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Effects of influenza vaccination on the morbidity and severity of COVID-19 in children 接种流感疫苗对儿童 COVID-19 发病率和严重程度的影响
Pub Date : 2023-10-24 DOI: 10.17021/1992-6499-2023-3-88-94
Yu. V. Ponomareva, I. N. Shisimorov, O. Magnitskaya, T. V. Plakhotnyuk, K. S. Krasnova
The pandemic of a new coronavirus infection COVID-19 initiated research to find methods of non-specific influence on the immune system that can change the course of infectious diseases. Adult study results have been demonstrated the positive effect of seasonal influenza vaccination on morbidity, hospitalization rates, and reducing the severe forms of SARS-CoV-2 infection. That suggests a similar action in children.   The aim of the study: to establish the possible impact of influenza vaccination on the morbidity and severity of COVID-19 in children in Volgograd.   Materials and methods. The 303 children 3-17 years old without a history of chronic diseases were included in comparative prospective cohort study on the impact of influenza vaccination (235/303) on morbidity and severity of a new coronavirus infection COVID-19 vs non-vaccinated group (68/303).   Results. All children with new coronavirus infection COVID-19 (diagnosis confirmed by laboratory testing - U07.1) had mild symptoms of the disease. In all age groups, the morbidity and the severity of the new coronavirus infection COVID-19 among children vaccinated against influenza did not have significant differences with non-vaccinated group.   Conclusion. The results of our study did not support the hypothesis of a protective role of seasonal influenza vaccination on the morbidity and severity of COVID-19 in healthy children. Further research is needed to establish the effect of influenza vaccination on the severity of COVID-19 in children with chronic diseases.
新型冠状病毒感染 COVID-19 的大流行促使人们开始研究如何找到对免疫系统产生非特异性影响的方法,从而改变传染病的病程。成人研究结果表明,接种季节性流感疫苗对发病率、住院率和减少严重形式的 SARS-CoV-2 感染有积极作用。这表明在儿童中也有类似的作用。 研究目的:确定流感疫苗接种对伏尔加格勒儿童 COVID-19 发病率和严重程度的可能影响。 材料和方法对 303 名 3-17 岁无慢性病史的儿童进行了流感疫苗接种(235/303)与未接种疫苗组(68/303)对新型冠状病毒感染 COVID-19 的发病率和严重程度影响的前瞻性队列比较研究。 结果。所有新感染冠状病毒COVID-19(经实验室检测确诊--U07.1)的儿童都有轻微的疾病症状。在所有年龄组中,接种过流感疫苗的儿童与未接种过流感疫苗的儿童在新发冠状病毒感染 COVID-19 的发病率和严重程度上没有显著差异。 结论我们的研究结果不支持接种季节性流感疫苗对健康儿童 COVID-19 的发病率和严重程度具有保护作用的假设。要确定流感疫苗接种对慢性病儿童 COVID-19 严重程度的影响,还需要进一步的研究。
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引用次数: 0
Pseudosarcoptic mange in a child. Case from practice 儿童假肉芽肿疥疮。临床病例
Pub Date : 2023-10-24 DOI: 10.17021/1992-6499-2023-3-120-124
G. R. Sagitova, A. A. Antonova, E. V. Smirnova, V. M. Sereda
The article describes a clinical case of pseudoscabies. The parents of the child G., 10 yearsт old, turned to the pediatrician at the place of residence with complaints about sluggish and long-lasting rashes in the neck area on the left. The boy has been ill for two months. He was observed by a dermatovenereologist with suspected allergic dermatitis, received treatment with desensitizing drugs and corticosteroids. It was noteworthy that on the skin of the neck on the left, multiple papules of a rounded shape, pink in color were visualized, some of them were covered with hemorrhagic crusts. Due to the lack of effect from therapy and due to the fact that pseudo-scabies was suspected, a 10 % sodium benzyl benzoate ointment was prescribed. On the 4th day from the start of therapy, there was a positive trend. Thus, this clinical case is of practical interest for attracting the attention of doctors to a thorough history taking, searching for the causes leading to a protracted course of the disease and timely change of treatment regimen.
