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Perioperative Safety Evaluation of Gastrointestinal Surgery in Patients With Prosthetic Valves. 胃肠手术假瓣膜患者围手术期安全性评价。
Pub Date : 2022-04-25 DOI: 10.1532/hsf.4533
Ling Chen, Jieyuan Sun, Hao Chen, Feng Liu
BACKGROUNDIn patients with prosthetic valves, the perioperative outcomes, as well as the risk factors, following gastrointestinal surgery remain to be defined.  Methods: From January 2010 to March 2018, the clinical data of 69 cases with prosthetic valves after gastrointestinal surgery retrospectively were collected. Univariate and multivariate analysis were applied to identify the risk factors associated with significant bleeding events and non-hemorrhagic complications.RESULTSAmong 69 cases, 9 patients (13.0%) presented major bleeding events, and 21 patients (30.4%) presented non-hemorrhagic complications. Major bleeding events were significantly higher in patients with simple aortic valve replacement (AVR) than in other types of prosthetic valves (27.6% vs. 2.5%, P = 0.003), and there was no significant difference in the incidence of non-hemorrhagic complications. Simple AVR was the significant risk factor for major bleeding events (P = 0.043). Significant risk factors for non-hemorrhagic complications were operative duration ≥ 160 minutes (P = 0.021), duration from heart valve replacement to gastrointestinal surgery ≥ 84 months (P = 0.039), and simple AVR (P = 0.047).CONCLUSIONThe patients with simple AVR had a much higher bleeding risk following gastrointestinal surgery.
背景:在胃肠手术患者中,假瓣膜的围手术期结局和危险因素仍有待确定。方法:回顾性收集2010年1月至2018年3月69例胃肠手术后置换术瓣膜的临床资料。应用单因素和多因素分析来确定与重大出血事件和非出血性并发症相关的危险因素。结果69例患者中有9例(13.0%)出现大出血事件,21例(30.4%)出现非出血性并发症。单纯性主动脉瓣置换术(AVR)患者的大出血事件明显高于其他类型的人工瓣膜(27.6% vs. 2.5%, P = 0.003),非出血性并发症的发生率无显著差异。单纯性AVR是大出血事件的重要危险因素(P = 0.043)。非出血性并发症的显著危险因素为手术时间≥160分钟(P = 0.021)、心脏瓣膜置换术至胃肠手术时间≥84个月(P = 0.039)和单纯AVR (P = 0.047)。结论单纯性AVR患者在胃肠道手术后出血风险较高。
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引用次数: 0
Analysis of Influencing Factors of Unplanned Readmission in Patients With Acute Coronary Syndrome Within 30 Days After PCI. 急性冠脉综合征患者PCI术后30天内意外再入院的影响因素分析。
Pub Date : 2022-04-25 DOI: 10.1532/hsf.4411
Yike Wang, Ya Wang, Xiaoxu Han, Han Zhang, Jianping Song
OBJECTIVEThe purpose of this study is to identify the influencing factors of unplanned readmission in patients with the acute coronary syndrome (ACS) within 30 days after percutaneous coronary intervention (PCI).METHODSFrom November 1, 2018, to October 31, 2019, the clinical data of 1277 patients with acute coronary syndrome and percutaneous coronary intervention retrospectively were collected. After screening by exclusion and rejection criteria, a total of 936 patients finally entered the study. Patients were divided into the readmission group (57 cases) and the non-readmission group (879 cases), according to whether unplanned readmission occurred within 30 days after PCI. To analyze the influence of patients' age, past disease history, medication history, laboratory data, vascular diseases, and other factors on readmission and the clinical characteristics of readmission patients.RESULTSFifty-seven patients had unplanned readmission within 30 days, and the readmission rate was 6.09%. The clinical features of readmission patients are older age, longer hospitalization days, more emergency percutaneous coronary intervention, more patients with diabetes history, and more patients diagnosed with ST-segment elevation myocardial infarction and non-ST-segment elevation myocardial infarction. Logistic regression analysis revealed that smoking index, number of diseased vessels, ACEF score, diabetes, and PCI status were the influencing factors of unplanned readmission of ACS patients within 30 days after PCI.CONCLUSIONSmoking index, number of diseased vessels, ACEF score, diabetes, and PCI status are the influencing factors of unplanned readmission within 30 days after percutaneous coronary intervention for patients with acute coronary syndrome.
