Objective: To determine the clinical value of applying individualized postpartum pelvic floor rehabilitation at different time points in the early postpartum period. Methods: 184 patients admitted to the Affiliated Hospital of Jiangsu University from February 2021 to December 2022 were included in the study. Upon admission, they were divided into two groups, a conventional group (n = 46) and an intervention group (n = 138), by the random number table method. The patients in the conventional group underwent postpartum routine rehabilitation, while those in the intervention group underwent individualized postpartum pelvic floor rehabilitation. The patients in the intervention group were further divided into intervention group 1 (6–8 weeks), intervention group 2 (8–10 weeks), and intervention group 3 (10–13 weeks) according to the time of care. The rehabilitation effects were compared between the groups. Results: The pelvic floor muscle function of the patients in the intervention group was more ideal compared with those in the conventional group, and the incidence of adverse reactions was lower among patients in the intervention group; the comparison of the above indicators was statistically significant (P < 0.05); however, there was no significant difference in the relevant indicators among intervention group 1, group 2, and group 3 (P > 0.05). Conclusion: Although our study showed no significant difference in the effects of individualized postpartum pelvic floor rehabilitation at different time points in the early postpartum period, individualized postpartum pelvic floor rehabilitation in the early postpartum period has definite clinical value, as it improves pelvic floor muscle function and reduces the incidence of adverse reactions.
{"title":"Comparison of the Effects of Individualized Postpartum Pelvic Floor Rehabilitation at Different Time Points in the Early Postpartum Period","authors":"T. Dong","doi":"10.26689/aogr.v1i1.5008","DOIUrl":"https://doi.org/10.26689/aogr.v1i1.5008","url":null,"abstract":"Objective: To determine the clinical value of applying individualized postpartum pelvic floor rehabilitation at different time points in the early postpartum period. Methods: 184 patients admitted to the Affiliated Hospital of Jiangsu University from February 2021 to December 2022 were included in the study. Upon admission, they were divided into two groups, a conventional group (n = 46) and an intervention group (n = 138), by the random number table method. The patients in the conventional group underwent postpartum routine rehabilitation, while those in the intervention group underwent individualized postpartum pelvic floor rehabilitation. The patients in the intervention group were further divided into intervention group 1 (6–8 weeks), intervention group 2 (8–10 weeks), and intervention group 3 (10–13 weeks) according to the time of care. The rehabilitation effects were compared between the groups. Results: The pelvic floor muscle function of the patients in the intervention group was more ideal compared with those in the conventional group, and the incidence of adverse reactions was lower among patients in the intervention group; the comparison of the above indicators was statistically significant (P < 0.05); however, there was no significant difference in the relevant indicators among intervention group 1, group 2, and group 3 (P > 0.05). Conclusion: Although our study showed no significant difference in the effects of individualized postpartum pelvic floor rehabilitation at different time points in the early postpartum period, individualized postpartum pelvic floor rehabilitation in the early postpartum period has definite clinical value, as it improves pelvic floor muscle function and reduces the incidence of adverse reactions.","PeriodicalId":269611,"journal":{"name":"Advances in Obstetrics and Gynecology Research","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134416584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Natacha B. Murillo, C. Ramacciotti, Carolina Fux-Otta, L. Cecenarro
Pregnancy in patients with Cushing’s disease (CD) is rare and is associated with significant maternal and fetal complications. We report a case of CD who achieved uncomplicated pregnancy and delivery after treatment with low-dose cabergoline. A 29-year-old woman was diagnosed with CD (adrenocorticotropic hormone-secreting macrotumor that causes displacement of the optic chiasm, infiltrates the right cavernous sinus, and engulfs the internal carotid artery) and underwent transsphenoidal surgery with incomplete tumor resection. After a year of clinical stability, her symptoms recurred, and cabergoline was initiated. During the treatment, the patient conceived, and the medication was suspended. In the first trimester, clinical and biochemical parameters indicate active CD, so cabergoline was reinstated at a low dose for the rest of the pregnancy. With the dopaminergic agonist, her clinical and laboratory parameters normalized, and the patient gave birth to a healthy girl at 38 weeks, within normal percentiles and without complications. Pregnancy in patients diagnosed with CD is a rare event, and the consequences of maternal-fetal exposure to hypercortisolism can be severe. Our experience with the use of cabergoline at low doses in a pregnant woman with CD contributes favorable data to the scarce existing literature reports, adding evidence on the safety profile of the drug in this population.