文章描述了一例假性疥疮的临床病例。10 岁儿童 G.的父母到居住地的儿科医生处就诊,主诉是左侧颈部出现疹子,且持续时间较长。男孩已经病了两个月。皮肤病学家对他进行了观察,怀疑他患了过敏性皮炎,并使用脱敏药物和皮质类固醇进行治疗。值得注意的是,在左侧颈部皮肤上发现了多个圆形的粉红色丘疹,其中一些丘疹上覆盖着出血的结痂。由于治疗效果不佳,而且怀疑是假性疥疮,医生给他开了 10 % 苯甲酸钠软膏。治疗开始后的第 4 天,病情出现好转趋势。因此,这个临床病例具有实际意义,可以引起医生的注意,全面询问病史,寻找导致病程延长的原因,并及时改变治疗方案。
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引用次数: 0
Human diphyllobothriasis: clinical and epidemiological characteristics of morbidity in the population of the Astrakhan region 人类二型钩端螺旋体病:阿斯特拉罕州居民发病率的临床和流行病学特征
Pub Date : 2023-10-24 DOI: 10.17021/1992-6499-2023-3-75-80
A. R. Kurbangalieva, R. S. Arakelyan, V. Vasil’kova, L. A. Sivtsova, K. Y. Zakaev, A. K. Akhmineeva
The clinical and epidemiological characteristics of the incidence of the population of the Astrakhan region with broad lentets are described. The clinical picture of the disease, the epidemiological process of diphyllobothriosis, methods of diagnosis and treatment of helminthiasis, as well as the probable causes of infection of the population are described.
该书描述了阿斯特拉罕州人口中阔大扁虱发病率的临床和流行病学特征。描述了该疾病的临床表现、双孢子虫病的流行过程、蠕虫病的诊断和治疗方法以及人口感染的可能原因。
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引用次数: 0
Modern principles of treatment of Peyronie's disease 治疗佩罗尼氏病的现代原则
Pub Date : 2023-10-24 DOI: 10.17021/1992-6499-2023-3-43-49
V. A. Zurnadzh'yants, D. V. Kurashov, E. Kchibekov, A. A. Proskurin
Fibroplastic induration of the penis, known as Peyronie's disease, remains one of the most difficult problems in medicine today. The prevalence of the disease among men ranges from 2.5 % to 9 % between the ages of 40 and 70 (statistics according to studies conducted by scientists in different countries). It is a benign, slowly progressive disease. It is characterized by the formation of idiopathic fibrous plaques in the albuginea of the penis. Peyronie's disease affects not only the organic part of a man's health, but also affects the psychological aspects of his activity, negatively affects the patient's professional activity and family life, which determines not only the medical, but also the social significance of the problem. The hypothesis of the occurrence of Peyronie's disease has received wide publicity as a result of a trauma to the penis, in which bleeding and delamination of the albuginea occur, and a neglected inflammatory process with disorganization of elastic fibers with collagen deposition heals with coarse scarring. Despite the fact that progress has been made in understanding the mechanisms of development of Peyronie's disease, the therapy of this disease remains one of the most complex and controversial. Analysis of literary sources shows that unsatisfactory results of surgical treatment are still at a high level. In modern medicine, there is practically no single focus that allows you to determine the tactics of treatment.
