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Incidence of antiphospholipid antibodies in new patients with non-Hodgkin lymphoma 新发非霍奇金淋巴瘤患者抗磷脂抗体的发生率
Pub Date : 2021-12-01 DOI: 10.52556/2587-3873.2021.4(91).34-38
S. Buruiana
Non-Hodgkin’s lymphoma (NHL) presents a group of histologically and biologically inhomogeneous B and T cell neoplasms of lymphoid tissue with a completely unidentified etiology. Antiphospholipid antibodies (aPL) are antibodies produced as a result of misinterpretation of platelet membrane phospholipids. It is well known that antiphospholipid antibodies are general risk factors that induce the disorder of the physiological process of hemostasis. Respectively, it is interesting to appreciate the incidence of antiphospholipid antibodies in new non-Hodgkin lymphomas patients depending on age, sex, type of non-Hodgkin’s lymphoma, the peculiarities of the onset of the disease, the degree of disease spread. According to the results of our study, we found a 14.8% incidence of aPL in primary patients with non-Hodgkin’s lymphoma, more frequently in men and people older than 50 years. The positivity of aPL antibodies depended on the immunohistochemical type of malignant lymphoma, the degree of dissemination of the tumor process and independent of the location of the tumor focus (nodal or extranodal) of NHL. The incidence of aPL antibody types was uneven with the obvious predominance of lupus anticoagulant. Th is study allowed the evaluation of the incidence of antiphospholipid antibodies in primary patients with non-Hodgkin’s lymphoma.
非霍奇金淋巴瘤(NHL)是一组组织学和生物学上不均匀的淋巴组织B细胞和T细胞肿瘤,其病因完全不明。抗磷脂抗体(aPL)是由于血小板膜磷脂被误读而产生的抗体。众所周知,抗磷脂抗体是引起止血生理过程紊乱的一般危险因素。新发非霍奇金淋巴瘤患者中抗磷脂抗体的发生率取决于年龄、性别、非霍奇金淋巴瘤的类型、疾病发病的特殊性、疾病传播的程度,这是很有趣的。根据我们的研究结果,我们发现原发性非霍奇金淋巴瘤患者aPL的发病率为14.8%,多见于男性和50岁以上的人群。aPL抗体的阳性取决于恶性淋巴瘤的免疫组织化学类型、肿瘤过程的播散程度,与NHL肿瘤病灶的位置(淋巴结或结外)无关。aPL抗体类型发生率不均匀,狼疮抗凝血药明显占优势。该研究允许评估非霍奇金淋巴瘤原发性患者抗磷脂抗体的发生率。
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引用次数: 0
Medical rehabilitation strategies in complex assistance of people with COVID-19. Literature review COVID-19患者复杂援助中的医疗康复策略文献综述
Pub Date : 2021-12-01 DOI: 10.52556/2587-3873.2021.4(91).16-22
Alisa Tabirta, Marina Bulai, Victoria Chihai, S. Plesca, Adrian Melnic
Covid-19 infection is a challenge for the medical system. The development of programs and strategies for the rehabilitation of people in different stages of the disease is relevant and current. The study is a bibliographic synthesis that aimed to analyze the methods and strategies of medical rehabilitation of patients with the new “coronavirus infection”. Data were collected from the academic databases PubMed, PubMed Central, Google, collecting relevant articles from 2019-2021, using the keywords: [“Covid-19” or “Covid 19” or “2019- CoV” or “SARS- CoV” or“ new coronavirus” or “SARS-CoV-2”] and [“rehabilitation ”or“ physical medicine”]. Th e aim of the study was to estimate the consequences of COVID-19 and to identify methods of recovery treatment. Because Covid-19 severely affects the respiratory system, pulmonary rehabilitation interventions with respiratory techniques and postural drainage combined with other physiotherapeutic methods may be used for a patient with COVID-19. The wide range of clinical manifestations in COVID-19 reveals the importance of adapting the rehabilitation program to functional deficits and patient needs. Multifactorial programs combined with active and supportive methods (physical therapy, exercise, occupational therapy, reflex therapy) are effective and can be used in the complex care of patients with COVID-19 at all stages of treatment.
