首页 > 最新文献

Kateb Journal of Medical Sciences and Biotechnology最新文献

英文 中文
Determination of the Course of COVID-19 Pandemic Using Modified Logistic Modeling 利用修正Logistic模型确定COVID-19大流行过程
Pub Date : 2021-07-04 DOI: 10.32592/kjmsb.2021.1.1.2
Introduction: COVID-19 appeared in China at the end of 2019. It then spread all over the world very quickly. The new type of corona virus COVID-19, which causes respiratory tract infection, is destructive with its high rate of transmission and mortality rate.Materials and Methods: In this study, determining the course of the COVID-19 pandemic for next 4 months in Afghanistan with the help of a specially modified mathematical modeling is intended to reveal.Results: results of our study show that the COVID-19 pandemic can affect a large population in Afghanistan in a short time. However, it is possible to reduce the number of cases and deaths very effectively with easy measures.Keywords: COVID-19, precautions, pandemic, logistic mathematical model, Afghanistan.
导语:2019年底,中国出现新冠肺炎疫情。然后它很快就传遍了世界。新型冠状病毒COVID-19可引起呼吸道感染,具有高传播率和高死亡率的破坏性。材料和方法:在本研究中,借助经过特殊修改的数学模型,确定未来4个月阿富汗COVID-19大流行的进程,旨在揭示。结果:我们的研究结果表明,COVID-19大流行可以在短时间内影响阿富汗的大量人口。然而,采取简单措施可以非常有效地减少病例和死亡人数。关键词:COVID-19,预防措施,大流行,logistic数学模型,阿富汗
{"title":"Determination of the Course of COVID-19 Pandemic Using Modified Logistic Modeling","authors":"","doi":"10.32592/kjmsb.2021.1.1.2","DOIUrl":"https://doi.org/10.32592/kjmsb.2021.1.1.2","url":null,"abstract":"Introduction: COVID-19 appeared in China at the end of 2019. It then spread all over the world very quickly. The new type of corona virus COVID-19, which causes respiratory tract infection, is destructive with its high rate of transmission and mortality rate.\u0000Materials and Methods: In this study, determining the course of the COVID-19 pandemic for next 4 months in Afghanistan with the help of a specially modified mathematical modeling is intended to reveal.\u0000Results: results of our study show that the COVID-19 pandemic can affect a large population in Afghanistan in a short time. However, it is possible to reduce the number of cases and deaths very effectively with easy measures.\u0000\u0000Keywords: COVID-19, precautions, pandemic, logistic mathematical model, Afghanistan.","PeriodicalId":282364,"journal":{"name":"Kateb Journal of Medical Sciences and Biotechnology","volume":"178 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133649124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Low and Slow COVID-19 Pandemic of Timor-Leste 2019冠状病毒病在东帝汶的低流行和缓慢流行
Pub Date : 1900-01-01 DOI: 10.32592/kjmsb.2021.1.1.6
COVID-19 is a highly contagious disease that has penetrated many countries including Timor-Leste. Being relatively new with frail healthcare system, lack of access to water and sanitation facilities, and high poverty level in addition to its proximity to Indonesia—a country with increasing number of infections and fatalities, it was expected that this country would be conquered by this public health threat. Conversely, it has managed to prevent community transmission, maintain low infection rate, and record zero deaths since the first case was confirmed on 21 March 2020. The country’s feat against this public health threat appears to be attributable to the immediate action of the government, support from international organizations, effective communication strategies, involvement of the church, and importance given to water, sanitation, and hygiene programs. The pandemic further emphasized the need of the country for more investments on the healthcare system. Nevertheless, despite the limitations on resources, the current tally of COVID-19 cases in Timor-Leste manifests how a neophyte and small country with limited resources could respond to a global health dilemma. As the country slowly lifts restrictions, vigilance must be kept to sustain its initial success especially that new and more infective strains of the disease are being discovered.
