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Using Contact-Specific Surface Area Estimates in Exposure Models 在暴露模型中使用接触比表面积估算
Pub Date : 2004-07-01 DOI: 10.3109/15417060490961944
R. Canales, J. Leckie
ABSTRACTThe objectives of this work are to demonstrate methods for the collection and incorporation of contact-specific surface area measurements in dermal exposure assessments and illustrate the potential difference in resulting dermal and non-dietary ingestion estimates using this type of surface area data. Continuing the work of Stanford's Exposure Research Group, categorical surface area data contained in children's sequential microlevel activity patterns were converted into quantitative coordinates, which in turn provided a foundation to map data on the skin surface. Programs were constructed to establish an accounting system of spatial coordinates, governed by categorical surface area data, to map exposure estimates or activity statistics on the skin. An illustrative example is provided that estimates the spatial variability of chlorpyrifos on the palm of a hand using contact-specific surface area data. Results show a maximum value of 14.6 ng on the fingertips and no chemical exposure along the edge...
摘要本研究的目的是展示在皮肤暴露评估中收集和结合接触比表面积测量的方法,并说明使用这种类型的表面积数据得出的皮肤和非饮食摄入估计的潜在差异。继续斯坦福大学暴露研究小组的工作,将儿童连续微水平活动模式中包含的分类表面积数据转换为定量坐标,从而为绘制皮肤表面数据提供基础。构建程序以建立一个由分类表面积数据控制的空间坐标核算系统,以绘制皮肤上的暴露估计或活动统计。提供了一个说明性的例子,利用接触比表面积数据估计毒死蜱在手掌上的空间变异性。结果表明,指尖的最大值为14.6 ng,边缘没有化学物质暴露。
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引用次数: 6
Exposure and Risk Assessment for Arsenic from Chromated Copper Arsenate (CCA)-Treated Wood Playground Equipment 铬化砷酸铜(CCA)处理木质游乐场设备中砷的暴露及风险评估
Pub Date : 2004-07-01 DOI: 10.3109/15417060490930056
K. Hatlelid, Patricia M. Bittner, J. Midgett, Treye Thomas, L. Saltzman
ABSTRACTIn June 2001, the U.S. Consumer Product Safety Commission (CPSC or the Commission) docketed a petition from the Environmental Working Group and the Healthy Building Network that requested that the Commission enact an immediate ban of chromated copper arsenate (CCA)-treated wood for use in playground equipment. The request was based on the concern about health risks due to the presence of arsenic in the CCA formulation.To address the petition, the authors reviewed available data; evaluated existing standards, regulations, and economic data; performed exposure studies; and conducted a quantitative exposure and risk assessment that evaluated the risks to children from the use of CCA-treated wood playground equipment. The assessment estimated a theoretical increased lifetime risk of 2 to 100 per million of developing lung or bladder cancer for children aged 2–6 years from regular contact with arsenic residues on the surface of CCA-treated wood playground equipment, with risks of 0.2 to 5,000 per milli...
摘要2001年6月,美国消费者产品安全委员会(CPSC或委员会)提交了一份来自环境工作组和健康建筑网络的请愿书,要求委员会立即颁布一项禁令,禁止铬化砷酸铜(CCA)处理的木材用于游乐场设备。这一请求是基于对CCA配方中存在砷所造成的健康风险的关切。为了回应请愿书,作者审查了现有数据;评估现有标准、法规和经济数据;进行暴露研究;并进行了定量暴露和风险评估,评估儿童使用经cca处理的木制游乐场设备的风险。该评估估计,经常接触经cca处理的木质游乐场设备表面的砷残留物,会使2 - 6岁儿童患肺癌或膀胱癌的理论风险增加2 - 100 /百万人,风险为0.2 - 5000 /百万人……
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引用次数: 7
Meta-Analysis of Physical Activity Level (PAL) Data for U.S. Youth 1 美国青少年身体活动水平(PAL)数据的meta分析
Pub Date : 2004-07-01 DOI: 10.3109/15417060490960224
T. Mccurdy, J. Xue
ABSTRACTThe U.S. Environmental Protection Agency uses energy expenditure metrics in some of its health risk assessments and is interested in evaluating physical activity level (PAL) data contained in its human activity database, shown previously to be an important surrogate for lifestyle characteristics. This article describes a meta-analysis of PAL measurement studies undertaken in children and adolescents ≤18 y in the United States in the 1984–2003 time period. The meta-analysis is supplemented by pooled re-analyses of individual records contained in some of the published studies. PAL and related data were obtained from 32 published studies that met objective criteria. These data were supplemented by validated Monte Carlo modeling techniques to simulate PAL from correlated total daily and resting energy expenditure measures to increase power of the meta-analysis. Statistical analyses were used to determine if age, gender, ethnic class, and temporal trend (year of the study) affected the PAL metric. Only...
