Pub Date : 2023-05-08DOI: 10.52340/gbmn.2023.01.01.17
Nino Sukhishvili, K. Mchedlidze, K. Mulkijanyan, L. Mskhiladze
Background: The characterization and study of plants begin with the study of morphological and micro-diagnostic signs. It is essential to determine the common and distinguishing features of the species of the genus Primula to facilitate their identification. Objectives: The paper presents the macro-and micromorphological characteristics of three species of the genus Primula L.: P. woronowii Losinsk., P. macrocalyx Bunge, and P. saguramica Gavr. In addition, based on the microstructural and anatomical characteristics, the paper distinguishes between two closely related species: P. macrocalyx Bunge and P. saguramica Gavr. Methods: Microstructural research on experimental samples was carried out using standard laboratory methods adopted in microtechnology. The microtechnical investigation used light microscopes (Carl Zeiss, Jeneval, and Omax). Materials were documented using a digital camera (Canon Digital IXUS 75), and microphotographs were graphically processed in the Adobe Photoshop CS5 program. Results: Based on the data, the following common and distinguishing microstructural features of P. woronowii, P. macrocalyx, and P. saguramica were established: The basal cells of the epidermis of the leaf of the studied species are non-circular, with a curved and curved-walled structure; The ventilation system is simple, a normocytic structure; the leaf is bifacial Dorsoventra luri, amphistomatous (P. woronowii, P. saguramica
{"title":"Microstructural Features of Primula woronowii Losinsk., Primula macrocalyx Bunge. and Primula saguramica Gavr. from Georgian Flora","authors":"Nino Sukhishvili, K. Mchedlidze, K. Mulkijanyan, L. Mskhiladze","doi":"10.52340/gbmn.2023.01.01.17","DOIUrl":"https://doi.org/10.52340/gbmn.2023.01.01.17","url":null,"abstract":"Background: The characterization and study of plants begin with the study of morphological and micro-diagnostic signs. It is essential to determine the common and distinguishing features of the species of the genus Primula to facilitate their identification. Objectives: The paper presents the macro-and micromorphological characteristics of three species of the genus Primula L.: P. woronowii Losinsk., P. macrocalyx Bunge, and P. saguramica Gavr. In addition, based on the microstructural and anatomical characteristics, the paper distinguishes between two closely related species: P. macrocalyx Bunge and P. saguramica Gavr. Methods: Microstructural research on experimental samples was carried out using standard laboratory methods adopted in microtechnology. The microtechnical investigation used light microscopes (Carl Zeiss, Jeneval, and Omax). Materials were documented using a digital camera (Canon Digital IXUS 75), and microphotographs were graphically processed in the Adobe Photoshop CS5 program. Results: Based on the data, the following common and distinguishing microstructural features of P. woronowii, P. macrocalyx, and P. saguramica were established: The basal cells of the epidermis of the leaf of the studied species are non-circular, with a curved and curved-walled structure; The ventilation system is simple, a normocytic structure; the leaf is bifacial Dorsoventra luri, amphistomatous (P. woronowii, P. saguramica","PeriodicalId":298383,"journal":{"name":"GEORGIAN BIOMEDICAL NEWS","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127373935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-08DOI: 10.52340/gbmn.2023.01.01.21
T. Kituashvili, T. Urushadze
Melanoma immunotherapy has emerged as a promising treatment approach for advanced melanoma, a lethal form of skin cancer. Despite the remarkable clinical outcomes observed with immune checkpoint inhibitors, melanoma still poses significant therapeutic challenges. In this review, we discuss the immune landscape of melanoma, including the interactions between tumor cells and immune cells in the tumor microenvironment, according to the latest research studies. We also cover the immunobiology of melanoma and the mechanisms by which melanoma can evade immunosurveillance. Additionally, the review highlights emerging immunotherapeutic strategies that can overcome these mechanisms, including combination therapies and the use of novel agents that target immune checkpoints, their efficacy, and potential adverse effects. The goal of this timely review is to provide an up-to-date understanding of the complex interplay between melanoma and the immune system, and to identify new opportunities for developing effective melanoma immunotherapies.
