Objective — to study the diagnostic significance of the serum level of calcitonin‑gene‑related peptide as a tool for the differential diagnosis of migraine with comorbid neck pain and tension of the pericranial muscles and cervicogenic headache. Methods and subjects. The study included 112 patients (84 women, 28 men) aged from 18 to 58 years. In 77 patients episodic migraine was diagnosed (with a typical aura in 17 and without aura in 60 patients), in 35 patients suffered from cervicalgia with muscle‑tonic syndromes and cervicogenic headache. Among patients with migraine, 42 had concomitant cervicalgia with muscle‑tonic dysfunction. The examined patients were distributed into 3 clinical groups: I — combination of episodic migraine with cervicalgia, II — episodic migraine, III — cervicalgia without migraine. In all patients, pain intensity was assessed using a visual analogue scale, the effect of migraine on daily activity and performance using the MIDAS and HIT‑6 scales, and the Neck Disability Index. The control group for comparing the serum level of CGRP consisted of 30 clinically healthy persons. The serum level of CGRP was determined by enzyme‑linked immunosorbent assay using the sandwich ELISA principle. Results. In the group of patients with a combination of episodic migraine with cervicalgia and cervicogenic headache, compared with the group with isolated migraine, the number of days with headache over the last 3 months was higher (р < 0.001), the influence of headache on daily activity and performance according to the MIDAS scales and HIT‑6 was more significant (both р < 0.001) and the number of combined analgesics used was higher (р < 0.001). Plasma level of CGRP was statistically significantly higher in patients with episodic migraine compared with the group with cervicalgia without migraine (р < 0.05), where it did not differ from the control. The CGRP level was statistically significantly higher in women with migraine compared to men (р < 0.001), but did not differ in patients with migraine with and without aura (р > 0.05). Conclusions. The serum level of calcitonin‑gene‑related peptide is a reliable diagnostic and differential diagnostic laboratory biomarker of episodic migraine. The presence of concomitant cervicalgia in patients with episodic migraine significantly affects the level of CGRP in the blood plasma and the course of the disease (an increase in the number of days with headache, the amount of analgesic use, decreased performance and daily activity).
{"title":"Diagnostic value of migraine biomarker — calcitonin-gene-related peptide","authors":"O. Dubenko, A. Chernenko","doi":"10.30978/UNJ2021-1-2-5","DOIUrl":"https://doi.org/10.30978/UNJ2021-1-2-5","url":null,"abstract":"Objective — to study the diagnostic significance of the serum level of calcitonin‑gene‑related peptide as a tool for the differential diagnosis of migraine with comorbid neck pain and tension of the pericranial muscles and cervicogenic headache.\u0000Methods and subjects. The study included 112 patients (84 women, 28 men) aged from 18 to 58 years. In 77 patients episodic migraine was diagnosed (with a typical aura in 17 and without aura in 60 patients), in 35 patients suffered from cervicalgia with muscle‑tonic syndromes and cervicogenic headache. Among patients with migraine, 42 had concomitant cervicalgia with muscle‑tonic dysfunction. The examined patients were distributed into 3 clinical groups: I — combination of episodic migraine with cervicalgia, II — episodic migraine, III — cervicalgia without migraine. In all patients, pain intensity was assessed using a visual analogue scale, the effect of migraine on daily activity and performance using the MIDAS and HIT‑6 scales, and the Neck Disability Index. The control group for comparing the serum level of CGRP consisted of 30 clinically healthy persons. The serum level of CGRP was determined by enzyme‑linked immunosorbent assay using the sandwich ELISA principle.\u0000Results. In the group of patients with a combination of episodic migraine with cervicalgia and cervicogenic headache, compared with the group with isolated migraine, the number of days with headache over the last 3 months was higher (р < 0.001), the influence of headache on daily activity and performance according to the MIDAS scales and HIT‑6 was more significant (both р < 0.001) and the number of combined analgesics used was higher (р < 0.001). Plasma level of CGRP was statistically significantly higher in patients with episodic migraine compared with the group with cervicalgia without migraine (р < 0.05), where it did not differ from the control. The CGRP level was statistically significantly higher in women with migraine compared to men (р < 0.001), but did not differ in patients with migraine with and without aura (р > 0.05).