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Treatment of unstable slipped capital femoral epiphysis with a modified Dunn’s procedure-a case report 改良的Dunn手术治疗不稳定股骨干骨骺滑动1例
Pub Date : 2019-10-31 DOI: 10.17511/ijoso.2019.i04.01
Rajiv Kaul, Chander Mohan Singh, Kamparsh Thakur
Slipped Capital Femoral Epiphysis (SCFE) is a relatively common disease of adolescents with drastic consequences in adult life if managed inappropriately. A number of surgical techniques are described to reposition the proximal femoral epiphysis and are frequently associated with a high rate of femoral head osteonecrosis. The modified Dunn’s procedure has been shown to be safe and effective in treating unstable SCFE. The incidence of development of osteonecrosis is dramatically reduced by carefully preserving the posterior periosteal sleeve, thereby maintaining the vascularity to the head. We have performed this procedure in a 21-year-old male with bilateral, sequential, unstable SCFEs and achieved a satisfactory functional outcome at the end of one year.
股骨头骨骺滑动(SCFE)是一种相对常见的青少年疾病,如果管理不当,会对成年生活造成严重后果。许多手术技术被描述为重新定位股骨近端骨骺,并且经常与股骨头坏死的高发生率相关。改进的Dunn手术已被证明是安全有效的治疗不稳定的SCFE。通过小心地保护后骨膜套,从而维持头部的血管供应,可显著减少骨坏死的发生。我们对一名21岁的男性双侧连续性不稳定SCFEs患者实施了该手术,并在一年后获得了令人满意的功能结果。
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引用次数: 0
A comparative study of topical sucralfate versus honey dressing in the management of diabetic foot ulcer 外用硫硫钠与蜂蜜敷料治疗糖尿病足溃疡的比较研究
Pub Date : 2019-10-31 DOI: 10.17511/ijoso.2019.i04.03
M. Reddy, Padmanabh Inamdar, Gogineni Mahesh
Background and Objectives: Local wound care is one of the mainstays in the management protocol for diabetic foot ulcers. Sucralfate and honey are inexpensive and easily available agents for local dressing. They are highly efficacious in achieving faster and better healing. Our study compares the effect of topical sucralfate with honey dressings in the management of diabetic foot ulcers. Methods: We conducted a prospective study on 50 patients of Diabetic foot ulcer admitted indoor and were evaluated clinically. Patients were divided into Group A (n=25) and Group B (n=25). Group A patients treated with topical application of Sucralfate and Group B patients were treated with topical honey. Wounds in both groups were inspected at the end of 7 days, 14 days and 21 days. Results in the two groups were compared and interpreted. Results: In our study, mean ulcer size was reduced in both the groups on day 7, day 14, and day21 (p>0.5). The percentage of reduction in mean ulcer size in Group A was 59.53% compared to 55.05% in Group B at the end of 21 days (p value > 0.05). Completely epithelized ulcers were 10 (40%) in Group A and 9 (36%) in Group B respectively. Complete epithelization of ulcer or ulcer bed ready for split skin grafting (primary end point of study) was 21.04 days in Group A and 23.20 days in Group B (P value < 0.05). Conclusion: Even though topical sucralfate and honey were both found to be effective in enhancing the wound healing process in diabetic foot ulcers, topical sucralfate was found to be better when compared to honey for local application.