被称为 "佩罗尼氏病 "的阴茎纤维增生性压痕,仍然是当今医学界最棘手的问题之一。该病在 40 岁至 70 岁男性中的发病率为 2.5%至 9%(根据各国科学家的研究统计)。这是一种缓慢进展的良性疾病。其特征是在阴茎白膜上形成特发性纤维斑块。佩罗尼氏病不仅影响男性健康的器质性部分,还会影响其活动的心理方面,对患者的职业活动和家庭生活造成负面影响,这不仅决定了该问题的医学意义,也决定了其社会意义。关于佩罗尼氏病发生的假说已得到广泛宣传,认为它是阴茎外伤的结果,在外伤过程中,阴茎包膜发生出血和分层,被忽视的炎症过程伴有弹性纤维的紊乱和胶原沉积,愈合后形成粗糙的瘢痕。尽管在了解佩罗尼氏病的发病机制方面取得了进展,但这种疾病的治疗仍然是最复杂和最有争议的。对文献资料的分析表明,手术治疗效果不理想的比例仍然很高。在现代医学中,几乎没有一个焦点可以让你确定治疗策略。
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引用次数: 0
Intravital age-related anatomical dynamics of brain stem volume 与年龄相关的脑干体积内视解剖动态变化
Pub Date : 2023-10-24 DOI: 10.17021/1992-6499-2023-3-50-55
A. A. Balandin, G. S. Yurushbaeva, I. A. Balandina
The brain stem is phylogenetically the most ancient and multifunctional, anatomically complex brain structure. In spite of considerable attention to the study of age variability and sexual dimorphism of the brain stem, no works devoted to determining its volume using in vivo imaging techniques in individuals of both sexes within such a huge age range – from adolescence to old age - have been found.   The aim is to carry out a comparative analysis of brain stem volume in men and women in adolescence, first and second periods of adulthood, elderly age and old age according to magnetic resonance imaging data.   Materials and methods. The work is based on the analysis of the results of magnetic resonance imaging studies of 240 patients (124 men and 116 women) who were examined in the Department of Radiation Diagnostics in 2020-2022. The age of the subjects ranged from 16 to 88 years inclusive. The study sample consisted of persons without central/peripheral nervous system pathology, without alcohol/drug addiction, and mesocranes. All investigated material was divided into five groups according to age anatomical periodization.   Results. We revealed statistically significant decrease of the brain stem volume from the first period of mature age to senile age in both sexes (p < 0,01). In all age groups there was a tendency for predominance of brain stem volume parameters in men compared to women (p > 0,05). The results obtained in the course of the study can form the basis for the age-related anatomy of the human central nervous system in the future. It will help to provide more individualized approach to patients in medical practice, using  these results in the further clinical and basic researches for detailed understanding of age variability of the brain.
脑干在系统发育上是最古老、最多功能、解剖结构最复杂的大脑结构。尽管人们对脑干的年龄变异性和性双态性的研究相当关注,但目前还没有发现专门利用体内成像技术测定从青春期到老年期这一巨大年龄范围内男女个体脑干体积的研究成果。 本研究旨在根据磁共振成像数据,对青春期、成年期第一和第二阶段、老年期和老年期男性和女性的脑干体积进行比较分析。 材料和方法这项工作基于对 2020-2022 年在放射诊断部接受检查的 240 名患者(124 名男性和 116 名女性)的磁共振成像研究结果的分析。研究对象的年龄从 16 岁到 88 岁不等。研究样本包括无中枢/外周神经系统病变、无酒精/药物成瘾和中颅的人。所有调查材料按年龄解剖期分为五组。 研究结果我们发现,从成熟期的第一阶段到衰老期,男女两性的脑干体积都有统计学意义上的明显下降(p < 0,01)。在所有年龄组中,与女性相比,男性的脑干体积参数有占优势的趋势(p > 0,05)。研究过程中获得的结果可作为未来人类中枢神经系统年龄相关解剖学的基础。在进一步的临床和基础研究中利用这些结果详细了解大脑的年龄变异性,将有助于在医疗实践中为患者提供更加个性化的方法。
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引用次数: 0
Аррlication of lаsеr dоррler flоwmetry in gynecological practice 在妇科实践中应用激光测量仪
Pub Date : 2023-10-23 DOI: 10.17021/1992-6499-2023-3-22-32
L. Dikareva, P. K. Gadzhieva, A. A. Suverneva, Yu. Yu. Ukhanova, N. A. Vlasova
The аrtiсlе summarizes the dаtа оf scientific litеrаturе on miсrocirculаtiоn disоrders in patients with variоus gynecоlogical disеаses. The technique оf lаser dоррler flowmetry fоr assеssing lосаl chаnges in the micrоcirculatiоn оf thе pelvic оrgans is presented, аs well аs the results of clinicаl use оf this method аre presented.
本报告总结了有关各种妇科疾病患者的科学研究结果。介绍了用于评估盆腔微循环变化的流量计技术,以及临床使用该方法的结果。
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引用次数: 0
Modern methods of surgical treatment of pelvic organ prolapse 盆腔器官脱垂的现代手术治疗方法
Pub Date : 2023-10-23 DOI: 10.17021/1992-6499-2023-3-8-21
Y. A. Boldyreva, V. B. Tskhay, A. Polstyanoy, O. Polstyanaya, M. S. Tabakaeva
Genital prolapse is a relevant healthcare issue due to the increase in life expectancy and the need to improve the quality of life for patients. This article provides a review of literature on surgical treatment of genital prolapse, including the history of the evolution of correction methods. The use of mesh implants for correcting genital prolapse is separately described, as well as the complications associated with these surgeries.