目的探讨急性冠脉综合征(ACS)患者经皮冠状动脉介入治疗(PCI)后30天内意外再入院的影响因素。方法回顾性收集2018年11月1日至2019年10月31日1277例急性冠状动脉综合征经皮冠状动脉介入治疗患者的临床资料。通过排除标准和排斥标准筛选后,最终共有936例患者进入研究。根据PCI术后30天内是否发生计划外再入院,将患者分为再入院组(57例)和非再入院组(879例)。分析患者年龄、既往病史、用药史、实验室资料、血管疾病等因素对再入院及再入院患者临床特征的影响。结果30 d内意外再入院57例,再入院率为6.09%。再入院患者的临床特点是年龄较大,住院天数较长,急诊经皮冠状动脉介入较多,有糖尿病病史较多,诊断为st段抬高型心肌梗死和非st段抬高型心肌梗死较多。Logistic回归分析显示,吸烟指数、病变血管数、ACEF评分、糖尿病、PCI状态是ACS患者PCI术后30 d内非计划再入院的影响因素。结论吸烟指数、病变血管数、ACEF评分、糖尿病、PCI状态是急性冠脉综合征患者经皮冠状动脉介入治疗后30天内意外再入院的影响因素。
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引用次数: 0
Prone Position in Treatment of Hypoxemia in Patients Who Underwent Type A Aortic Dissection Surgery. 俯卧位治疗A型主动脉夹层手术患者低氧血症。
Pub Date : 2022-04-22 DOI: 10.1532/hsf.4535
Junjunn Gu, Yulan Feng, Si Chen, Yingdan Cao, Kexin Li, Yanze Du, Ning Li, Haiyan Li
BACKGROUNDPostoperative hypoxemia is a high-risk complication after acute type A aortic dissection (TAAD) surgery. Prone position (PP) is an effective treatment for acute respiratory failure, which may improve the gas exchange of the injured lung and the patient's survival. PP is reported to improve the respiratory condition after cardiac surgery. However, limited data exist on the effect of PP in patients who underwent acute TAAD surgery.METHODSWe retrospectively analyzed the clinical outcomes of seven patients with severe hypoxemia who underwent PP after acute TAAD surgery. The results of arterial blood gas, chest X-ray, and survival were collected.RESULTSSeven patients (3 female, mean age 48.3±11.7 years) were recruited in this study. All patients received total arch replacement and frozen elephant trunk implantation procedure. The PaO2 at day 1 after PP was higher than before PP (126.3±49.3 vs. 77.8±15.5 mmHg). The oxygenation index rose sharply from 83.0 (80.0, 87.0) to 188.3±56.5 at day 3 after PP. There was no significant difference in heart rate between before and after PP procedure. Chest X-ray showed the diffuse shadow was significantly improved after PP. All patients responded well to PP, and all patients were discharged except for one patient, who died perioperatively due to multiple organ failure.CONCLUSIONSPP is a safe and feasible option for severe hypoxemia patients after TAAD surgery.
背景:术后低氧血症是急性a型主动脉夹层(TAAD)手术后的高危并发症。俯卧位(俯卧位)是治疗急性呼吸衰竭的有效方法,可改善损伤肺的气体交换,提高患者的生存率。据报道,PP可以改善心脏手术后的呼吸状况。然而,关于PP对急性TAAD手术患者的影响的数据有限。方法回顾性分析7例急性TAAD术后重度低氧血症患者行PP治疗的临床结果。收集动脉血气、胸片、生存结果。结果共纳入7例患者,其中女性3例,平均年龄48.3±11.7岁。所有患者均行全弓置换术和冷冻象鼻植入术。术后第1天PaO2明显高于术前(126.3±49.3 vs. 77.8±15.5 mmHg)。术后第3天氧合指数由83.0(80.0,87.0)急剧上升至188.3±56.5,心率与术前无显著差异。胸部x线片显示PP术后弥漫性影明显改善,除1例患者因多器官功能衰竭围手术期死亡外,其余患者均出院。结论spp是TAAD术后严重低氧血症患者安全可行的治疗方案。
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引用次数: 1
The First Case of Composite Hemangioendothelioma in The Heart. 心脏复合血管内皮瘤第1例。
Pub Date : 2022-04-22 DOI: 10.1532/hsf.4587
Xiaojie Zhang, Shiqiang Wang, Mei Jin
Composite hemangioendothelioma (CHE) is an extremely rare vascular neoplasm that is characterized by an admixture of benign, low-grade malignant, and malignant vascular components. It is usually located superficially in the dermis and subcutis of the extremities, and other sites involved include the head and neck region, oral mucosa, and viscera of the kidney and spleen. CHE has a low-grade malignant potential because it is locally aggressive. Here, we report a case of CHE in the heart in a 46-year-old man, who presented with a palpable mass arising from his right ventricle. Echocardiogram imaging revealed a 13.3 × 14.2 mm mass with high-signal intensity. Excision was performed, and microscopic examination revealed a heterogeneous mixture of vascular components, consisting of spindle-cell hemangioma, retiform hemangioendothelioma, and epithelioid-like hemangioendothelioma areas. To our knowledge, this is the first report on the behavior of this distinctive vascular neoplasm occurring in the right ventricle. Due to the unclear biological behavior of CHE in the heart and the paucity of cases, no further therapy was undertaken despite the risk of local recurrence and distant metastasis. The result of a six-month follow-up after surgery was disease-free.
