Pub Date : 2023-05-01DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1312
Y. Ohne, D. Sims, S. Lee, S. Cohen, J. Kearley
{"title":"Corticosteroid Changes Mast Cell Receptor Expression and Responses to Asthma-associated Cytokines","authors":"Y. Ohne, D. Sims, S. Lee, S. Cohen, J. Kearley","doi":"10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1312","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1312","url":null,"abstract":"","PeriodicalId":297069,"journal":{"name":"A31. GLOBAL AND ENVIRONMENTAL INFLUENCES IN ASTHMA","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116126318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-01DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1310
K. Kostikas, E. Topole, D. Singh, G. Brusselle, M. Kots, A. Vele, G. Georges, A. Papi
{"title":"The MiSTIC Study Design: Medium Strength Triple Therapy Vs High Strength ICS/LABA for Adult Patients With Asthma Uncontrolled on Medium Strength ICS/LABA","authors":"K. Kostikas, E. Topole, D. Singh, G. Brusselle, M. Kots, A. Vele, G. Georges, A. Papi","doi":"10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1310","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1310","url":null,"abstract":"","PeriodicalId":297069,"journal":{"name":"A31. GLOBAL AND ENVIRONMENTAL INFLUENCES IN ASTHMA","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121015921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-01DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1320
I. Tibério, T. Santos, S. Fukuzaki, E. Campos, T. Galli, L.L.S.D. Silva, J. Barbosa, J. João, L. Camargo, B. Saraiva-Romanholo, J. Cirillo, S. Bezerra, C. Prado, M. A. Martins, R. Righetti, F. Lopes, E. Leick, F.J.A. Silva, B. G. Rezende, C. Bourotte, I. Benseñor, P. Lotufo
{"title":"Cholinergic System in the Exposure of Iron Particles in an Experimental Model of Chronic Allergic Inflammation","authors":"I. Tibério, T. Santos, S. Fukuzaki, E. Campos, T. Galli, L.L.S.D. Silva, J. Barbosa, J. João, L. Camargo, B. Saraiva-Romanholo, J. Cirillo, S. Bezerra, C. Prado, M. A. Martins, R. Righetti, F. Lopes, E. Leick, F.J.A. Silva, B. G. Rezende, C. Bourotte, I. Benseñor, P. Lotufo","doi":"10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1320","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1320","url":null,"abstract":"","PeriodicalId":297069,"journal":{"name":"A31. GLOBAL AND ENVIRONMENTAL INFLUENCES IN ASTHMA","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131114900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-01DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1308
N. Marozkina, M. Chmiel, L. Smith, T. Edwards, D. Newcomb, Y. Zhao, J. Zein, T. Lahm, B. Gaston, A. Waltz
{"title":"Effects of DHEA Treatment on Normal Airway Epithelial Cell Proteins","authors":"N. Marozkina, M. Chmiel, L. Smith, T. Edwards, D. Newcomb, Y. Zhao, J. Zein, T. Lahm, B. Gaston, A. Waltz","doi":"10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1308","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1308","url":null,"abstract":"","PeriodicalId":297069,"journal":{"name":"A31. GLOBAL AND ENVIRONMENTAL INFLUENCES IN ASTHMA","volume":"169 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114733492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-01DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1304
A.M. Hernandez Botero, K. Stelzig, C. Pabelick, Y. Prakash, S. Chiarella
{"title":"Tmem178 Regulates Calcium Responses in Normal Human Bronchial Epithelial Cells","authors":"A.M. Hernandez Botero, K. Stelzig, C. Pabelick, Y. Prakash, S. Chiarella","doi":"10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1304","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1304","url":null,"abstract":"","PeriodicalId":297069,"journal":{"name":"A31. GLOBAL AND ENVIRONMENTAL INFLUENCES IN ASTHMA","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122631490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-01DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1289
Y.-Y. Han, J. Celedón, E. Forno
{"title":"Serum α-klotho Level and Lung Function in a Nationwide Study of U.S. Adults","authors":"Y.-Y. Han, J. Celedón, E. Forno","doi":"10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1289","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1289","url":null,"abstract":"","PeriodicalId":297069,"journal":{"name":"A31. GLOBAL AND ENVIRONMENTAL INFLUENCES IN ASTHMA","volume":"214 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121240748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-01DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1317
R. Tsuzuki, K. Kaburagi, S. Sasada, Y. Kono, M. To, Y. To
{"title":"Predictive Factors of Favorable Outcome for Mepolizumab Treatment to for Eosinophilic Granulomatosis With Polyangiitis: A Case Series","authors":"R. Tsuzuki, K. Kaburagi, S. Sasada, Y. Kono, M. To, Y. To","doi":"10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1317","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1317","url":null,"abstract":"","PeriodicalId":297069,"journal":{"name":"A31. GLOBAL AND ENVIRONMENTAL INFLUENCES IN ASTHMA","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122472557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-01DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1313
