Myasthenia gravis (MG) and chronic inflammatory demyelinating polyneuropathy (CIDP) are autoimmune diseases aimed at different targets: in MG, it is the postsynaptic membrane of the skeletal musculature, while in CIDP, it is the peripheral nerves. Unlike MG, which can be observed in a significant percentage of patients with thymoma, the association of CIDP with MG and thymoma is rare. This is a report on a patient with a long-term history of myasthenia gravis with an unstable course, who was operated on several times because of the recurrence of thymoma. In the patient, after a long-term clinical remission lasting 16 years, and as part of the re-exacerbation of the thymoma, CIDP developed without signs of myasthenic weakness.
{"title":"Myasthenia gravis and chronic inflammatory demyelinating polyneuropathy in a patient with recurrent thymoma","authors":"V. Martić, Esmer Fejzić, Nebojša Marić","doi":"10.5937/smclk4-43219","DOIUrl":"https://doi.org/10.5937/smclk4-43219","url":null,"abstract":"Myasthenia gravis (MG) and chronic inflammatory demyelinating polyneuropathy (CIDP) are autoimmune diseases aimed at different targets: in MG, it is the postsynaptic membrane of the skeletal musculature, while in CIDP, it is the peripheral nerves. Unlike MG, which can be observed in a significant percentage of patients with thymoma, the association of CIDP with MG and thymoma is rare. This is a report on a patient with a long-term history of myasthenia gravis with an unstable course, who was operated on several times because of the recurrence of thymoma. In the patient, after a long-term clinical remission lasting 16 years, and as part of the re-exacerbation of the thymoma, CIDP developed without signs of myasthenic weakness.","PeriodicalId":286220,"journal":{"name":"Srpski medicinski casopis Lekarske komore","volume":"63 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124272351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jasmina Pavlović-Stojanović, Aleksandra Perović, Minja Stojanović, Tijana Kosanovic, Đorđe Radanović, L. Lazić, Dragana Antonijević-Đorđević, Magdalena Bjelica
Introduction: The celiac trunk is an arterial trunk that has been the subject of numerous anatomical and radiological studies. From its origin, at the front of the abdominal aorta, the trunk extends for 1.5 - 2 cm and then divides into three branches: the left gastric artery, the common hepatic artery and the splenic artery. This type of trifurcation was first described by Haller, in 1756, and is considered the most common anatomical pattern. Anatomical variations of the celiac trunk are numerous, both in terms of branching and dimensions. The complete absence of the celiac trunk is a rare anatomical variation, wherein all three branches arise directly and independently from the abdominal aorta. Case report: A 63-year-old oncology patient was referred to the radiology department for an Mr examination of the abdomen, in order to differentially diagnose changes in the adrenal glands. During the examination, complete absence of the celiac trunk was observed. The left gastric artery, splenic artery, and common hepatic artery arose directly and independently from the abdominal aorta. Conclusion: A variation of this type is mostly asymptomatic and has no negative effect on the blood supply of visceral organs. In literature, the prevalence of this vascular pattern ranges from 0.1% to 4%. Knowledge of vascular variations in the abdomen is very important during surgical, diagnostic and endovascular procedures.