复合血管内皮瘤(CHE)是一种极其罕见的血管肿瘤,其特征是良性、低度恶性和恶性血管成分的混合。它通常位于四肢的真皮和皮下,其他受累部位包括头颈部、口腔黏膜、肾和脾脏器。CHE具有低度恶性潜能,因为它具有局部侵袭性。在这里,我们报告一个46岁男性的心脏CHE病例,他的右心室出现可触及的肿块。超声心动图示13.3 × 14.2 mm肿块,高信号强度。手术切除后,显微镜检查显示血管成分的异质性混合物,包括梭状细胞血管瘤、网状血管内皮瘤和上皮样血管内皮瘤区域。据我们所知,这是首次报道发生在右心室的这种独特的血管肿瘤的行为。由于CHE在心脏中的生物学行为尚不清楚,且病例较少,尽管存在局部复发和远处转移的风险,但未进行进一步治疗。手术后六个月的随访结果是无疾病。
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引用次数: 3
That's No Moon, It's a Giant Left Ventricular Aneurysm: A Case Report and Literature Review. 这不是月亮,这是一个巨大的左心室动脉瘤:一个病例报告和文献回顾。
Pub Date : 2022-04-22 DOI: 10.1532/hsf.4537
Tom Liu, Huzaifa A. Shakir
BACKGROUNDAlthough the most common causes of left ventricular aneurysm (LVA) is ischemic disease, other infectious, traumatic, genetic and iatrogenic etiologies exist. With the improvement of medical therapy for ischemic disease and earlier interventions such as PCI, the incidence of large LVA (>3cm) and surgical treatment for it is increasingly rare.  Case study: We describe a case report and literature review of a giant LVA in a patient, who presented with unclear etiology. A 61-year-old male was referred to our tertiary center. He underwent aneurysmectomy and mitral valve replacement for a giant (10cm x 10cm) LVA with severe mitral regurgitation.  Conclusion: Surgery for LVA is becoming less common. Early intervention can restore cardiac geometry with good short and long-term surgical outcomes, especially in patients with preserved EF. Ultimately, a giant ventricular aneurysm remains an indication for surgical intervention. Patients with markedly reduced EF may derive reduced benefits from aneurysmectomy.
背景:虽然左心室动脉瘤(LVA)最常见的病因是缺血性疾病,但也存在其他感染性、外伤性、遗传性和医源性病因。随着缺血性疾病药物治疗水平的提高和PCI等早期介入治疗,大LVA (>3cm)的发生率和手术治疗越来越少。病例研究:我们描述了一个病例报告和文献综述的一个巨大的左心室静脉的病人,谁提出了不明确的病因。一位61岁男性被转介到我们的三级中心。他接受了动脉瘤切除术和二尖瓣置换术治疗一个巨大的(10cm × 10cm) LVA,伴有严重的二尖瓣反流。结论:下肢下腔静脉的手术治疗越来越少见。早期干预可以恢复心脏几何形状,具有良好的短期和长期手术效果,特别是对于保留EF的患者。最终,巨大的室性动脉瘤仍然是手术干预的指征。EF明显降低的患者从动脉瘤切除术中获得的益处可能会减少。
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引用次数: 0
Native Coronary Artery Pseudoaneurysm after Coronary Artery Bypass Grafting. 冠状动脉旁路移植术后原生冠状动脉假性动脉瘤。
Pub Date : 2022-04-22 DOI: 10.1532/hsf.4531
Alexander D Ghannam, N. Amoroso, Mohammad F. Mathbout, A. Kilic, L. Witer, Sanford M Zeigler, D. Steinberg, M. Katz, Nicolas H. Pope
Coronary artery pseudoaneurysms are extremely rare and most often occur after trauma or endovascular procedures [Aoki 2008; Kar 2017]. Delay in diagnosis or treatment may lead to coronary thrombosis with resultant ischemia or hemorrhage subsequent tamponade. Here, we present the case of a 66-year-old female who developed a coronary artery pseudoaneurysm of a non-grafted vessel three weeks after coronary artery bypass grafting. To avoid re-sternotomy, the pseudoaneurysm was successfully managed with a covered coronary stent and mini-left anterior thoracotomy to evacuate the hemopericardium and relieve tamponade.