背景与目的:局部伤口护理是糖尿病足溃疡治疗方案的主要内容之一。蔗糖酸盐和蜂蜜是便宜且容易获得的局部敷料。它们在实现更快和更好的愈合方面非常有效。我们的研究比较了局部硫糖钠与蜂蜜敷料在糖尿病足溃疡治疗中的作用。方法:对50例室内住院的糖尿病足溃疡患者进行前瞻性研究,并进行临床评价。患者分为A组(n=25)和B组(n=25)。A组患者局部应用硫酸氢钠,B组患者局部应用蜂蜜。两组分别于第7天、第14天和第21天结束时检查伤口。对两组结果进行比较和解释。结果:在我们的研究中,两组患者在第7天、第14天和第21天的平均溃疡大小均减小(p>0.5)。21 d时,A组溃疡平均缩小率为59.53%,B组为55.05% (p值> 0.05)。完全上皮溃疡A组10例(40%),B组9例(36%)。A组溃疡或溃疡床上皮完全形成,可用于裂皮移植(主要研究终点)为21.04 d, B组为23.20 d (P值< 0.05)。结论:尽管局部应用硫糖钠和蜂蜜都能有效促进糖尿病足溃疡的伤口愈合过程,但与局部应用蜂蜜相比,局部应用硫糖钠效果更好。
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引用次数: 0
Comparison of functional outcome and quality of life following treatment of unstable intertrochanteric fractures with intramedullary nailing and dynamic hip screw 髓内钉与动力髋螺钉治疗不稳定股骨粗隆间骨折的功能结局和生活质量比较
Pub Date : 2019-10-31 DOI: 10.17511/ijoso.2019.i04.04
A. Reddy, R. C. Reddy
Background: The dynamic hip screw is considered as the standard treatment for Intertrochanteric fracture. The procedure per se requires long term hospitalization and other complications. Researchers have proposed intramedullary nailing as an alternate procedure. The present study aims to compare the radiological and functional outcome following treatment of unstable intertrochanteric fractures with intramedullary nailing and dynamic hip screw and to compare Health-related quality of life between the two treatment methods. Methods: A prospective observational study was conducted during March 2014 to July 2016. Patients presenting with unstable Intertrochanteric fractures were recruited prospectively. The study was conducted in the department of orthopedics, Rajiv Gandhi Institute of medical sciences, Kadapa, which is a tertiary care teaching hospital. The participants were divided into two groups. Group, I constitute 25 patients who underwent DHS and Group II had 23 patients who underwent IHN. The mean age of Group DHS participants were 71.4  5.86 years, and group IMN participants were 69.7  6.13 years. The mean intraoperative bleeding of subjects in DHS group was325.24  67.32 (in ml) and it was 325.24  67.32 (in ml) in IMN group. Results: The mean time taken for the radiological union of subjects in DHS group was22.3  1.73 weeks, and it was 20.6  2.13 weeks in IMN group. Conclusions: The treatment of unstable Intertrochanteric fracture can be done in geriatric patients through surgical intervention without much morbidity and mortality. The postoperative quality of life returns to near normal at
背景:动力髋螺钉被认为是治疗转子间骨折的标准方法。手术本身需要长期住院治疗和其他并发症。研究人员建议髓内钉作为一种替代方法。本研究旨在比较髓内钉和动力髋螺钉治疗不稳定转子间骨折后的放射学和功能结果,并比较两种治疗方法的健康相关生活质量。方法:于2014年3月至2016年7月进行前瞻性观察研究。前瞻性地招募以不稳定转子间骨折为表现的患者。这项研究是在卡达帕拉吉夫·甘地医学研究所骨科进行的,这是一家三级保健教学医院。参与者被分成两组。组I有25例DHS患者,组II有23例IHN患者。DHS组参与者平均年龄为71.45.86岁,IMN组参与者平均年龄为69.76.13岁。DHS组患者术中平均出血量为325.2467.32 (in ml), IMN组患者术中平均出血量为325.2467.32 (in ml)。结果:DHS组患者放射愈合平均时间为22.31.73周,IMN组平均时间为20.62.13周。结论:老年不稳定股骨粗隆间骨折可通过手术治疗,发病率和死亡率均不高。术后生活质量恢复到接近正常
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引用次数: 0
Profile and complication rate of thyroid surgeries performed in a tertiary care teaching hospital, a prospective observational study 三级护理教学医院甲状腺手术的概况和并发症发生率:一项前瞻性观察研究
Pub Date : 2019-10-31 DOI: 10.17511/ijoso.2019.i04.08
Dr. Vijaiaboobbathi Sathiah, Dr. Karpagavel Chandrabose
Background: One of the most common endocrine disorder is the thyroid diseases. The prevalence and pattern of these conditions depends on sex, age, ethnic and geographic patterns. The incidence of thyroid nodules increases with the age hence benign and malignant thyroid disease is common in the elderly population. Aim: To compare the complication rate of various thyroid surgeries for benign and malignant diseases in a tertiary care teaching hospital. Methods: This study was a prospective observational study, Velammal medical college hospital at Tamil Nadu from December 2018-June 2019. The patients who underwent thyroid surgery for various thyroid disorders were enrolled in the study. Results: Out of117 cases, 107 were women and 10 were men. Multinodular goiter (MNG)was the most common (38.46%) condition, followed by solitary nodule (29.06%) and toxic MNG (18.8%). Among women, 40.19% were identified with multinodular goiter followed by solitary nodule (28.97%). Subtotal thyroidectomy was performed for 88.89% of MNGs, while 91.18% of the solitary nodule were managed by hemithyroidectomy Majority of the patients with toxic MNG underwent subtotal thyroidectomy with 99.91%. While 84.61% of the patients with thyroid cancer were treated by total thyroidectomy. The overall incidence of complications was 27.35%. The incidence rate of complications was high in patients with malignant disease, as compared to benign disease (69.23% in Malignant Vs 36.36% in toxic MNG and 24.44% in MNG). Conclusion: Through the present study, it was concluded that the complications associated with the different thyroid surgeries and various precautions that can be taken to reduce the complications.
