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A31. GLOBAL AND ENVIRONMENTAL INFLUENCES IN ASTHMA最新文献

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Corticosteroid Changes Mast Cell Receptor Expression and Responses to Asthma-associated Cytokines 皮质类固醇改变肥大细胞受体表达和对哮喘相关细胞因子的反应
Pub Date : 2023-05-01 DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1312
Y. Ohne, D. Sims, S. Lee, S. Cohen, J. Kearley
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引用次数: 0
The MiSTIC Study Design: Medium Strength Triple Therapy Vs High Strength ICS/LABA for Adult Patients With Asthma Uncontrolled on Medium Strength ICS/LABA MiSTIC研究设计:中等强度三联疗法Vs高强度ICS/LABA对中等强度ICS/LABA未控制的成人哮喘患者
Pub Date : 2023-05-01 DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1310
K. Kostikas, E. Topole, D. Singh, G. Brusselle, M. Kots, A. Vele, G. Georges, A. Papi
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引用次数: 0
Cholinergic System in the Exposure of Iron Particles in an Experimental Model of Chronic Allergic Inflammation 慢性变应性炎症实验模型中铁颗粒暴露中的胆碱能系统
Pub Date : 2023-05-01 DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1320
I. Tibério, T. Santos, S. Fukuzaki, E. Campos, T. Galli, L.L.S.D. Silva, J. Barbosa, J. João, L. Camargo, B. Saraiva-Romanholo, J. Cirillo, S. Bezerra, C. Prado, M. A. Martins, R. Righetti, F. Lopes, E. Leick, F.J.A. Silva, B. G. Rezende, C. Bourotte, I. Benseñor, P. Lotufo
{"title":"Cholinergic System in the Exposure of Iron Particles in an Experimental Model of Chronic Allergic Inflammation","authors":"I. Tibério, T. Santos, S. Fukuzaki, E. Campos, T. Galli, L.L.S.D. Silva, J. Barbosa, J. João, L. Camargo, B. Saraiva-Romanholo, J. Cirillo, S. Bezerra, C. Prado, M. A. Martins, R. Righetti, F. Lopes, E. Leick, F.J.A. Silva, B. G. Rezende, C. Bourotte, I. Benseñor, P. Lotufo","doi":"10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1320","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1320","url":null,"abstract":"","PeriodicalId":297069,"journal":{"name":"A31. GLOBAL AND ENVIRONMENTAL INFLUENCES IN ASTHMA","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131114900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of DHEA Treatment on Normal Airway Epithelial Cell Proteins 脱氢表雄酮对正常气道上皮细胞蛋白的影响
Pub Date : 2023-05-01 DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1308
N. Marozkina, M. Chmiel, L. Smith, T. Edwards, D. Newcomb, Y. Zhao, J. Zein, T. Lahm, B. Gaston, A. Waltz
{"title":"Effects of DHEA Treatment on Normal Airway Epithelial Cell Proteins","authors":"N. Marozkina, M. Chmiel, L. Smith, T. Edwards, D. Newcomb, Y. Zhao, J. Zein, T. Lahm, B. Gaston, A. Waltz","doi":"10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1308","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1308","url":null,"abstract":"","PeriodicalId":297069,"journal":{"name":"A31. GLOBAL AND ENVIRONMENTAL INFLUENCES IN ASTHMA","volume":"169 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114733492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tmem178 Regulates Calcium Responses in Normal Human Bronchial Epithelial Cells Tmem178调节正常人支气管上皮细胞钙反应
Pub Date : 2023-05-01 DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1304
A.M. Hernandez Botero, K. Stelzig, C. Pabelick, Y. Prakash, S. Chiarella
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引用次数: 0
Serum α-klotho Level and Lung Function in a Nationwide Study of U.S. Adults 美国成人血清α-klotho水平与肺功能的全国性研究
Pub Date : 2023-05-01 DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1289
Y.-Y. Han, J. Celedón, E. Forno
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引用次数: 0
Predictive Factors of Favorable Outcome for Mepolizumab Treatment to for Eosinophilic Granulomatosis With Polyangiitis: A Case Series Mepolizumab治疗嗜酸性肉芽肿合并多血管炎的有利预后预测因素:一个病例系列