COVID-19是一种高度传染性疾病,已蔓延到包括东帝汶在内的许多国家。作为一个相对较新的国家,卫生保健系统薄弱,缺乏水和卫生设施,贫困程度高,而且靠近感染和死亡人数不断增加的印度尼西亚,人们预计这个国家将被这一公共卫生威胁所征服。相反,自2020年3月21日确诊首例病例以来,它成功地防止了社区传播,保持了低感染率,并创下了零死亡的记录。该国在应对这一公共卫生威胁方面取得的成就似乎要归功于政府的迅速行动、国际组织的支持、有效的沟通策略、教会的参与,以及对水、环境卫生和个人卫生项目的重视。大流行进一步强调了该国需要对医疗保健系统进行更多投资。然而,尽管资源有限,但东帝汶目前的COVID-19病例统计表明,一个资源有限的新手小国如何应对全球卫生困境。随着该国逐渐解除限制,必须保持警惕,以保持初步成功,特别是正在发现新的和更具传染性的疾病毒株。
{"title":"The Low and Slow COVID-19 Pandemic of Timor-Leste","authors":"","doi":"10.32592/kjmsb.2021.1.1.6","DOIUrl":"https://doi.org/10.32592/kjmsb.2021.1.1.6","url":null,"abstract":"COVID-19 is a highly contagious disease that has penetrated many countries including Timor-Leste. Being relatively new with frail healthcare system, lack of access to water and sanitation facilities, and high poverty level in addition to its proximity to Indonesia—a country with increasing number of infections and fatalities, it was expected that this country would be conquered by this public health threat. Conversely, it has managed to prevent community transmission, maintain low infection rate, and record zero deaths since the first case was confirmed on 21 March 2020. The country’s feat against this public health threat appears to be attributable to the immediate action of the government, support from international organizations, effective communication strategies, involvement of the church, and importance given to water, sanitation, and hygiene programs. The pandemic further emphasized the need of the country for more investments on the healthcare system. Nevertheless, despite the limitations on resources, the current tally of COVID-19 cases in Timor-Leste manifests how a neophyte and small country with limited resources could respond to a global health dilemma. As the country slowly lifts restrictions, vigilance must be kept to sustain its initial success especially that new and more infective strains of the disease are being discovered.","PeriodicalId":282364,"journal":{"name":"Kateb Journal of Medical Sciences and Biotechnology","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129368216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Mothers’ Intentions for Physical Activity Education in Children: A Test of Theory of Planned Behavior 母亲意向对儿童体育活动教育的作用:计划行为理论的检验
Pub Date : 1900-01-01 DOI: 10.32592/kjmsb.2021.1.1.4
Background: One of the important agents in the development of children physical activity is mothers.Objective: The present study aimed to assessing the role of socio-cognitive determinants in mothers’ intention to physical activity education for children based on the theory of planned behavior.Methods: This cross-sectional study was conducted among a sample of mothers who have 3 to 6 old child in the west of Iran, 2018. Participants were randomly selected to participate voluntarily in the study. A structured questionnaire was applied for collecting data and data were analyzed by SPSS version 20 using correlations, and linear regression statistical tests.Results: Mean age of the mothers was 31.68 [95% CI: 31.17, 32.19]. Attitude, subjective norms and perceived behavior control variables predictors accounted for 42% of the variation in the intention of physical activity education for children by mothers. Perceived behavior control (Beta=-0.654 and P≤ 0.001) was the more influential predictor on physical activity education intention.Conclusion: It seems that designing and implementation of educational programs to increase perceived behavior control of mothers regarding the physical activity education for children may be the usefulness of the results in order to the promotion of physical activity among their children.
