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Cognitive disorders in patients with atrial fibrillation 心房颤动患者的认知障碍
Pub Date : 2023-09-19 DOI: 10.31928/2305-3127-2023.1-2.1521
O.A. Yepanchintseva, A.S. Solonovych, O.S. Solonovych
Atrial fibrillation (AF) is one of the most common arrhythmias, and its prevalence increases with age. Cognitive impairment (CI) is a frequent concomitant disorder in AF and is an additional factor in reducing the quality of life and adherence to treatment in such patients. AF is associated with an increased risk of dementia in patients with and without history of stroke. It is well known that AF and CI share common risk factors such as age, hypertension, diabetes, dyslipidemia, obstructive sleep apnea, coronary heart disease, heart failure, chronic kidney disease, obesity, etc. The available data show that AF and CI have common pathophysiological factors, which, in addition to stroke, include hypoperfusion, microhemorrhages, brain atrophy, systemic atherosclerotic vascular damage, endothelial dysfunction, and inflammation. Screening neuropsychological scales might be used to assess the state of cognitive functions in patients with AF, and contemporary neuroimaging methods allow detecting structural changes in the brain. Specific methods of treatment of CI in AF have not yet been developed. Optimal antithrombotic therapy is the main means of prevention of cerebrovascular events, and therefore CI in AF.
心房颤动(AF)是最常见的心律失常之一,其患病率随着年龄的增长而增加。认知障碍(CI)是房颤中常见的伴随性疾病,是降低此类患者生活质量和治疗依从性的另一个因素。心房颤动与卒中史及无卒中史患者痴呆风险增加相关。众所周知,房颤和CI具有共同的危险因素,如年龄、高血压、糖尿病、血脂异常、阻塞性睡眠呼吸暂停、冠心病、心力衰竭、慢性肾病、肥胖等。现有资料显示,房颤和CI具有共同的病理生理因素,除卒中外,还包括灌注不足、微出血、脑萎缩、全身动脉粥样硬化性血管损伤、内皮功能障碍和炎症。筛选神经心理学量表可用于评估AF患者的认知功能状态,现代神经影像学方法可以检测大脑的结构变化。房颤中CI的具体治疗方法尚未开发。最佳抗血栓治疗是预防脑血管事件的主要手段,因此是房颤患者CI的主要手段。
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引用次数: 0
Hybrid surgery for aneurysm of the arch and descending part of the aorta. Right-left subclavian bypass as a variant of subtotal debranching 主动脉弓部及降部动脉瘤的混合手术。右-左锁骨下旁路作为次全脱支的一种变体
Pub Date : 2023-09-19 DOI: 10.31928/2305-3127-2023.1-2.7787
O.V. Zelenchuk, A.V. Khokhlov, A.Yu. Shkandala, K.S. Boiko, O.Yu. Polishchuk, Z.V. Press, B.M. Todurov
The article presents the experience of our team in various surgical methods of treating aortic pathology. Surgical pathology of the thoracic aorta, namely aneurysms and dissections, remains controversial for the «heart team». In recent years, endovascular aortic replacement (TEVAR) has proven itself as a treatment option for many aortic diseases with a mortality rate up to 7.5 %. According to the latest clinical recommendations, TEVAR has become the method of choice in the treatment of acute aortic dissection, showing better results compared to medical therapy and open surgery. However, the endovascular approach requires certain anatomical features that allow the correct placement of the stent-graft, which is not always possible. Thus, when the brachiocephalic arteries are involved in the pathological process, artificial blood circulation is required with the use of additional methods to protect the brain, such as cerebral perfusion and hypothermia. All these factors increase the risk of intra- and postoperative complications, as well as early mortality. Different methods of open surgery to replace all or most of the thoracic aorta are described, which represent a radical approach and require a high level of professional skills of the surgeon and experience in working with artificial blood circulation.
本文介绍了我组治疗主动脉病变的各种手术方法的经验。外科病理的胸主动脉,即动脉瘤和夹层,仍然有争议的“心脏小组”。近年来,血管内主动脉置换术(TEVAR)已被证明是许多主动脉疾病的治疗选择,死亡率高达7.5%。根据最新的临床推荐,TEVAR已成为治疗急性主动脉夹层的首选方法,与内科治疗和开放手术相比效果更好。然而,血管内入路需要一定的解剖学特征,以允许正确放置支架移植物,这并不总是可能的。因此,当头臂动脉参与病理过程时,需要人工血液循环,并使用额外的方法来保护大脑,如脑灌注和低温。所有这些因素都增加了手术内和术后并发症以及早期死亡的风险。本文描述了不同的开放手术方法来替换全部或大部分胸主动脉,这些方法代表了一种激进的方法,需要外科医生的高水平专业技能和人工血液循环的工作经验。
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引用次数: 0
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Kardiohirurgia ta Intervencijna Kardiologia
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