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Vaccination for COVID-19 in Patients with Heart Failure with Reduced Ejection Fraction 心力衰竭伴射血分数降低患者的COVID-19疫苗接种
Pub Date : 2022-04-06 DOI: 10.51941/amcr.2022.2103
I. Schonhofen, Andreya Fernandes, T. Macêdo, B. Silveira, B. Costa, M. Feitosa
The new Coronavirus disease was first identified from an outbreak in Wuhan, China, in December 2019. Patients with cardiovascular diseases or risk factors, especially those who had been diagnosed with Heart Failure (HF) have been expressing great concern.This population became more vulnerable when contaminated with the Sars cov 2 virus [1]. Questions have been raised about vaccines as they were developed by research centers and pharmacy industry.
这种新型冠状病毒疾病最初是在2019年12月中国武汉的一次疫情中发现的。有心血管疾病或危险因素的患者,特别是那些被诊断为心力衰竭(HF)的患者已经表达了极大的关注。这一人群在感染Sars冠状病毒后变得更加脆弱[1]。在研究中心和制药行业开发疫苗的过程中,人们对疫苗提出了质疑。
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引用次数: 0
Topical Treatment of Cutaneous Leishmaniasis: A Case Treated with A Glucantime-Based Lotion Experienced in Ecuador and A Mini Review 局部治疗皮肤利什曼病:一例治疗与葡聚糖为基础的洗剂在厄瓜多尔的经验和一个小回顾
Pub Date : 2021-03-26 DOI: 10.51941/AMCR.2021.1103
Rajiv Kumar
Cell shrinkage is a biological process and when it started naturally or by any means, it indicates programmed cell death. A proper understanding of cell volume regulation, and routes involved in the movement of ions at the activation spot of apoptosis in the cell, can disclose the cell shrinkage process. Focused research on the concentration of potassium and sodium ions further leads to disclose the concerned process in maintaining the normal physiological intracellular concentration.
细胞萎缩是一个生物过程,当它自然地或以任何方式开始时,它表明细胞程序性死亡。正确认识细胞体积调节,以及细胞凋亡活化点离子运动的途径,可以揭示细胞收缩的过程。对钾、钠离子浓度的集中研究,进一步揭示了维持正常生理细胞内浓度的相关过程。
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引用次数: 0
Incidence of HIV Cases and Associated Factors in The Northeast Region of Brazil 巴西东北地区艾滋病毒病例发生率及相关因素
Pub Date : 2021-02-23 DOI: 10.51941/AMCR.2021.1102
Ting-Ting Zhou, L. Du, W. Liu
A 51-year-old female was admitted to the gastroenterology clinic in October 2020 because of a 2-year history of epigastric pain unrelated to food intake. No diarrhea was noted. Her documented medical history was notable for well-controlled hypertension. Her physical examination and Helicobacter pylori antigen detection showed no remarkable abnormalities. A computed tomography scan of the abdomen revealed a 0.5 x 0.5 cm well-defined hyperattenuating structure in the wall of the descending duodenum, which was confirmed by esophagogastroduodenoscopy demonstrating a 0.5 cm nodule in the descending duodenum (Fig. A). The lesion was located within the deep mucosa and submucosa without invasion of adjacent structures detected by endoscopic ultrasound (Fig. B). Endoscopic submucosal dissection was performed to remove the nodule despite the high risk for postoperative complications. Microscopic examination of the specimen by hematoxylin and eosin staining (Fig. C) and the lesion staining strongly immunoreactive for synaptophysin (Fig. D) and chromogranin (Fig. E) by immunohistochemistry were consistent with a well-differentiated grade 2 neuroendocrine neoplasm, which was further defined by a low proliferation index Ki67 around 3% in neoplastic cells (Fig. F). No etiology for patient’s epigastric pain was discovered on esophagogastroduodenoscopic examination. Duodenal neuroendocrine tumors consist of 2% of all gastrointestinal neuroendocrine tumors and 1% of all duodenal tumors, which are very rare (Baliss et al., 2021). The rarity of duodenal neuroendocrine tumors coupled with the absence of neuroendocrine clinical syndromes creates a noteworthy diagnostic challenge (Delle et al., 2016). Patients with nonfunctional and nonmetastatic duodenal neuroendocrine tumors should be considered for resection regardless of tumor size (Sato et al., 2016).