背景:母亲是影响儿童体育活动发展的重要因素之一。目的:基于计划行为理论,探讨社会认知因素对母亲子女体育教育意向的影响。方法:本横断面研究于2018年在伊朗西部有3至6岁孩子的母亲样本中进行。参与者被随机选择自愿参加这项研究。采用结构化问卷收集数据,采用SPSS version 20对数据进行相关性分析和线性回归统计检验。结果:母亲的平均年龄为31.68岁[95% CI: 31.17, 32.19]。态度、主观规范和感知行为控制变量预测因子占母亲对儿童体育活动教育意向变化的42%。知觉行为控制(Beta=-0.654, P≤0.001)是影响体育活动教育意愿的主要预测因子。结论:通过设计和实施教育方案,提高母亲对儿童体育教育行为的感知控制能力,可能对促进儿童体育教育有一定的参考价值。
{"title":"The Role of Mothers’ Intentions for Physical Activity Education in Children: A Test of Theory of Planned Behavior","authors":"","doi":"10.32592/kjmsb.2021.1.1.4","DOIUrl":"https://doi.org/10.32592/kjmsb.2021.1.1.4","url":null,"abstract":"Background: One of the important agents in the development of children physical activity is mothers.\u0000Objective: The present study aimed to assessing the role of socio-cognitive determinants in mothers’ intention to physical activity education for children based on the theory of planned behavior.\u0000Methods: This cross-sectional study was conducted among a sample of mothers who have 3 to 6 old child in the west of Iran, 2018. Participants were randomly selected to participate voluntarily in the study. A structured questionnaire was applied for collecting data and data were analyzed by SPSS version 20 using correlations, and linear regression statistical tests.\u0000Results: Mean age of the mothers was 31.68 [95% CI: 31.17, 32.19]. Attitude, subjective norms and perceived behavior control variables predictors accounted for 42% of the variation in the intention of physical activity education for children by mothers. Perceived behavior control (Beta=-0.654 and P≤ 0.001) was the more influential predictor on physical activity education intention.\u0000Conclusion: It seems that designing and implementation of educational programs to increase perceived behavior control of mothers regarding the physical activity education for children may be the usefulness of the results in order to the promotion of physical activity among their children.","PeriodicalId":282364,"journal":{"name":"Kateb Journal of Medical Sciences and Biotechnology","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123640976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Somaliland: a self-declared country’s fight against COVID-19 索马里兰:自封国家抗击新冠肺炎
Pub Date : 1900-01-01 DOI: 10.32592/kjmsb.2021.1.1.7
Somaliland despite having a weak health system, managed COVID-19 better than some well-resourced countries in the continent by establishing a National Task Force to direct efforts in early detection, surveillance, risk communication and infection control of the virus. The Ministry of Health has been able to garner personnel with medical skills to increase the response workforce and also supervise the activities of medical facilities across the country. However, these measures have shown unfavorable effect on the economy. Somaliland is in active trade with other African countries and neglecting the impact of the virus can greatly affect the trade partner countries. Appropriate relief funds should be offered by capable countries to lessen the economic impact of the pandemic in the country. In the meantime, it is time to reframe the health system of Somaliland and improve sectors that have been underfunded like emergency, intensive care units and the surgical departments.
尽管卫生系统薄弱,但索马里兰通过建立国家工作队指导病毒的早期发现、监测、风险沟通和感染控制工作,比非洲大陆一些资源充足的国家更好地管理了COVID-19。卫生部已经能够召集具有医疗技能的人员,以增加应对工作人员,并监督全国各地医疗设施的活动。然而,这些措施对经济产生了不利影响。索马里兰与其他非洲国家进行了积极的贸易,忽视病毒的影响可能会对贸易伙伴国家造成很大影响。有能力的国家应提供适当的救济资金,以减轻该流行病对该国的经济影响。与此同时,现在是时候重新构建索马里兰的卫生系统,改善资金不足的部门,如急诊、重症监护病房和外科。
{"title":"Somaliland: a self-declared country’s fight against COVID-19","authors":"","doi":"10.32592/kjmsb.2021.1.1.7","DOIUrl":"https://doi.org/10.32592/kjmsb.2021.1.1.7","url":null,"abstract":"Somaliland despite having a weak health system, managed COVID-19 better than some well-resourced countries in the continent by establishing a National Task Force to direct efforts in early detection, surveillance, risk communication and infection control of the virus. The Ministry of Health has been able to garner personnel with medical skills to increase the response workforce and also supervise the activities of medical facilities across the country. However, these measures have shown unfavorable effect on the economy. Somaliland is in active trade with other African countries and neglecting the impact of the virus can greatly affect the trade partner countries. Appropriate relief funds should be offered by capable countries to lessen the economic impact of the pandemic in the country. In the meantime, it is time to reframe the health system of Somaliland and improve sectors that have been underfunded like emergency, intensive care units and the surgical departments.","PeriodicalId":282364,"journal":{"name":"Kateb Journal of Medical Sciences and Biotechnology","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131389057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
COVID-19 situation in Indonesia: Efforts and challenges 印尼新冠疫情形势:努力与挑战
Pub Date : 1900-01-01 DOI: 10.32592/kjmsb.2021.1.1.8
More than a year has passed since the emergence of Coronavirus Disease 2019 (COVID-19) pandemic. However, Indonesia still tussles to flatten the curve. To curb the infection rate, the Government of Indonesia passed public health policies to increase its healthcare system capacity and Indonesians’ awareness about COVID-19. However, existing health disparities between its regions, funding and political concern, and misinformation continue to hinder the effectiveness of these policies. This paper aims to provide a critical commentary on the current efforts against the COVID-19 pandemic and the challenges facing it’s in responses in Indonesia.