摘要美国环境保护署在一些健康风险评估中使用能量消耗指标,并对评估其人类活动数据库中包含的身体活动水平(PAL)数据感兴趣,PAL数据先前被证明是生活方式特征的重要替代指标。本文描述了1984-2003年期间在美国≤18岁的儿童和青少年中进行的PAL测量研究的荟萃分析。荟萃分析的补充是对一些已发表的研究中包含的个人记录进行汇总再分析。PAL和相关数据来自32项已发表的符合客观标准的研究。这些数据通过经过验证的蒙特卡罗建模技术进行补充,通过相关的每日总能量消耗和静息能量消耗测量来模拟PAL,以提高meta分析的有效性。统计分析用于确定年龄、性别、种族和时间趋势(研究年份)是否影响PAL指标。只有……
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引用次数: 0
Data for Physiologically Based Pharmacokinetic Modeling in Neonatal Animals: Physiological Parameters in Mice and Sprague-Dawley Rats 基于生理的新生动物药代动力学建模数据:小鼠和Sprague-Dawley大鼠的生理参数
Pub Date : 2004-07-01 DOI: 10.3109/15417060490970430
P. Gentry, L. Haber, Tracy B. McDonald, Qiyu Zhao, T. Covington, P. Nance, H. Clewell, J. Lipscomb, H. Barton
ABSTRACTRecent scientific and policy initiatives have resulted in increased interest in risk to fetuses, infants, and children and consideration of how such risks should be evaluated. A useful way of addressing this issue is to use physiologically based pharmacokinetic (PBPK) models to compare the tissue dose that children and adults receive for a given amount of a chemical ingested or inhaled. The response in children and adults for a given tissue dose can also be compared. To aid in the development of age-specific PBPK models for experimental animals, we have collected information on physiological parameters in neonates and young animals, through 60 days of age. Our effort focused on generic physiological values, such as tissue weight (termed tissue volume in the context of PBPK modeling), intake (alveolar ventilation, food intake, water intake), and flows (blood flows to tissues, bile flow, creatinine clearance, and glomerular filtration rate). To date, parameters for Sprague-Dawley rats and mice of mu...
摘要最近的科学和政策举措导致了对胎儿、婴儿和儿童风险的兴趣增加,并考虑了如何评估这些风险。解决这个问题的一个有用的方法是使用基于生理的药代动力学(PBPK)模型来比较儿童和成人在摄入或吸入一定量的化学物质时所接受的组织剂量。儿童和成人对特定组织剂量的反应也可以进行比较。为了帮助开发实验动物的年龄特异性PBPK模型,我们收集了新生儿和幼龄动物的生理参数信息,直到60日龄。我们的研究重点是一般的生理值,如组织重量(在PBPK模型中称为组织体积)、摄入(肺泡通气、食物摄入、水摄入)和流量(血液流向组织、胆汁流量、肌酐清除率和肾小球滤过率)。到目前为止,Sprague-Dawley大鼠和mu…
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引用次数: 28
Overview of Children and Exposure to Toxic Chemicals 儿童与接触有毒化学品概述
Pub Date : 2004-07-01 DOI: 10.3109/15417060490930038
C. Winder
Exposure of toxic chemicals to children is a poorly understood public health issue. Evidence indicates that children may be more vulnerable than adults to such exposures, and in some cases specific physiological, behavioral, toxicological, and environmental related factors may contribute to this vulnerability. The range of chemical exposures that have been reported that cause health problems in children is not small and continues to grow. Toxicological risk management offers an approach that may assist in identifying and assessing hazards, risks and exposures, characterizing risks and identifying the means by which they may be eliminated or minimized. However, better methods for the identification of those hazards, risks, and exposures that are specific to children is needed. Further, while some of the options for the control of chemical exposures to children are well known, others need to be prioritized, properly resourced, and still others need to be identified.