一名51岁女性因与食物摄入无关的2年胃脘痛病史于2020年10月入住胃肠病学诊所。没有发现腹泻。她的病史有控制良好的高血压。体检及幽门螺杆菌抗原检测未见明显异常。腹部计算机断层扫描显示十二指肠降管壁有0.5 x 0.5 cm清晰的高衰减结构。经食管胃十二指肠镜检查证实,在十二指肠降段可见0.5 cm结节(图a)。病变位于黏膜深部及黏膜下层,超声内镜未发现病变侵犯邻近结构(图B)。尽管术后并发症风险高,但仍行内镜下粘膜下层夹层切除结节。显微镜下对标本进行苏木精和伊红染色(图C),免疫组化对synaptophysin(图D)和chromogranin(图E)免疫反应强烈的病变,符合分化良好的2级神经内分泌肿瘤,肿瘤细胞的低增殖指数Ki67约为3%(图F)进一步定义了该肿瘤。食管胃十二指肠镜检查未发现患者胃脘痛的病因。十二指肠神经内分泌肿瘤占胃肠道神经内分泌肿瘤的2%,占十二指肠肿瘤的1%,非常罕见(Baliss et al., 2021)。十二指肠神经内分泌肿瘤的罕见性,加上缺乏神经内分泌临床综合征,给诊断带来了重大挑战(Delle et al., 2016)。对于非功能性和非转移性十二指肠神经内分泌肿瘤,无论肿瘤大小,都应考虑切除(Sato et al., 2016)。
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引用次数: 0
Does Ultrasonography, In Conjunction with Nerve Conduction Study, Plays Any Role in The Diagnosis and The Evaluation of Severity in Patients with Clinically Diagnosed Carpal Tunnel Syndrome? A Prospective Study 超声检查联合神经传导研究对临床诊断的腕管综合征患者的诊断和严重程度评价有作用吗?前瞻性研究
Pub Date : 1900-01-01 DOI: 10.51941/amcr.2021.1203
Christina Angelopoulou, I. Chrysafis, Anthimos Keskinis, K. Tilkeridis, G. Trypsianis, Konstantinos Paraskevopoulos, G. Drosos, A. Ververidis
Background: Although nerve conduction study (NCS) represents the commonly performed test to functionally confirm the presence of carpal tunnel syndrome (CTS) in the daily clinical practice, the value of ultrasonography (U/S) is well established as a diagnostic tool for structural evaluation of CTS. Τhe purpose of this study was to compare U/S and nerve conduction velocity in patients with clinically diagnosed CTS, for assessing the usefulness of U/S in determining CTS severity. Material and Methods: A cross-sectional study with prospective data collection was carried out. 71 patients (100 hands) with clinically diagnosed idiopathic CTS were included in this study. Τhe protocol was comprised of a NCS and an U/S where the cross sectional area (CSA) and the flattening ratio (FR) of the median nerve at the carpal tunnel inlet (level of the pisiform) were measured. Results: In 94 hands (65 patients) out of 100 hands (71 patients), CTS was electrophysiologically confirmed. The CSA increase of the median nerve was proportional to the electrophysiological severity of the CTS. ROC analysis demonstrated good diagnostic value in both CSA and FR (CSA: AUC = 0.974, p<0.001, FR: AUC = 0.928, p <0.001). The CSA at the tunnel inlet with a threshold of 10.5 mm2 had the best diagnostic accuracy with a sensitivity of 94.7% and a specificity of 92.5%, as well as the FR with a threshold of 3.1 had the best diagnostic accuracy with a sensitivity and a specificity of 78.7% and 98.8%, respectively. Furthermore, ROC curve analysis for CTS electrophysiological severity showed a superior performance of the CSA (AUC=0.911, p<0.001) compared to the FR (AUC=0.647, p=0.023). The optimal cut-off point of 15.5 mm2 for CSA at the carpal tunnel inlet was defined to determine severe CTS, which yielded a sensitivity of 82.8% and a specificity of 92.3%. Conclusions: The U/S of the median nerve combined with electrodiagnostic study, increases significantly the sensitivity and reliability of the patient's diagnostic approach suffering from CTS. It can also be used for the assessment of CTS severity, replacing NCS, as its benefits such as low cost, non-invasive procedure, less time and patient’s convenience are remarkable.
