Pub Date : 2020-07-31DOI: 10.30579/mbse.2020.3.2.41
Suyoeng Cho, J. Choi, Seongtae Jeong
Subclavian artery injury during central venous catheterization appears to be reported less than in actual cases. We report management of incidental subclavian artery catheterization in a 65-year-old man who has limited neck motion, undergoing emergency spine hematoma re-moval surgery. Despite the use of ultrasonography for central venous catheterization via right internal jugular vein, incidental subclavian artery injury has not been prevented. The management of incidental arterial injury during central venous catheterization is discussed, and a review of the literature is provided. To prevent injury to the right subclavian artery during right IJV catheterization, the location of adjacent blood vessels should be ascertained and not damaged. It is important to note that the damage can also occur due to ultrasonography. When right subclavian artery injury is suspected, the catheter should not be removed. Early detection of injury and early intervention may reduce morbidity and mortality.
{"title":"Incidental subclavian artery injury during right internal jugular vein catheterization via ultrasonography","authors":"Suyoeng Cho, J. Choi, Seongtae Jeong","doi":"10.30579/mbse.2020.3.2.41","DOIUrl":"https://doi.org/10.30579/mbse.2020.3.2.41","url":null,"abstract":"Subclavian artery injury during central venous catheterization appears to be reported less than in actual cases. We report management of incidental subclavian artery catheterization in a 65-year-old man who has limited neck motion, undergoing emergency spine hematoma re-moval surgery. Despite the use of ultrasonography for central venous catheterization via right internal jugular vein, incidental subclavian artery injury has not been prevented. The management of incidental arterial injury during central venous catheterization is discussed, and a review of the literature is provided. To prevent injury to the right subclavian artery during right IJV catheterization, the location of adjacent blood vessels should be ascertained and not damaged. It is important to note that the damage can also occur due to ultrasonography. When right subclavian artery injury is suspected, the catheter should not be removed. Early detection of injury and early intervention may reduce morbidity and mortality.","PeriodicalId":259565,"journal":{"name":"Medical Biological Science and Engineering","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128362847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-07-31DOI: 10.30579/mbse.2020.3.2.52
Su Nam Lee, Young Woong Choi, S. Han, I. Choi
Corresponding author Young Woong Choi Department of Anesthesiology and Pain Medicine, Korean Cancer Center Hospital, 75 Nowon-ro, Nowon-gu, Seoul 01812, Korea Tel: +82-2-2970-2161 Fax: +82-2-2970-2436 E-mail: ywchoi1123@gmail.com ORCID: https://orcid.org/0000-0002-0386-5638 Perioperative peroneal neuropathy is an uncommon complication following surgeries performed with patients positioned supine. It may be caused by various factors aside from intraoperative compression. The authors report a case of common peroneal nerve palsy in a patient who underwent total thyroidectomy with central and bilateral selective neck dissection. The patient’s body mass index was 31.3 kg/m. She was positioned supine and the operative time was 7 h. During surgery, her mean arterial pressure intermittently dropped to 50-60 mmHg for 55 min and 61-70 mmHg for 195 min. She developed common peroneal nerve palsy on postoperative day 1. Nevertheless, the patient fully recovered without any complications within 3 weeks.
