Pub Date : 2023-04-27DOI: 10.29074/ascls.2020002444
Teresa M. Wolfe, Robert E. Nickla
{"title":"Integration of the Centers for Disease Control Competency Guidelines for Public Health Laboratory Professionals Into a Medical Laboratory Training Program","authors":"Teresa M. Wolfe, Robert E. Nickla","doi":"10.29074/ascls.2020002444","DOIUrl":"https://doi.org/10.29074/ascls.2020002444","url":null,"abstract":"","PeriodicalId":263458,"journal":{"name":"American Society for Clinical Laboratory Science","volume":"154 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131832533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-27DOI: 10.29074/ascls.2020002527
E. Hendrix, Taylor Eaves, K. Bennett
{"title":"Demonstration of the Nanopore MinION DNA Sequencer","authors":"E. Hendrix, Taylor Eaves, K. Bennett","doi":"10.29074/ascls.2020002527","DOIUrl":"https://doi.org/10.29074/ascls.2020002527","url":null,"abstract":"","PeriodicalId":263458,"journal":{"name":"American Society for Clinical Laboratory Science","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115932644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-27DOI: 10.29074/ascls.2020002949
Leah J. Ames
{"title":"Perceptions of Collaboration With a Doctor of Clinical Laboratory Science","authors":"Leah J. Ames","doi":"10.29074/ascls.2020002949","DOIUrl":"https://doi.org/10.29074/ascls.2020002949","url":null,"abstract":"","PeriodicalId":263458,"journal":{"name":"American Society for Clinical Laboratory Science","volume":"227 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122149665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-27DOI: 10.29074/ascls.2020002352
Kristina Jackson Behan
{"title":"The Benefits of Rolling Admission to a University-Based Medical Laboratory Sciences Program","authors":"Kristina Jackson Behan","doi":"10.29074/ascls.2020002352","DOIUrl":"https://doi.org/10.29074/ascls.2020002352","url":null,"abstract":"","PeriodicalId":263458,"journal":{"name":"American Society for Clinical Laboratory Science","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131267764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-27DOI: 10.29074/ascls.2020002535
Tiffany Anderson
{"title":"Implementation of MediaLab in Hematology Courses","authors":"Tiffany Anderson","doi":"10.29074/ascls.2020002535","DOIUrl":"https://doi.org/10.29074/ascls.2020002535","url":null,"abstract":"","PeriodicalId":263458,"journal":{"name":"American Society for Clinical Laboratory Science","volume":"7 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132792790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-27DOI: 10.29074/ascls.2020002600
Kaitlin Walsh, T. C. Moon, Troy Dang, C. Immel
Multiple myeloma is an incurable disease characterized by the proliferation of malignant plasma cells in the bone marrow. Daratumumab (DARA), a monoclonal antibody that targets the CD38 antigen expressed on malignant myeloma cells, has been approved as a promising new treatment for patients with this disease. Although it is an e ff ective medication, DARA presents challenges in transfusion medicine. Because normal red cells weakly express the CD38 antigen, panreactivity is observed during antibody-detection workups on patients treated with DARA; the panreactivity can mask the presence of any underlying alloantibodies. The American Association of Blood Banks (AABB) has issued a method on how to resolve DARA interference by managing reagent red cells with dithiothreitol (DTT), which cleaves the disul fi de bonds of the CD38 antigen. The primary objective of this study was to develop a protocol for resolving DARA interference in pretransfusion testing at the University of North Carolina Medical Center ’ s Transfusion Medicine Services based on the method described by the AABB. Optimal procedural conditions required 4 drops of DTT to 1 drop of packed phosphate-bu ff ered saline – washed reagent red cells incubated at 37 °C for 45 minutes. An antibody screen using untreated and DTT-treated reagent red cells with appropriate quality-control results indicated that DTT was successful at eliminating DARA-induced panreactivity. A cost analysis was performed to consider the expenses and time required for the implementation of an in-house procedure.