\u0000Conclusions. The serum level of calcitonin‑gene‑related peptide is a reliable diagnostic and differential diagnostic laboratory biomarker of episodic migraine. The presence of concomitant cervicalgia in patients with episodic migraine significantly affects the level of CGRP in the blood plasma and the course of the disease (an increase in the number of days with headache, the amount of analgesic use, decreased performance and daily activity).\u0000 ","PeriodicalId":296251,"journal":{"name":"Ukrainian Neurological Journal","volume":"67 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132313994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective — to investigate the indicators of the quality of life in patients suffering from a hemorrhagic hemispherestroke in the early recovery period in dynamics using SF‑36v2 questionnaire and to reveal the factors which affect these indicators. Methods and subjects. An open‑label, cohort study of 46 patients suffering from a hemorrhagic hemispherestroke (HHS) in the early recovery period was performed in ZSMU nervous diseases clinic. Among the patients there were 31 (67.4 %) men and 15 (32.6 %) women. The average age of the patients was 57.15 ± 9.53 years. The patients underwent comprehensive investigation of HHS on the 30th, 90th, and 180th day of the disease using the following scales: National Institutes of Health Stroke Scale (NIHSS) to objectively evaluate the condition severity; Modified Rankin Scale (mRS) to assess the rate of functional recuperation and disability; Barthel Index (BI) to evaluate the possibility of everyday skills and self‑care; Motor Assessment Scale (MAS) to indicate the muscle spasticity in the upper and lower limbs; quality of life assessment according to the SF‑36v2 Health Survey questionnaire. Results. The study found that significant decrease of all life quality indicators, evaluated on SF‑36v2 scale, was observed on the 30th day of HHS patients. The physical functioning, the physical role functioning, and the social role functioning section scores were the most decreased. A reliable improvement of the physical and mental part of health during the early recovery period was observed. Conclusions. A statistically significant correlation was found between the NIHSS, mRS, BI scores and all quality of life indicators according to SF‑36v2, except for the intensity of pain on the 30th day of the disease. A statistically significant effect of the presence of manifestations of spasticity on the physical component of health during the early recovery period, as well as on the indicator of pain intensity on the 30th day of the disease, was established.
{"title":"Dynamics of quality of life indicators of patients with hemorrhagic hemisphere stroke at the early recovery period of the disease","authors":"S. Medvedkova, A. Dronova","doi":"10.30978/UNJ2021-1-2-12","DOIUrl":"https://doi.org/10.30978/UNJ2021-1-2-12","url":null,"abstract":"Objective — to investigate the indicators of the quality of life in patients suffering from a hemorrhagic hemispherestroke in the early recovery period in dynamics using SF‑36v2 questionnaire and to reveal the factors which affect these indicators. \u0000Methods and subjects. An open‑label, cohort study of 46 patients suffering from a hemorrhagic hemispherestroke (HHS) in the early recovery period was performed in ZSMU nervous diseases clinic. Among the patients there were 31 (67.4 %) men and 15 (32.6 %) women. The average age of the patients was 57.15 ± 9.53 years. The patients underwent comprehensive investigation of HHS on the 30th, 90th, and 180th day of the disease using the following scales: National Institutes of Health Stroke Scale (NIHSS) to objectively evaluate the condition severity; Modified Rankin Scale (mRS) to assess the rate of functional recuperation and disability; Barthel Index (BI) to evaluate the possibility of everyday skills and self‑care; Motor Assessment Scale (MAS) to indicate the muscle spasticity in the upper and lower limbs; quality of life assessment according to the SF‑36v2 Health Survey questionnaire. \u0000Results. The study found that significant decrease of all life quality indicators, evaluated on SF‑36v2 scale, was observed on the 30th day of HHS patients. The physical functioning, the