{"title":"Understanding the Complexities of Melanoma Immunobiology and a Review of Immunotherapeutic Checkpoint Inhibito","authors":"T. Kituashvili, T. Urushadze","doi":"10.52340/gbmn.2023.01.01.21","DOIUrl":"https://doi.org/10.52340/gbmn.2023.01.01.21","url":null,"abstract":"Melanoma immunotherapy has emerged as a promising treatment approach for advanced melanoma, a lethal form of skin cancer. Despite the remarkable clinical outcomes observed with immune checkpoint inhibitors, melanoma still poses significant therapeutic challenges. In this review, we discuss the immune landscape of melanoma, including the interactions between tumor cells and immune cells in the tumor microenvironment, according to the latest research studies. We also cover the immunobiology of melanoma and the mechanisms by which melanoma can evade immunosurveillance. Additionally, the review highlights emerging immunotherapeutic strategies that can overcome these mechanisms, including combination therapies and the use of novel agents that target immune checkpoints, their efficacy, and potential adverse effects. The goal of this timely review is to provide an up-to-date understanding of the complex interplay between melanoma and the immune system, and to identify new opportunities for developing effective melanoma immunotherapies.","PeriodicalId":298383,"journal":{"name":"GEORGIAN BIOMEDICAL NEWS","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132226968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-08DOI: 10.52340/gbmn.2023.01.01.20
N. Shavlakadze, Dali Kobuladze
Background: Background: SARS-CoV-2 is still active and spreading among us, even though the COVID-19 disease pandemic is believed to have been terminated due to the extraordinary efforts of healthcare professionals and scientists. Thousands of people are being infected today. Objectives: The current study aimed to analyze existing data on the transmission of the SARS-CoV-2 virus among the West Georgia population and investigate the humoral immune response generated by the viral infection and vaccination as well. Methods: The research was conducted between March 2022 and March 2023. The study group included 400 adults (69% women and 31% men) residing in Kutaisi. Study patients were distributed among four groups: (i) Group 1: patients with confirmed SARS-CoV-2 infection without previous vaccination; (ii) Group 2: previously vaccinated patients without SARS-CoV-2 infection; (iii) Group 3: previously vaccinated patients with confirmed SARS-CoV-2 infection; and (iv) Group 4: uninfected and unvaccinated patients. All groups were divided into subgroups with positive and negative humoral responses. Each subgroup was further divided into subgroups based on gender. The data were analyzed by STATA 17. Statistical significance was defined as p < 0.05. Results: 55% of the study population was vaccinated, mainly with Pfizer's vaccine. The incidence of SARS-CoV-2 infection was equal for women and men, and they developed active immunity almost equally. The average rate of humoral im munity was 60%, with the highest rate (≈85% (r<0.05, p<0.001) in the triple-vaccinated individuals. Finally, the concentration of anti-SARS-CoV-2 IgG antibodies was particularly high (32% in the previously vaccinated patients with confirmed SARS-CoV-2 infection). The average duration of effective concentration of G-class immunoglobulins was maintained for 6-12 months. Conclusions: In most cases, the SARS-CoV-2 infection in combination with the Pfizer vaccination induces a maximal humoral immune response, although not always and not for long.
{"title":"The Humoral Immunity Features of COVID-19 in the West Georgia Population","authors":"N. Shavlakadze, Dali Kobuladze","doi":"10.52340/gbmn.2023.01.01.20","DOIUrl":"https://doi.org/10.52340/gbmn.2023.01.01.20","url":null,"abstract":"Background: Background: SARS-CoV-2 is still active and spreading among us, even though the COVID-19 disease pandemic is believed to have been terminated due to the extraordinary efforts of healthcare professionals and scientists. Thousands of people are being infected today. Objectives: The current study aimed to analyze existing data on the transmission of the SARS-CoV-2 virus among the West Georgia population and investigate the humoral immune response generated by the viral infection and vaccination as well. Methods: The research was conducted between March 2022 and March 2023. The study group included 400 adults (69% women and 31% men) residing in Kutaisi. Study patients were distributed among four groups: (i) Group 1: patients with confirmed SARS-CoV-2 infection without previous vaccination; (ii) Group 2: previously vaccinated patients without SARS-CoV-2 infection; (iii) Group 3: previously vaccinated patients with confirmed SARS-CoV-2 infection; and (iv) Group 4: uninfected and unvaccinated patients. All groups were divided into subgroups with positive and negative humoral responses. Each subgroup was further divided into subgroups based on gender. The data were analyzed by STATA 17. Statistical significance was defined as p < 0.05. Results: 55% of the study population was vaccinated, mainly with Pfizer's vaccine. The incidence of SARS-CoV-2 infection was equal for women and men, and they developed active immunity almost