冠状动脉假性动脉瘤极为罕见,通常发生在创伤或血管内手术后[Aoki 2008;冰斗2017]。诊断或治疗的延误可能导致冠状动脉血栓形成,导致缺血或出血,随后发生心包填塞。在这里,我们提出的情况下,66岁的女性谁发展冠状动脉假性动脉瘤的非移植血管冠状动脉搭桥术后三周。为了避免再次切开胸骨,假性动脉瘤成功地通过覆盖冠状动脉支架和迷你左前开胸术来排出心包积血并缓解心包填塞。
{"title":"Native Coronary Artery Pseudoaneurysm after Coronary Artery Bypass Grafting.","authors":"Alexander D Ghannam, N. Amoroso, Mohammad F. Mathbout, A. Kilic, L. Witer, Sanford M Zeigler, D. Steinberg, M. Katz, Nicolas H. Pope","doi":"10.1532/hsf.4531","DOIUrl":"https://doi.org/10.1532/hsf.4531","url":null,"abstract":"Coronary artery pseudoaneurysms are extremely rare and most often occur after trauma or endovascular procedures [Aoki 2008; Kar 2017]. Delay in diagnosis or treatment may lead to coronary thrombosis with resultant ischemia or hemorrhage subsequent tamponade. Here, we present the case of a 66-year-old female who developed a coronary artery pseudoaneurysm of a non-grafted vessel three weeks after coronary artery bypass grafting. To avoid re-sternotomy, the pseudoaneurysm was successfully managed with a covered coronary stent and mini-left anterior thoracotomy to evacuate the hemopericardium and relieve tamponade.","PeriodicalId":257138,"journal":{"name":"The heart surgery forum","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122413554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outcomes After Transcatheter Closure of Atrial Septal Defect Without Using a Balloon-Sizing Technique: A Randomized Controlled Comparison with Closures Using a Balloon-Sizing Technique. 房间隔缺损经导管闭合后不使用球囊缩小术的结果:与球囊缩小术的随机对照比较。
Pub Date : 2022-04-22 DOI: 10.1532/hsf.4571
Beom Joon Kim, Jinyoung Song, J. Huh, I. Kang
BACKGROUNDThe transcatheter closure of atrial septal defect could be completed without the balloon-sizing technique, so we evaluated long-term outcomes compared with closure using balloon sizing, which was the conventional method. Even without using the balloon-sizing technique, transcatheter closure of atrial septal defect might be safe and effective.METHODSWe included 124 patients with isolated atrial septal defects who underwent device closure without balloon sizing between 2012 and 2016, and we further included 257 patients as a control group. Patients who received closure with multiple devices or who experienced postoperative residual defects were excluded. Immediate procedural results, as well as long-term outcomes for closure without balloon sizing, were investigated and compared with the control group.RESULTSThe procedural success rate was 96.7%, and there were no mortalities. No embolization or cardiac erosions were observed; however, one patient experienced residual shunt, and another developed progressed mitral regurgitation during the follow-up period (983±682 days). Newly onset persistent atrial fibrillation developed in one patient (1.0%). There were no significant differences in procedures or follow-up between the study and control groups. Despite the shorter procedural time in the study group, fluoro time was not different. Atrial arrhythmias were more frequently observed in the control group, but the difference was not significant. Persistent atrial fibrillation was observed in two patients in the control group (0.8%).CONCLUSIONSTranscatheter closure of atrial septal defect can be performed safely and effectively without using the balloon-sizing technique. The long-term outcomes were similar to outcomes with balloon sizing.