Covid-19感染是医疗系统面临的挑战。为处于不同疾病阶段的人制定康复计划和战略是相关的和当前的。本研究是一项文献综合研究,旨在分析新型“冠状病毒感染”患者医学康复的方法和策略。数据收集自学术数据库PubMed、PubMed Central、Google,收集2019-2021年的相关文章,关键词:[“Covid”或“Covid 19”或“2019- CoV”或“SARS-CoV”或“新型冠状病毒”或“SARS-CoV-2”]和[“康复”或“物理医学”]。该研究的目的是估计COVID-19的后果,并确定康复治疗的方法。由于Covid-19严重影响呼吸系统,可对Covid-19患者采用呼吸技术和体位引流相结合的肺部康复干预措施,并结合其他物理治疗方法。COVID-19的广泛临床表现揭示了使康复计划适应功能缺陷和患者需求的重要性。多因素方案结合积极和支持性方法(物理治疗、运动、职业治疗、反射治疗)是有效的,可用于COVID-19患者治疗各个阶段的复杂护理。
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引用次数: 0
Biopharmaceutical and pharmacokinetic aspects of hopantenic acid in pediatric pharmacotherapy 小儿药物治疗中天麻酸的生物制药和药代动力学方面
Pub Date : 2021-08-01 DOI: 10.52556/2587-3873.2021.2(89).02
C. Ciobanu, D. Guranda, V. Oprea
The development of efficient, high-quality, harmless and affordable pharmaceutical forms for drug treatment in pediatrics is a current task of contemporary pharmacy. Currently, psychiatrists and neurologists from various curative-prophylactic institutions prescribe for children and adolescents nootropic preparations in the form of tablets, powders and syrups, in various neurological diseases, the share of which, according to national and international statistics, is constantly increasing. Currently, the prescription of hopanthenic acid is gaining popularity, thanks to its neuroprotective, neurotrophic, neurometabolic, antidepressant, anxiolytic and analgesic effects. The presented paper has as starting point the analysis of the structural-molecular properties of hopanthenic acid, exposed by biopharmaceutical study, pharmacokinetic parameters and strategies for optimizing pharmaceutical formulations with gastric release.
开发高效、优质、无害、价格合理的儿科药物治疗剂型是当代药学研究的重要课题。目前,来自各预防治疗机构的精神科医生和神经科医生为儿童和青少年开出片剂、粉剂和糖浆形式的益智制剂,用于治疗各种神经系统疾病,根据国家和国际统计数据,这一比例不断增加。目前,由于其神经保护、神经营养、神经代谢、抗抑郁、抗焦虑和镇痛作用,藿烷酸的处方越来越受欢迎。本文从生物药剂学研究、药代动力学参数和胃释药处方优化策略等方面分析了藿烷酸的结构分子特性。
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引用次数: 0
Obtaining and determining antioxidant activity of polyphenolic extracts obtained from propolis 蜂胶多酚提取物的制备及抗氧化活性测定
Pub Date : 2021-08-01 DOI: 10.52556/2587-3873.2021.2(89).01
C. Ciobanu, D. Guranda, N. Ciobanu, Maria Cojocaru-Toma, Rodica Solonari
Over the years, time has given us a whole series of novelties in the fi eld of natural medicine, which have managed to truly prove their value and keep up to date. Th e application of apitherapy has been known since ancient times and today the interest in this branch of natural medicine is growing worldwide. Among bee products, with an indisputable value is also propolis, which is currently widely studied, and as a result is the subject of multiple therapeutic uses based on evidence. Research in the fi eld of propolis preparations has expanded considerably and is of major medical and pharmaceutical interest. Propolis is an excellent anti-infl ammatory, healing and epithelializing, hepatoprotective, immuno-biostimulator, capillary tonic and tissue regenerator. It is remarkable that, due to its complexity and compositional variability, propolis retains its full antimicrobial capacity, unlike synthetic antibiotics, which bacteria develop resistance over time, requiring the periodic introduction of new antibiotics. Th e study on obtaining and analyzing propolis extracts, by determining the total polyphenolic and antioxidant activity, by scavenging method of the free radical DPPH, is an important premise for the use and development of new pharmaceutical forms containing propolis for multiple curative-prophylactic uses based on local raw materials.