{"title":"Cushing’s Disease in Pregnancy and Cabergoline Use: Obstetric and Neonatal Outcomes","authors":"Natacha B. Murillo, C. Ramacciotti, Carolina Fux-Otta, L. Cecenarro","doi":"10.26689/aogr.v1i1.4947","DOIUrl":"https://doi.org/10.26689/aogr.v1i1.4947","url":null,"abstract":"Pregnancy in patients with Cushing’s disease (CD) is rare and is associated with significant maternal and fetal complications. We report a case of CD who achieved uncomplicated pregnancy and delivery after treatment with low-dose cabergoline. A 29-year-old woman was diagnosed with CD (adrenocorticotropic hormone-secreting macrotumor that causes displacement of the optic chiasm, infiltrates the right cavernous sinus, and engulfs the internal carotid artery) and underwent transsphenoidal surgery with incomplete tumor resection. After a year of clinical stability, her symptoms recurred, and cabergoline was initiated. During the treatment, the patient conceived, and the medication was suspended. In the first trimester, clinical and biochemical parameters indicate active CD, so cabergoline was reinstated at a low dose for the rest of the pregnancy. With the dopaminergic agonist, her clinical and laboratory parameters normalized, and the patient gave birth to a healthy girl at 38 weeks, within normal percentiles and without complications. Pregnancy in patients diagnosed with CD is a rare event, and the consequences of maternal-fetal exposure to hypercortisolism can be severe. Our experience with the use of cabergoline at low doses in a pregnant woman with CD contributes favorable data to the scarce existing literature reports, adding evidence on the safety profile of the drug in this population.","PeriodicalId":269611,"journal":{"name":"Advances in Obstetrics and Gynecology Research","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130295377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To investigate the actual sleep conditions at four time points from the last trimester of pregnancy to 3 months postpartum, and to examine the relationship between sleep and minor problems affecting sleep. Methods: A cross-sectional survey on the frequency of minor problems, Pittsburgh Sleep Quality Index (PSQI), and observations in a sleep diary was carried out on women at the end of pregnancy, 2 weeks postpartum, 1 month postpartum, and 3 months postpartum. The questionnaires were distributed to 165 participants. Correlation coefficients were obtained for each item and each scale, and the associations were analyzed. Results: The number of valid responses was 127. In the evaluation of sleep, sleep duration was the shortest and sleep quality was the lowest in the first month after delivery based on the PSQI score. In the correlation between “psychiatric symptoms” and sleep, women with anxiety and nervousness at the end of pregnancy were associated with poorer sleep quality. At all time-points, there was a significant association between “psychiatric symptoms” and poor sleep quality. Conclusion: An association exists between “psychiatric symptoms” and poor sleep quality in women from the last trimester of pregnancy to 3 months postpartum.
{"title":"Actual Sleep Conditions from the Last Trimester of Pregnancy to Three Months Postpartum and the Associated Minor Problems","authors":"Yumi Takagi, Kyoko Hanahara, Yumiko Tateoka","doi":"10.26689/aogr.v1i1.4942","DOIUrl":"https://doi.org/10.26689/aogr.v1i1.4942","url":null,"abstract":"Objective: To investigate the actual sleep conditions at four time points from the last trimester of pregnancy to 3 months postpartum, and to examine the relationship between sleep and minor problems affecting sleep. Methods: A cross-sectional survey on the frequency of minor problems, Pittsburgh Sleep Quality Index (PSQI), and observations in a sleep diary was carried out on women at the end of pregnancy, 2 weeks postpartum, 1 month postpartum, and 3 months postpartum. The questionnaires were distributed to 165 participants. Correlation coefficients were obtained for each item and each scale, and the associations were analyzed. Results: The number of valid responses was 127. In the evaluation of sleep, sleep duration was the shortest and sleep quality was the lowest in the first month after delivery based on the PSQI score. In the correlation between “psychiatric symptoms” and sleep, women with anxiety and nervousness at the end of pregnancy were associated with poorer sleep quality. At all time-points, there was a significant association between “psychiatric symptoms” and poor sleep quality. Conclusion: An association exists between “psychiatric symptoms” and poor sleep quality in women from the last trimester of pregnancy to 3 months postpartum.","PeriodicalId":269611,"journal":{"name":"Advances in Obstetrics and Gynecology Research","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115200730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thayná Champe da Silva, Maria Goreti Finkler, Letícia Slodkowski, Jaíne Gabriela Frank, Poliana Ribas Tolfo, Dionéia Dalcin, Iara Denise Endruweit Battisti, Z. Anastácio
Background: Considering the development model adopted in Brazilian agriculture, which is based on the increasing demand for chemicals, studies that analyze the impact of pesticide use are relevant to measure the developments in affected populations. Objective: The aim of this study was to conduct a literature review using the digital platform, searching for scientific publications from 2009–2019 on exposure of pregnant women to pesticides. Methods: We used PubMed to search for scientific articles published between January 1, 2009, and December 31, 2019, and related to exposure of pregnant women to pesticides in rural areas. Results: Initially, 207 publications were selected considering the titles and abstracts. Literature works that did not meet the inclusion criteria were excluded. After selection, 15 studies remained. According to the publications on the exposure of pregnant women to pesticides in rural areas from 2009 to 2019, it was found that the damage caused by pesticide exposure to the health of pregnant women and their babies includes problems in gestational weight gain, premature birth, low birth weight, presence of pesticides in blood of both mother and newborn, presence of agricultural pesticides in the cerebral cortex of fetus, and miscarriages. Conclusion: Future prospective studies at individual level are needed to better assess the potential impact of pesticide exposure on the health of pregnant women and newborns.