背景:虽然神经传导研究(NCS)是日常临床实践中常用的功能确认腕管综合征(CTS)存在的测试,但超声检查(U/S)作为CTS结构评估的诊断工具的价值已经得到了很好的确立。Τhe本研究的目的是比较临床诊断为CTS的患者的U/S和神经传导速度,以评估U/S在确定CTS严重程度方面的有用性。材料和方法:采用前瞻性数据收集的横断面研究。本研究纳入71例(100手)临床诊断为特发性CTS的患者。Τhe方案由NCS和U/S组成,其中测量腕管入口(鹰嘴状水平)正中神经的横截面积(CSA)和平坦比(FR)。结果:100只手(71例)中94只手(65例)电生理证实CTS。正中神经CSA的增加与CTS的电生理严重程度成正比。ROC分析显示CSA和FR均具有良好的诊断价值(CSA: AUC = 0.974, p<0.001, FR: AUC = 0.928, p<0.001)。阈值为10.5 mm2的隧道入口CSA诊断准确率最高,敏感性为94.7%,特异性为92.5%;阈值为3.1的FR诊断准确率最高,敏感性为78.7%,特异性为98.8%。此外,CTS电生理严重程度的ROC曲线分析显示,CSA (AUC=0.911, p<0.001)优于FR (AUC=0.647, p=0.023)。确定腕管入口CSA的最佳截断点为15.5 mm2,以确定严重CTS,其敏感性为82.8%,特异性为92.3%。结论:正中神经U/S结合电诊断研究,显著提高了CTS诊断入路的敏感性和可靠性。它也可替代NCS用于CTS严重程度的评估,具有成本低、无创、时间短、患者方便等优点。
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引用次数: 0
Covid-19 Diagnosis, Therapeutic Approaches and Post Disease Complications: A Literature Review Covid-19的诊断、治疗方法和疾病后并发症:文献综述
Pub Date : 1900-01-01 DOI: 10.51941/amcr.2021.1205
S. Ranjith, P. Somesh
Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has made a serious health risk globally with millions of people at risk. Till currently there are not any clinically approved antiviral medication and vaccines, clinical trials are going on in patients with COVID-19. We have discussed recent literature data on COVID-19 treatment, Post COVID complications and current progress and upcoming perceptions in COVID-19 treatment.