多年来,在自然医学领域,时间给了我们一系列的新奇事物,这些事物已经真正证明了它们的价值,并保持了与时俱进。自古以来,蜂疗的应用就已为人所知,如今,全世界对这一自然医学分支的兴趣正在增长。在蜂产品中,具有无可争议价值的还有蜂胶,目前蜂胶被广泛研究,并因此成为基于证据的多种治疗用途的主题。蜂胶制剂领域的研究已经大大扩展,具有重要的医学和药学意义。蜂胶是一种极好的抗炎、愈合和上皮化、肝脏保护、免疫生物刺激、毛细血管滋补和组织再生。值得注意的是,由于其复杂性和组成的可变性,蜂胶保留了其全部的抗菌能力,不像合成抗生素,细菌会随着时间的推移产生耐药性,需要定期引入新的抗生素。通过测定蜂胶提取物的总多酚和抗氧化活性,通过清除自由基DPPH的方法来获取和分析蜂胶提取物,是利用和开发基于当地原料的具有多种治疗和预防用途的含蜂胶新剂型的重要前提。
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引用次数: 0
Nutritional status and determinants of malnutrition in institutionalized elderly people, provisional data 机构老年人营养状况和营养不良的决定因素,临时数据
Pub Date : 2021-08-01 DOI: 10.52556/2587-3873.2021.2(89).04
G. Soric, F. Lupascu-Volentir, Ana-Cristina Popescu, Elena Coşciug, A. Popa, Irina Stoicova, A. Negara
Nutrition is an important factor for health, physical and cognitive function, vitality, quality of life and longevity. Elderly people oft en have low food intake, induced by multifactorial causes, as a result, malnutrition is an independent risk factor for increased morbidity and mortality, regardless of the underlying pathologies (chronic organ failure, cognitive impairment, cancer, cardiovascular disease, type 2 diabetes etc.) including overweight or obese subjects.The prevalence of malnutrition varies from 4% to 10% in the elderly population from the community, from 15% to 38% for institutionalized elderly people and from 30% to 70% for hospitalized ones. The purpose of this study was to assess the nutritional status of institutionalized elderly people and establish correlations between the determinants of malnutrition and fragility syndrome.Th e epidemiological study is part of the project 20.80009.8007.25 “Fragility: diagnosis and prophylaxis in relation to medicopsychosocial problems of the vulnerable elderly”, included 50 patients institutionalized in the Republican Asylum for the Disabled and Retired in Chisinau.All persons were examined by the complex geriatric evaluation, approved by the order of the Ministry of Health no. 619 of 07.09.2010. According to the results, both malnutrition and the risk of malnutrition were high in institutionalized elderly people.Among the determinants of malnutrition, the highest association had the number of concomitant diseases, decreased functionality of the elderly, the presence of depression syndrome and cognitive disorders. At the same time, the malnutrition syndrome correlated with the fragility criteria but also with the degree of severity of frailty of the institutionalized elderly people.
营养是健康、身体和认知功能、活力、生活质量和长寿的重要因素。由于多因素的原因,老年人往往食物摄入量低,因此,营养不良是发病率和死亡率增加的一个独立危险因素,无论其潜在病理(慢性器官衰竭、认知障碍、癌症、心血管疾病、2型糖尿病等),包括超重或肥胖受试者。社区老年人营养不良的发生率从4%到10%不等,机构老年人的发生率从15%到38%不等,住院老年人的发生率从30%到70%不等。本研究的目的是评估机构老年人的营养状况,并建立营养不良和脆弱性综合征决定因素之间的相关性。流行病学研究是20.80009.8007.25“脆弱性:与脆弱老年人的医学心理社会问题有关的诊断和预防”项目的一部分,研究对象包括在基希讷乌共和国残疾人和退休人员收容所收容的50名患者。所有人都接受了复杂的老年评估检查,该检查得到了卫生部第539号命令的批准。2010年9月7日第619号。结果表明,机构老年人营养不良和营养不良的风险都很高。在营养不良的决定因素中,相关性最高的是伴随疾病的数量、老年人的功能下降、抑郁综合症和认知障碍的存在。同时,营养不良综合征不仅与机构老年人的脆弱性标准相关,而且与机构老年人的脆弱性严重程度相关。
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引用次数: 0
Nutritional status in the elderly with fragility syndrome 老年人脆性综合征的营养状况
Pub Date : 2021-08-01 DOI: 10.52556/2587-3873.2021.2(89).03
Ana-Cristina Popescu, G. Soric, F. Lupascu-Volentir, A. Negara, A. Popa, Elena Coşciug, Irina Stoicova
During the twentieth century life expectancy has increased significantly and it was estimated that by 2030, 21% of the world’s population will be >65 years. According to observations, fragility syndrome and nutritional status problems are very common among the elderly population, especially in old age. Fragility syndrome has a multifactorial origin and is a fundamental risk factor for deteriorating health and the installation of disability in the elderly. The purpose of the study was to establish the interrelationship of nutritional status with fragility syndrome and the impact on the functionality of the elderly. The information was searched in the PubMed, Hinari, Cochrane, Elsevier, Springer databases, including the offi cial pages of the European Geriatric Society, European Society for Clinical Nutrition and Metabolism, to identify scientifi c journals dedicated to nutrition in the elderly with fragility syndrome. Studies published in the period 2010-2020, in romanian and english, were selected. Th e specialized literature, scientifi c journals, clinical studies were researched, from which the most relevant 34 were selected. Elderly malnutrition is currently a global problem, its prevalence in people is 10-40%. Th e diagnosis of malnutrition aims to identify it and elucidate the causes. Weight loss is a criterion of the development of fragility, and nutrition-focused interventions can prevent the progression of fragility syndrome and loss of autonomy with the onset of dependence. Fragility is a geriatric syndrome that aff ects several areas of physical status, and malnutrition is one of the risk factors for this syndrome.