{"title":"Common peroneal nerve palsy following operation in the supine position","authors":"Su Nam Lee, Young Woong Choi, S. Han, I. Choi","doi":"10.30579/mbse.2020.3.2.52","DOIUrl":"https://doi.org/10.30579/mbse.2020.3.2.52","url":null,"abstract":"Corresponding author Young Woong Choi Department of Anesthesiology and Pain Medicine, Korean Cancer Center Hospital, 75 Nowon-ro, Nowon-gu, Seoul 01812, Korea Tel: +82-2-2970-2161 Fax: +82-2-2970-2436 E-mail: ywchoi1123@gmail.com ORCID: https://orcid.org/0000-0002-0386-5638 Perioperative peroneal neuropathy is an uncommon complication following surgeries performed with patients positioned supine. It may be caused by various factors aside from intraoperative compression. The authors report a case of common peroneal nerve palsy in a patient who underwent total thyroidectomy with central and bilateral selective neck dissection. The patient’s body mass index was 31.3 kg/m. She was positioned supine and the operative time was 7 h. During surgery, her mean arterial pressure intermittently dropped to 50-60 mmHg for 55 min and 61-70 mmHg for 195 min. She developed common peroneal nerve palsy on postoperative day 1. Nevertheless, the patient fully recovered without any complications within 3 weeks.","PeriodicalId":259565,"journal":{"name":"Medical Biological Science and Engineering","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116987032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-31DOI: 10.30579/mbse.2020.3.1.7
Kyungmi Kim, Jun-Young Park, Jihion Yu, J. Chon, Sukyung Chung, Jai-hyun Hwang, Young-Kug Kim
Corresponding author Jun-Young Park Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea Tel: +82-2-3010-1415 Fax: +82-2-3010-6790 E-mail: parkjy@amc.seoul.kr ORCID: http://orcid.org/0000-0003-4476-4945 A 60-year-old man with a 12 cm mass involving the right kidney and a renal vein tumor thrombus extending to the intrahepatic inferior vena cava (IVC), was scheduled for a radical nephrectomy concomitant with an IVC thrombectomy. During the operation, through intraoperative transesophageal echocardiography (TEE) monitoring, a migrating tumor thrombus was promptly detected. After the operation, a filling defect in the posterior basal segmental or subsegmental pulmonary arteries of the lower lobe of the right lung was observed on chest computed tomography. Intraoperative TEE provides additional information to help guide the surgical intervention and medical treatment.
{"title":"Migration of a tumor thrombus promptly detected by transesophageal echocardiography during radical nephrectomy concomitant with inferior vena cava thrombectomy: a case report","authors":"Kyungmi Kim, Jun-Young Park, Jihion Yu, J. Chon, Sukyung Chung, Jai-hyun Hwang, Young-Kug Kim","doi":"10.30579/mbse.2020.3.1.7","DOIUrl":"https://doi.org/10.30579/mbse.2020.3.1.7","url":null,"abstract":"Corresponding author Jun-Young Park Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea Tel: +82-2-3010-1415 Fax: +82-2-3010-6790 E-mail: parkjy@amc.seoul.kr ORCID: http://orcid.org/0000-0003-4476-4945 A 60-year-old man with a 12 cm mass involving the right kidney and a renal vein tumor thrombus extending to the intrahepatic inferior vena cava (IVC), was scheduled for a radical nephrectomy concomitant with an IVC thrombectomy. During the operation, through intraoperative transesophageal echocardiography (TEE) monitoring, a migrating tumor thrombus was promptly detected. After the operation, a filling defect in the posterior basal segmental or subsegmental pulmonary arteries of the lower lobe of the right lung was observed on chest computed tomography. Intraoperative TEE provides additional information to help guide the surgical intervention and medical treatment.","PeriodicalId":259565,"journal":{"name":"Medical Biological Science and Engineering","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124577270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-31DOI: 10.30579/mbse.2020.3.1.24
Tae Gyoung Lee, Eun Yi Lee, C. So, S. Yu
Intussusception is the most common cause of intestinal obstruction in children younger than 2 years. Despite successful reduction, recurrence of intussusception may occur. Recurrence after intestinal resection rarely occurs. We present a case of recurrent intussusception in a patient with a history of ileocecectomy for ileocolic intussusception. The patient was diagnosed with ileocolic intussusception with peritonitis at the age of 5 months, which was managed with ileocecectomy. At 9 months postoperatively, the patient presented with hematochezia. Ultrasound imaging showed ileocolic intussusception; thus, we performed air reduction, which resulted in successful outcomes. No recurrence has occurred at three years postoperatively.