{"title":"Development of a Procedure to Resolve Daratumumab Interference in Pretransfusion Testing","authors":"Kaitlin Walsh, T. C. Moon, Troy Dang, C. Immel","doi":"10.29074/ascls.2020002600","DOIUrl":"https://doi.org/10.29074/ascls.2020002600","url":null,"abstract":"Multiple myeloma is an incurable disease characterized by the proliferation of malignant plasma cells in the bone marrow. Daratumumab (DARA), a monoclonal antibody that targets the CD38 antigen expressed on malignant myeloma cells, has been approved as a promising new treatment for patients with this disease. Although it is an e ff ective medication, DARA presents challenges in transfusion medicine. Because normal red cells weakly express the CD38 antigen, panreactivity is observed during antibody-detection workups on patients treated with DARA; the panreactivity can mask the presence of any underlying alloantibodies. The American Association of Blood Banks (AABB) has issued a method on how to resolve DARA interference by managing reagent red cells with dithiothreitol (DTT), which cleaves the disul fi de bonds of the CD38 antigen. The primary objective of this study was to develop a protocol for resolving DARA interference in pretransfusion testing at the University of North Carolina Medical Center ’ s Transfusion Medicine Services based on the method described by the AABB. Optimal procedural conditions required 4 drops of DTT to 1 drop of packed phosphate-bu ff ered saline – washed reagent red cells incubated at 37 °C for 45 minutes. An antibody screen using untreated and DTT-treated reagent red cells with appropriate quality-control results indicated that DTT was successful at eliminating DARA-induced panreactivity. A cost analysis was performed to consider the expenses and time required for the implementation of an in-house procedure.","PeriodicalId":263458,"journal":{"name":"American Society for Clinical Laboratory Science","volume":"140 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132110007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-27DOI: 10.29074/ascls.2021003161
Jed Doxtater, Charlie Cruz
{"title":"Knowledge, Risk Perceptions, and Preventive Behaviors in COVID-19 Pandemic Among Medical Laboratory Students in Wyoming","authors":"Jed Doxtater, Charlie Cruz","doi":"10.29074/ascls.2021003161","DOIUrl":"https://doi.org/10.29074/ascls.2021003161","url":null,"abstract":"","PeriodicalId":263458,"journal":{"name":"American Society for Clinical Laboratory Science","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134136950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-27DOI: 10.29074/ascls.2020002584
Melanie Belk, Ariana Irby, Giti Bayhaghi
{"title":"Presence of Group B Streptococcus in Raw and Dehydrated Placentas","authors":"Melanie Belk, Ariana Irby, Giti Bayhaghi","doi":"10.29074/ascls.2020002584","DOIUrl":"https://doi.org/10.29074/ascls.2020002584","url":null,"abstract":"","PeriodicalId":263458,"journal":{"name":"American Society for Clinical Laboratory Science","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114652584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-27DOI: 10.29074/ascls.2020002881
Kathryn Golab, Maria Hintzke, E. Atallah
{"title":"Case Study: Therapy-related Acute Myeloid Leukemia: A Three-case Review","authors":"Kathryn Golab, Maria Hintzke, E. Atallah","doi":"10.29074/ascls.2020002881","DOIUrl":"https://doi.org/10.29074/ascls.2020002881","url":null,"abstract":"","PeriodicalId":263458,"journal":{"name":"American Society for Clinical Laboratory Science","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115974739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-27DOI: 10.29074/ascls.2020002980
Corey Swackhammer, Jacob Gault, A. Beaver, Estephania Yanez, Taylor Eaves
{"title":"Rapid Molecular Detection ofPseudomonas aeruginosaUsing Real-Time PCR","authors":"Corey Swackhammer, Jacob Gault, A. Beaver, Estephania Yanez, Taylor Eaves","doi":"10.29074/ascls.2020002980","DOIUrl":"https://doi.org/10.29074/ascls.2020002980","url":null,"abstract":"","PeriodicalId":263458,"journal":{"name":"American Society for Clinical Laboratory Science","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123523183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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