背景:经导管房间隔缺损闭合无需球囊缩小技术即可完成,因此我们比较了常规球囊缩小方法与经导管房间隔缺损闭合的远期疗效。即使不使用球囊缩小技术,经导管房间隔缺损闭合也可能是安全有效的。方法纳入124例2012 - 2016年间行房间隔闭合术且无球囊充填的孤立性房间隔缺损患者,并进一步纳入257例患者作为对照组。排除了使用多个装置闭合或经历术后残留缺陷的患者。研究了即刻手术结果,以及无球囊充填的长期结果,并与对照组进行了比较。结果手术成功率96.7%,无死亡病例。未见栓塞或心脏糜烂;然而,在随访期间(983±682天),1例患者出现残留分流,1例患者出现进展性二尖瓣返流。新发持续性心房颤动1例(1.0%)。在治疗过程和随访中,实验组和对照组之间没有显著差异。尽管实验组的手术时间较短,但氟化时间并无差异。对照组房性心律失常发生率较高,但差异无统计学意义。对照组持续房颤2例(0.8%)。结论不采用球囊缩小技术,可安全、有效地完成房间隔缺损的导管闭合。长期结果与球囊定型的结果相似。
{"title":"Outcomes After Transcatheter Closure of Atrial Septal Defect Without Using a Balloon-Sizing Technique: A Randomized Controlled Comparison with Closures Using a Balloon-Sizing Technique.","authors":"Beom Joon Kim, Jinyoung Song, J. Huh, I. Kang","doi":"10.1532/hsf.4571","DOIUrl":"https://doi.org/10.1532/hsf.4571","url":null,"abstract":"BACKGROUND\u0000The transcatheter closure of atrial septal defect could be completed without the balloon-sizing technique, so we evaluated long-term outcomes compared with closure using balloon sizing, which was the conventional method. Even without using the balloon-sizing technique, transcatheter closure of atrial septal defect might be safe and effective.\u0000\u0000\u0000METHODS\u0000We included 124 patients with isolated atrial septal defects who underwent device closure without balloon sizing between 2012 and 2016, and we further included 257 patients as a control group. Patients who received closure with multiple devices or who experienced postoperative residual defects were excluded. Immediate procedural results, as well as long-term outcomes for closure without balloon sizing, were investigated and compared with the control group.\u0000\u0000\u0000RESULTS\u0000The procedural success rate was 96.7%, and there were no mortalities. No embolization or cardiac erosions were observed; however, one patient experienced residual shunt, and another developed progressed mitral regurgitation during the follow-up period (983±682 days). Newly onset persistent atrial fibrillation developed in one patient (1.0%). There were no significant differences in procedures or follow-up between the study and control groups. Despite the shorter procedural time in the study group, fluoro time was not different. Atrial arrhythmias were more frequently observed in the control group, but the difference was not significant. Persistent atrial fibrillation was observed in two patients in the control group (0.8%).\u0000\u0000\u0000CONCLUSIONS\u0000Transcatheter closure of atrial septal defect can be performed safely and effectively without using the balloon-sizing technique. The long-term outcomes were similar to outcomes with balloon sizing.","PeriodicalId":257138,"journal":{"name":"The heart surgery forum","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126918824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anesthesia Management of a Premature Neonate with Congenital Heart Disease during Emergency Diaphragmatic Hernia Surgery: A Case Report. 早产儿先天性心脏病急诊膈疝手术麻醉处理一例报告。
Pub Date : 2022-04-21 DOI: 10.1532/hsf.4499
Fan Zhang, Zebing Zheng, Taowu Gong, Zhaoqiong Zhu
In this medical report, we successfully implemented anesthesia management for an infant with congenital heart disease undergoing congenital diaphragmatic hernia (CDH) repair. Left-sided CDH was diagnosed on a postnatal chest X-ray on day 1 of her life. The child was complicated with congenital heart diseases and pulmonary hypertension and showed severe dyspnea immediately after birth. Thoracoscopic CDH repair puts forward high requirements for anesthesia. Neonatal CDH combined with congenital heart disease brings more challenges to anesthesia. For high-risk premature neonates, anesthesia selections are essential, as those factors directly affect the prognosis. We report the application of S-ketamine as an anesthetic in this kind of operation for the first time. The postoperative recovery was uneventful. This case report reviews anesthesia management of critical CDH neonates, hoping to provide information to healthcare professionals unfamiliar with the treatment of this kind of patient.