由于预期寿命的延长和提高患者生活质量的需要,生殖器脱垂成为一个相关的医疗保健问题。本文回顾了有关生殖器脱垂手术治疗的文献,包括矫正方法的演变历史。另外还介绍了使用网状植入物矫正生殖器脱垂的方法,以及与这些手术相关的并发症。
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引用次数: 0
ON THE ISSUE OF PREPARING STANDARDS OF OPERATING PROCEDURES IN THE ASPECTS OF ENSURING THE SAFETY OF MEDICAL CARE 关于在确保医疗安全方面制定操作程序标准的问题
Pub Date : 2023-07-31 DOI: 10.29039/1992-6499-2023-39-46
A. Perminov, I. A. Kudryasheva, V. Kolomin, Natalya Fomenko
Among the key performance indicators of the health care system, the priority is to ensure the quality and safety of medical care. State regulation of these aspects of medical activity is certainly necessary, however, the regulations adopted at this level define the principles and foundations, which, in order to ensure their rigorous implementation, in most cases are subject to substantive detailing and development in local acts. In practice, the creation of comprehensive standards for each specific treatment and diagnostic process and operation is the prerogative and duty of the management of medical institutions. With the adoption in 2021 of sanitary and epidemiological requirements for the prevention of infectious diseases, the obligation to stand ardize operational processes is enshrined in law. At the same time, due to the lack of an approved development procedure and the form of standard operating procedures, the search for an optimal approach to the implementation of this quality management tool continues. The authors believe that the implementation of the development of standards of operating procedures should be carried out on the basis of the regulations for interaction within the framework of diagnostic and treatment processes, in turn, formed in accordance with the current state regulations in the direction of medical care. According to the authors, the effectiveness of standards of operating procedures in terms of ensuring the quality and safety of medical care and the introduction of the principle of lean operation into the work of a medical organization, among other things, largely depends on the regulation of the training processes for performers, control and evaluation system for the performance of standards of operating procedures. The paper presents a possible approach to the process of developing a standard of operating procedures as the basis of a quality management system for medical care
在医疗卫生体系的关键绩效指标中,确保医疗质量和安全是重中之重。国家对医疗活动的这些方面进行监管当然是必要的,但是,在这一级通过的监管规定了原则和基础,为了确保这些原则和基础得到严格执行,在大多数情况下,这些原则和基础需要在地方法律中进行实质性的细化和发展。在实践中,为每一个具体的治疗和诊断过程和操作制定综合标准是医疗机构管理层的特权和职责。随着2021年通过了预防传染病的卫生和流行病要求,法律规定了规范业务流程的义务。同时,由于缺乏经过批准的开发程序和标准操作程序的形式,对实施这一质量管理工具的最佳方法的探索仍在继续。作者认为,实施制定的操作程序标准,应在规章制度的基础上进行相互作用,在诊疗流程的框架内,依次按照国家现行规章制度形成医疗护理方向。作者认为,除其他外,操作程序标准在确保医疗质量和安全以及将精益操作原则引入医疗机构工作方面的有效性在很大程度上取决于对表演者的培训过程的规定,操作程序标准绩效的控制和评估体系。本文提出了一种可能的方法来制定一个标准的操作程序,作为医疗质量管理体系的基础
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引用次数: 0
RESEARCH OF THE POSSIBILITY OF THE SYSTEM COBALT – PHTHALEXON SA APPLICATION AS REAGENT ON SODIUM CAFFEINE-BENZOAT 对苯二甲酸钴体系作为咖啡因苯甲酸钠试剂的可行性研究
Pub Date : 2023-07-26 DOI: 10.29039/1992-6499-2023-26-31
M. Mazhitova, Suzanna G Azatyan, YU.V. Ocheredko, Milita Karibyants
The development of new and increasing the sensitivity of already known techniques of high quality and quantitative definition of medicinal substances is one of pharmaceutical chemistry problems. This paper presents the results of a study of the interaction of sodium caffeine benzoate with phthalexone SA in the presence of cobalt ions. It has been shown that the identification of this drug substance, as well as its quanti tative determination by reaction with the Co2 + - phthalexone SA system, is possible in highly acidic media. The use of the Co2 + - phthalexone SA complex was confirmed in an experiment using aqueous analytical systems.