背景:甲状腺疾病是最常见的内分泌疾病之一。这些疾病的流行程度和模式取决于性别、年龄、种族和地理模式。甲状腺结节的发病率随着年龄的增长而增加,因此良性和恶性甲状腺疾病在老年人中很常见。目的:比较三级教学医院甲状腺良、恶性疾病各种手术的并发症发生率。方法:本研究是一项前瞻性观察研究,于2018年12月至2019年6月在泰米尔纳德邦Velammal医学院医院进行。接受甲状腺手术治疗各种甲状腺疾病的患者被纳入研究。结果:117例患者中,女性107例,男性10例。多结节性甲状腺肿(MNG)最为常见(38.46%),其次是单发结节(29.06%)和中毒性甲状腺肿(18.8%)。在女性中,40.19%为多结节性甲状腺肿,其次为单发结节(28.97%)。88.89%的MNG患者行甲状腺次全切除术,91.18%的单发结节行甲状旁腺切除术。绝大多数中毒性MNG患者行甲状腺次全切除术,占99.91%。84.61%的甲状腺癌患者行甲状腺全切除术。总并发症发生率为27.35%。恶性病变的并发症发生率高于良性病变(恶性69.23% Vs中毒性MNG 36.36%和MNG 24.44%)。结论:通过本文的研究,总结了不同甲状腺手术的并发症及可采取的各种预防措施,以减少并发症。
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引用次数: 0
Recurrent abdominal pain in school children in a rural tertiary hospital 某农村三级医院学龄儿童复发性腹痛分析
Pub Date : 2019-10-31 DOI: 10.17511/ijoso.2019.i04.06
S. Prabhu, Consultant Paediatric Surgeon, G. Abraham, L. Nair
Background: Recurrent abdominal pain is one of the most common presenting complaints among school going children, with a prevalence of 10-12%. Most of the children with recurrent abdominal pain are not evaluated further, either due to the mild abdominal pain or transient nature of the symptoms. Recurrent abdominal pain requires complete evaluation to look for organic causes. However, in many cases, where no specific organic cause can be identified, a psychosomatic component has been shown to play a role. The aim of the study is to evaluate children with recurrent abdominal pain in the age group 2-12 years for a cause at a tertiary rural hospital, in an attempt to better understand this syndrome. Methods: Retrospectively collected data from 210 consecutive patients aged between 2-12 years from January 2015 to January 2017, who presented to Department of Surgery and Emergency department in MOSC Medical College with recurrent abdominal pain were studied. Data collection included demographic details, symptomatology and clinical details, and response to treatment. Each patient was thoroughly evaluated to identify an organic cause for the pain. All the patients were evaluated by the paediatrician for any underlying medical cause. Results: During the two-year period, 210 patients were evaluated and investigated, and an organic cause was detected in 44 patients, while 166 patients were diagnosed to have RAP. The 44 patients with an organic cause were treated for the primary condition and were asymptomatic on follow up. Investigations revealed that 20 patients suffered from acute appendicitis, 20 patients were diagnosed with habitual constipation Patients without an organic cause were reassured, counselled and treated symptomatically. All the patients were on follow up for the entire period of the study. Of the 166 patients diagnosed with RAP, 110 patients responded to symptomatic measures, while 21 patients were referred to child psychiatry and are on long term follow up. Conclusion: Recurrent abdominal pain is a significant cause of functional impairment in the life of a child. Thorough evaluation of the patient to rule out organic causes is vital. Majority of the children diagnosed with recurrent abdominal pain respond to counselling. Acknowledging the existence of the symptoms instead of dismissing it, and empathising with the child is often all that is required in the management of these patients