在20世纪,预期寿命显著增加,据估计,到2030年,世界人口的21%将超过65岁。据观察,脆弱综合征和营养状况问题在老年人群中非常普遍,特别是在老年人群中。脆弱性综合症具有多因素的根源,是老年人健康恶化和残疾的根本风险因素。本研究的目的是建立营养状况与脆弱综合征的相互关系,以及对老年人功能的影响。这些信息在PubMed, Hinari, Cochrane, Elsevier, Springer数据库中进行了搜索,包括欧洲老年学会,欧洲临床营养与代谢学会的官方页面,以确定专门研究脆性综合征老年人营养的科学期刊。选取了2010-2020年期间以罗马尼亚语和英语发表的研究。研究了专业文献、科学期刊、临床研究,从中选择了最相关的34篇。老年人营养不良目前是一个全球性问题,其在人群中的患病率为10-40%。营养不良诊断的目的是识别营养不良并阐明其原因。体重减轻是脆弱性发展的一个标准,以营养为重点的干预措施可以防止脆弱性综合征的进展和随着依赖的发生而丧失自主性。脆弱是一种老年综合症,影响身体状况的几个方面,营养不良是这种综合症的危险因素之一。
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引用次数: 0
Use of glucocorticoids in SARS CoV 2 infection: pros and cons 糖皮质激素在SARS冠状病毒感染中的应用:利弊
Pub Date : 1900-01-01 DOI: 10.52556/2587-3873.2021.1(88).01
Nicolae Bacinschi, Lucia Ţurcan, Lilia Podgurschi, Ina Gutu, Tatiana Covalschi, Maria Mihalachi-Anghel, Marin Chianu, Anastasia Caracas, E. Vasilache
Treatment of SARS CoV-2 infection is a major problem in contemporary medicine caused by the absence of specifi c antiviral drugs. Attempts to use many groups of drugs have had some successes and failures. Th e pathophysiological approach to the rationality of drug use is the basis of the eff ectiveness and safety of treatment. Glucocorticoids are a group of drugs capable of solving health problems in serious and critical situations. Physicians, despite the absence of evidence-based data, continue to use corticosteroids in critical situations based on pharmacological properties and experience. In SARS CoV-2 infection initially, at the beginning of the pandemic, the use of glucocorticoids was not recommended, and later, based on clinical studies, the World Health Organization issued a series of recommendations regarding the rationality of their use through an individualized approach. Th e latter involves determining the timing of initiation, selection of the drug, doses and duration of treatment. Th e key moment in this context is the time of the onset of the cytokine storm (the second week aft er the onset of symptoms) on which the administration of glucocorticoids is directed.
由于缺乏特异性抗病毒药物,治疗SARS - CoV-2感染是当代医学的一个主要问题。尝试使用多种药物有成功也有失败。病理生理学方法对用药合理性的判断是治疗有效性和安全性的基础。糖皮质激素是一组能够在严重危急情况下解决健康问题的药物。尽管缺乏循证数据,医生仍根据药理学性质和经验在危急情况下继续使用皮质类固醇。在SARS - CoV-2感染中,最初,在大流行开始时,不建议使用糖皮质激素,后来,根据临床研究,世界卫生组织发布了一系列关于通过个体化方法使用糖皮质激素的合理性的建议。后者包括确定起始时间、药物选择、剂量和治疗持续时间。在这种情况下,关键时刻是细胞因子风暴开始的时间(症状开始后的第二周),糖皮质激素的施用是针对的。
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引用次数: 0
Pure embryonal carcinoma of the testis in an adult male patient: case report 成年男性睾丸纯胚胎性癌1例
Pub Date : 1900-01-01 DOI: 10.52556/2587-3873.2021.1(88).03
S. Kucuk, Izzet Goker Kucuk, B. Mızrak, K. Ongel
As a case presentation, the present paper aims to present a patient with pure embryonal carcinoma, which is rarely seen, together with the relevant literature. Th e case is a 36-year-old male patient, who applied to the clinic with complaints of pain and swelling in the left testis. In the scrotal doppler ultrasonography, hypoechoic solid lesion contoured to the lobule almost fi lling the left testis and having the size of 25x60 mm were observed. Histopathological and immunohistochemical analysis of the this case was diagnosed with pure embryonal carcinoma. All the patients with complaint of pain-free mass in testis should be investigated. Although the pure embryonal carcinoma is rarely seen, it is one of the tumors that can be clinically and histopathologically confused with other testis tumors and should be considered for the patients applying to the clinic with complaints of pain-free mass in testis.
