: developed research protocol for the creation of Russian biological age calculators RUSS-AGE:为创建俄罗斯生物年龄计算器制定研究协议
Pub Date : 2024-01-17 DOI: 10.37586/2686-8636-4-2023-239-247
A. A. Melnitskaia, L. Matchekhina, O. N. Tkacheva, A. K. Ilyushchenko, A. A. Tyazhelnikov, V. S. Polunin, A. V. Yumukyan, I. Strazhesko
Background. Life expectancy is  increasing around the globe. However, chronological age is  not the best indicator of  health. For a  more accurate assessment of  body condition throughout life, in  general, and aging, in  particular, and identify potential points of geroprotective intervention, a specialized tool is needed. A tool that could prove beneficial is a biological age calculator, utilizing a range of biomarkers to analyze the degree of functional preservation of the body. Many existing biological age calculators are limited by a small number of parameters to analyze and sensitivity to use in a specific population.Aim. Large-scale studies to create a mathematical model for calculating biological age based on the Russian population have not previously been carried out. In 2022, the RUSS-AGE study was launched to create biochemical, cognitive and microbiotic calculators of biological age and determine possible points of geroprotective interventions.Materials and methods. The study intends to  enroll at  least 3,500 participants and analyze more than a  hundred biomarkers using laboratory tests, questionnaires, neurocognitive and functional testing, and collection of anthropometric and physical indicators.Results. Currently, the recruitment of participants is supported by a government grant under the Priority 2030 program. By November 2023, 510 participants had been enrolled in the study.Conclusion. Further statistical processing of the information received and the development of prototypes of biological age calculators are planned.
背景。全球人口的预期寿命都在延长。然而,计时年龄并不是健康的最佳指标。为了更准确地评估人一生的身体状况,特别是衰老状况,并确定潜在的老年保护干预点,需要一种专门的工具。生物年龄计算器就是一种可以证明很有益处的工具,它利用一系列生物标志物来分析身体功能的保存程度。许多现有的生物年龄计算器都受限于需要分析的参数数量较少以及在特定人群中使用的敏感性。此前尚未开展过大规模研究,以建立基于俄罗斯人口的生物年龄计算数学模型。2022 年,俄罗斯启动了 RUSS-AGE 研究,旨在创建生物年龄的生化、认知和微生物计算器,并确定老年保护干预措施的可能要点。该研究计划招募至少 3500 名参与者,并通过实验室测试、问卷调查、神经认知和功能测试以及人体测量和身体指标的收集,分析百余种生物标志物。目前,招募参与者的工作由 "2030 年优先计划 "下的政府拨款支持。截至 2023 年 11 月,已有 510 人参加了这项研究。计划对收到的信息进行进一步统计处理,并开发生物年龄计算器原型。
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引用次数: 0
Clinical Guidelines for Perioperative Care of Older and Oldest-Old Patients Living with Frailty Undergoing Elective Surgery 为接受择期手术的年老体弱患者提供围手术期护理临床指南
Pub Date : 2024-01-17 DOI: 10.37586/2686-8636-4-2023-218-232
O. N. Tkacheva, N. Runikhina, Yulia V. Kotovskaya, S. Gilyarevsky, L. Aleksanyan, A. V. Rozanov, A. A. Pronchenko, A. Y. Molchanova, K. Eruslanova, A. Naumov, N. M. Vorobyova, E. Mkhitaryan, M. Cherdak, A. A. Galaeva, N. V. Sharashkina, V. S. Ostapenko, M. R. Khokonov, I. Sirotin, G. Krivoborodov, A. Z. Khashukoeva, G. O. Andreasyan, I. G. Chulovskaya, A. Magdiev, D. V. Kolesnikov, V. Y. Vlasov, E. V. Prusov, A. F. Farzutdinov, N. O. Khovasova, E. Dudinskaya, M. M. Balaeva, A. Y. Shchedrina, L. Merkusheva, E. Ivannikova, R. I. Isaev
The population of older and oldest-old individuals is increasing at a rapid pace, leading to a notable proportion of this age group requiring surgical procedures due to multimorbidity. It is known that, compared with young people, patients over 60 have a whole set of factors, such as decreased physiological functions, the presence of several concomitant diseases, polypharmacy, cognitive dysfunction and specific geriatric syndromes, which may lead to  a higher risk of  postoperative complications and prolonged recovery. Therefore, an integrated multidisciplinary approach on management is necessary for this group of patients, but the use of such an approach is currently rare. The purpose of this document is to review the literature, summarize current recommendations, and provide a  set of  expert recommendations to  assist practicing geriatricians, surgeons, anesthetists, and allied health professionals.
老年人口和高龄人口正在快速增长,导致这一年龄组中因多病而需要外科手术的患者比例明显增加。众所周知,与年轻人相比,60 岁以上的患者具有一系列因素,如生理功能减退、多种并发症、多种药物、认知功能障碍和特殊的老年综合征,这些因素可能导致术后并发症和恢复期延长的风险更高。因此,有必要对这类患者采取多学科综合管理方法,但这种方法目前还很少使用。本文旨在回顾文献,总结当前的建议,并提供一套专家建议,为老年病学执业医师、外科医生、麻醉师和专职医疗人员提供帮助。
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引用次数: 0
Rehabilitation Programs for Older Surgical Patients in the Postoperative Period 老年手术患者术后康复计划
Pub Date : 2024-01-17 DOI: 10.37586/2686-8636-4-2023-261-272
M. S. Arefieva, K. Eruslanova, N. Runikhina, Yulia V. Kotovskaya, A. V. Luzina
In  recent years, Russia has seen an  increase in  the proportion of  older patients receiving surgical care. In  the majority of cases, an older patient is burdened with multiple long-term conditions (MLTC) and geriatric syndromes. To improve the consensus clinical and / or functional outcomes after surgery, rehabilitation measures are required in the postoperative period. In this review, spanning the last 10 years, the value of rehabilitation programs for older and oldest-old patients was assessed. The clinical effectiveness of multidisciplinary rehabilitation measures in the postoperative period is analyzed.
近年来,俄罗斯接受外科治疗的老年患者比例有所增加。在大多数情况下,老年患者都患有多种长期疾病(MLTC)和老年综合症。为了改善手术后的临床和/或功能效果,需要在术后采取康复措施。本综述横跨过去 10 年,对老年患者和高龄患者康复计划的价值进行了评估。分析了术后多学科康复措施的临床效果。
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引用次数: 0
Laxatives in Geriatric Practice: From Preoperative Bowel Preparation to Correction of Chronic Constipation 老年病治疗中的泻药:从术前肠道准备到纠正慢性便秘
Pub Date : 2024-01-17 DOI: 10.37586/2686-8636-4-2023-289-294
V. S. Ostapenko
The first part of  the article discusses the issues of  preoperative bowel preparation in  older and oldest-old patients, with a  particular emphasis on  the safest drugs. The second part of  the article presents the problem of  chronic constipation as a geriatric syndrome, including a description of age-associated changes in the structure and function of colon, causes of constipation and features of correction in geriatric practice.
文章的第一部分讨论了老年和高龄患者术前肠道准备的问题,特别强调了最安全的药物。文章的第二部分介绍了作为老年综合征的慢性便秘问题,包括与年龄相关的结肠结构和功能变化、便秘的原因以及在老年实践中纠正便秘的特点。
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引用次数: 0
期刊
Russian Journal of Geriatric Medicine
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