{"title":"Exposure to Pesticides in Pregnant Women: An Integrative Review","authors":"Thayná Champe da Silva, Maria Goreti Finkler, Letícia Slodkowski, Jaíne Gabriela Frank, Poliana Ribas Tolfo, Dionéia Dalcin, Iara Denise Endruweit Battisti, Z. Anastácio","doi":"10.26689/aogr.v1i1.4941","DOIUrl":"https://doi.org/10.26689/aogr.v1i1.4941","url":null,"abstract":"Background: Considering the development model adopted in Brazilian agriculture, which is based on the increasing demand for chemicals, studies that analyze the impact of pesticide use are relevant to measure the developments in affected populations. Objective: The aim of this study was to conduct a literature review using the digital platform, searching for scientific publications from 2009–2019 on exposure of pregnant women to pesticides. Methods: We used PubMed to search for scientific articles published between January 1, 2009, and December 31, 2019, and related to exposure of pregnant women to pesticides in rural areas. Results: Initially, 207 publications were selected considering the titles and abstracts. Literature works that did not meet the inclusion criteria were excluded. After selection, 15 studies remained. According to the publications on the exposure of pregnant women to pesticides in rural areas from 2009 to 2019, it was found that the damage caused by pesticide exposure to the health of pregnant women and their babies includes problems in gestational weight gain, premature birth, low birth weight, presence of pesticides in blood of both mother and newborn, presence of agricultural pesticides in the cerebral cortex of fetus, and miscarriages. Conclusion: Future prospective studies at individual level are needed to better assess the potential impact of pesticide exposure on the health of pregnant women and newborns.","PeriodicalId":269611,"journal":{"name":"Advances in Obstetrics and Gynecology Research","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115218985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Serin, P. Savaş, N. Özdemir, O. Zekioğlu, L. Akman
Objective: Molecular classification has been the most important development in endometrial carcinomas in recent years. This classification divides tumors into four groups: (i) POLE mutant group, (ii) microsatellite instable (MSI) group, (iii) high copy number group (P53 mutation), and (iv) low copy number group. Among these groups, POLE and MSI groups stand out with their better prognosis and potential to benefit from immune-control inhibitor therapy. In our study, we aimed to compare the prognostic parameters of patients with and without nuclear expression loss in MMR proteins (MLH-1, PMS-2, MSH-2, MSH-6) by immunohistochemical (IHC) method. Methods: Between 2017 and 2020, 80 patients who were diagnosed with endometrial carcinoma in hysterectomy material and whose MMR proteins were evaluated as IHC were included in the study. Patients with and without MMR loss were compared in terms of tumor size, histological grade (HD), depth of myometrial invasion, lymphovascular invasion (LVI), and cervical involvement. Results: Loss of any of the MMR proteins was present in 37 cases (46.3%), while 43 cases (53.7%) had no loss. When the cases were compared in terms of loss of MMR protein nuclear expression, 45.9% (17/37) of the cases with loss and 27.9% (12/43) of the cases without loss had histologic grade III (P = 0.03). There was no statistically significant difference between the two groups in terms of myometrium 1/2 external invasion, cervical stromal involvement, and LVI. Conclusion: Approximately half of the patients in our study lost at least one of the MMR proteins. The most common losses were MLH-1 and PMS-2. The HD of patients with loss of nuclear expression of MMR proteins tended to be statistically significantly higher than those without loss.