儿童接触有毒化学品是一个鲜为人知的公共卫生问题。有证据表明,儿童可能比成人更容易受到这种暴露,在某些情况下,特定的生理、行为、毒理学和环境相关因素可能导致这种脆弱性。已报告的对儿童造成健康问题的化学品接触范围不小,而且还在继续扩大。毒理学风险管理提供了一种方法,可以帮助确定和评估危害、风险和接触,确定风险的特征,并确定消除或尽量减少风险的手段。然而,需要更好的方法来确定儿童特有的危害、风险和接触。此外,虽然控制儿童接触化学品的一些备选办法是众所周知的,但还需要确定其他办法的优先次序,提供适当的资源,还需要确定其他办法。
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引用次数: 0
A Field Study of Dislodgeable Arsenic from CCA-Treated Wood Using Human-Hand and Surrogate Wipes 人工手拭和替代湿巾对cca处理木材中可溶砷的实地研究
Pub Date : 2004-07-01 DOI: 10.3109/15417060490930074
M. Levenson, Treye Thomas, W. K. Porter, D. G. Cobb, Dwayne Davis, J. Midgett, L. Saltzman, Patricia M. Bittner
ABSTRACTIn 2001, the U.S. Consumer Product Safety Commission (CPSC) docketed a petition to ban the use of chromated copper arsenate (CCA)-treated wood in playground equipment because of the carcinogenicity of arsenic. In addressing the request, CPSC staff conducted a series of laboratory and field studies to measure the amount of dislodgeable arsenic from CCA-treated wood. The field studies consisted of sampling eight CCA-treated wood decks and 12 sets of CCA-treated wood playground equipment. The sampling was performed using human-hand wipes and surrogate wipes. The sampling protocols were developed by CPSC staff in laboratory experiments. The estimated dislodgeable arsenic from the human-hand wipes ranged from 1.0 μ g to 20.9 μ g with a mean value of 7.7 μ g for the eight decks and from 0.3 to 33.7 μ g with a mean of 7.6 μ g for the 12 sets of playground equipment. The results are in agreement with a similar study conducted by another laboratory. Mathematical relationships between the hand-wipe and the ...
2001年,美国消费者产品安全委员会(CPSC)提交了一份请愿书,要求禁止在游乐场设备中使用铬化砷酸铜(CCA)处理的木材,因为砷具有致癌性。消费品安全委员会的工作人员在回应有关要求时,进行了一系列实验室和实地研究,以测量经cca处理的木材中可溶解砷的含量。实地研究包括对8个经cca处理的木制甲板和12套经cca处理的木制游乐场设备进行抽样。使用人手湿巾和替代湿巾进行采样。抽样方案是由CPSC工作人员在实验室实验中制定的。8个平台的人体湿巾可去除性砷含量在1.0 ~ 20.9 μ g之间,平均值为7.7 μ g; 12套游乐场设备的人体湿巾可去除性砷含量在0.3 ~ 33.7 μ g之间,平均值为7.6 μ g。结果与另一个实验室进行的类似研究一致。手巾和…的数学关系
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引用次数: 3
Young children's mouthing behavior: an observational study via videotaping in a primarily outdoor residential setting 幼儿的嘴部行为:一项主要在室外住宅环境中通过录像进行的观察性研究
Pub Date : 2004-07-01 DOI: 10.3109/15417060490960215
Willa Auyeung, R. Canales, P. Beamer, A. Ferguson, J. Leckie
ABSTRACTDetailed information on children's mouthing activities helps researchers assess children's exposure to toxicants via the non-dietary ingestion route (i.e., exposure resulting from contacts between the mouth and non-dietary objects such as fingers, toys, and dirt). For the analyses presented in this article, 38 children (20 female and 18 male) aged 1 to 6 years were videotaped for 2 hours each during natural play primarily in the outdoor residential environment.The data were analyzed separately by location (i.e., indoor or outdoor). For each location, mouthing frequency, contact duration, and hourly duration data were analyzed along gender and ≤ 24 months > 24 months age groupings. Several significant differences were found for mouthing activities occurring outdoors. Children ≤ 24 months of age were found to have significantly longer contact durations with the hands than children > 24 months of age (p = 0.04). Furthermore, for all ages, frequencies of mouthing contacts with the hands and non-dietar...