{"title":"Absence of the celiac trunk: A case report","authors":"Jasmina Pavlović-Stojanović, Aleksandra Perović, Minja Stojanović, Tijana Kosanovic, Đorđe Radanović, L. Lazić, Dragana Antonijević-Đorđević, Magdalena Bjelica","doi":"10.5937/smclk3-40388","DOIUrl":"https://doi.org/10.5937/smclk3-40388","url":null,"abstract":"Introduction: The celiac trunk is an arterial trunk that has been the subject of numerous anatomical and radiological studies. From its origin, at the front of the abdominal aorta, the trunk extends for 1.5 - 2 cm and then divides into three branches: the left gastric artery, the common hepatic artery and the splenic artery. This type of trifurcation was first described by Haller, in 1756, and is considered the most common anatomical pattern. Anatomical variations of the celiac trunk are numerous, both in terms of branching and dimensions. The complete absence of the celiac trunk is a rare anatomical variation, wherein all three branches arise directly and independently from the abdominal aorta. Case report: A 63-year-old oncology patient was referred to the radiology department for an Mr examination of the abdomen, in order to differentially diagnose changes in the adrenal glands. During the examination, complete absence of the celiac trunk was observed. The left gastric artery, splenic artery, and common hepatic artery arose directly and independently from the abdominal aorta. Conclusion: A variation of this type is mostly asymptomatic and has no negative effect on the blood supply of visceral organs. In literature, the prevalence of this vascular pattern ranges from 0.1% to 4%. Knowledge of vascular variations in the abdomen is very important during surgical, diagnostic and endovascular procedures.","PeriodicalId":286220,"journal":{"name":"Srpski medicinski casopis Lekarske komore","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122386488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Dokić, D. Šljivančanin, Sandra Babic, B. Milošević
Introduction: Previously, the laparoscopic approach was not considered for obese people, because of the increased risk of operative and postoperative complications. In recent years, however, the approach has changed in favor of minimally invasive procedures that avoid laparotomy, which, in obese people, is the most common cause of complications, in the form of slower and aggravated wound healing, bleeding, and infections at the laparotomy site. In emergency situations, extreme obesity accompanied by multiple comorbidities still remains a real challenge for endoscopic surgery, the surgeon and the entire surgical and anesthesiology team. Case report: We present a case of a 61-year-old, extremely obese patient, who was admitted to hospital as an emergency case, due to prolonged vaginal bleeding and anemia. After preoperative preparation, the patient underwent surgery - laparoscopic total hysterectomy with bilateral salpingo-oophorectomy. Conclusion: Obesity is a major problem in modern society. In addition to directly affecting health, excessive body weight in a patient makes it very difficult to perform surgical procedures. The thickness of the abdominal wall and accompanying health problems are a contraindication for laparoscopic operations. In such cases, performing surgery, especially laparoscopic procedures, requires a trained team of professionals and appropriate equipment. Laparoscopic surgery is more and more present, even in the most difficult cases. In presenting this case, we aimed to demonstrate that it is possible to successfully perform total laparoscopic hysterectomy in extremely obese patients with associated health problems, even in emergency situations.
{"title":"Extreme obesity and total laparoscopic hysterectomy: Case report","authors":"M. Dokić, D. Šljivančanin, Sandra Babic, B. Milošević","doi":"10.5937/smclk3-37790","DOIUrl":"https://doi.org/10.5937/smclk3-37790","url":null,"abstract":"Introduction: Previously, the laparoscopic approach was not considered for obese people, because of the increased risk of operative and postoperative complications. In recent years, however, the approach has changed in favor of minimally invasive procedures that avoid laparotomy, which, in obese people, is the most common cause of complications, in the form of slower and aggravated wound healing, bleeding, and infections at the laparotomy site. In emergency situations, extreme obesity accompanied by multiple comorbidities still remains a real challenge for endoscopic surgery, the surgeon and the entire surgical and anesthesiology team. Case report: We present a case of a 61-year-old, extremely obese patient, who was admitted to hospital as an emergency case, due to prolonged vaginal bleeding and anemia. After preoperative preparation, the patient underwent surgery - laparoscopic total hysterectomy with bilateral salpingo-oophorectomy. Conclusion: Obesity is a major problem in modern society. In addition to directly affecting health, excessive body weight in a patient makes it very difficult to perform surgical procedures. The thickness of the abdominal wall and accompanying health problems are a contraindication for laparoscopic operations. In such cases, performing surgery, especially laparoscopic procedures, requires a trained team of professionals and appropriate equipment. Laparoscopic surgery is more and more present, even in the most difficult cases. In presenting this case, we aimed to demonstrate that it is possible to successfully perform total laparoscopic hysterectomy in extremely obese patients with associated health problems, even in emergency situations.","PeriodicalId":286220,"journal":{"name":"Srpski medicinski casopis Lekarske komore","volume":"118 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121893295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jelena Aritonović-Pribaković, Milica Perić, J. Milosevic, Aleksandra Janićević