背景:复发性腹痛是学龄儿童最常见的主诉之一,患病率为10-12%。大多数复发性腹痛患儿由于腹痛轻微或症状短暂性,没有得到进一步的评估。复发性腹痛需要完整的评估以寻找器质性原因。然而,在许多情况下,没有特定的有机原因可以确定,心身成分已被证明发挥作用。本研究的目的是评估某三级农村医院2-12岁年龄组复发性腹痛患儿的病因,试图更好地了解这种综合征。方法:回顾性收集2015年1月至2017年1月在MOSC医学院外科和急诊科连续就诊的210例2-12岁复发性腹痛患者的资料。数据收集包括人口统计学细节、症状学和临床细节以及对治疗的反应。每个病人都经过彻底的评估,以确定疼痛的器质性原因。所有患者都由儿科医生评估任何潜在的医学原因。结果:2年期间共对210例患者进行了评估和调查,其中44例发现器质性原因,166例诊断为RAP。44例器质性原因的患者接受了原发治疗,随访时无症状。调查发现,20例患者出现急性阑尾炎,20例患者确诊为习惯性便秘,对无器质性原因的患者进行了安抚、辅导和对症治疗。在整个研究期间,所有患者都接受了随访。在166例诊断为RAP的患者中,110例患者对症状测量有反应,而21例患者被转介到儿童精神病学并进行了长期随访。结论:反复腹痛是儿童生活中功能损害的重要原因。对病人进行彻底的评估以排除器质性原因是至关重要的。大多数被诊断为复发性腹痛的儿童对咨询有反应。承认症状的存在,而不是忽视它,对孩子感同身受,往往是管理这些病人所需要的全部
{"title":"Recurrent abdominal pain in school children in a rural tertiary hospital","authors":"S. Prabhu, Consultant Paediatric Surgeon, G. Abraham, L. Nair","doi":"10.17511/ijoso.2019.i04.06","DOIUrl":"https://doi.org/10.17511/ijoso.2019.i04.06","url":null,"abstract":"Background: Recurrent abdominal pain is one of the most common presenting complaints among school going children, with a prevalence of 10-12%. Most of the children with recurrent abdominal pain are not evaluated further, either due to the mild abdominal pain or transient nature of the symptoms. Recurrent abdominal pain requires complete evaluation to look for organic causes. However, in many cases, where no specific organic cause can be identified, a psychosomatic component has been shown to play a role. The aim of the study is to evaluate children with recurrent abdominal pain in the age group 2-12 years for a cause at a tertiary rural hospital, in an attempt to better understand this syndrome. Methods: Retrospectively collected data from 210 consecutive patients aged between 2-12 years from January 2015 to January 2017, who presented to Department of Surgery and Emergency department in MOSC Medical College with recurrent abdominal pain were studied. Data collection included demographic details, symptomatology and clinical details, and response to treatment. Each patient was thoroughly evaluated to identify an organic cause for the pain. All the patients were evaluated by the paediatrician for any underlying medical cause. Results: During the two-year period, 210 patients were evaluated and investigated, and an organic cause was detected in 44 patients, while 166 patients were diagnosed to have RAP. The 44 patients with an organic cause were treated for the primary condition and were asymptomatic on follow up. Investigations revealed that 20 patients suffered from acute appendicitis, 20 patients were diagnosed with habitual constipation Patients without an organic cause were reassured, counselled and treated symptomatically. All the patients were on follow up for the entire period of the study. Of the 166 patients diagnosed with RAP, 110 patients responded to symptomatic measures, while 21 patients were referred to child psychiatry and are on long term follow up. Conclusion: Recurrent abdominal pain is a significant cause of functional impairment in the life of a child. Thorough evaluation of the patient to rule out organic causes is vital. Majority of the children diagnosed with recurrent abdominal pain respond to counselling. Acknowledging the existence of the symptoms instead of dismissing it, and empathising with the child is often all that is required in the management of these patients","PeriodicalId":267909,"journal":{"name":"Surgical Update: International Journal of Surgery and Orthopedics","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121140617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Technical tip: fixation of extra-articular fractures of distal humerus with modified distal tibial locking plate 技术提示:改良胫骨远端锁定钢板固定肱骨远端关节外骨折