摘要儿童口腔活动的详细信息有助于研究人员评估儿童通过非膳食摄入途径(即通过口腔与非膳食物体(如手指、玩具和污垢)接触而暴露的有毒物质。为了进行本文的分析,研究人员对38名1至6岁的儿童(20名女性和18名男性)进行了2小时的录像,主要是在室外居住环境中进行自然玩耍。数据按地点(即室内或室外)分开分析。对于每个地点,按性别和≤24月龄> 24月龄分组分析口腔频率、接触时间和每小时持续时间数据。在户外进行的嘴部活动中发现了几个显著的差异。≤24月龄儿童与手的接触时间明显长于> 24月龄儿童(p = 0.04)。此外,对于所有年龄段,用嘴与手和非饮食接触的频率…
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引用次数: 37
Evaluating Children's Health Risk from Exposure to Municipal Solid Waste Truck Leachate in the United States: Complementary Evidence-Based and Risk-Based Assessments 美国儿童接触城市固体废物卡车渗滤液的健康风险评估:基于证据和基于风险的补充性评估
Pub Date : 2004-07-01 DOI: 10.3109/15417060490960233
J. Shatkin, James C. Smith, N. Moyer
ABSTRACTThe general public is exposed to leached material from municipal solid waste (MSW) trucks on a daily basis and some of this waste may harbor human pathogens. Children may be especially susceptible to exposure to such waste due to behavior during outdoor play and perhaps due to greater susceptibility to infection. We assess the public health risk through exposure to leachate from MSW haulers in two ways: a review of literature dealing with worker exposure to waste and incidence of illness, and by a risk assessment of exposure to leachate from MSW trucks with loads containing diapers from children with active infections caused by Shigella or Salmonella. Infectious risk was evaluated by a Monte Carlo simulation of exposure via ingestion of one milliliter of MSW truck leachate. Forecast doses of pathogenic bacteria were compared to published values of infectious doses (N50). A low level of concern was found from exposure of the public to municipal solid waste leachate by either evidence-based evaluati...
摘要公众每天都暴露在城市固体废物(MSW)卡车的浸出物质中,其中一些废物可能含有人类病原体。由于儿童在户外玩耍时的行为以及可能更容易受到感染,他们可能特别容易接触到这类废物。我们通过接触城市生活垃圾运输车的渗滤液来评估公众健康风险,方法有两种:一种是回顾有关工人接触废物和疾病发生率的文献,另一种是对接触城市生活垃圾运输车的渗滤液进行风险评估,车上装着由志贺氏菌或沙门氏菌引起的活动力感染的儿童的尿布。通过摄入一毫升城市生活垃圾卡车渗滤液进行蒙特卡罗模拟,评估了感染风险。预测致病菌剂量与公布的感染剂量(N50)进行比较。无论是基于证据的评估还是…
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引用次数: 2
The Development of a Standard Hand Method and Correlated Surrogate Method for Sampling CCA (Pressure)-Treated Wood Surfaces for Chemical Residue 压力处理木材表面化学残留物取样标准手工法和相关替代法的发展
Pub Date : 2004-07-01 DOI: 10.3109/15417060490930047
Treye Thomas, M. Levenson, D. G. Cobb, J. Midgett, W. K. Porter, L. Saltzman, Patricia M. Bittner
ABSTRACTThe U.S. Consumer Product Safety Commission (CPSC) staff completed a series of investigations that estimated the potential exposure and risk of young children to arsenic while playing on playground equipment composed of CCA (chromated copper arsenate)-treated wood. Prior to sampling in-use field structures composed of CCA-treated wood, studies were undertaken to create a standard sampling protocol for quantifying arsenic migration from CCA-treated wood and to establish a correlation between the amount of chemical removed by a human hand and a cloth surrogate. These studies resulted in: 1) the development of an efficient extraction method for chemical residues collected on a human hand, 2) the development of a sampling device for consistent surrogate measurements, 3) establishment of a correlation between surrogate and hand measurements, and 4) the development of a standard human hand and surrogate sampling protocol for quantifying arsenic migration from CCA-treated wood. These studies also examine...
摘要美国消费者产品安全委员会(CPSC)的工作人员完成了一系列的调查,评估了儿童在由CCA(铬化砷酸铜)处理的木材组成的游乐场设备上玩耍时砷的潜在暴露和风险。在对由cca处理过的木材组成的使用中的现场结构进行采样之前,进行了研究,以制定标准采样方案,以量化cca处理过的木材的砷迁移量,并建立人工去除的化学物质量与布替代品之间的相关性。这些研究成果包括:1)开发了一种有效的提取人类手上化学残留物的方法;2)开发了一种取样装置,用于一致的替代测量;3)建立了替代测量和手部测量之间的相关性;4)开发了一种标准的人类手部和替代采样方案,用于量化cca处理木材中的砷迁移。这些研究还考察了……
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引用次数: 11
Childhood Exposure to Environmental Chemicals: Implications for Public Health—International Conference 儿童接触环境化学品:对公众健康的影响-国际会议
Pub Date : 2004-07-01 DOI: 10.3109/15417060490929517
A. Parsons
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引用次数: 0
期刊
Journal of Children's Health
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