R. Allehebi, V. Nagarjuna Maturu, B. Mahboub, S. Bavbek, P. Fernández, D.J. Cano Rosales, C. Soares, G. Abreu, R. Valladares, J. Queiroz, P. Menezes, A. Raimondi, F. Aziz, E. Pizzichini, M. Laucho-Contreras, S. Noibi
{"title":"Baseline Characteristics of Patients With Severe Asthma Treated With Mepolizumab: An Interim Analysis of a Multi-country Real-world Cohort","authors":"R. Allehebi, V. Nagarjuna Maturu, B. Mahboub, S. Bavbek, P. Fernández, D.J. Cano Rosales, C. Soares, G. Abreu, R. Valladares, J. Queiroz, P. Menezes, A. Raimondi, F. Aziz, E. Pizzichini, M. Laucho-Contreras, S. Noibi","doi":"10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1313","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1313","url":null,"abstract":"","PeriodicalId":297069,"journal":{"name":"A31. GLOBAL AND ENVIRONMENTAL INFLUENCES IN ASTHMA","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130435285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-28DOI: 10.1101/2023.01.24.23284954
N. Wenger, L. Qiao, T. Nicola, Z. Nizami, I. Martin, B. Halloran, K. Tanaka, M. Evans, X. Xu, T. Dinan, C. Kakilla, G. Dunngalvin, N. Ambalavanan, K. Willis, A. Gaggar, C. Lal
Rationale: Dysbiosis of the gut microbiome may augment lung disease via the gut-lung axis. Proteobacteria may increase MMP-9 release and contribute to tissue proteolysis followed by neutrophil recruitment, lung tissue injury, and perpetuation of chronic lung disease. Trial Design: We sought to determine if a probiotic and herbal blend was safe and well-tolerated in healthy volunteers and asthmatic patients. Methods: We conducted a 1-month randomized, open-label clinical trial in Cork, Ireland with healthy and asthmatic patients who took the blend twice a day. The primary endpoint was safety with secondary endpoints including quality of life, lung function, gut microbiome ecology, and inflammatory biomarkers. Results: All subjects tolerated the blend without adverse events. Asthmatic subjects who took the blend showed significant improvements in lung function and serum short chain fatty acid levels from baseline to Week 4. The gut microbiome of asthmatic subjects differed significantly from controls, with the most prominent difference in the relative abundance of the proteobacteria Escherichia coli. Administration of the probiotic maintained overall microbial community architecture with the only significant difference being an increase in absolute abundance of the probiotic strains measured by strain-specific PCR. Conclusions: This study supports the safety and efficacy potential of oral probiotic administration of the probiotic and herbal to act on the gut-lung axis.
{"title":"Clinical Trial of a Probiotic and Herbal Supplement for Lung and Gut Health","authors":"N. Wenger, L. Qiao, T. Nicola, Z. Nizami, I. Martin, B. Halloran, K. Tanaka, M. Evans, X. Xu, T. Dinan, C. Kakilla, G. Dunngalvin, N. Ambalavanan, K. Willis, A. Gaggar, C. Lal","doi":"10.1101/2023.01.24.23284954","DOIUrl":"https://doi.org/10.1101/2023.01.24.23284954","url":null,"abstract":"Rationale: Dysbiosis of the gut microbiome may augment lung disease via the gut-lung axis. Proteobacteria may increase MMP-9 release and contribute to tissue proteolysis followed by neutrophil recruitment, lung tissue injury, and perpetuation of chronic lung disease. Trial Design: We sought to determine if a probiotic and herbal blend was safe and well-tolerated in healthy volunteers and asthmatic patients. Methods: We conducted a 1-month randomized, open-label clinical trial in Cork, Ireland with healthy and asthmatic patients who took the blend twice a day. The primary endpoint was safety with secondary endpoints including quality of life, lung function, gut microbiome ecology, and inflammatory biomarkers. Results: All subjects tolerated the blend without adverse events. Asthmatic subjects who took the blend showed significant improvements in lung function and serum short chain fatty acid levels from baseline to Week 4. The gut microbiome of asthmatic subjects differed significantly from controls, with the most prominent difference in the relative abundance of the proteobacteria Escherichia coli. Administration of the probiotic maintained overall microbial community architecture with the only significant difference being an increase in absolute abundance of the probiotic strains measured by strain-specific PCR. Conclusions: This study supports the safety and efficacy potential of oral probiotic administration of the probiotic and herbal to act on the gut-lung axis.","PeriodicalId":297069,"journal":{"name":"A31. GLOBAL AND ENVIRONMENTAL INFLUENCES IN ASTHMA","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128705613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}