2019冠状病毒病(COVID-19)是一种由严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2)引起的传染病,在全球造成了严重的健康风险,数百万人面临风险。到目前为止,还没有临床批准的抗病毒药物和疫苗,正在对COVID-19患者进行临床试验。我们讨论了关于COVID-19治疗的最新文献数据、COVID-19后并发症以及COVID-19治疗的当前进展和即将到来的看法。
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引用次数: 0
Traditional Chinese Medicine Fulonggan (Terra Flava Usta) Improves the Clinical Syndrome and Comorbidity of Regressive Autism: A Case Report 中药伏龙肝改善退行性自闭症临床证候及合并症1例
Pub Date : 1900-01-01 DOI: 10.51941/amcr.2022.2102
Dongrui Zhou, Mengjie Li, Zhimao Bai, Na Li, Zhiqing Zhu, Yangyang Dong, Honglin Zhang
The occurrence of regressive autism is closely related to the disturbance of immunity and intestinal microbiota. The intestinal microbiota plays an important role in maintaining the balance of the human immune system, and also regulated central nervous system activity. Soil is a micro-ecological environment that contains the majority of all known microbial species. The number of species found in human feces is around 1/10 times of that found in soil. Therefore, soil can be considered as the microbial “seed bank”. Our previous research indicated that everyday living environments are too clean, which, combined with the lack of contact with soil, results in the loss of a large number of microorganisms, and eating soil increased the gut microbial diversity and immune function in mice. As a special soil, Fulonggan (Terra Flava Usta) is a safe traditional Chinese medicine that has been used in the clinic for 1500 years. Here we report a case of 4.5-year-old male regressive autism with comorbidities of food allergy, allergic rhinitis, and constipation. Fulonggan was used to treat for 12 months from the age of 52 months to 63 months. For the first month of taking Fulonggan, he was also receiving the allergy medicine Singulair (montelukast). The constipation disappeared 5 days after taking Fulonggan, the allergic rhinitis disappeared 4 months later, and the food allergy disappeared after the treatment was stopped. Furthermore, the language skills, social skills, and mood were obviously better according to the Gesell Developmental Scale–Chinese Revised Version and Autism Behavior Checklist. At present, the child has returned to kindergarten. This report proposes a new method for the treatments of regressive autism and comorbidities including food allergy, allergic rhinitis, and constipation. The therapeutic method is effective and safe, and worth to be an alternative for regressive autism or allergy diseases.
退行性自闭症的发生与免疫功能紊乱和肠道菌群紊乱密切相关。肠道菌群在维持人体免疫系统的平衡中起着重要作用,并调节中枢神经系统的活动。土壤是一个微生态环境,包含了大多数已知的微生物物种。在人类粪便中发现的物种数量大约是土壤中发现的物种数量的1/10。因此,土壤可以看作是微生物的“种子库”。我们之前的研究表明,日常生活环境过于清洁,再加上缺乏与土壤的接触,导致大量微生物的流失,而食用土壤增加了小鼠肠道微生物的多样性和免疫功能。伏龙干是一种特殊的土壤,是一种安全的中药,在临床上已经使用了1500年。我们在此报告一例4.5岁男性退行性自闭症,同时伴有食物过敏、变应性鼻炎和便秘。用扶龙肝治疗12个月,年龄52个月~ 63个月。在服用扶龙肝的第一个月,他还接受了过敏药物欣古拉(孟鲁司特)。服药后5天便秘消失,4个月变应性鼻炎消失,停止治疗后食物过敏消失。此外,根据格塞尔发展量表-中文修订版和自闭症行为检查表,语言技能、社交技能和情绪均有明显改善。目前,孩子已经回到幼儿园。本报告提出了一种治疗退行性自闭症和合并症的新方法,包括食物过敏、变应性鼻炎和便秘。该治疗方法安全有效,值得作为退行性自闭症或过敏性疾病的一种替代方法。
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引用次数: 0
The Teenager and The Drugs in The Municipality of Guadalajara, Jalisco, México 哈利斯科州瓜达拉哈拉市的青少年和毒品
Pub Date : 1900-01-01 DOI: 10.51941/amcr.2022.2105
María A. Valle-Barbosa, Armando Muñoz-de la Torre, José R. Robles-Bañuelos
Drug abuse in young people is a public health problem worldwide. In Mexico it is also a social problem. Methodology: Descriptive, cross-sectional study, the sample was random. A survey and Excel base analysis were used. Objective: Identify knowledge and consumption of drugs in adolescents of basic secondary education. Discussion: Schoolchildren in Mexico have extensive knowledge about drugs, as in other countries in the world. Marijuana is mostly consumed, followed by cocaine, the main factors that led to consumption were problems, friends, curiosity, depression and combinations of these factors. Men are the biggest consumers, starting at 13 years of age. Consumers report that it is not a major problem, but not in all schools. More and more scientific papers are warning about the progressive normalization of the consumption of illicit substances among young people.