2019冠状病毒病(COVID-19)大流行已经过去一年多了。然而,印尼仍在努力使经济曲线趋平。为了遏制感染率,印度尼西亚政府通过了公共卫生政策,以提高其医疗保健系统的能力和印度尼西亚人对COVID-19的认识。然而,各区域之间现有的卫生差距、资金和政治关切以及错误信息继续阻碍这些政策的有效性。本文旨在对当前抗击COVID-19大流行的努力及其在印度尼西亚应对措施中面临的挑战提供批判性评论。
{"title":"COVID-19 situation in Indonesia: Efforts and challenges","authors":"","doi":"10.32592/kjmsb.2021.1.1.8","DOIUrl":"https://doi.org/10.32592/kjmsb.2021.1.1.8","url":null,"abstract":"More than a year has passed since the emergence of Coronavirus Disease 2019 (COVID-19) pandemic. However, Indonesia still tussles to flatten the curve. To curb the infection rate, the Government of Indonesia passed public health policies to increase its healthcare system capacity and Indonesians’ awareness about COVID-19. However, existing health disparities between its regions, funding and political concern, and misinformation continue to hinder the effectiveness of these policies. This paper aims to provide a critical commentary on the current efforts against the COVID-19 pandemic and the challenges facing it’s in responses in Indonesia.","PeriodicalId":282364,"journal":{"name":"Kateb Journal of Medical Sciences and Biotechnology","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115091908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of IQ between 4-16 year-old children after cochlear implantation in the left or right ear 4 ~ 16岁儿童左、右耳人工耳蜗植入后智商的比较
Pub Date : 1900-01-01 DOI: 10.32592/kjmsb.2021.1.1.5
Purpose: Hemispheric dominance is associated with more activity in one half of the body, which is very important in the presence of a relationship between the intelligence and brain lateralization. Delayed language development in the children undergoing cochlear implantation can have deleterious effects on their growth, academic performance, adaptation, and social interactions. Regarding this, the present study aimed to determine the relationship between the dominant hand and intelligence in the 4-16 year-old children undergoing cochlear implantation in the left or right ear.Methods: This cross-sectional study was conducted on the records of the patients aged within 4-16 years who had undergone cochlear implantation during 2008-2011. The subjects’ IQ was measured using Wechsler test by a neuroscience specialist. Then, the IQ of the children with the right cochlear implant was compared to that of those with left implant. The data were analyzed using the t-test, Fisher’s exact test, Mann-Whitney U test, and Chi-square test in SPSS version 18.Results: According to the results, there was no significant difference between the children with right and left cochlear implants in terms of the mean IQ score (P=0.54). Furthermore, no significant association was observed between IQ score and right-handedness or left-handedness in the children undergoing cochlear implantation (P=0.17, P=0.8, respectively).Conclusion: As the findings indicated, there was no relationship between the dominant hand and IQ score in the children undergoing cochlear implantation.