physical role functioning, and the social role functioning section scores were the most decreased. A reliable improvement of the physical and mental part of health during the early recovery period was observed. \u0000Conclusions. A statistically significant correlation was found between the NIHSS, mRS, BI scores and all quality of life indicators according to SF‑36v2, except for the intensity of pain on the 30th day of the disease. A statistically significant effect of the presence of manifestations of spasticity on the physical component of health during the early recovery period, as well as on the indicator of pain intensity on the 30th day of the disease, was established. \u0000 ","PeriodicalId":296251,"journal":{"name":"Ukrainian Neurological Journal","volume":"169 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126650013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective — to evaluate the place of pain in the structure of neurological symptoms from the patient’s point of view in patients with multiple sclerosis and determine the characteristics of the MS, pain syndromes and social factors that affect the perception of pain as a most disturbing symptom in patients with MS. Methods and subjects. 104 patients with a confirmed diagnosis of multiple sclerosis and existing pain syndromes were examined. An analysis of medical records, neurological and general medical examination, medical history and history of pain, as well as life history with clarification of education background and religiousness were conducted. VAS and SF‑MPQ2 questionnaires were used to assess the characteristics of pain syndromes. Patients were asked which multiple sclerosis syndrome disturbed them the most. Results. Among the examined patients with MS, pain was the most disturbing syndrome for 41.3 % of patients. Gender and religiosity did not affect this perception. There was a tendency to more frequent perception of pain as the syndrome that disturbed the most among patients with lower levels of education, but this trend was not statistically significant (p = 0.14). Among patients with pain as the syndrome that disturbs them the most, there is a larger proportion of patients with a small number of MS relapses (1 — 10): 65.1 ± 7.3 % vs. 44.3 ± 6.4 %, respectively, p = 0.04. Among patients who considered pain to be the first manifestation of MS, pain was considered to be the most disturbing syndrome more often (p = 0.02). The results of pain characteristics comparison based on SF‑MPQ‑2 results showed significantly higher rates of continuous, intermittent pain components of pain in patients with pain as the most disturbing syndrome: 27.0 [18.5; 36.5] and 21.0 [10.0; 33.0] point, p = 0.04; 20.0 [13.0; 30.0] and 12.0 [4.0; 26.0] points, p = 0.03, respectively. The VAS scores of strongest pain for the last month where higher in the group of patients whose pain was the most disturbing syndrome — 8 [7; 9] points than in the group of patients whose pain was not the most disturbing syndrome — 6 [4; 8] points (p = 0.0001). The proportion of patients with pain, as the most disturbing symptom of MS, was 2.2 times higher than the proportion of patients for whom pain was not the most disturbing symptom of MS in the group with the strongest pain intensity for the last month of 8 — 10 points: 67.4 ± 7.1 % vs. 31.1 ± 5.9 %, respectively (p = 0.0003). A similar difference was found when comparing the distribution of patients by the intensity of average pain per month, where the proportion of patients with high‑intensity average pain per month is more than 2 times higher among patients who consider pain the syndrome that disturbing them the most in the structure of MS. Conclusions. More than a third of MS patients consider pain as a most disturbing symptom in the structure of this disease. Such an assessment of pain does not depend on gender or religiosi
