Revista Medica del Hospital General de Mexico最新文献

Gastrointestinal stromal tumours (GISTs) are the most common mesenchymal tumour in the gastrointestinal tract. More than half of these originate in the stomach, the rest in the small intestine, colon, rectum and oesophagus, and rarely in the omentum.

Case report

A 48-year-old woman, with painful abdominal growth developing over two years. Radiological studies showed a heterogeneous solid lesion in the pelvis, so she underwent surgery and the omentum was resected, no evidence of a tumour was found in the gastrointestinal tract. The omentum measured 50 cm × 30 cm × 15 cm. Its surface was heterogeneous and showed multiple nodules of varying sizes. A microscopically diffuse pattern of spindle cells was observed, some of them epithelioid, with three mitoses in 50 high-power fields. The immunohistochemical study is positive for CD117 and DOG-1.

E-GIST should be considered for the differential diagnosis of patients with multinodular lesions in the omentum and mesentery.

Background

The 5-hydroxytryptamine-1A receptors are known to be involved in the inhibition of seizures in epilepsy.

Objective

The main aim of the present study is to determine the functional coupling to G-protein of the 5-HT_1A receptor through 8-OH-DPAT-stimulated [³⁵S]GTPγS binding assay in lateral temporal neocortex tissue of patients with mesial temporal lobe epilepsy (mTLE) and correlate it with clinical data.

Material and methods

The activation of the G protein complex was determined by [³⁵S]GTPγS binding assay. The temporal neocortex tissue was obtained from 5 patients with mTLE during epilepsy surgery and from 5 subjects (autopsies) who died due to an accident and without history of neurological disease.

Results

We found that values of maximal stimulation (E_max) of [³⁵S]GTPγS binding significant decreased in the mTLE group (30.8%, p < .05) when compared to the autopsy samples (65.9%). The values of potency (pEC₅₀) were similar in both groups. However, we found no significant differences between the E_max and age of patient, age of seizure onset, duration of epilepsy and frequency of seizures. Also, the pEC₅₀ values revealed no significant correlations with the clinical data.

Conclusions

Our data provide evidence that the lateral temporal neocortex of patients with pharmacoresistant mTLE presents alterations in the functional coupling to G-protein of the 5-HT_1A receptor. Such a change could be involved in hyperexcitability in the neocortex of patients with mTLE.

Current studies based on specific naming subcategories are scarce and specially if they are combined with cortical electrical stimulation mapping (CES). Most researchers use generic categories of objects that have not shown to be useful for epileptic patients. The present study explores the ability to retrieve words with the aim of naming entities through CES during surgery of a patient with left temporal lobe epilepsy (TLE) prior to anterior temporal lobectomy (ATL). During the CES we observed alterations in the naming of faces, living things (LTh) and parts of the body, with conservation of non-living things (NLTh). CES allowed the identification and prediction of regions at risk of being resected. This result shows that the naming deficits are selective and can be used as indicators and predictors of post-operative cognitive dysfunction in TLE since the regions involved in this function are associated with the pole and inferior and medial temporal gyrus.