作为病例报告,本文报道一例罕见的纯胚胎性癌,并结合相关文献。该病例为一名36岁男性患者,因左侧睾丸疼痛和肿胀前来就诊。阴囊多普勒超声示低回声实性病灶,轮廓为小叶,几乎填满左侧睾丸,大小为25x60mm。经组织病理及免疫组化分析,诊断为纯胚胎性癌。所有主诉睾丸无痛性肿块的患者都应接受检查。纯胚胎性癌虽少见,但在临床及组织病理学上可与其他睾丸肿瘤混淆,对于以睾丸无痛性肿块为主诉的临床患者应予以考虑。
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引用次数: 1
Problematic aspects in the implementation of the legal mechanisms regarding the management of the waste resulted from the medical activity 在执行管理医疗活动产生的废物的法律机制方面存在的问题
Pub Date : 1900-01-01 DOI: 10.52556/2587-3873.2021.1(88).04
Igor Seremet
Medical services in Moldova remain behind the minimum European standards, which exposes workers in the fi eld and hospitalized patients to the risk of transmitting nosocomial infections in medical institutions. In this respect, the hygiene conditions related to the management and destruction of waste from medical activity are not good enough: the health and environmental risks persist. Th e Moldovan health authorities, aware of this issue, have recently taken some real steps to standardize medical waste management procedures by publishing a 2018 Sanitary Regulation on Waste Management in order to strengthen waste legislation. However, the standardized practices of medical waste management, which are to be applied at the moment in various medical institutions in the country, remain only at the level of normative acts, without identifying the real mechanisms to implement them. Th e problem is not «what to do», but «how to do it».
摩尔多瓦的医疗服务仍然落后于欧洲最低标准,这使外勤工作人员和住院病人面临在医疗机构传播医院感染的风险。在这方面,与医疗活动产生的废物的管理和销毁有关的卫生条件不够好:健康和环境风险仍然存在。摩尔多瓦卫生当局意识到这一问题,最近采取了一些切实措施,通过发布2018年《废物管理卫生条例》,使医疗废物管理程序标准化,以加强废物立法。然而,目前将在国内各医疗机构实施的医疗废物管理的标准化做法仍停留在规范性行为的层面,没有确定执行这些行为的真正机制。问题不在于“做什么”,而在于“怎么做”。
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引用次数: 0
Harmful effects of electromagnetic field on different tissues: a review 电磁场对不同组织的危害研究进展
Pub Date : 1900-01-01 DOI: 10.52556/2587-3873.2021.1(88).02
Ahmet Murat Ișil, B. Erden, K. Ongel
Studies about the potential eff ects of the electromagnetic fi eld on the human body are increasing day by day. In this study; new investigations on this fi eld were tried to be explained by the help of literature. It is shown in many studies that electromagnetic waves as well as the electromagnetic field that is given out by some of the equipment we use, create negative eff ects on biological systems of humans. Moreover; it had concluded that there are roles of molecular pathways such as oxidative stress on electromagnetic fi eld induced diseases. Th ese eff ects are the short term eff ects and long term eff ects. Preventitive measures should be high priority and risks should be minimized.
关于电磁场对人体潜在影响的研究日益增多。在本研究中;这一领域的新研究试图借助文献加以解释。许多研究表明,电磁波以及我们使用的一些设备发出的电磁场对人类的生物系统产生负面影响。此外;结论认为,氧化应激等分子途径在电磁场诱发疾病中具有一定的作用。这些影响包括短期影响和长期影响。应高度重视预防措施,并尽量减少风险。
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引用次数: 0
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Public Health, Economy and Management in Medicine
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