{"title":"Investigation of the Relationship Between Immunohistochemical Mismatch Repair (MMR) Protein Expression and Prognostic Parameters in Endometrial Carcinomas","authors":"G. Serin, P. Savaş, N. Özdemir, O. Zekioğlu, L. Akman","doi":"10.26689/aogr.v1i1.4943","DOIUrl":"https://doi.org/10.26689/aogr.v1i1.4943","url":null,"abstract":"Objective: Molecular classification has been the most important development in endometrial carcinomas in recent years. This classification divides tumors into four groups: (i) POLE mutant group, (ii) microsatellite instable (MSI) group, (iii) high copy number group (P53 mutation), and (iv) low copy number group. Among these groups, POLE and MSI groups stand out with their better prognosis and potential to benefit from immune-control inhibitor therapy. In our study, we aimed to compare the prognostic parameters of patients with and without nuclear expression loss in MMR proteins (MLH-1, PMS-2, MSH-2, MSH-6) by immunohistochemical (IHC) method. Methods: Between 2017 and 2020, 80 patients who were diagnosed with endometrial carcinoma in hysterectomy material and whose MMR proteins were evaluated as IHC were included in the study. Patients with and without MMR loss were compared in terms of tumor size, histological grade (HD), depth of myometrial invasion, lymphovascular invasion (LVI), and cervical involvement. Results: Loss of any of the MMR proteins was present in 37 cases (46.3%), while 43 cases (53.7%) had no loss. When the cases were compared in terms of loss of MMR protein nuclear expression, 45.9% (17/37) of the cases with loss and 27.9% (12/43) of the cases without loss had histologic grade III (P = 0.03). There was no statistically significant difference between the two groups in terms of myometrium 1/2 external invasion, cervical stromal involvement, and LVI. Conclusion: Approximately half of the patients in our study lost at least one of the MMR proteins. The most common losses were MLH-1 and PMS-2. The HD of patients with loss of nuclear expression of MMR proteins tended to be statistically significantly higher than those without loss.","PeriodicalId":269611,"journal":{"name":"Advances in Obstetrics and Gynecology Research","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121154183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rodolfo E. Lopez-Orellana, Francisco J. Kaplan-Delmar, Andres I. Yuivar-Santana, Tiare A. Hevia-Grez
Background: Pelvic organ prolapse (POP) is a common pathology affecting up to 60% of women. Transvaginal high uterosacral ligament suspension (HUSLS) is an alternative treatment for apical prolapse. HUSLS has short operative and recovery time, as well as low complication rate. Objective: To evaluate the objective and subjective success rates in patients with apical prolapse who underwent HUSLS at Quilpué Hospital over a 24-month follow-up. Materials: A retrospective, observational, descriptive study was carried out, and all symptomatic patients with apical prolapse ? stage 2 POP-Q classification who underwent HUSLS between September 2014 and October 2019 were included in the study. Data were obtained from the database of the Urogynecology Unit of Quilpué Hospital, after approval by the ethics committee. Objective success was defined as C-point at 1 cm above the hymen, while subjective success was defined as “better” or “much better” in the Patient Global Impression of Improvement (PGI-I) scale and/or a visual analog scale (VAS) greater than 80% at 24 months of follow-up. Results: Of the 46 patients included in the study, the objective success rate was 84%, while the subjective success rate was 70%. Conclusion: Transvaginal HUSLS with permanent sutures is an excellent alternative treatment for apical prolapse, with a success rate similar to the gold standard at 24 months follow-up.
{"title":"High Uterosacral Ligament Suspension with Nonabsorbable Sutures in Apical Prolapse: A 24-Month Follow-Up","authors":"Rodolfo E. Lopez-Orellana, Francisco J. Kaplan-Delmar, Andres I. Yuivar-Santana, Tiare A. Hevia-Grez","doi":"10.26689/aogr.v1i1.4944","DOIUrl":"https://doi.org/10.26689/aogr.v1i1.4944","url":null,"abstract":"Background: Pelvic organ prolapse (POP) is a common pathology affecting up to 60% of women. Transvaginal high uterosacral ligament suspension (HUSLS) is an alternative treatment for apical prolapse. HUSLS has short operative and recovery time, as well as low complication rate. Objective: To evaluate the objective and subjective success rates in patients with apical prolapse who underwent HUSLS at Quilpué Hospital over a 24-month follow-up. Materials: A retrospective, observational, descriptive study was carried out, and all symptomatic patients with apical prolapse ? stage 2 POP-Q classification who underwent HUSLS between September 2014 and October 2019 were included in the study. Data were obtained from the database of the Urogynecology Unit of Quilpué Hospital, after approval by the ethics committee. Objective success was defined as C-point at 1 cm above the hymen, while subjective success was defined as “better” or “much better” in the Patient Global Impression of Improvement (PGI-I) scale and/or a visual analog scale (VAS) greater than 80% at 24 months of follow-up. Results: Of the 46 patients included in the study, the objective success rate was 84%, while the subjective success rate was 70%. Conclusion: Transvaginal HUSLS with permanent sutures is an excellent alternative treatment for apical prolapse, with a success rate similar to the gold standard at 24 months follow-up.","PeriodicalId":269611,"journal":{"name":"Advances in Obstetrics and Gynecology Research","volume":"135 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122136239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Uterine torsion is a rare gynecological emergency. It occurs mainly in gravid uterus and extremely rarely in non-gravid uterus. In this article, we report a case of torsion of non-gravid uterus accompanied by a large intramural leiomyoma with focus on computed tomography and magnetic resonance imaging.