Introduction/Aim: Pleural effusions are rarely seen on computerized tomography (CT) or radiography (X-ray) images of the chest, in coronavirus disease of 2019 (COVID-19). When present, they usually occur late in the course of the disease; they are mostly unilateral but can also be bilateral, and are absorbed after two days. Studies have also shown that pleural effusions occur primarily in the elderly and individuals with underlying respiratory disease. The incidence of respiratory failure and acute respiratory distress syndrome, as well as the mortality rates are higher in patients with pleural effusion than in patients without it. Our aim is to report a case that is different from the most commonly described cases in available literature. Patient presentation: We present a 49-year-old, comorbidity-free COVID-19 patient, who developed pleural effusion on the 10th day of hospitalization. The pleural effusion was unilateral and did not appear on a repeat lung radiography after four days. Except an elevated platelet count, the blood count parameters were in the reference ranges, while the value of CRP was slightly elevated. The patient was discharged with a good general health status, after 16 days of hospitalization. Conclusion: This case provides insight into the course and prognosis of the COVID-19 disease that is different from what has been reported in previously published papers and shows that pleural effusions do not occur only in elderly patients with comorbidities and a severe clinical presentation of the COVID-19 infection.
{"title":"Pleural effusion in a COVID-19 patient","authors":"Jelena Aritonović-Pribaković, Milica Perić, J. Milosevic, Aleksandra Janićević","doi":"10.5937/smclk2-34669","DOIUrl":"https://doi.org/10.5937/smclk2-34669","url":null,"abstract":"Introduction/Aim: Pleural effusions are rarely seen on computerized tomography (CT) or radiography (X-ray) images of the chest, in coronavirus disease of 2019 (COVID-19). When present, they usually occur late in the course of the disease; they are mostly unilateral but can also be bilateral, and are absorbed after two days. Studies have also shown that pleural effusions occur primarily in the elderly and individuals with underlying respiratory disease. The incidence of respiratory failure and acute respiratory distress syndrome, as well as the mortality rates are higher in patients with pleural effusion than in patients without it. Our aim is to report a case that is different from the most commonly described cases in available literature. Patient presentation: We present a 49-year-old, comorbidity-free COVID-19 patient, who developed pleural effusion on the 10th day of hospitalization. The pleural effusion was unilateral and did not appear on a repeat lung radiography after four days. Except an elevated platelet count, the blood count parameters were in the reference ranges, while the value of CRP was slightly elevated. The patient was discharged with a good general health status, after 16 days of hospitalization. Conclusion: This case provides insight into the course and prognosis of the COVID-19 disease that is different from what has been reported in previously published papers and shows that pleural effusions do not occur only in elderly patients with comorbidities and a severe clinical presentation of the COVID-19 infection.","PeriodicalId":286220,"journal":{"name":"Srpski medicinski casopis Lekarske komore","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122190786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ana D. Sekulic, O. Marinković, D. Mrda, B. Tošković, M. Zdravković, Predrag Đuran
Introduction: The infection caused by the SARS-CoV-2 virus is known to cause a hypercoagulable condition resulting in acute thrombotic events. Thromboembolic events occur in as many as 21.0% of cases with a mortality rate of about 74.0% in persons infected with COVID-19. Anticoagulant therapy is used in severe COVID-19 infections in order to prevent thrombosis and has been shown to reduce mortality. The use of anticoagulants is not without risks. Bleeding complications can range from mild to severe or even life-threatening, such as retroperitoneal bleeding into the psoas muscle. Case report: We present a case of a patient who developed a complication of bleeding into the retroperitoneal space during the treatment of bilateral bronchopneumonia caused by the SARS-CoV-2 virus. After the diagnosis was established, on the basis of a clinical examination, laboratory and radiological examinations, and after initial conservative treatment at the UHMC Bežanijska kosa, the patient underwent embolization of the left lumbar arteries from the right inguinal fossa, during procedural analgosedation. After the radiological procedure, the recovery was satisfactory, but due to the impossibility of resorption of an encapsulated hematoma with a zone of central necrosis, a mini left lumbotomy and evacuation of the hematoma were performed. The patient was discharged from the hospital on the 23rd day of admission in stable general condition. Conclusion: The effect of anticoagulant therapy, especially in patients with existing risk factors, early diagnosis, and prompt therapy of spontaneous retroperitoneal hematomas is imperative to reduce mortality from this severe complication, in patients with the COVID-19 infection.
