Pub Date : 2005-12-10DOI: 10.2174/1567204052931104
Ming D. Li, J. Kane, O. Konu
{"title":"Regulation by Nicotine of Food Intake and Body Weight: Implications for Obesity Treatment","authors":"Ming D. Li, J. Kane, O. Konu","doi":"10.2174/1567204052931104","DOIUrl":"https://doi.org/10.2174/1567204052931104","url":null,"abstract":"","PeriodicalId":286890,"journal":{"name":"Frontiers in Medicinal Chemistry - Online","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129273625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2005-12-10DOI: 10.2174/1567204052930925
Gregory N. Barnes and John T. Slevin
{"title":"Effect of Genetic Background on Ionotropic Glutamate Receptor and Neurotrophin Biology: Synaptic Connectivity and Function in Neurological Disease","authors":"Gregory N. Barnes and John T. Slevin","doi":"10.2174/1567204052930925","DOIUrl":"https://doi.org/10.2174/1567204052930925","url":null,"abstract":"","PeriodicalId":286890,"journal":{"name":"Frontiers in Medicinal Chemistry - Online","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114374635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2005-12-10DOI: 10.2174/1567204052931087
M. Presta, D. Leali, H. Stabile, R. Ronca, M. Camozzi, E. Moroni, S. Nicoli, S. Liekens, Marco
Angiogenesis is the process of generating new capillary blood vessels. Uncontrolled endothelial cell proliferation is observed in tumor neovascularization and in angioproliferative diseases. Tumors cannot grow as a mass above few mm unless a new blood supply is induced. It derives that the control of the neovascularization process may affect tumor growth and may represent a novel approach to tumor therapy. Angiogenesis is controlled by a balance between proangiogenic and antiangiogenic factors. The angiogenic switch represents the net result of the activity of angiogenic stimulators and inhibitors, suggesting that counteracting even a single major angiogenic factor could shift the balance towards inhibition. Heparan sulfate proteoglycans are involved in the modulation of the neovascularization that takes place in different physiological and pathological conditions. This modulation occurs through the interaction with angiogenic growth factors or with negative regulators of angiogenesis. Thus, the study of the biochemical bases of this interaction may help to design glycosaminoglycan analogs endowed with angiostatic properties. The purpose of this review is to provide an overview of the structure/function of heparan sulfate proteoglycans in endothelial cells and to summarize the angiostatic properties of synthetic heparin-like compounds, chemically modified heparins, and biotechnological heparins.
{"title":"Heparin Derivatives and Semisynthetic Biotechnological Heparins as Angiogenesis Inhibitors","authors":"M. Presta, D. Leali, H. Stabile, R. Ronca, M. Camozzi, E. Moroni, S. Nicoli, S. Liekens, Marco","doi":"10.2174/1567204052931087","DOIUrl":"https://doi.org/10.2174/1567204052931087","url":null,"abstract":"Angiogenesis is the process of generating new capillary blood vessels. Uncontrolled endothelial cell proliferation is observed in tumor neovascularization and in angioproliferative diseases. Tumors cannot grow as a mass above few mm unless a new blood supply is induced. It derives that the control of the neovascularization process may affect tumor growth and may represent a novel approach to tumor therapy. Angiogenesis is controlled by a balance between proangiogenic and antiangiogenic factors. The angiogenic switch represents the net result of the activity of angiogenic stimulators and inhibitors, suggesting that counteracting even a single major angiogenic factor could shift the balance towards inhibition. Heparan sulfate proteoglycans are involved in the modulation of the neovascularization that takes place in different physiological and pathological conditions. This modulation occurs through the interaction with angiogenic growth factors or with negative regulators of angiogenesis. Thus, the study of the biochemical bases of this interaction may help to design glycosaminoglycan analogs endowed with angiostatic properties. The purpose of this review is to provide an overview of the structure/function of heparan sulfate proteoglycans in endothelial cells and to summarize the angiostatic properties of synthetic heparin-like compounds, chemically modified heparins, and biotechnological heparins.","PeriodicalId":286890,"journal":{"name":"Frontiers in Medicinal Chemistry - Online","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133267866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2005-12-10DOI: 10.2174/1567204052930907
L. Somsák, V. Nagy, Zsuzsa Hadady, N. Felfoldi, T. Docsa, P. Gergely
{"title":"Recent Developments in the Synthesis and Evaluation of Glucose Analog Inhibitors of Glycogen Phosphorylases as Potential Antidiabetic Agents","authors":"L. Somsák, V. Nagy, Zsuzsa Hadady, N. Felfoldi, T. Docsa, P. Gergely","doi":"10.2174/1567204052930907","DOIUrl":"https://doi.org/10.2174/1567204052930907","url":null,"abstract":"","PeriodicalId":286890,"journal":{"name":"Frontiers in Medicinal Chemistry - Online","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123657419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2005-12-10DOI: 10.2174/1567204052931140
M. Lloyd
{"title":"Understanding the Molecular Mechanism of Action of Estrogen Receptor Modulators","authors":"M. Lloyd","doi":"10.2174/1567204052931140","DOIUrl":"https://doi.org/10.2174/1567204052931140","url":null,"abstract":"","PeriodicalId":286890,"journal":{"name":"Frontiers in Medicinal Chemistry - Online","volume":"2014 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121396896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2005-12-10DOI: 10.2174/1567204052930899
A. Contestabile, Barbara Monti, A. Contestabile, E. Ciani
{"title":"Updating the Dual Role of Brain Nitric Oxide in Neurodegeneration/Neuroprotection: Understanding Molecular Mechanisms to Devise Drug Approaches","authors":"A. Contestabile, Barbara Monti, A. Contestabile, E. Ciani","doi":"10.2174/1567204052930899","DOIUrl":"https://doi.org/10.2174/1567204052930899","url":null,"abstract":"","PeriodicalId":286890,"journal":{"name":"Frontiers in Medicinal Chemistry - Online","volume":"125 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131497786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2005-12-10DOI: 10.2174/1567204052931041
H. Kwon
{"title":"Chemical Genomics-Based Target Mining and Validation of Biologically Active Small Molecules","authors":"H. Kwon","doi":"10.2174/1567204052931041","DOIUrl":"https://doi.org/10.2174/1567204052931041","url":null,"abstract":"","PeriodicalId":286890,"journal":{"name":"Frontiers in Medicinal Chemistry - Online","volume":"96 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133256135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2005-12-10DOI: 10.2174/1567204052930934
Chung‐Ming Sun
{"title":"Combinatorial Synthesis of Small Molecule Libraries by Microwave Technology","authors":"Chung‐Ming Sun","doi":"10.2174/1567204052930934","DOIUrl":"https://doi.org/10.2174/1567204052930934","url":null,"abstract":"","PeriodicalId":286890,"journal":{"name":"Frontiers in Medicinal Chemistry - Online","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126651411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2005-12-10DOI: 10.2174/1567204052931069
B. Cacciari, G. Pastorin, S. Moro, G. Spalluto
{"title":"Potent and Selective A2A Adenosine Receptor Antagonists: Recent Improvement","authors":"B. Cacciari, G. Pastorin, S. Moro, G. Spalluto","doi":"10.2174/1567204052931069","DOIUrl":"https://doi.org/10.2174/1567204052931069","url":null,"abstract":"","PeriodicalId":286890,"journal":{"name":"Frontiers in Medicinal Chemistry - Online","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122082087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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