Pub Date : 2019-08-31 DOI: 10.17511/ijoso.2019.i03.02
Rajul Gupta, Vaibhav Maheshwari, S. Gour, Narendra Kumar, Avtar Singh
Introduction- Treatment of extra-articular distal humerus fractures is often difficult using conventional plates. Plates having enough screws (three to four) in the distal fragment either impinge on the olecranon fossa, or gain purchase by placing screws in the lateral or medial column of the distal humerus avoiding the olecranon fossa. Objectives- This study was to ascertain the effectiveness of modified distal tibial locking plate for use in distal third shaft humerus fracture. Methods- By using a modified distal tibial locking plate, a six to eight locking head screws can be easily placed in the in the limited length of distal fragment proximal to the olecranon fossa. Fourteen cases treated in such manner were followed up for a minimum of 24 months. Results- Union was achieved in all cases with no loss of reduction or implant failure. No patient complained of hardware complication, functional limitation or infection. Conclusion- Modified distal locking plate can be safely used in the limited space above olecrenon fossa in distal thirds humerus shaft fractures
引言-使用传统钢板治疗肱骨远端关节外骨折通常很困难。在远端碎片上有足够螺钉的钢板(三到四个),要么撞击鹰嘴窝,要么通过在肱骨远端外侧或内侧柱上放置螺钉来获得固定,避免鹰嘴窝。目的:本研究旨在确定改良胫骨远端锁定钢板用于肱骨远端第三骨干骨折的有效性。方法-使用改良的胫骨远端锁定钢板,可在鹰嘴窝近端有限长度的远端碎片内轻松放置6 - 8个锁定头螺钉。以这种方式治疗的14例患者至少随访24个月。结果:所有病例均成功愈合,无复位损失或种植体失败。没有患者抱怨硬件并发症,功能限制或感染。结论-改良远端锁定钢板可安全用于肱骨远端三分之一骨折尺骨鹰嘴窝上方有限空间
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引用次数: 0
Spectra of bacterial growth in ulcers 溃疡细菌生长的光谱
Pub Date : 2019-08-31 DOI: 10.17511/ijoso.2019.i03.06
Va Bhagat, S. Brahmachari
Objectives: To study the spectra of bacterial growth in ulcers in patients and to compare the range and efficacy of Povidoneiodine, Nitrofurazone and silver sulphadiazine with Metronidazole with sucralfate as topical agents. Methods: 100 patients with different types of ulcers with either foul smell or showing response to systemic or local treatment were selected and divided into two groups. Study Group or Group A: 1% Metronidazole gel with sucralfate. Control group or Group B: for burns and scalds silver sulphadiazine, for trophic ulcers nitofurazone (Furacin ) in remaining types of ulcer/wounds Povidone iodine (Betadine) ointment was used. Periodic debridement of ulcer/wound was done in both the groups as per requirement. Other general and specific treatment of the patient with regard of his illness was same in both the groups. Systemic antibiotics were given, bacteriological and clinical assessment was daily done. Results: 93% of cases in Group A and 42% in Group B showed grade III healing within 35 days. Healing was over all faster in Group C and 95% reached grade III within 35 days. One patient in Group B died after 24 days with no signs of healing and remaining 18 patients were converted to Group C after 45 days of treatment. In Group C one patient absconded with grade II healing. Conclusion: It was observed that results with topical Metronidazole with sucralfatewere definitely superior as compared to Povidone iodine, Nitrofurazone or Silver sulfadiazine.