{"title":"Spontaneous retroperitoneal hematoma in a COVID-19 patient","authors":"Ana D. Sekulic, O. Marinković, D. Mrda, B. Tošković, M. Zdravković, Predrag Đuran","doi":"10.5937/smclk2-34956","DOIUrl":"https://doi.org/10.5937/smclk2-34956","url":null,"abstract":"Introduction: The infection caused by the SARS-CoV-2 virus is known to cause a hypercoagulable condition resulting in acute thrombotic events. Thromboembolic events occur in as many as 21.0% of cases with a mortality rate of about 74.0% in persons infected with COVID-19. Anticoagulant therapy is used in severe COVID-19 infections in order to prevent thrombosis and has been shown to reduce mortality. The use of anticoagulants is not without risks. Bleeding complications can range from mild to severe or even life-threatening, such as retroperitoneal bleeding into the psoas muscle. Case report: We present a case of a patient who developed a complication of bleeding into the retroperitoneal space during the treatment of bilateral bronchopneumonia caused by the SARS-CoV-2 virus. After the diagnosis was established, on the basis of a clinical examination, laboratory and radiological examinations, and after initial conservative treatment at the UHMC Bežanijska kosa, the patient underwent embolization of the left lumbar arteries from the right inguinal fossa, during procedural analgosedation. After the radiological procedure, the recovery was satisfactory, but due to the impossibility of resorption of an encapsulated hematoma with a zone of central necrosis, a mini left lumbotomy and evacuation of the hematoma were performed. The patient was discharged from the hospital on the 23rd day of admission in stable general condition. Conclusion: The effect of anticoagulant therapy, especially in patients with existing risk factors, early diagnosis, and prompt therapy of spontaneous retroperitoneal hematomas is imperative to reduce mortality from this severe complication, in patients with the COVID-19 infection.","PeriodicalId":286220,"journal":{"name":"Srpski medicinski casopis Lekarske komore","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116824636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: The COVID-19 pandemic has brought many problems and challenges to the medical profession, including psychiatry. These include the emergence of de novo disorders in the population, the worsening of the condition in previously diagnosed patients, but also problems in the mental functioning of health professionals, who were involved in the treatment of COVID-19 patients. Numerous international papers address these problems and challenges, as is the case with a large number of studies and papers published by Serbian researchers and experts in Serbian and international publications. Objective: The objective of the paper is to present research conducted in the Republic of Serbia related to the COVID-19 infection and its impact on mental health. Methods: This paper presents the results of Serbian research as well as expert opinions related to the COVID-19 infection and its impact on mental health. The basis for the preparation of this paper were publications of Serbian authors published mostly in international journals. These publications present the results of original studies, but also expert considerations related to the impact of the COVID-19 infection on mental health. Results: Previous research and extensive clinical practice in the Republic of Serbia show the existence of frequent and intensive problems related to mental health, resulting from the COVID-19 pandemic, present in both the general population and in specific populations, such as health workers and patients suffering from psychiatric disorders. Conclusion: Based on the presented results, the conclusion is that, in order to deal with this issue, a number of specialized institutions should be opened in the territory of the entire Republic of Serbia, where patients could find support and help for their problems.