{"title":"Successful air reduction in a patient with recurrent intussusception with a history of ileocecectomy for ileocolic intussusception","authors":"Tae Gyoung Lee, Eun Yi Lee, C. So, S. Yu","doi":"10.30579/mbse.2020.3.1.24","DOIUrl":"https://doi.org/10.30579/mbse.2020.3.1.24","url":null,"abstract":"Intussusception is the most common cause of intestinal obstruction in children younger than 2 years. Despite successful reduction, recurrence of intussusception may occur. Recurrence after intestinal resection rarely occurs. We present a case of recurrent intussusception in a patient with a history of ileocecectomy for ileocolic intussusception. The patient was diagnosed with ileocolic intussusception with peritonitis at the age of 5 months, which was managed with ileocecectomy. At 9 months postoperatively, the patient presented with hematochezia. Ultrasound imaging showed ileocolic intussusception; thus, we performed air reduction, which resulted in successful outcomes. No recurrence has occurred at three years postoperatively.","PeriodicalId":259565,"journal":{"name":"Medical Biological Science and Engineering","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115155985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-31DOI: 10.30579/mbse.2020.3.1.12
S. Moon, Y. Seo, Chang Hee Cho, Sung Sik Park
Corresponding author Sung Sik Park Department of Anesthesiology and Pain Medicine, School of Medicine, Kyungpook National University, 130, Dongdeok-ro, Jung-gu, Daegu 41944, Korea Tel: +82-53-200-5877 Fax: +82-53-426-2760 E-mail : sspark@knu.ac.kr ORCID: http://orcid.org/0000-0001-5574-7513 Pulmonary thromboembolism is a fatal disease most frequently caused by deep vein thrombosis. It is important to early diagnose, prevent, and manage deep vein thrombosis and pulmonary thromboembolism. However, under general anesthesia, the clinical signs of pulmonary thromboembolism are vague, which complicates its timely diagnosis and treatment. In the present case, transesophageal echocardiography was first performed to diagnose severe pulmonary embolism during pelvic fracture surgery; after computed tomography confirmation, embolectomy was successfully performed.
{"title":"Management of severe pulmonary thromboembolism undetected by intraoperative transesophageal echocardiography: a case report","authors":"S. Moon, Y. Seo, Chang Hee Cho, Sung Sik Park","doi":"10.30579/mbse.2020.3.1.12","DOIUrl":"https://doi.org/10.30579/mbse.2020.3.1.12","url":null,"abstract":"Corresponding author Sung Sik Park Department of Anesthesiology and Pain Medicine, School of Medicine, Kyungpook National University, 130, Dongdeok-ro, Jung-gu, Daegu 41944, Korea Tel: +82-53-200-5877 Fax: +82-53-426-2760 E-mail : sspark@knu.ac.kr ORCID: http://orcid.org/0000-0001-5574-7513 Pulmonary thromboembolism is a fatal disease most frequently caused by deep vein thrombosis. It is important to early diagnose, prevent, and manage deep vein thrombosis and pulmonary thromboembolism. However, under general anesthesia, the clinical signs of pulmonary thromboembolism are vague, which complicates its timely diagnosis and treatment. In the present case, transesophageal echocardiography was first performed to diagnose severe pulmonary embolism during pelvic fracture surgery; after computed tomography confirmation, embolectomy was successfully performed.","PeriodicalId":259565,"journal":{"name":"Medical Biological Science and Engineering","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120909837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-31DOI: 10.30579/mbse.2020.3.1.16
Daehoon Kim, S. Kim, Joungmin Kim, Seongtae Jeong
In obese patients, correct insertion of the intravenous line and early identification of subcutaneous injection may be difficult. We report management of accidental subcutaneous rocuronium administration in a 38-year-old, obese Korean woman undergoing elective breast cancer sur-gery. The perioperative management of the patient is discussed, and a review of the literature is provided. Little information is available regarding the absorption of medications outside of the typical route of administration. The accidental subcutaneous infiltration of neuromuscular blocking agents may lead to pulmonary complications. Early identification of subcutaneous infiltration is important and open discussion with many treatment team members is critical. Careful monitoring including neuromuscular monitoring in the post-anesthesia care unit is essential.