开发新的、提高现有的高质量和定量测定方法的灵敏度是药物化学的难题之一。本文介绍了在钴离子存在下苯甲酸咖啡因钠与酞醌SA相互作用的研究结果。研究表明,在高酸性介质中,通过与Co2 + -酞醌SA体系的反应,可以对该原料药进行鉴别和定量测定。在水分析系统的实验中证实了Co2 + -邻苯二酮SA配合物的使用。
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引用次数: 0
HYGIENIC EDUCATION OF SCHOOLCHILDREN AS A MEANS OF PREVENTING THE ADVERSE EFFECTS OF OUT-OF-SCHOOL FACTORS 对学龄儿童进行卫生教育,作为预防校外因素不利影响的手段
Pub Date : 2023-05-16 DOI: 10.29039/2712-8164-2023-1-27-34
R. Devrishov, N. Skoblina, I. Khorosheva, I. A. Kudryasheva, E. Selina, E.V. Metelkina, Victoria Kuzmina, Natalia Barskova
Preservation and strengthening of children and adolescents' health is one of the most important direc-tions of the state policy of the Russian Federation. Purpose of the study: to assess the effectiveness of hygiene education techniques to prevent adverse effects of out-of-school factors on the health of schoolchildren. Materials and methods: In the dynamics from 2017 to 2019 in three educational or-ganizations of Astrakhan the hygienic education of schoolchildren and their parents was carried out. The influence of extracurricular factors on schoolchildren's health was assessed on the basis of a risk-based model. A total of 1940 Astrakhan schoolchildren aged 7–17 (878 boys and 1062 girls) partici-pated in the questionnaire-based survey. The data was statistically processed using Microsoft Office Excel 2007. Results: A cause-effect relationship was found to be 95,0 %, RR = 6,40, CI = 4,92–8.33, the etiological component was 67,5 %, sensitivity was 0,889, specificity was 0,778. There was a caus-al relationship between occurrence of myopia and failure to perform eye exercises by school children at home, 95,0 %, RR = 1,80, CI = 1,52–2,15, etiological component 26,7 %, sensitivity 0,750, speci-ficity 0,500. A causal relationship was found between the occurrence of musculoskeletal disorders and the use of shoes that did not meet hygienic recommendations, including those outside educational institutions – 95,0 %, RR = 1,75, CI = 1,50–2,00, etiological component 25,0 %, sensitivity – 0,700, specificity – 0,500. Within the framework of the conducted activities short recommendations – check-lists on the rational organization of the day and nutrition, motor activity, night sleep and leisure time organization were formulated. The information was also presented to the parents of the schoolchil-dren. Conclusion. Identification of intra-school and extra-school factors, establishment of cause-effect relationships and evaluation of possible adverse effects, will make it possible to develop relevant techniques of hygiene education, which will contribute to preservation
保护和加强儿童和青少年的健康是俄罗斯联邦国家政策的最重要方向之一。本研究的目的:评估卫生教育技术在预防校外因素对学童健康的不良影响方面的有效性。材料和方法:在2017 - 2019年的动态中,在阿斯特拉罕的三个教育组织中对学童及其家长进行了卫生教育。基于风险模型评估课外活动因素对小学生健康的影响。共有1940名7-17岁的阿斯特拉罕学童(878名男孩和1062名女孩)参加了以问卷为基础的调查。数据采用Microsoft Office Excel 2007进行统计处理。结果:两者的因果关系为95.0%,RR = 6,40, CI = 4,92 ~ 8.33,病因成分为67.5%,敏感性为0.889,特异性为0.778。小学生在家不做眼保健术与近视发生率有因果关系,为95,0 %,RR = 1,80, CI = 1,52 - 2,15,病因成分26.7%,敏感性0.750,特异性0.500。发现肌肉骨骼疾病的发生与使用不符合卫生建议的鞋子之间存在因果关系,包括教育机构以外的鞋子- 95,0 %,RR = 1,75, CI = 1,50 - 2,00,病因成分25.0 %,敏感性- 0,700,特异性- 0,500。在开展的活动框架内,制定了关于合理安排白天和营养、运动活动、夜间睡眠和休闲时间安排的简短建议清单。这些信息也提交给了学生的家长。结论。识别校内和校外因素,建立因果关系,评价可能的不良影响,将有可能发展相关的卫生教育技术,这将有助于保存
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引用次数: 0
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