{"title":"COVID-19: Current state of mental health with a reference to health workers","authors":"M. Latas, M. Pantović-Stefanović, B. Đukić","doi":"10.5937/smclk2-35256","DOIUrl":"https://doi.org/10.5937/smclk2-35256","url":null,"abstract":"Introduction: The COVID-19 pandemic has brought many problems and challenges to the medical profession, including psychiatry. These include the emergence of de novo disorders in the population, the worsening of the condition in previously diagnosed patients, but also problems in the mental functioning of health professionals, who were involved in the treatment of COVID-19 patients. Numerous international papers address these problems and challenges, as is the case with a large number of studies and papers published by Serbian researchers and experts in Serbian and international publications. Objective: The objective of the paper is to present research conducted in the Republic of Serbia related to the COVID-19 infection and its impact on mental health. Methods: This paper presents the results of Serbian research as well as expert opinions related to the COVID-19 infection and its impact on mental health. The basis for the preparation of this paper were publications of Serbian authors published mostly in international journals. These publications present the results of original studies, but also expert considerations related to the impact of the COVID-19 infection on mental health. Results: Previous research and extensive clinical practice in the Republic of Serbia show the existence of frequent and intensive problems related to mental health, resulting from the COVID-19 pandemic, present in both the general population and in specific populations, such as health workers and patients suffering from psychiatric disorders. Conclusion: Based on the presented results, the conclusion is that, in order to deal with this issue, a number of specialized institutions should be opened in the territory of the entire Republic of Serbia, where patients could find support and help for their problems.","PeriodicalId":286220,"journal":{"name":"Srpski medicinski casopis Lekarske komore","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128429159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Early death is a known complication in the treatment of patients suffering from acute myeloid leukemia (AML). It has been defined as death occurring within 28 days of the initiation of induction chemotherapy. Aim: Determining the clinical characteristics of the patient, the risk factors, the frequency, and the most common causes of early death in AML patients. Materials and methods: This retrospective study included 248 patients with diagnosed AML. At diagnosis, the following demographic and clinical-laboratory characteristics were recorded: sex, age, general functional status, i.e., performance status according to the ECOG scale, complete blood count, LDH level in the blood, percentage of blasts in peripheral blood and bone marrow, fibrinogen, PT, aPTT, D-dimer, and BMI. Patients were treated with induction and reduction chemotherapy and palliative therapy. Statistical analysis was performed using the data from the discharge summaries taken from the registers of the Clinic for Hematology of the Clinical Center of Serbia. Results: Early death occurred in 53 (21.4%) patients. The prognostic risk factors for early death were the following: age (p = 0.047), ECOG ≥ 2 (p = 0.001), leukocyte count ≥ 30 x 109 /l (p = 0.022), LDH level ≥ 450 U/l (p = 0.022), the percentage of blasts in peripheral blood (p = 0.005) and the percentage of blasts in bone marrow (p = 0.003), PT (p < 0.001), as well as the ISTH score (p = 0.018). The most common cause of early death in patients aged 40 - 65 years was sepsis, while in patients older than 65 years it was respiratory failure. Conclusion: The study showed that age, the leukocyte count, the percentage of peripheral blood and bone marrow blasts, the ECOG score, LDH, PT, and the ISTH score were significant prognostic risk factors of early death in patients with AML, and that the most common cause of early death in patients aged 40 - 65 years was sepsis, while in patients older than 65 years it was respiratory failure.