{"title":"Sugammadex reversal of large subcutaneous injection of rocuronium in an obese patient","authors":"Daehoon Kim, S. Kim, Joungmin Kim, Seongtae Jeong","doi":"10.30579/mbse.2020.3.1.16","DOIUrl":"https://doi.org/10.30579/mbse.2020.3.1.16","url":null,"abstract":"In obese patients, correct insertion of the intravenous line and early identification of subcutaneous injection may be difficult. We report management of accidental subcutaneous rocuronium administration in a 38-year-old, obese Korean woman undergoing elective breast cancer sur-gery. The perioperative management of the patient is discussed, and a review of the literature is provided. Little information is available regarding the absorption of medications outside of the typical route of administration. The accidental subcutaneous infiltration of neuromuscular blocking agents may lead to pulmonary complications. Early identification of subcutaneous infiltration is important and open discussion with many treatment team members is critical. Careful monitoring including neuromuscular monitoring in the post-anesthesia care unit is essential.","PeriodicalId":259565,"journal":{"name":"Medical Biological Science and Engineering","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130645730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-31DOI: 10.30579/mbse.2020.3.1.1
H. Son, Y. Choi, Ji Yoon Lee, Y. Ro
Corresponding author Hyo Jung Son Department of Anesthesiology and Pain Medicine, National Police Hospital, Songee-ro 123, Songpagu, Seoul 05715, Korea Tel: +82-2-3400-1492 Fax: +82-2-3400-1249 E-mail: gidget80@police.go.kr ORCID: http://orcid.org/0000-0001-7710-7605 Blood transfusion is an important method of fluid management and benefits patients when properly used; however, it involves the risk of side effects such as critical organ damage. This study was designed to evaluate the efficacy and safety of a restrictive transfusion strategy (transfusion threshold of hemoglobin 8 g/dL) compared to a conventional transfusion strategy (transfusion threshold of hemoglobin 10 g/dL) on postoperative AKI among patients undergoing total hip replacement arthroplasty (THRA). Patients undergoing THRA were divided into two groups: restrictive transfusion strategy (n=72) and conventional transfusion strategy (n=72). Stroke volume variation was performed to maintain methods, complications, and preoperative and postoperative laboratory tests. They were categorized according to changes in plasma creatinine (Cr) concentration within 48 hours after THRA using Acute Kidney Injury Network criteria. Acute kidney injury (AKI) occurred in three patients (4.2%) in the restrictive transfusion strategy group and two patients (2.8%) in the conventional transfusion strategy group (p=0.99). The mean serum Cr levels 48 hours after surgery were 0.76±0.36 and 0.66±0.20 mg/dL in the restrictive transfusion strategy group and the conventional transfusion strategy group, respectively (p=0.30). Perioperative restrictive transfusion or conventional transfusion in patients undergoing elective THRA is not related to AKI when maintaining proper volume status during surgery.