Pub Date : 2023-05-01 DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1317
R. Tsuzuki, K. Kaburagi, S. Sasada, Y. Kono, M. To, Y. To
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引用次数: 0
Baseline Characteristics of Patients With Severe Asthma Treated With Mepolizumab: An Interim Analysis of a Multi-country Real-world Cohort Mepolizumab治疗严重哮喘患者的基线特征:一项多国现实世界队列的中期分析
Pub Date : 2023-05-01 DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1313
R. Allehebi, V. Nagarjuna Maturu, B. Mahboub, S. Bavbek, P. Fernández, D.J. Cano Rosales, C. Soares, G. Abreu, R. Valladares, J. Queiroz, P. Menezes, A. Raimondi, F. Aziz, E. Pizzichini, M. Laucho-Contreras, S. Noibi
{"title":"Baseline Characteristics of Patients With Severe Asthma Treated With Mepolizumab: An Interim Analysis of a Multi-country Real-world Cohort","authors":"R. Allehebi, V. Nagarjuna Maturu, B. Mahboub, S. Bavbek, P. Fernández, D.J. Cano Rosales, C. Soares, G. Abreu, R. Valladares, J. Queiroz, P. Menezes, A. Raimondi, F. Aziz, E. Pizzichini, M. Laucho-Contreras, S. Noibi","doi":"10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1313","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1313","url":null,"abstract":"","PeriodicalId":297069,"journal":{"name":"A31. GLOBAL AND ENVIRONMENTAL INFLUENCES IN ASTHMA","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130435285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Trial of a Probiotic and Herbal Supplement for Lung and Gut Health 肺和肠道健康益生菌和草药补充剂的临床试验
Pub Date : 2023-01-28 DOI: 10.1101/2023.01.24.23284954
N. Wenger, L. Qiao, T. Nicola, Z. Nizami, I. Martin, B. Halloran, K. Tanaka, M. Evans, X. Xu, T. Dinan, C. Kakilla, G. Dunngalvin, N. Ambalavanan, K. Willis, A. Gaggar, C. Lal
Rationale: Dysbiosis of the gut microbiome may augment lung disease via the gut-lung axis. Proteobacteria may increase MMP-9 release and contribute to tissue proteolysis followed by neutrophil recruitment, lung tissue injury, and perpetuation of chronic lung disease. Trial Design: We sought to determine if a probiotic and herbal blend was safe and well-tolerated in healthy volunteers and asthmatic patients. Methods: We conducted a 1-month randomized, open-label clinical trial in Cork, Ireland with healthy and asthmatic patients who took the blend twice a day. The primary endpoint was safety with secondary endpoints including quality of life, lung function, gut microbiome ecology, and inflammatory biomarkers. Results: All subjects tolerated the blend without adverse events. Asthmatic subjects who took the blend showed significant improvements in lung function and serum short chain fatty acid levels from baseline to Week 4. The gut microbiome of asthmatic subjects differed significantly from controls, with the most prominent difference in the relative abundance of the proteobacteria Escherichia coli. Administration of the probiotic maintained overall microbial community architecture with the only significant difference being an increase in absolute abundance of the probiotic strains measured by strain-specific PCR. Conclusions: This study supports the safety and efficacy potential of oral probiotic administration of the probiotic and herbal to act on the gut-lung axis.
理由:肠道菌群失调可能通过肠-肺轴增加肺部疾病。变形菌可能增加MMP-9的释放,促进组织蛋白水解,随后中性粒细胞募集,肺组织损伤和慢性肺病的持续存在。试验设计:我们试图确定益生菌和草药混合物在健康志愿者和哮喘患者中是否安全且耐受性良好。方法:我们在爱尔兰科克进行了一项为期1个月的随机,开放标签临床试验,健康和哮喘患者每天服用两次混合物。主要终点是安全性,次要终点包括生活质量、肺功能、肠道微生物群生态和炎症生物标志物。结果:所有受试者耐受该混合物,无不良事件。从基线到第4周,哮喘受试者的肺功能和血清短链脂肪酸水平均有显著改善。哮喘患者的肠道微生物群与对照组有显著差异,其中最显著的差异是大肠杆菌的相对丰度。益生菌的施用维持了整体微生物群落结构,唯一显著的区别是菌株特异性PCR测量的益生菌菌株的绝对丰度增加。结论:本研究支持口服益生菌和草药对肠-肺轴作用的安全性和有效性。
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引用次数: 0
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A31. GLOBAL AND ENVIRONMENTAL INFLUENCES IN ASTHMA
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