{"title":"The place of pain in the structure of neurological symptoms in patients with multiple sclerosis and the characteristics that affect the prioritization of pain by the patient","authors":"M. Bozhenko","doi":"10.30978/UNJ2021-1-2-19","DOIUrl":"https://doi.org/10.30978/UNJ2021-1-2-19","url":null,"abstract":"Objective — to evaluate the place of pain in the structure of neurological symptoms from the patient’s point of view in patients with multiple sclerosis and determine the characteristics of the MS, pain syndromes and social factors that affect the perception of pain as a most disturbing symptom in patients with MS.\u0000Methods and subjects. 104 patients with a confirmed diagnosis of multiple sclerosis and existing pain syndromes were examined. An analysis of medical records, neurological and general medical examination, medical history and history of pain, as well as life history with clarification of education background and religiousness were conducted. VAS and SF‑MPQ2 questionnaires were used to assess the characteristics of pain syndromes. Patients were asked which multiple sclerosis syndrome disturbed them the most.\u0000Results. Among the examined patients with MS, pain was the most disturbing syndrome for 41.3 % of patients. Gender and religiosity did not affect this perception. There was a tendency to more frequent perception of pain as the syndrome that disturbed the most among patients with lower levels of education, but this trend was not statistically significant (p = 0.14). Among patients with pain as the syndrome that disturbs them the most, there is a larger proportion of patients with a small number of MS relapses (1 — 10): 65.1 ± 7.3 % vs. 44.3 ± 6.4 %, respectively, p = 0.04. Among patients who considered pain to be the first manifestation of MS, pain was considered to be the most disturbing syndrome more often (p = 0.02). The results of pain characteristics comparison based on SF‑MPQ‑2 results showed significantly higher rates of continuous, intermittent pain components of pain in patients with pain as the most disturbing syndrome: 27.0 [18.5; 36.5] and 21.0 [10.0; 33.0] point, p = 0.04; 20.0 [13.0; 30.0] and 12.0 [4.0; 26.0] points, p = 0.03, respectively. The VAS scores of strongest pain for the last month where higher in the group of patients whose pain was the most disturbing syndrome — 8 [7; 9] points than in the group of patients whose pain was not the most disturbing syndrome — 6 [4; 8] points (p = 0.0001). The proportion of patients with pain, as the most disturbing symptom of MS, was 2.2 times higher than the proportion of patients for whom pain was not the most disturbing symptom of MS in the group with the strongest pain intensity for the last month of 8 — 10 points: 67.4 ± 7.1 % vs. 31.1 ± 5.9 %, respectively (p = 0.0003). A similar difference was found when comparing the distribution of patients by the intensity of average pain per month, where the proportion of patients with high‑intensity average pain per month is more than 2 times higher among patients who consider pain the syndrome that disturbing them the most in the structure of MS.\u0000Conclusions. More than a third of MS patients consider pain as a most disturbing symptom in the structure of this disease. Such an assessment of pain does not depend on gender or religiosi","PeriodicalId":296251,"journal":{"name":"Ukrainian Neurological Journal","volume":"279 7","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120838071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The Functional Independence Measure and Functional Assessment Measure (FIM + FAM) is an effective, efficient, and objective tool for tracking changes in the motor, cognitive, and psychosocial functions of patients over the entire treatment and rehabilitation period. It is estimated that in the Czech Republic (CR), stroke is the third most common cause of death and the most common cause of adult disability. To develop faster, better, and more cost‑effective stroke treatments and reduce or mitigate functional losses and restrictive situations, it is very important that patients be objectively evaluated, relative to their functional abilities, as soon as possible after a stroke. A critical part of stroke treatment is to calculate the length of in‑hospital treatment and estimate the length of the rehabilitation period after the stroke. Contemporary methods for evaluating and analyzing a patient’s condition are based on test results and evidence.The FIM offers a more sensitive rating scale compared to BI due to the presence of cognitive items and is used worldwide for assessment during the acute stage of the disease. Thus, it is an efficient instrument for setting therapy goals and evaluating the effects of rehabilitation. Not only can it assist the therapist in clinical decision making, but it also functions as a tool for evaluating rehabilitation outcomes. Based on this test, short‑term and long‑term rehabilitation plans can be determined. At the end of the rehabilitation process, assessing the patient’s functional condition helps to predict the specific long‑term rehabilitation services the patient will need as they return to society and regain their quality of life.