在此医学报告中,我们成功地实施麻醉管理的婴儿先天性心脏病先天性膈疝(CDH)修复。出生第1天通过胸片诊断为左侧CDH。患儿并发先天性心脏病和肺动脉高压,出生后立即出现严重的呼吸困难。胸腔镜CDH修复对麻醉的要求较高。新生儿CDH合并先天性心脏病给麻醉带来了更多的挑战。对于高危早产儿,麻醉的选择是必要的,因为这些因素直接影响预后。本文报道s -氯胺酮在该类手术中的首次应用。术后恢复顺利。本病例报告回顾了危重新生儿CDH的麻醉处理,希望能为不熟悉这类患者治疗的医护人员提供一些信息。
{"title":"Anesthesia Management of a Premature Neonate with Congenital Heart Disease during Emergency Diaphragmatic Hernia Surgery: A Case Report.","authors":"Fan Zhang, Zebing Zheng, Taowu Gong, Zhaoqiong Zhu","doi":"10.1532/hsf.4499","DOIUrl":"https://doi.org/10.1532/hsf.4499","url":null,"abstract":"In this medical report, we successfully implemented anesthesia management for an infant with congenital heart disease undergoing congenital diaphragmatic hernia (CDH) repair. Left-sided CDH was diagnosed on a postnatal chest X-ray on day 1 of her life. The child was complicated with congenital heart diseases and pulmonary hypertension and showed severe dyspnea immediately after birth. Thoracoscopic CDH repair puts forward high requirements for anesthesia. Neonatal CDH combined with congenital heart disease brings more challenges to anesthesia. For high-risk premature neonates, anesthesia selections are essential, as those factors directly affect the prognosis. We report the application of S-ketamine as an anesthetic in this kind of operation for the first time. The postoperative recovery was uneventful. This case report reviews anesthesia management of critical CDH neonates, hoping to provide information to healthcare professionals unfamiliar with the treatment of this kind of patient.","PeriodicalId":257138,"journal":{"name":"The heart surgery forum","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131514487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perioperative Use of Pituitrin after Cardiac Defect Repair in Adult Patients with Severe Pulmonary Hypertension. 成人重度肺动脉高压心脏缺损修复术后围手术期垂体后叶素的应用。
Pub Date : 2022-04-21 DOI: 10.1532/hsf.4569
YunTao Li, Mingwui Tung, Jianping Xu, Guangyu Pan, Rui Jiang
BACKGROUNDVasopressin can constrict peripheral arteries without constricting the pulmonary artery. Theoretically, vasopressin is suitable for the perioperative treatment of pulmonary hypertension. Few studies have investigated the use of pituitrin (a substitute for vasopressin) after cardiac defect repair surgery. This study aimed to analyze the effect of pituitrin on hemodynamics and to determine whether pituitrin can be used after surgical repair in adult patients with pulmonary arterial hypertension-congenital heart disease (PAH-CHD).METHODSA pulmonary artery catheter was used in all the patients for hemodynamic monitoring. Hemodynamic parameters were recorded before and at 0.5 h, 1 h, 6 h, 12 h and 24 h after pituitrin administration. The changes in the hemodynamic parameters before and after pituitrin use were analyzed through repeated measures analysis of variance.RESULTSA total of 110 patients with PAH-CHD underwent repair surgery; 23 patients were included in further analysis, including 11 with atrial septal defect, 9 with ventricular septal defect, and 3 with patent ductus arteriosus. Ten (43.5%) were men, with a mean age of 29.4 ± 6.8 years. Hemodynamic parameters before and after the oxygen test were as follows: radial artery oxygen saturation, 91.5% ± 4.4 vs. 97.9 ± 2.4%; pulmonary vascular resistance, 10.5 ± 1.8 Wood units (wu) vs. 5 ± 1.2 wu; systemic-pulmonary blood flow ratio (QP/QS), 1.1 ± 0.2 vs. 2.1 ± 0.9. With prolonged use, the systolic blood pressure of the radial artery increased significantly (P = 0.001), that of the pulmonary artery decreased significantly (P = 0.009), and RP/s decreased significantly (P < 0.001).CONCLUSIONPituitrin as an alternative to vasopressin can increase arterial pressure, decrease pulmonary artery pressure, and reduce the pulmonary artery pressure/arterial pressure ratio after repair surgery in adult patients with PAH-CHD.
