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Critical Care Pediatric Nephrology and Dialysis: A Practical Handbook最新文献

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CRRT in a Sick Child 病童的CRRT
Pub Date : 1900-01-01 DOI: 10.1007/978-981-13-2276-1_11
T. Bunchman
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引用次数: 0
Acute Kidney Injury: Definitions and Epidemiology 急性肾损伤:定义和流行病学
Pub Date : 1900-01-01 DOI: 10.1007/978-981-13-2276-1_1
Neziha Celebi, A. Arıkan
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引用次数: 0
Long-Term Outcome of Acute Kidney Injury in Children: A Practical Approach for Follow-up 儿童急性肾损伤的长期预后:一种实用的随访方法
Pub Date : 1900-01-01 DOI: 10.1007/978-981-13-2276-1_28
C. W. Teoh, M. Zappitelli
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引用次数: 0
Pharmacology of a Critically Ill Child and Drug Dosing 一个危重儿童的药理学和药物剂量
Pub Date : 1900-01-01 DOI: 10.1007/978-981-13-2276-1_6
J. Zaritsky, Carl Gerdine
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引用次数: 0
Sepsis-Associated Acute Kidney Injury 脓毒症相关的急性肾损伤
Pub Date : 1900-01-01 DOI: 10.5772/INTECHOPEN.69612
W. Chancharoenthana, A. Leelahavanichkul, S. Eiam‐Ong
Sepsis is a life-threatening condition caused by a dysregulated immune response to infection. Interestingly, sepsis mortality increases with acute kidney injury (AKI) and patients with AKI worsen with sepsis. It is interesting to note that most of the clinical trials on sepsis treatment that derived from the results of translational researches are a failure. This is, in part, because of the complexity of human sepsis in comparison with animal models. Another reason for the failure-translation might be the improper matching of the animal models to the individual patient. It is possible that the main mechanism of sepsis induction in each patient with the variety causes of sepsis might be different. Indeed, immune response to sepsis depends on genetic background, route of immune activation, and organisms. Thus, sepsis treatment classified by “mechanistic approach” to individual patient might be more proper than the classification with “sepsis severity”. Specific treatment of sepsis in individual patient according to the specific immune response characteristic might be a more proper translational strategy. Indeed, the understanding in immune response pattern of sepsis and sepsis pathophysiology is necessary for “sepsis mechanistic approach”. Then, we conclude most of the topics and our hypothesis regarding SA-AKI in this review.
败血症是一种危及生命的疾病,由对感染的免疫反应失调引起。有趣的是,脓毒症死亡率随着急性肾损伤(AKI)而增加,AKI患者随着脓毒症而恶化。有趣的是,大多数来自转化研究结果的败血症治疗临床试验都是失败的。这在一定程度上是因为与动物模型相比,人类败血症的复杂性。翻译失败的另一个原因可能是动物模型与个体患者的匹配不当。由于脓毒症的病因不同,每个患者脓毒症诱导的主要机制可能不同。事实上,对败血症的免疫反应取决于遗传背景、免疫激活途径和生物体。因此,以“机制方法”对个体患者进行脓毒症治疗分类可能比以“脓毒症严重程度”进行分类更合适。根据特异性免疫反应特征对脓毒症患者进行特异性治疗可能是一种更合适的翻译策略。事实上,了解脓毒症的免疫反应模式和脓毒症的病理生理是“脓毒症机制研究”所必需的。然后,我们总结了本综述中关于SA-AKI的大部分主题和我们的假设。
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引用次数: 241
Plasmapheresis in Pediatric Renal Disease 血浆置换在儿童肾脏疾病中的应用
Pub Date : 1900-01-01 DOI: 10.1007/978-981-13-2276-1_13
Daniella Levy-Erez, Haewon C. Kim
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引用次数: 0
Renal Replacement Therapy for Patients Requiring ECMO Support 需要ECMO支持的患者的肾脏替代治疗
Pub Date : 1900-01-01 DOI: 10.1007/978-981-13-2276-1_12
A. Maslach-Hubbard, R. Nelson, J. Furlong-Dillard
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引用次数: 1
Acute Kidney Injury: Principles of Management 急性肾损伤:处理原则
Pub Date : 1900-01-01 DOI: 10.1007/978-981-13-2276-1_3
Jitendra Kumar Meena, A. Bagga
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引用次数: 0
期刊
Critical Care Pediatric Nephrology and Dialysis: A Practical Handbook
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