equally. The average rate of humoral im munity was 60%, with the highest rate (≈85% (r<0.05, p<0.001) in the triple-vaccinated individuals. Finally, the concentration of anti-SARS-CoV-2 IgG antibodies was particularly high (32% in the previously vaccinated patients with confirmed SARS-CoV-2 infection). The average duration of effective concentration of G-class immunoglobulins was maintained for 6-12 months. Conclusions: In most cases, the SARS-CoV-2 infection in combination with the Pfizer vaccination induces a maximal humoral immune response, although not always and not for long.","PeriodicalId":298383,"journal":{"name":"GEORGIAN BIOMEDICAL NEWS","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130629249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-19DOI: 10.52340/gbmn.2023.01.01.15
A. Aydin, Aliyeva Kamila Ali Agha, Musayev Shirkhan Aftandil, Rasulov Elkhan, Mammad Rasul
{"title":"Genetic Heterogeneity of Iduronate-2-Sulfatase in Children Diagnosed with Mucopolysaccharidosis Type II in Azerbaijan","authors":"A. Aydin, Aliyeva Kamila Ali Agha, Musayev Shirkhan Aftandil, Rasulov Elkhan, Mammad Rasul","doi":"10.52340/gbmn.2023.01.01.15","DOIUrl":"https://doi.org/10.52340/gbmn.2023.01.01.15","url":null,"abstract":"","PeriodicalId":298383,"journal":{"name":"GEORGIAN BIOMEDICAL NEWS","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130667579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-23DOI: 10.52340/gbmn.2023.01.01.13
B. Kulumbegov, M. Gotua, T. Chikovani
{"title":"Autoimmunity and Clinical Markers in Chronic Spontaneous Urticaria: A Retrospective Cohort Study","authors":"B. Kulumbegov, M. Gotua, T. Chikovani","doi":"10.52340/gbmn.2023.01.01.13","DOIUrl":"https://doi.org/10.52340/gbmn.2023.01.01.13","url":null,"abstract":"","PeriodicalId":298383,"journal":{"name":"GEORGIAN BIOMEDICAL NEWS","volume":"100 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117138508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-16DOI: 10.52340/gbmn.2023.01.01.12
Ioseb Sikharulidze, K. Chelidze, L. Chelidze, T. Kajaia, I. Bakhlishvili
{"title":"Comparison of Inflammatory and Oxidative Stress Markers Among Patients with Non-Obstructive vs. Obstructive Coronary Artery Disease","authors":"Ioseb Sikharulidze, K. Chelidze, L. Chelidze, T. Kajaia, I. Bakhlishvili","doi":"10.52340/gbmn.2023.01.01.12","DOIUrl":"https://doi.org/10.52340/gbmn.2023.01.01.12","url":null,"abstract":"","PeriodicalId":298383,"journal":{"name":"GEORGIAN BIOMEDICAL NEWS","volume":"5 6","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120851481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-16DOI: 10.52340/gbmn.2023.01.01.11
E. Bayandurov, Z. Orjonikidze, T. Sanikidze
{"title":"Peri-Implant Sulcular Fluid (PISF) Nitric Oxide (NO) as an Early Marker of Inflammation","authors":"E. Bayandurov, Z. Orjonikidze, T. Sanikidze","doi":"10.52340/gbmn.2023.01.01.11","DOIUrl":"https://doi.org/10.52340/gbmn.2023.01.01.11","url":null,"abstract":"","PeriodicalId":298383,"journal":{"name":"GEORGIAN BIOMEDICAL NEWS","volume":"253 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130449391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-16DOI: 10.52340/gbmn.2023.01.01.10
S. Kalmakhelidze, E. Shekiladze, Davit Topuria, T. Sanikidze
{"title":"Protective Effect of Herniarin on the Ionizing Radiation-Induced Alterations of Erythrocyte Membrane Proteins","authors":"S. Kalmakhelidze, E. Shekiladze, Davit Topuria, T. Sanikidze","doi":"10.52340/gbmn.2023.01.01.10","DOIUrl":"https://doi.org/10.52340/gbmn.2023.01.01.10","url":null,"abstract":"","PeriodicalId":298383,"journal":{"name":"GEORGIAN BIOMEDICAL NEWS","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128098998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-02DOI: 10.52340/gbmn.2023.01.01.03
Zaza Lominadze, K. Chelidze, L. Chelidze, E. Lominadze
{"title":"The High-Grade Oxidative Profile (OXpr), Aortic Stiffness Parameters, and Hemogram-Derived Indices (HDI) as Predictors of Long-Term Major Adverse Cardiovascular Events (MACEs) Following Percutaneous Coronary Intervention (PCI) in Patients with Non-ST-Elevation Acute Coronary Syndrome (NSTE-ACS) and ","authors":"Zaza Lominadze, K. Chelidze, L. Chelidze, E. Lominadze","doi":"10.52340/gbmn.2023.01.01.03","DOIUrl":"https://doi.org/10.52340/gbmn.2023.01.01.03","url":null,"abstract":"","PeriodicalId":298383,"journal":{"name":"GEORGIAN BIOMEDICAL NEWS","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121047088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-02DOI: 10.52340/gbmn.2023.01.01.08
Ioseb Sikharulidze, K. Chelidze, M. Mamatsashvili, L. Chelidze, T. Kajaia, I. Bakhlishvili
{"title":"Antiplatelet Therapy for Secondary Prevention After Myocardial Infarction in Antiplatelet-Naive High Cardiovascular Risk Patients with Non-Obstructive Coronary Artery Disease","authors":"Ioseb Sikharulidze, K. Chelidze, M. Mamatsashvili, L. Chelidze, T. Kajaia, I. Bakhlishvili","doi":"10.52340/gbmn.2023.01.01.08","DOIUrl":"https://doi.org/10.52340/gbmn.2023.01.01.08","url":null,"abstract":"","PeriodicalId":298383,"journal":{"name":"GEORGIAN BIOMEDICAL NEWS","volume":"634 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116207954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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