Pub Date : 2011-12-15DOI: 10.31557/APJCB.2016.1.1.3-7
N. Panahi, M. Hashemi
Abstract Oligonucleotides Aptamers are single strands of DNA and RNA with the length of 20-100 nucleotides or peptides and unique three dimensional structure that is affected by nucleotide sequence. The structure exclusively influences aptamers’ bindings with its target molecule. It reduces performance or inactivate protein and this feature is used for therapeutic purposes. In addition and through connecting to signature molecule, aptamers are used to detect specific proteins. High efficiency of aptamer technology makes them a valuable tool for diagnosing and treating different diseases including cancer. The present study is an attempt to review recent studies in this field.
{"title":"Aptamers and Cancer","authors":"N. Panahi, M. Hashemi","doi":"10.31557/APJCB.2016.1.1.3-7","DOIUrl":"https://doi.org/10.31557/APJCB.2016.1.1.3-7","url":null,"abstract":"Abstract Oligonucleotides Aptamers are single strands of DNA and RNA with the length of 20-100 nucleotides or peptides and unique three dimensional structure that is affected by nucleotide sequence. The structure exclusively influences aptamers’ bindings with its target molecule. It reduces performance or inactivate protein and this feature is used for therapeutic purposes. In addition and through connecting to signature molecule, aptamers are used to detect specific proteins. High efficiency of aptamer technology makes them a valuable tool for diagnosing and treating different diseases including cancer. The present study is an attempt to review recent studies in this field.","PeriodicalId":313705,"journal":{"name":"Genetics in the Third Millennium","volume":"170 6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116385107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Kalanie, Z. Hosseinzadeh, K. Gharagozli, A. Kalanie, M. Kamgooyan
Multiple sclerosis (MS) is a demyelinating disease of the central nervous system, with unknown etiology in which both genetic and environmental factors are thought to be involved. The human leukocyte antigen (HLA) system provides a set of genetic markers which lend themselves to systematic study. In Iran, HLA-A24, HLA-DR2, and HLA- DR15 are significantly increased in MS patients. The disease also has 3 main clinical presentations, consisting of relapsingremitting (88%) primary progressive (7%) and secondary progressive with a gender ratio of 2.5:1 (female: male) and a mean age at onset of 27+ 7.4 years in our country. Five percent of our patients had a positive family history for the disease, 14% of patients had benign MS, and 12% with disease duration longer than five years had an Expanded Disability Status Scale <2. The opticospinal form of MS was not a common form of presentation of the disease in Iran.
{"title":"HLA Profile and Clinical Presentation of Multiple Sclerosis in IRAN","authors":"H. Kalanie, Z. Hosseinzadeh, K. Gharagozli, A. Kalanie, M. Kamgooyan","doi":"10.22037/IJCN.V2I1.467","DOIUrl":"https://doi.org/10.22037/IJCN.V2I1.467","url":null,"abstract":"Multiple sclerosis (MS) is a demyelinating disease of the central nervous system, with unknown etiology in which both genetic and environmental factors are thought to be involved. The human leukocyte antigen (HLA) system provides a set of genetic markers which lend themselves to systematic study. In Iran, HLA-A24, HLA-DR2, and HLA- DR15 are significantly increased in MS patients. The disease also has 3 main clinical presentations, consisting of relapsingremitting (88%) primary progressive (7%) and secondary progressive with a gender ratio of 2.5:1 (female: male) and a mean age at onset of 27+ 7.4 years in our country. Five percent of our patients had a positive family history for the disease, 14% of patients had benign MS, and 12% with disease duration longer than five years had an Expanded Disability Status Scale <2. The opticospinal form of MS was not a common form of presentation of the disease in Iran.","PeriodicalId":313705,"journal":{"name":"Genetics in the Third Millennium","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130919859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Congenital Myasthenic Syndromes","authors":"S. Nafissi","doi":"10.1201/9780203912966-9","DOIUrl":"https://doi.org/10.1201/9780203912966-9","url":null,"abstract":"","PeriodicalId":313705,"journal":{"name":"Genetics in the Third Millennium","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133948455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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