目的:半球优势与身体的一半活动更多有关,这在智力和大脑侧化之间的关系中是非常重要的。接受人工耳蜗植入的儿童语言发育迟缓会对他们的成长、学习成绩、适应能力和社会交往产生不利影响。因此,本研究旨在确定4-16岁左右接受左耳或右耳人工耳蜗植入的儿童的优势手与智力的关系。方法:对2008-2011年4-16岁人工耳蜗植入术患者资料进行横断面研究。研究对象的智商是由一位神经科学专家用韦氏测试来测量的。然后,将右耳蜗植入儿童的智商与左耳蜗植入儿童的智商进行比较。采用SPSS 18版的t检验、Fisher确切检验、Mann-Whitney U检验和卡方检验对数据进行分析。结果:结果显示,右耳蜗植入组与左耳蜗植入组儿童的平均智商得分差异无统计学意义(P=0.54)。此外,人工耳蜗植入儿童的左、右利手与智商得分无显著相关(P=0.17, P=0.8)。结论:研究结果表明,人工耳蜗植入儿童的优势手与智商得分没有关系。
{"title":"Comparison of IQ between 4-16 year-old children after cochlear implantation in the left or right ear","authors":"","doi":"10.32592/kjmsb.2021.1.1.5","DOIUrl":"https://doi.org/10.32592/kjmsb.2021.1.1.5","url":null,"abstract":"Purpose: Hemispheric dominance is associated with more activity in one half of the body, which is very important in the presence of a relationship between the intelligence and brain lateralization. Delayed language development in the children undergoing cochlear implantation can have deleterious effects on their growth, academic performance, adaptation, and social interactions. Regarding this, the present study aimed to determine the relationship between the dominant hand and intelligence in the 4-16 year-old children undergoing cochlear implantation in the left or right ear.\u0000Methods: This cross-sectional study was conducted on the records of the patients aged within 4-16 years who had undergone cochlear implantation during 2008-2011. The subjects’ IQ was measured using Wechsler test by a neuroscience specialist. Then, the IQ of the children with the right cochlear implant was compared to that of those with left implant. The data were analyzed using the t-test, Fisher’s exact test, Mann-Whitney U test, and Chi-square test in SPSS version 18.\u0000Results: According to the results, there was no significant difference between the children with right and left cochlear implants in terms of the mean IQ score (P=0.54). Furthermore, no significant association was observed between IQ score and right-handedness or left-handedness in the children undergoing cochlear implantation (P=0.17, P=0.8, respectively).\u0000Conclusion: As the findings indicated, there was no relationship between the dominant hand and IQ score in the children undergoing cochlear implantation.","PeriodicalId":282364,"journal":{"name":"Kateb Journal of Medical Sciences and Biotechnology","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128479855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dopaminergic pathway and athletic mind 多巴胺能通路和运动思维
Pub Date : 1900-01-01 DOI: 10.32592/kjmsb.2021.1.1.3
Purpose: we reviewed that the mental fatigue is influenced by dopaminedepletion, and we assume that increasing DA level can increase athleticstamina and promote athletic performance after prolong exercise.Methods: The search strategy was according to key words contain, Mentalfatigue , Decision making , Dopamine, Stroboscope training through theGoogle scholar, PubMed, and Elsevier. Among the literatures, 100 papersinclude review and original articles were studied. Finally, we decided to select49 papers based on similarity and recent studies so more than 50 percent ofpapers were excluded, because of they were out of date or irrelevant to keywords.Results: Based on many studies, it was found dopamine has an essential roleon athletic performance and his stamina.Conclusion: The stroboscope vision training in sports could enhance thedopaminergic neurons and associated visuo-motor skills
目的:我们回顾了多巴胺耗竭对精神疲劳的影响,并假设在长时间运动后,提高DA水平可以提高运动耐力,提高运动成绩。方法:通过google scholar、PubMed和Elsevier搜索关键词:contain、Mentalfatigue、Decision making、多巴胺、频闪训练。在文献中,研究了100篇综述和原创文章。最后,我们决定根据相似度和最近的研究选择49篇论文,因此超过50%的论文被排除在外,因为它们过时或与关键词无关。结果:根据许多研究,发现多巴胺对运动表现和耐力有重要作用。结论:运动频闪视觉训练可增强多巴胺能神经元及相关的视运动技能