{"title":"Prognostic risk factors for early death in patients with acute myeloid leukemia","authors":"Marijana Juga, M. Virijević","doi":"10.5937/smclk3-32545","DOIUrl":"https://doi.org/10.5937/smclk3-32545","url":null,"abstract":"Introduction: Early death is a known complication in the treatment of patients suffering from acute myeloid leukemia (AML). It has been defined as death occurring within 28 days of the initiation of induction chemotherapy. Aim: Determining the clinical characteristics of the patient, the risk factors, the frequency, and the most common causes of early death in AML patients. Materials and methods: This retrospective study included 248 patients with diagnosed AML. At diagnosis, the following demographic and clinical-laboratory characteristics were recorded: sex, age, general functional status, i.e., performance status according to the ECOG scale, complete blood count, LDH level in the blood, percentage of blasts in peripheral blood and bone marrow, fibrinogen, PT, aPTT, D-dimer, and BMI. Patients were treated with induction and reduction chemotherapy and palliative therapy. Statistical analysis was performed using the data from the discharge summaries taken from the registers of the Clinic for Hematology of the Clinical Center of Serbia. Results: Early death occurred in 53 (21.4%) patients. The prognostic risk factors for early death were the following: age (p = 0.047), ECOG ≥ 2 (p = 0.001), leukocyte count ≥ 30 x 109 /l (p = 0.022), LDH level ≥ 450 U/l (p = 0.022), the percentage of blasts in peripheral blood (p = 0.005) and the percentage of blasts in bone marrow (p = 0.003), PT (p < 0.001), as well as the ISTH score (p = 0.018). The most common cause of early death in patients aged 40 - 65 years was sepsis, while in patients older than 65 years it was respiratory failure. Conclusion: The study showed that age, the leukocyte count, the percentage of peripheral blood and bone marrow blasts, the ECOG score, LDH, PT, and the ISTH score were significant prognostic risk factors of early death in patients with AML, and that the most common cause of early death in patients aged 40 - 65 years was sepsis, while in patients older than 65 years it was respiratory failure.","PeriodicalId":286220,"journal":{"name":"Srpski medicinski casopis Lekarske komore","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127774057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The COVID-19 pandemic represents one of the most serious public health threats that our world has faced in recent history. Clinical laboratories play a significant role in the global fight against this pandemic. This paper is based on the experiences of the Center for Medical Biochemistry of the University Clinical Center of Serbia. Using mixed methods research, the study sheds light on the many challenges that the Center has been facing during the pandemic, it outlines the implementation of change, and makes recommendations for functioning during the COVID-19 pandemic and in the post-COVID era.
{"title":"Clinical laboratories in the era of the COVID-19 pandemic: An analysis of experiences in Serbia","authors":"S. Stanković, M. Ašanin","doi":"10.5937/smclk2-33424","DOIUrl":"https://doi.org/10.5937/smclk2-33424","url":null,"abstract":"The COVID-19 pandemic represents one of the most serious public health threats that our world has faced in recent history. Clinical laboratories play a significant role in the global fight against this pandemic. This paper is based on the experiences of the Center for Medical Biochemistry of the University Clinical Center of Serbia. Using mixed methods research, the study sheds light on the many challenges that the Center has been facing during the pandemic, it outlines the implementation of change, and makes recommendations for functioning during the COVID-19 pandemic and in the post-COVID era.","PeriodicalId":286220,"journal":{"name":"Srpski medicinski casopis Lekarske komore","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131982535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Mioljević, M. Ercegovac, P. Gregorić, Dušan Jovanovič, G. Tulić, S. Jovanović, Stevana Vukašinović
In less than a year, humanity has managed to start a long and difficult battle against a virus, with a powerful weapon - the vaccine. In addition to vaccination, which is undoubtedly the most important measure in preventing COVID-19, our responsible behavior (wearing masks, hand hygiene, observing physical distance), especially in this period of an increase in the number of patients and the emergence of new strains, also remains an important measure in preventing and controlling the spread of COVID-19. In this paper, an overview of professional recommendations and instructions for the epidemiological surveillance of health care institutions is given. The study objective is to present the manner of organizing the epidemiological surveillance of the Epidemiology Department of the University Clinical Center of Serbia (UCCS) at the Emergency Center of the UCCS (EC-UCCS) as well as the application of measures to prevent and control COVID-19. To this end the method of the triage of patients with suspected COVID-19 in the Emergency Center of the UCCS has been shown. The Guidelines for the Rational Use of Personal Protective Equipment in Healthcare Facilities Depending on the Activities Performed, as well as the Recommendations of the Centers for Disease Prevention and Control (Atlanta, USA) have been presented. The Algorithm for the Procedures with Patients with Suspected and Proven COVID-19 Infection for Patients of the EC-UCCS has been formed. This Algorithm has been in use since March 1, 2020, in the EC-UCCS Admissions Service Triage Facility. In addition to this Algorithm, the screening of medical staff for SARS-CoV-2 has been performed by sampling nasopharyngeal and throat swabs (for PCR analysis and antigen tests) and blood (for serological analyses).