年轻人滥用药物是全世界的一个公共卫生问题。在墨西哥,这也是一个社会问题。方法:采用描述性、横断面研究,随机抽样。采用问卷调查和Excel基础分析。目的:了解基础中等教育青少年的药物知识和药物消费情况。讨论:与世界上其他国家的学生一样,墨西哥的学生对毒品有着广泛的了解。吸食最多的是大麻,其次是可卡因,导致吸食的主要因素是问题、朋友、好奇心、抑郁以及这些因素的组合。男性是最大的消费者,从13岁开始。消费者报告说,这不是一个主要问题,但并不是在所有的学校。越来越多的科学论文警告说,年轻人吸食非法药物的现象正在逐渐正常化。
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引用次数: 0
Metachronous Multiple Clinical Presentations Involving the Skin in a Patient with Immunoglobulin G4–Related Sclerosing Disease 涉及免疫球蛋白g4相关硬化疾病患者皮肤的异时性多重临床表现
Pub Date : 1900-01-01 DOI: 10.51941/amcr.2022.2107
Wei-Feng Huang, Yi-Ping Chen, Wei Liu
years after resection without recognition of IgG4-RD. As the primary skin lesion prior to the systemic symptoms was rare and mostly appeared in head and neck (Charrow et al ., 2016). Once again at this recurrence, cutaneous dermatofibroma wasn’t initially identified as the primary symptom of IgG4 -RD. Therefore, IgG4-RD should be fully considered and evaluated in clinical practices to avoid unnecessary and potentially harmful operations.
术后数年未发现IgG4-RD。由于全身性症状出现之前的原发性皮肤病变很少,且多出现在头颈部(Charrow et al ., 2016)。同样,在复发时,皮肤皮肤纤维瘤最初并未被确定为IgG4 -RD的主要症状。因此,在临床实践中应充分考虑和评估IgG4-RD,以避免不必要和潜在有害的手术。
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引用次数: 0
Colocutaneous Fistula in the Untreated Elderly with Quiescent Crohn's Disease 未经治疗的老年静止性克罗恩病的结肠皮瘘
Pub Date : 1900-01-01 DOI: 10.51941/amcr.2022.2108
Lei Liu, Si Qin, Wei Liu
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引用次数: 0
Air Pollution and It’s Effects on Human Health: A Review Literature 空气污染及其对人体健康的影响:文献综述
Pub Date : 1900-01-01 DOI: 10.51941/amcr.2021.1204
K. Kumar, R. Sunder
Air pollution is currently a major concern for human health and the environment of the world. Rapid growth of metropolitan cities has led to an increase of vehicles and industries which emits toxic substances. India is experiencing a major growing risk factor for Human Health. Due to high concentrations of particulate and gaseous material, toxic metals and aldehydes, with a significant increase in acute cardiopulmonary mortality, particularly in certain high-risk population subgroups, and with an acute increase in hospitalizations for cardiovascular and pulmonary diseases. In this the authors have explained the impact of air pollution and their consequences in India
空气污染是当今世界人类健康和环境的一个主要问题。大城市的快速发展导致了排放有毒物质的车辆和工业的增加。印度正在经历一个日益严重的人类健康风险因素。由于微粒和气体物质、有毒金属和醛的高浓度,急性心肺死亡率显著增加,特别是在某些高危人群亚群中,心血管和肺部疾病住院人数急剧增加。在这篇文章中,作者解释了空气污染对印度的影响及其后果
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引用次数: 0
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Archives of Medical and Clinical Research
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