背景:加压素可以收缩外周动脉而不收缩肺动脉。理论上,加压素适用于肺动脉高压的围手术期治疗。很少有研究调查心脏缺损修复手术后垂体后叶素(一种抗利尿激素的替代品)的使用。本研究旨在分析垂体后叶素对血流动力学的影响,探讨成人肺动脉高压-先天性心脏病(PAH-CHD)患者手术修复后是否可以使用垂体后叶素。方法所有患者均采用sa肺动脉导管进行血流动力学监测。记录垂体后叶素给药前及给药后0.5 h、1 h、6 h、12 h、24 h血流动力学参数。通过重复测量方差分析分析垂体后叶素使用前后血流动力学参数的变化。结果共110例PAH-CHD患者行修复手术;23例患者纳入进一步分析,其中房间隔缺损11例,室间隔缺损9例,动脉导管未闭3例。男性10例(43.5%),平均年龄29.4±6.8岁。血氧试验前后血流动力学参数:桡动脉血氧饱和度:91.5%±4.4 vs. 97.9±2.4%;肺血管阻力:10.5±1.8 Wood units (wu) vs. 5±1.2 wu;系统-肺血流比(QP/QS): 1.1±0.2 vs. 2.1±0.9。随着使用时间的延长,桡动脉收缩压显著升高(P = 0.001),肺动脉收缩压显著降低(P = 0.009), RP/s显著降低(P < 0.001)。结论垂体后叶素替代血管加压素可使成年PAH-CHD患者修复术后动脉压升高,肺动脉压降低,肺动脉压/动脉压比降低。
{"title":"Perioperative Use of Pituitrin after Cardiac Defect Repair in Adult Patients with Severe Pulmonary Hypertension.","authors":"YunTao Li, Mingwui Tung, Jianping Xu, Guangyu Pan, Rui Jiang","doi":"10.1532/hsf.4569","DOIUrl":"https://doi.org/10.1532/hsf.4569","url":null,"abstract":"BACKGROUND\u0000Vasopressin can constrict peripheral arteries without constricting the pulmonary artery. Theoretically, vasopressin is suitable for the perioperative treatment of pulmonary hypertension. Few studies have investigated the use of pituitrin (a substitute for vasopressin) after cardiac defect repair surgery. This study aimed to analyze the effect of pituitrin on hemodynamics and to determine whether pituitrin can be used after surgical repair in adult patients with pulmonary arterial hypertension-congenital heart disease (PAH-CHD).\u0000\u0000\u0000METHODS\u0000A pulmonary artery catheter was used in all the patients for hemodynamic monitoring. Hemodynamic parameters were recorded before and at 0.5 h, 1 h, 6 h, 12 h and 24 h after pituitrin administration. The changes in the hemodynamic parameters before and after pituitrin use were analyzed through repeated measures analysis of variance.\u0000\u0000\u0000RESULTS\u0000A total of 110 patients with PAH-CHD underwent repair surgery; 23 patients were included in further analysis, including 11 with atrial septal defect, 9 with ventricular septal defect, and 3 with patent ductus arteriosus. Ten (43.5%) were men, with a mean age of 29.4 ± 6.8 years. Hemodynamic parameters before and after the oxygen test were as follows: radial artery oxygen saturation, 91.5% ± 4.4 vs. 97.9 ± 2.4%; pulmonary vascular resistance, 10.5 ± 1.8 Wood units (wu) vs. 5 ± 1.2 wu; systemic-pulmonary blood flow ratio (QP/QS), 1.1 ± 0.2 vs. 2.1 ± 0.9. With prolonged use, the systolic blood pressure of the radial artery increased significantly (P = 0.001), that of the pulmonary artery decreased significantly (P = 0.009), and RP/s decreased significantly (P < 0.001).\u0000\u0000\u0000CONCLUSION\u0000Pituitrin as an alternative to vasopressin can increase arterial pressure, decrease pulmonary artery pressure, and reduce the pulmonary artery pressure/arterial pressure ratio after repair surgery in adult patients with PAH-CHD.","PeriodicalId":257138,"journal":{"name":"The heart surgery forum","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129206321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Impact of Nutritional Status on the Outcome of Transcatheter Aortic Valve Implantation. 营养状况对经导管主动脉瓣植入术结果的影响。
Pub Date : 2022-04-20 DOI: 10.1532/hsf.4547
Vivendar Sihag, Wen-yu Li, Abdullah Hagar, Yong Peng, Yuan Feng, Sandeep Bhushan, Mao Chen
BACKGROUNDThe present study aims to evaluate how nutritional status may affect transcatheter aortic valve implantation (TAVI) outcomes.MATERIALS AND METHODSThis is a retrospective study of 383 TAVI patients. In-hospital, 1-month, and 12-month survival was evaluated. Since most patients undergoing TAVI are over 75 years old, the NRI definition for a geriatric population (GNRI) was used. Preoperative baseline clinical and laboratory data were collected and then the corresponding nutritional status was calculated, including Geriatric Nutritional Risk Index (GNRI), Prognostic Nutritional Index (PNRI), and Controlling Nutritional Status Score (CONUT). Survival analysis and receiver operating characteristic curve (ROC) analysis were used to evaluate the correlation between these parameters and TAVI outcome.RESULTSBy CONUT and GNRI scores, 168 (58.9%) and 40 (14.0%) patients were considered to have mild malnutrition, respectively. By using PNI, CONUT, and GNRI scores, 16 (5.7%), 29 (10.3%), and 39 (13.7%) patients were moderately or severely malnourished. Survival analysis showed that patients with worse nutritional status had a worse prognosis regardless of the nutritional score used. Subgroup analysis showed that these differences remained significant in subgroups of patients over age 75. COX multivariate analysis showed that GNRI, PNI, and CONUT were independently associated with all-cause mortality during the follow-up.CONCLUSIONPatients with worse nutritional status had a worse prognosis regardless of the nutritional score used. Subgroup analysis showed that these differences remained significant in subgroups of patients over age 75. GNRI, PNI, and CONUT were independent predictors of all-cause mortality after TAVI.