{"title":"Uterine Torsion Due to Uterine Fibroid in Non-Pregnant Women: A Case Report","authors":"Yuri Kim, Y. Ku, Y. Won","doi":"10.26689/aogr.v1i1.4922","DOIUrl":"https://doi.org/10.26689/aogr.v1i1.4922","url":null,"abstract":"Uterine torsion is a rare gynecological emergency. It occurs mainly in gravid uterus and extremely rarely in non-gravid uterus. In this article, we report a case of torsion of non-gravid uterus accompanied by a large intramural leiomyoma with focus on computed tomography and magnetic resonance imaging.","PeriodicalId":269611,"journal":{"name":"Advances in Obstetrics and Gynecology Research","volume":"91 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126191598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To analyze the therapeutic effect of Guishen Yugong Decoction + sequential hormone (estrogen and progesterone) replacement therapy and its effect on serum sex hormones in patients with premature ovarian failure. Methods: From July 2020 to July 2022, 100 patients with premature ovarian failure were included in the study. Random number table method was used to divide the patients into groups: the control group received sequential hormone replacement therapy, whereas the treatment group received Guishen Yugong Decoction + sequential hormone replacement therapy. The curative effect, traditional Chinese medicine (TCM) syndrome scores, serum sex hormone levels, and incidence of adverse reactions of both groups of patients were compared. Results: The total effective rate in the treatment group was higher than that in the control group, P < 0.05; the TCM syndrome scores in the treatment group were lower than those in the control group, P < 0.05; the serum sex hormone indices in the treatment group were better than those in the control group (P < 0.05); the treatment group had lower incidence of adverse reactions, as compared to the control group (P < 0.05). Conclusion: Guishen Yugong Decoction + sequential hormone replacement therapy can regulate serum sex hormone levels and relieve symptoms of premature ovarian failure. This treatment is not only effective, but also safe for clinical use.
{"title":"Guishen Yugong Decoction Combined with Sequential Hormone Replacement Therapy in the Treatment of Premature Ovarian Failure and Its Effect on Serum Sex Hormones","authors":"Limei Qin, Jia-Xin Qin","doi":"10.26689/aogr.v1i1.5081","DOIUrl":"https://doi.org/10.26689/aogr.v1i1.5081","url":null,"abstract":"Objective: To analyze the therapeutic effect of Guishen Yugong Decoction + sequential hormone (estrogen and progesterone) replacement therapy and its effect on serum sex hormones in patients with premature ovarian failure. Methods: From July 2020 to July 2022, 100 patients with premature ovarian failure were included in the study. Random number table method was used to divide the patients into groups: the control group received sequential hormone replacement therapy, whereas the treatment group received Guishen Yugong Decoction + sequential hormone replacement therapy. The curative effect, traditional Chinese medicine (TCM) syndrome scores, serum sex hormone levels, and incidence of adverse reactions of both groups of patients were compared. Results: The total effective rate in the treatment group was higher than that in the control group, P < 0.05; the TCM syndrome scores in the treatment group were lower than those in the control group, P < 0.05; the serum sex hormone indices in the treatment group were better than those in the control group (P < 0.05); the treatment group had lower incidence of adverse reactions, as compared to the control group (P < 0.05). Conclusion: Guishen Yugong Decoction + sequential hormone replacement therapy can regulate serum sex hormone levels and relieve symptoms of premature ovarian failure. This treatment is not only effective, but also safe for clinical use.","PeriodicalId":269611,"journal":{"name":"Advances in Obstetrics and Gynecology Research","volume":"63 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122148800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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