目的:研究溃疡患者的细菌生长谱,比较聚维多碘定、硝基呋喃酮和磺胺嘧啶银与甲硝唑加硫酸氢盐外用药物的范围和疗效。方法:选择100例不同类型的溃疡患者,有恶臭或对全身或局部治疗有反应,分为两组。研究组或A组:1%甲硝唑硫酸氢盐凝胶。对照组或B组:用于烧伤、烫伤用磺胺嘧啶银,用于营养性溃疡其余类型溃疡/创面用硝呋唑酮(呋喃星)软膏。两组均按要求进行溃疡/创面定期清创。两组患者对其疾病的其他一般和特殊治疗方法相同。给予全身抗生素治疗,每日进行细菌学和临床评估。结果:A组93%、B组42%的病例在35 d内达到III级愈合。C组总体愈合更快,95%在35天内达到III级。B组1例患者治疗24天后死亡,无愈合迹象,其余18例患者治疗45天后转入C组。C组1例患者潜逃,II级愈合。结论:与聚维酮碘、硝基呋喃酮或磺胺嘧啶银相比,甲硝唑与三氯蔗糖脂外用效果明显更好。
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引用次数: 0
Treatment of grade 3a and 3b compound tibial fractures with external fixation and primary immediate bone grafting 外固定+一期即刻植骨治疗3a级、3b级复合胫骨骨折
Pub Date : 2019-08-31 DOI: 10.17511/ijoso.2019.i03.01
Rajul Gupta, Vaibhav Maheshwari, S. Gour, Deepak Nadkarni, K. Verma
Introduction- The present study report results of a series of type 3A and 3B open fractures treated with debridement and fracture fixation and immediate bone grafting. Methods- Twenty one patients were treated from January 2017 to January 2018. All fractures were treated with a modular external fixator. Nine fractures were type 3A and 12 were type 3B. All fractures received debridement, external fixation, bone grafting and flap or skin graft coverage. All fractures were analyzed for time to fracture union, incidence of pin tract infection, incidence of wound infection, flap complications, and delayed or non union. Results- After a mean follow up period of 14 months (range 12 to 16 months), it was concluded that the time to fracture union was 22 weeks, and all fixators were removed only after radiological evidence of fracture union. 1 (5%) patients developed deep wound infection, one experienced delayed union. Conclusion- Along with early wound coverage and external fixation, primary bone grafting can be employed in grade 3 open fractures of tibia with good results and without any increased risk of wound complications ………………………………………………………………………………………………………………………...............
本研究报告了一系列3A和3B型开放性骨折的清创、骨折固定和即刻植骨治疗的结果。方法:2017年1月至2018年1月对21例患者进行治疗。所有骨折均采用模块化外固定架治疗。9例为3A型,12例为3B型。所有骨折均行清创、外固定、植骨及皮瓣或植皮覆盖。分析所有骨折骨折愈合时间、针道感染发生率、伤口感染发生率、皮瓣并发症、延迟愈合或不愈合。结果-平均随访14个月(12 - 16个月),结论是骨折愈合时间为22周,只有在有骨折愈合的放射证据后才拆除所有固定物。1例(5%)患者发生深部伤口感染,1例延迟愈合。结论——连同早期伤口覆盖和外固定,主要可以使用骨移植在三年级开放骨折的胫骨,效果很好,没有任何伤口并发症的风险增加 ......................................................................................................................................................
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引用次数: 0
A real life experience with novel biosimilar InfimabTM in biologic naive patients with active rheumatoid arthritis 新型生物仿制药inimabtm在生物幼稚型活动性类风湿关节炎患者中的临床应用
Pub Date : 2019-08-31 DOI: 10.17511/ijoso.2019.i03.09
N. Kaura, A. Ray, Amit Kumar, India. Nicobar Islands
Objective: To determine the efficacy and safety of novel infliximab biosimilar, Infimab TM (IFB) in rheumatoid arthritis (RA) patients. Materials and Methods: Eight patients with active RA who failed to demonstrate clinical improvement with methotrexate were enrolled. Post consent, patients were administered infliximab biosimilar 3mg/kg body weight as intra venous infusion at weeks 0, 2, 6 then every 8 weeks on demand. Patients were assessed for Health assessment questionnaire (HAQ, India Score), disease activity score 28 (DAS 28), Western Ontario and McMaster Universities Osteoarthritis Index score (WOMAC), erythrocyte sedimentation rate (ESR) and Visual Analogue Scale (VAS) score at baseline and at each visit. They were also observed for any adverse effects or tuberculosis infection. Wilcoxon sign rank test was used to assess the change between baseline to each follow-up visit. Results: On any average 3 infusions were administered to patients. At visit 3 there was significant improvement in HAQ score (p=0.046), WOMAC score (p=0.018), Tender joints count (p=0.027), swollen joints count (p=0.027) and also in general health (p=0.043). Though the VAS scores and ESR values decreased at visit 3, they were not significant. At the end of visit 5, there was considerable decrease in the tested parameters, except in tender joint count. None of the patients reported any adverse effects, indicating that infliximab biosimilar was well-tolerated in tested patients. Conclusion: In this preliminary trial conducted in eight RA patients, treatment with IFB improved clinical outcomes and was well-tolerated in RA patients who failed initial treatment with methotrexate