本研究旨在评估营养状况如何影响经导管主动脉瓣植入术(TAVI)的结果。材料与方法对383例TAVI患者进行回顾性研究。评估住院、1个月和12个月生存率。由于大多数接受TAVI的患者年龄超过75岁,因此采用了老年人口的NRI定义(GNRI)。收集术前基线临床和实验室数据,计算相应的营养状况,包括老年营养风险指数(GNRI)、预后营养指数(PNRI)和控制营养状况评分(CONUT)。采用生存分析和受试者工作特征曲线(ROC)分析评价这些参数与TAVI结局的相关性。结果根据CONUT和GNRI评分,168例(58.9%)和40例(14.0%)患者被认为患有轻度营养不良。通过使用PNI、CONUT和GNRI评分,分别有16例(5.7%)、29例(10.3%)和39例(13.7%)患者出现中度或重度营养不良。生存分析显示,无论采用何种营养评分,营养状况较差的患者预后较差。亚组分析显示,这些差异在75岁以上患者的亚组中仍然显著。COX多因素分析显示,GNRI、PNI和CONUT与随访期间的全因死亡率独立相关。结论无论采用何种营养评分,营养状况越差的患者预后越差。亚组分析显示,这些差异在75岁以上患者的亚组中仍然显著。GNRI、PNI和CONUT是TAVI后全因死亡率的独立预测因子。
{"title":"The Impact of Nutritional Status on the Outcome of Transcatheter Aortic Valve Implantation.","authors":"Vivendar Sihag, Wen-yu Li, Abdullah Hagar, Yong Peng, Yuan Feng, Sandeep Bhushan, Mao Chen","doi":"10.1532/hsf.4547","DOIUrl":"https://doi.org/10.1532/hsf.4547","url":null,"abstract":"BACKGROUND\u0000The present study aims to evaluate how nutritional status may affect transcatheter aortic valve implantation (TAVI) outcomes.\u0000\u0000\u0000MATERIALS AND METHODS\u0000This is a retrospective study of 383 TAVI patients. In-hospital, 1-month, and 12-month survival was evaluated. Since most patients undergoing TAVI are over 75 years old, the NRI definition for a geriatric population (GNRI) was used. Preoperative baseline clinical and laboratory data were collected and then the corresponding nutritional status was calculated, including Geriatric Nutritional Risk Index (GNRI), Prognostic Nutritional Index (PNRI), and Controlling Nutritional Status Score (CONUT). Survival analysis and receiver operating characteristic curve (ROC) analysis were used to evaluate the correlation between these parameters and TAVI outcome.\u0000\u0000\u0000RESULTS\u0000By CONUT and GNRI scores, 168 (58.9%) and 40 (14.0%) patients were considered to have mild malnutrition, respectively. By using PNI, CONUT, and GNRI scores, 16 (5.7%), 29 (10.3%), and 39 (13.7%) patients were moderately or severely malnourished. Survival analysis showed that patients with worse nutritional status had a worse prognosis regardless of the nutritional score used. Subgroup analysis showed that these differences remained significant in subgroups of patients over age 75. COX multivariate analysis showed that GNRI, PNI, and CONUT were independently associated with all-cause mortality during the follow-up.\u0000\u0000\u0000CONCLUSION\u0000Patients with worse nutritional status had a worse prognosis regardless of the nutritional score used. Subgroup analysis showed that these differences remained significant in subgroups of patients over age 75. GNRI, PNI, and CONUT were independent predictors of all-cause mortality after TAVI.","PeriodicalId":257138,"journal":{"name":"The heart surgery forum","volume":"102 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115565445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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The heart surgery forum
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