Pub Date : 2016-09-12DOI: 10.6084/m9.figshare.3822264.v1
Minho Hwang, Hyunwoo Yang, Younsoo Kim, J. Youn, Jongkyu Park, Y. Huh, Hee-Tae Kim, J. Cho
AIMS To elucidate different patterns of progression of midbrain atrophy in patients with Richardson's syndrome (RS), progressive supranuclear palsy-parkinsonism (PSP-P), and Parkinson's disease (PD) using magnetic resonance imaging (MRI)-based visual rating indexes. METHODS We recruited 12 patients with PSP-RS, 12 with PSP-P, and 23 with PD for whom MRIs had been followed up for at least 2 years (mean ± SD, 4.9 ± 1.6 years) after the initial MRI. MRI-based visual rating indexes were used to estimate midbrain atrophy, including the ratio of the pontine to midbrain tegmental areas (P/M ratio) on a midsagittal image, the length between the interpeduncular fossa and the center of the cerebral aqueduct at the midmammillary-body level (MTEGM) on axial images, and the morning glory sign. RESULTS Initially, there were no differences in MRI-based visual rating indexes between PSP-P and PD, while PSP-RS showed a higher P/M ratio and lower MTEGM compared with PSP-P and PD. In PD, the P/M ratio and MTEGM remained stable with disease progression. However, the extent of changes between initial and follow-up indexes was similarly greater for both PSP-RS and PSP-P than for PD. Finally, PSP-P showed a higher P/M ratio and lower MTEGM compared with PD in the follow-up, while PSP-RS still exhibited the most profound changes. CONCLUSIONS Midbrain atrophy progresses differentially in patients with PSP-RS, PSP-P, and PD. Longitudinal measurements of midbrain atrophy using MRI-based visual rating indexes can help distinguish patients with PSP-P from those with PSP-RS and PD.
{"title":"Differential Progression of Midbrain Atrophy in Parkinsonism: Longitudinal MRI Study.","authors":"Minho Hwang, Hyunwoo Yang, Younsoo Kim, J. Youn, Jongkyu Park, Y. Huh, Hee-Tae Kim, J. Cho","doi":"10.6084/m9.figshare.3822264.v1","DOIUrl":"https://doi.org/10.6084/m9.figshare.3822264.v1","url":null,"abstract":"AIMS\u0000To elucidate different patterns of progression of midbrain atrophy in patients with Richardson's syndrome (RS), progressive supranuclear palsy-parkinsonism (PSP-P), and Parkinson's disease (PD) using magnetic resonance imaging (MRI)-based visual rating indexes.\u0000\u0000\u0000METHODS\u0000We recruited 12 patients with PSP-RS, 12 with PSP-P, and 23 with PD for whom MRIs had been followed up for at least 2 years (mean ± SD, 4.9 ± 1.6 years) after the initial MRI. MRI-based visual rating indexes were used to estimate midbrain atrophy, including the ratio of the pontine to midbrain tegmental areas (P/M ratio) on a midsagittal image, the length between the interpeduncular fossa and the center of the cerebral aqueduct at the midmammillary-body level (MTEGM) on axial images, and the morning glory sign.\u0000\u0000\u0000RESULTS\u0000Initially, there were no differences in MRI-based visual rating indexes between PSP-P and PD, while PSP-RS showed a higher P/M ratio and lower MTEGM compared with PSP-P and PD. In PD, the P/M ratio and MTEGM remained stable with disease progression. However, the extent of changes between initial and follow-up indexes was similarly greater for both PSP-RS and PSP-P than for PD. Finally, PSP-P showed a higher P/M ratio and lower MTEGM compared with PD in the follow-up, while PSP-RS still exhibited the most profound changes.\u0000\u0000\u0000CONCLUSIONS\u0000Midbrain atrophy progresses differentially in patients with PSP-RS, PSP-P, and PD. Longitudinal measurements of midbrain atrophy using MRI-based visual rating indexes can help distinguish patients with PSP-P from those with PSP-RS and PD.","PeriodicalId":294908,"journal":{"name":"Neuro-degenerative diseases","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122954964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.1159/isbn.978-3-8055-9359-5
R. Nitsch, A. Fisher, M. Windisch
{"title":"Alzheimer's and Parkinson's diseases: advances, concepts and new challenges. Proceedings of the 9th International Conference on Alzheimer's and Parkinson's Diseases. Prague, Czech Republic. March 11-15, 2009.","authors":"R. Nitsch, A. Fisher, M. Windisch","doi":"10.1159/isbn.978-3-8055-9359-5","DOIUrl":"https://doi.org/10.1159/isbn.978-3-8055-9359-5","url":null,"abstract":"","PeriodicalId":294908,"journal":{"name":"Neuro-degenerative diseases","volume":"92 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117299450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.1159/isbn.978-3-8055-8519-4
Manfred Windisch, Abraham Fisher
{"title":"Alzheimer's and Parkinson's Diseases: Progress and New Perspectives. Proceedings of the 8th International Conference AD/PD, Salzburg, Austria, March 14-18, 2007.","authors":"Manfred Windisch, Abraham Fisher","doi":"10.1159/isbn.978-3-8055-8519-4","DOIUrl":"https://doi.org/10.1159/isbn.978-3-8055-8519-4","url":null,"abstract":"","PeriodicalId":294908,"journal":{"name":"Neuro-degenerative diseases","volume":"5 3-4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130474241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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