{"title":"Effect of restrictive blood transfusion on postoperative acute kidney injury after total hip replacement arthroplasty: a prospective randomized controlled trial","authors":"H. Son, Y. Choi, Ji Yoon Lee, Y. Ro","doi":"10.30579/mbse.2020.3.1.1","DOIUrl":"https://doi.org/10.30579/mbse.2020.3.1.1","url":null,"abstract":"Corresponding author Hyo Jung Son Department of Anesthesiology and Pain Medicine, National Police Hospital, Songee-ro 123, Songpagu, Seoul 05715, Korea Tel: +82-2-3400-1492 Fax: +82-2-3400-1249 E-mail: gidget80@police.go.kr ORCID: http://orcid.org/0000-0001-7710-7605 Blood transfusion is an important method of fluid management and benefits patients when properly used; however, it involves the risk of side effects such as critical organ damage. This study was designed to evaluate the efficacy and safety of a restrictive transfusion strategy (transfusion threshold of hemoglobin 8 g/dL) compared to a conventional transfusion strategy (transfusion threshold of hemoglobin 10 g/dL) on postoperative AKI among patients undergoing total hip replacement arthroplasty (THRA). Patients undergoing THRA were divided into two groups: restrictive transfusion strategy (n=72) and conventional transfusion strategy (n=72). Stroke volume variation was performed to maintain methods, complications, and preoperative and postoperative laboratory tests. They were categorized according to changes in plasma creatinine (Cr) concentration within 48 hours after THRA using Acute Kidney Injury Network criteria. Acute kidney injury (AKI) occurred in three patients (4.2%) in the restrictive transfusion strategy group and two patients (2.8%) in the conventional transfusion strategy group (p=0.99). The mean serum Cr levels 48 hours after surgery were 0.76±0.36 and 0.66±0.20 mg/dL in the restrictive transfusion strategy group and the conventional transfusion strategy group, respectively (p=0.30). Perioperative restrictive transfusion or conventional transfusion in patients undergoing elective THRA is not related to AKI when maintaining proper volume status during surgery.","PeriodicalId":259565,"journal":{"name":"Medical Biological Science and Engineering","volume":"497 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123414360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-31DOI: 10.30579/mbse.2020.3.1.20
Jia Song, Taehee Pyeon, Daehoon Kim, Chang-Joon Lee, Joungmin Kim
Corresponding author Joungmin Kim Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School,160, Baekseo-ro, Gwangju 61469, Korea Tel: +82-62-220-6895 Fax: + 82-62-232-6294 E-mail: tca77@hanmail.net ORCID: http://orcid.org/0000-0003-1135-1968 Nasotracheal intubation is commonly used in surgery requiring space of the orofacial field. The endotracheal tube used for nasotracheal intubation is either a conventional tube or a preformed nasotracheal tube considering nasal passage. Conventional nasotracheal intubation starts with blind passage of an endotracheal tube via the nostril followed by laryngoscopy-assisted intubation through the vocal cord with or without the aid of Magill forceps. During intubation, anesthesiologists may experience interruption of endotracheal tube passage because of resistance in nasal cavity. It is known that any excessive force may significantly increase the risk of damage to nasal structures. One way to prevent this damage is Guided-technique. Guided technique is easier, cheaper and safer than conventional technique. Here we report a case of successful endotracheal intubation with preformed nasotracheal tube following endobronchial suction catheter guidance. Guided technique with endobronchial suction catheter is useful for nasotracheal intubation with preformed nasotracheal intubation tube.
{"title":"Endobronchial suction catheter guided nasotracheal intubation with preformed nasotracheal tube","authors":"Jia Song, Taehee Pyeon, Daehoon Kim, Chang-Joon Lee, Joungmin Kim","doi":"10.30579/mbse.2020.3.1.20","DOIUrl":"https://doi.org/10.30579/mbse.2020.3.1.20","url":null,"abstract":"Corresponding author Joungmin Kim Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School,160, Baekseo-ro, Gwangju 61469, Korea Tel: +82-62-220-6895 Fax: + 82-62-232-6294 E-mail: tca77@hanmail.net ORCID: http://orcid.org/0000-0003-1135-1968 Nasotracheal intubation is commonly used in surgery requiring space of the orofacial field. The endotracheal tube used for nasotracheal intubation is either a conventional tube or a preformed nasotracheal tube considering nasal passage. Conventional nasotracheal intubation starts with blind passage of an endotracheal tube via the nostril followed by laryngoscopy-assisted intubation through the vocal cord with or without the aid of Magill forceps. During intubation, anesthesiologists may experience interruption of endotracheal tube passage because of resistance in nasal cavity. It is known that any excessive force may significantly increase the risk of damage to nasal structures. One way to prevent this damage is Guided-technique. Guided technique is easier, cheaper and safer than conventional technique. Here we report a case of successful endotracheal intubation with preformed nasotracheal tube following endobronchial suction catheter guidance. Guided technique with endobronchial suction catheter is useful for nasotracheal intubation with preformed nasotracheal intubation tube.","PeriodicalId":259565,"journal":{"name":"Medical Biological Science and Engineering","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131529724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-31DOI: 10.30579/MBSE.2019.2.2.40