目的:探讨新型英夫利昔单抗生物仿制药英夫昔单抗TM (IFB)治疗类风湿性关节炎(RA)的疗效和安全性。材料和方法:纳入8例使用甲氨蝶呤未能显示临床改善的活动性RA患者。同意后,患者在第0、2、6周静脉滴注英夫利昔单抗生物仿制药3mg/kg体重,然后根据需要每8周注射一次。在基线和每次就诊时对患者进行健康评估问卷(HAQ, India Score)、疾病活动评分28 (DAS 28)、西安大略省和麦克马斯特大学骨关节炎指数评分(WOMAC)、红细胞沉降率(ESR)和视觉模拟量表(VAS)评分。同时观察他们是否有任何不良反应或结核感染。采用Wilcoxon符号秩检验评估基线至每次随访之间的变化。结果:患者平均每次输注3次。在第3次就诊时,HAQ评分(p=0.046)、WOMAC评分(p=0.018)、压痛关节计数(p=0.027)、肿胀关节计数(p=0.027)和总体健康状况(p=0.043)均有显著改善。虽然VAS评分和ESR值在就诊3时有所下降,但差异不显著。在访问5结束时,除了投标接头数量外,测试参数都有相当大的减少。没有患者报告任何不良反应,表明英夫利昔单抗生物类似药在测试患者中耐受性良好。结论:在这项对8名RA患者进行的初步试验中,IFB治疗改善了临床结果,并且在甲氨蝶呤初始治疗失败的RA患者中耐受性良好
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引用次数: 0
Comparative study on the degree of correction and type of complication between modified French and dome supracondylar osteotomy in a tertiary care centre of West Bengal 西孟加拉邦一家三级医疗中心改良法国式和圆顶式髁上截骨术矫正程度和并发症类型的比较研究
Pub Date : 2019-08-31 DOI: 10.17511/ijoso.2019.i03.03
S. Mitra, Saswata Ghosh
Introduction: Cubitus Varus is one of the most common deformity around the elbow. Malunited supracondylar fracture of humerus is the most common cause of the deformity in children. This study was conducted to compare the degree of correction and type of complication between modified French and dome supracondylar osteotomy. Materials and Methods: The present study is a prospective study of 61 children with Cubitus Varus treated surgically between January 2017 to May 2018. In our series of 61 cases, 31 were treated with modified French osteotomy and 30 with dome osteotomy. The patients were followed up periodically. Results: At final follow-up by Flynn’s criteria for functional outcome 19 had excellent outcome, 9 had good result, 3 had fair result and none had poor result in modified French group. In dome osteotomy group 15 had excellent result, 10 had good result, 5 had fair result. There was 1 case of infection, 1 case of delayed union, 1 case of implant failure and no nerve injury. In modified French group. There were 2 cases of infection, 1 case of delayed union, 2 cases of implant failure, and 1 case of nerve injury in dome osteotomy group. Conclusion: The present study found that the degree of correction was same, but rate of complication was less in modified French treated group than in dome osteotomy group. Though lateral prominence was corrected in dome osteotomy it was associated with more complication, inadequate correction, nerve palsy, loss of motion and circulatory compromise. KeywordsCubitus Varus, Dome osteotomy, Modified French osteotomy ...................................................................................................................................................
肘内翻是肘部最常见的畸形之一。肱骨髁上骨折不愈合是儿童肱骨髁上骨折最常见的畸形原因。本研究的目的是比较改良的法国式和圆顶式髁上截骨术的矫正程度和并发症类型。材料与方法:本研究是一项前瞻性研究,对2017年1月至2018年5月手术治疗的61例肘内翻患儿进行研究。在我们的61例病例中,31例采用改良的法式截骨术,30例采用圆顶截骨术。对患者进行定期随访。结果:经Flynn功能预后标准随访,改良法组预后优良者19例,良者9例,一般者3例,无不良者。穹窿截骨组优15例,良10例,一般5例。感染1例,延迟愈合1例,假体失败1例,无神经损伤。在修改后的法国组。穹窿截骨组感染2例,延迟愈合1例,假体失败2例,神经损伤1例。结论:改良法治疗组的矫正程度相同,但并发症发生率低于穹窿截骨组。尽管圆顶截骨术矫正了外侧突出,但其并发症较多,矫正不足,神经麻痹,运动丧失和循环系统受损。KeywordsCubitus弓形腿,圆顶截骨术、修改法国截骨术 ...................................................................................................................................................
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Surgical Update: International Journal of Surgery and Orthopedics
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