{"title":"Dopaminergic pathway and athletic mind","authors":"","doi":"10.32592/kjmsb.2021.1.1.3","DOIUrl":"https://doi.org/10.32592/kjmsb.2021.1.1.3","url":null,"abstract":"Purpose: we reviewed that the mental fatigue is influenced by dopamine\u0000depletion, and we assume that increasing DA level can increase athletic\u0000stamina and promote athletic performance after prolong exercise.\u0000Methods: The search strategy was according to key words contain, Mental\u0000fatigue , Decision making , Dopamine, Stroboscope training through the\u0000Google scholar, PubMed, and Elsevier. Among the literatures, 100 papers\u0000include review and original articles were studied. Finally, we decided to select\u000049 papers based on similarity and recent studies so more than 50 percent of\u0000papers were excluded, because of they were out of date or irrelevant to key\u0000words.\u0000Results: Based on many studies, it was found dopamine has an essential role\u0000on athletic performance and his stamina.\u0000Conclusion: The stroboscope vision training in sports could enhance the\u0000dopaminergic neurons and associated visuo-motor skills","PeriodicalId":282364,"journal":{"name":"Kateb Journal of Medical Sciences and Biotechnology","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122803919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Real Time PCR; A new, fast and accurate technique in diagnosing the severe type of hemophilia A patients 实时PCR;一种快速、准确诊断重症A型血友病的新技术
Pub Date : 1900-01-01 DOI: 10.32592/kjmsb.2021.1.1.1
Introduction: Hemophilia A (HA) is one of the most deleterious X-linked bleeding disorders in male patients. Early and rapid detection could provide management strategies for this disease. This study aims to improve the classic method for detection of important intron 22 inversion mutations (INV22).Materials and Methods: Whole blood samples were taken from 21 male children with a history of severe HA, referred to the Iranian comprehensive hemophilia care center. Two groups were involved for detection of INV22 and two methods were examined in a double-blind manner. The first method used a classical method, inverse PCR, and the second method was Real-time inverse PCR. Results: Results showed that both methods could separately detect the INV22 in 11 out of 21 patients with severe HA (52%) in the same accuracy, but with this difference that only one day was needed for detecting of INV22 by Real-time inverse PCR and on other hand 3 days were needed for the classical methods.Concusion: Because of the medical importance of early detection or prenatal/postnatal diagnosis of this disease, this study recommends the Real-time inverse PCR technique for the rapid detection of this mutation in well-equipped genetic laboratories everywhere.
血友病A (HA)是男性患者中最有害的x连锁出血性疾病之一。早期和快速发现可为该病提供管理策略。本研究旨在改进检测重要内含子22倒置突变(INV22)的经典方法。材料与方法:采集21例伊朗血友病综合护理中心重症血凝血病史的男童全血样本。两组采用双盲方法检测INV22。第一种方法采用经典的反相PCR,第二种方法采用实时反相PCR。结果:结果两种方法分别检测21例严重HA患者中11例(52%)的INV22的准确率相同,但Real-time逆PCR检测INV22只需要1天,而经典方法检测INV22需要3天。结论:由于该疾病的早期检测或产前/产后诊断具有重要的医学意义,本研究建议在设备齐全的遗传实验室中使用实时逆PCR技术快速检测该突变。
{"title":"Real Time PCR; A new, fast and accurate technique in diagnosing the severe type of hemophilia A patients","authors":"","doi":"10.32592/kjmsb.2021.1.1.1","DOIUrl":"https://doi.org/10.32592/kjmsb.2021.1.1.1","url":null,"abstract":"Introduction: Hemophilia A (HA) is one of the most deleterious X-linked bleeding disorders in male patients. Early and rapid detection could provide management strategies for this disease. This study aims to improve the classic method for detection of important intron 22 inversion mutations (INV22).\u0000Materials and Methods: Whole blood samples were taken from 21 male children with a history of severe HA, referred to the Iranian comprehensive hemophilia care center. Two groups were involved for detection of INV22 and two methods were examined in a double-blind manner. The first method used a classical method, inverse PCR, and the second method was Real-time inverse PCR. \u0000Results: Results showed that both methods could separately detect the INV22 in 11 out of 21 patients with severe HA (52%) in the same accuracy, but with this difference that only one day was needed for detecting of INV22 by Real-time inverse PCR and on other hand 3 days were needed for the classical methods.\u0000Concusion: Because of the medical importance of early detection or prenatal/postnatal diagnosis of this disease, this study recommends the Real-time inverse PCR technique for the rapid detection of this mutation in well-equipped genetic laboratories everywhere.","PeriodicalId":282364,"journal":{"name":"Kateb Journal of Medical Sciences and Biotechnology","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123003127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Kateb Journal of Medical Sciences and Biotechnology
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1