R. Hong
Several kinds of atypical keratinocytic lesions including seborrheic keratosis (SK), actinic keratosis (AK), Bowen’s disease (BD) and squamous cell carcinoma (SqCC) are common lesion in pathologic practice. While most of them show characteristic histological feature, occasionally we meet the diagnostic difficulty by overlapping or mixed histologic features. The aim of this study was to evaluate the immunostaining pattern of p16 (INK4a) in SK, AK, BD and SqCC, and identify the utility of p16 immunohistochemical staining in differential diagnosis of above cutaneous keratinocytic lesions. We studied 50 cases of keratinocytic lesions (20 examples of SK and 10 cases of each of AK, BD and SqCC). The cases were stained for p16. Ninety percent of BD cases showed strong block-positivity and typical SK not show reactivity with p16, just only one case showed patch staining pattern. In AK, only one case showed block-positivity and another cases showed patchy staining pattern. In SqCC, only 3 out of 10 cases showed strong staining pattern. This study demonstrated that the expression of p16 is strongly associated with the progression of BD (p < 0.001). This staining pattern was not seen in AK and SK. Accordingly, immunohistochemistry for p16 is a useful test in the differential diagnosis of intra-epidermal atypical keratinocytic lesion. However, despite the statistical significance (p < 0.001), our small series suggests that as not all typical cases of BD are positive with p16, negative p16 staining alone cannot be used to classify atypical keratinocytic lesions, and the finding of hematoxylin and eosin staining remains paramount.
{"title":"The utility of p16 immunostaining in cutaneous keratinocytic lesion","authors":"R. Hong","doi":"10.30579/MBSE.2019.2.2.40","DOIUrl":"https://doi.org/10.30579/MBSE.2019.2.2.40","url":null,"abstract":"Several kinds of atypical keratinocytic lesions including seborrheic keratosis (SK), actinic keratosis (AK), Bowen’s disease (BD) and squamous cell carcinoma (SqCC) are common lesion in pathologic practice. While most of them show characteristic histological feature, occasionally we meet the diagnostic difficulty by overlapping or mixed histologic features. The aim of this study was to evaluate the immunostaining pattern of p16 (INK4a) in SK, AK, BD and SqCC, and identify the utility of p16 immunohistochemical staining in differential diagnosis of above cutaneous keratinocytic lesions. We studied 50 cases of keratinocytic lesions (20 examples of SK and 10 cases of each of AK, BD and SqCC). The cases were stained for p16. Ninety percent of BD cases showed strong block-positivity and typical SK not show reactivity with p16, just only one case showed patch staining pattern. In AK, only one case showed block-positivity and another cases showed patchy staining pattern. In SqCC, only 3 out of 10 cases showed strong staining pattern. This study demonstrated that the expression of p16 is strongly associated with the progression of BD (p < 0.001). This staining pattern was not seen in AK and SK. Accordingly, immunohistochemistry for p16 is a useful test in the differential diagnosis of intra-epidermal atypical keratinocytic lesion. However, despite the statistical significance (p < 0.001), our small series suggests that as not all typical cases of BD are positive with p16, negative p16 staining alone cannot be used to classify atypical keratinocytic lesions, and the finding of hematoxylin and eosin staining remains paramount.","PeriodicalId":259565,"journal":{"name":"Medical Biological Science and Engineering","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125266653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-31DOI: 10.30579/MBSE.2019.2.2.60
B. Kim, Yun Hee Kim, Y. Lee, W. Kim, Jae Hwan Kim
{"title":"Perioperative considerations of hyperthyroidism in a patient with liver failure: case report","authors":"B. Kim, Yun Hee Kim, Y. Lee, W. Kim, Jae Hwan Kim","doi":"10.30579/MBSE.2019.2.2.60","DOIUrl":"https://doi.org/10.30579/MBSE.2019.2.2.60","url":null,"abstract":"","PeriodicalId":259565,"journal":{"name":"Medical Biological Science and Engineering","volume":"359 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122766013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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