{"title":"COVID-19 prevention and control measures: Emergency center of the University Clinical Center of Serbia","authors":"V. Mioljević, M. Ercegovac, P. Gregorić, Dušan Jovanovič, G. Tulić, S. Jovanović, Stevana Vukašinović","doi":"10.5937/smclk2-32950","DOIUrl":"https://doi.org/10.5937/smclk2-32950","url":null,"abstract":"In less than a year, humanity has managed to start a long and difficult battle against a virus, with a powerful weapon - the vaccine. In addition to vaccination, which is undoubtedly the most important measure in preventing COVID-19, our responsible behavior (wearing masks, hand hygiene, observing physical distance), especially in this period of an increase in the number of patients and the emergence of new strains, also remains an important measure in preventing and controlling the spread of COVID-19. In this paper, an overview of professional recommendations and instructions for the epidemiological surveillance of health care institutions is given. The study objective is to present the manner of organizing the epidemiological surveillance of the Epidemiology Department of the University Clinical Center of Serbia (UCCS) at the Emergency Center of the UCCS (EC-UCCS) as well as the application of measures to prevent and control COVID-19. To this end the method of the triage of patients with suspected COVID-19 in the Emergency Center of the UCCS has been shown. The Guidelines for the Rational Use of Personal Protective Equipment in Healthcare Facilities Depending on the Activities Performed, as well as the Recommendations of the Centers for Disease Prevention and Control (Atlanta, USA) have been presented. The Algorithm for the Procedures with Patients with Suspected and Proven COVID-19 Infection for Patients of the EC-UCCS has been formed. This Algorithm has been in use since March 1, 2020, in the EC-UCCS Admissions Service Triage Facility. In addition to this Algorithm, the screening of medical staff for SARS-CoV-2 has been performed by sampling nasopharyngeal and throat swabs (for PCR analysis and antigen tests) and blood (for serological analyses).","PeriodicalId":286220,"journal":{"name":"Srpski medicinski casopis Lekarske komore","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134585303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Milica Apostolović-Stojanović, M. Radojković, A. Stojanovic, V. Vukomanovic
Introduction: Several classes of drugs can cause atrial fibrillation (AF) in patients without heart disease, as well as the occurrence of AF in pre-existing heart disease. Drug-induced AF is most often clinically manifested in the form of paroxysms. High doses of intravenous methylprednisolone (HDMP) in the treatment of chronic lymphocytic leukemia (CLL) have been associated with the occurrence of various adverse effects, including AF. The exact mechanism of HDMP-induced AF is unknown. Case presentation: We present the case of a patient with CLL in whom AF occurred after the administration of a high dose of intravenous methylprednisolone. Conclusion: Physicians should be aware of the special circumstances in the treatment of CLL, because drug-induced AF can be a side effect that limits further therapy.
{"title":"Cardiotoxicity of high-dose methylprednisolone in patients with chronic lymphocytic leukemia: A case report","authors":"Milica Apostolović-Stojanović, M. Radojković, A. Stojanovic, V. Vukomanovic","doi":"10.5937/smclk3-36683","DOIUrl":"https://doi.org/10.5937/smclk3-36683","url":null,"abstract":"Introduction: Several classes of drugs can cause atrial fibrillation (AF) in patients without heart disease, as well as the occurrence of AF in pre-existing heart disease. Drug-induced AF is most often clinically manifested in the form of paroxysms. High doses of intravenous methylprednisolone (HDMP) in the treatment of chronic lymphocytic leukemia (CLL) have been associated with the occurrence of various adverse effects, including AF. The exact mechanism of HDMP-induced AF is unknown. Case presentation: We present the case of a patient with CLL in whom AF occurred after the administration of a high dose of intravenous methylprednisolone. Conclusion: Physicians should be aware of the special circumstances in the treatment of CLL, because drug-induced AF can be a side effect that limits further therapy.","PeriodicalId":286220,"journal":{"name":"Srpski medicinski casopis Lekarske komore","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133913215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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