{"title":"The Functional Independence Measure and the Functional Assessment Measure (FIM + FAM) as an effective tool for the evaluation of functional status in stroke rehabilitation","authors":"L. Shuranova, J. Vacková","doi":"10.30978/UNJ2021-1-2-43","DOIUrl":"https://doi.org/10.30978/UNJ2021-1-2-43","url":null,"abstract":"The Functional Independence Measure and Functional Assessment Measure (FIM + FAM) is an effective, efficient, and objective tool for tracking changes in the motor, cognitive, and psychosocial functions of patients over the entire treatment and rehabilitation period. It is estimated that in the Czech Republic (CR), stroke is the third most common cause of death and the most common cause of adult disability. To develop faster, better, and more cost‑effective stroke treatments and reduce or mitigate functional losses and restrictive situations, it is very important that patients be objectively evaluated, relative to their functional abilities, as soon as possible after a stroke. A critical part of stroke treatment is to calculate the length of in‑hospital treatment and estimate the length of the rehabilitation period after the stroke. Contemporary methods for evaluating and analyzing a patient’s condition are based on test results and evidence.The FIM offers a more sensitive rating scale compared to BI due to the presence of cognitive items and is used worldwide for assessment during the acute stage of the disease. Thus, it is an efficient instrument for setting therapy goals and evaluating the effects of rehabilitation. Not only can it assist the therapist in clinical decision making, but it also functions as a tool for evaluating rehabilitation outcomes. Based on this test, short‑term and long‑term rehabilitation plans can be determined. At the end of the rehabilitation process, assessing the patient’s functional condition helps to predict the specific long‑term rehabilitation services the patient will need as they return to society and regain their quality of life.","PeriodicalId":296251,"journal":{"name":"Ukrainian Neurological Journal","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130882611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cognitive impairment in patients with multiple sclerosis","authors":"H. V. Hudzenko","doi":"10.30978/UNJ2020-4-37","DOIUrl":"https://doi.org/10.30978/UNJ2020-4-37","url":null,"abstract":"","PeriodicalId":296251,"journal":{"name":"Ukrainian Neurological Journal","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130847701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Relation between spasticity in patients with multiple sclerosis with the degree of disability, neurofunctional and neuropsychological disorders","authors":"N. V. Domres, T. Kobys, L. Sokolova","doi":"10.30978/UNJ2020-4-30","DOIUrl":"https://doi.org/10.30978/UNJ2020-4-30","url":null,"abstract":"","PeriodicalId":296251,"journal":{"name":"Ukrainian Neurological Journal","volume":"80 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122773403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Complex approach to early diagnostics of mental disorders in adolescents with somatic diseases","authors":"O. Masik","doi":"10.30978/UNJ2020-4-43","DOIUrl":"https://doi.org/10.30978/UNJ2020-4-43","url":null,"abstract":"","PeriodicalId":296251,"journal":{"name":"Ukrainian Neurological Journal","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121802795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Transcranial magnetic stimulation in treatment of motor and nonmotor symptoms of Parkinson’s disease","authors":"A. Demchenko, G. N. Aravitska, A. Revenko","doi":"10.30978/UNJ2020-4-5","DOIUrl":"https://doi.org/10.30978/UNJ2020-4-5","url":null,"abstract":"","PeriodicalId":296251,"journal":{"name":"Ukrainian Neurological Journal","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128794711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Transcranial Doppler diagnostics for moderate traumatic brain injuryin acute, intermediate and distant periods in the participants in the operation of the joined forces and victims outside the conflict zone","authors":"M. Semchyshyn","doi":"10.30978/unj2020-1-41","DOIUrl":"https://doi.org/10.30978/unj2020-1-41","url":null,"abstract":"","PeriodicalId":296251,"journal":{"name":"Ukrainian Neurological Journal","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121972976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Virus persistence in atherosclerotic plaques in ischemic stroke/TIA patients with carotid endarterectomy","authors":"N. Turchyna, T. Cherenko, V. Chernyak","doi":"10.30978/unj2020-1-34","DOIUrl":"https://doi.org/10.30978/unj2020-1-34","url":null,"abstract":"","PeriodicalId":296251,"journal":{"name":"Ukrainian Neurological Journal","volume":"487 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116322924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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