Pub Date : 2022-09-01DOI: 10.1136/jnnp-2022-ehdn.58
P. Joachimiak, A. Ciesiolka, Grzegorz Figura, Emilia Kozłowska, Pawel M. Switonski, M. Surdyka, Żaneta Kalinowska-Pośka, M. Figiel, N. Caron, Michael R. Hayden, Agnieszka Fiszer
{"title":"D02 Precise and allele-specific quantitation of endogenous HTT transcript alleles using droplet-digital PCR","authors":"P. Joachimiak, A. Ciesiolka, Grzegorz Figura, Emilia Kozłowska, Pawel M. Switonski, M. Surdyka, Żaneta Kalinowska-Pośka, M. Figiel, N. Caron, Michael R. Hayden, Agnieszka Fiszer","doi":"10.1136/jnnp-2022-ehdn.58","DOIUrl":"https://doi.org/10.1136/jnnp-2022-ehdn.58","url":null,"abstract":"","PeriodicalId":318593,"journal":{"name":"D: Wet biomarkers","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124394068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-01DOI: 10.1136/jnnp-2022-ehdn.66
Marina Herrero-Lorenzo, Jesús Pérez, G. Escaramís, R. Pérez-González, J. Kulisevsky, Ana Gámez-Valero, E. Martí
{"title":"D10 Plasma extracellular small RNAS are early deregulated in Huntington’s disease and correlate with cognitive symptoms","authors":"Marina Herrero-Lorenzo, Jesús Pérez, G. Escaramís, R. Pérez-González, J. Kulisevsky, Ana Gámez-Valero, E. Martí","doi":"10.1136/jnnp-2022-ehdn.66","DOIUrl":"https://doi.org/10.1136/jnnp-2022-ehdn.66","url":null,"abstract":"","PeriodicalId":318593,"journal":{"name":"D: Wet biomarkers","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126668648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-01DOI: 10.1136/jnnp-2022-ehdn.61
Julia Natan, Franziska Hoschek, A. Neueder
{"title":"D05 Expression of HTT1A in models of Huntington disease","authors":"Julia Natan, Franziska Hoschek, A. Neueder","doi":"10.1136/jnnp-2022-ehdn.61","DOIUrl":"https://doi.org/10.1136/jnnp-2022-ehdn.61","url":null,"abstract":"","PeriodicalId":318593,"journal":{"name":"D: Wet biomarkers","volume":"27 31","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"113954952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-01DOI: 10.1136/jnnp-2022-ehdn.74
N. R. Tartaglia, F. Farina, Lorena Martín-Jaular, D. Loew, Florent Dingli, E. Brouillet, C. Théry, C. Néri
{"title":"D18 Small extracellular vesicles in response to mutant huntingtin","authors":"N. R. Tartaglia, F. Farina, Lorena Martín-Jaular, D. Loew, Florent Dingli, E. Brouillet, C. Théry, C. Néri","doi":"10.1136/jnnp-2022-ehdn.74","DOIUrl":"https://doi.org/10.1136/jnnp-2022-ehdn.74","url":null,"abstract":"","PeriodicalId":318593,"journal":{"name":"D: Wet biomarkers","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130139485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-01DOI: 10.1136/jnnp-2022-ehdn.75
Bjoern von Einem, A. Abdelmoez, J. Lewerenz, G. Landwehrmeyer, A. Neueder
{"title":"D19 Purification of extracellular vesicles from human control and HTT mutant carrier CSF and quantitative analysis of their RNA content","authors":"Bjoern von Einem, A. Abdelmoez, J. Lewerenz, G. Landwehrmeyer, A. Neueder","doi":"10.1136/jnnp-2022-ehdn.75","DOIUrl":"https://doi.org/10.1136/jnnp-2022-ehdn.75","url":null,"abstract":"","PeriodicalId":318593,"journal":{"name":"D: Wet biomarkers","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129722427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-01DOI: 10.1136/jnnp-2022-ehdn.57
M. Ciosi, R. Young, S. Kwak, D. Monckton
{"title":"D01 Longitudinal analysis of somatic expansion of the HTT repeat in blood as a potential biomarker of somatic instability in Huntingon disease","authors":"M. Ciosi, R. Young, S. Kwak, D. Monckton","doi":"10.1136/jnnp-2022-ehdn.57","DOIUrl":"https://doi.org/10.1136/jnnp-2022-ehdn.57","url":null,"abstract":"","PeriodicalId":318593,"journal":{"name":"D: Wet biomarkers","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133923040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-01DOI: 10.1136/jnnp-2022-ehdn.60
R. Harding, Y. Xie, N. Potluri, C. Arrowsmith, B. Leavitt, D. Langbehn, A. Southwell
{"title":"D04 Challenges and advances in cerebrospinal fluid HTT detection: in support of relative quantification","authors":"R. Harding, Y. Xie, N. Potluri, C. Arrowsmith, B. Leavitt, D. Langbehn, A. Southwell","doi":"10.1136/jnnp-2022-ehdn.60","DOIUrl":"https://doi.org/10.1136/jnnp-2022-ehdn.60","url":null,"abstract":"","PeriodicalId":318593,"journal":{"name":"D: Wet biomarkers","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123961681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-01DOI: 10.1136/jnnp-2022-ehdn.65
G. D. Lazzaro, P. Zinzi, A. Picca, M. Petracca, Marcella Solito, M. L. Lo Monaco, Anna Sofia Grandolfo, P. Calabresi, A. Bentivoglio
{"title":"D09 Exploring neurodegeneration and inflammation blood biomarkers in a cohort of italian patients with Huntington’s disease","authors":"G. D. Lazzaro, P. Zinzi, A. Picca, M. Petracca, Marcella Solito, M. L. Lo Monaco, Anna Sofia Grandolfo, P. Calabresi, A. Bentivoglio","doi":"10.1136/jnnp-2022-ehdn.65","DOIUrl":"https://doi.org/10.1136/jnnp-2022-ehdn.65","url":null,"abstract":"","PeriodicalId":318593,"journal":{"name":"D: Wet biomarkers","volume":"52 4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123230950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-01DOI: 10.1136/jnnp-2022-ehdn.71
Birna Ásbjörnsdóttir, C. Musaeus, M. N. Hellem, T. Vinther-Jensen, L. Hjermind, A. Simonsen, M. V. von Essen, F. Sellebjerg, J. E. Nielsen
{"title":"D15 The blood-brain barrier integrity and frequency of CSF Th17.1 cells in Huntington´s disease","authors":"Birna Ásbjörnsdóttir, C. Musaeus, M. N. Hellem, T. Vinther-Jensen, L. Hjermind, A. Simonsen, M. V. von Essen, F. Sellebjerg, J. E. Nielsen","doi":"10.1136/jnnp-2022-ehdn.71","DOIUrl":"https://doi.org/10.1136/jnnp-2022-ehdn.71","url":null,"abstract":"","PeriodicalId":318593,"journal":{"name":"D: Wet biomarkers","volume":"379 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123452502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-01DOI: 10.1136/jnnp-2022-ehdn.76
R. Pérez-González, S. Martínez-Horta, Elisa Rivas-Asensio, J. Pérez-Pérez, Marta Garcia-Forn, E. Pérez-Navarro, J. Kulisevsky
{"title":"D20 Altered levels of brain extracellular vesicle subpopulations in Huntington’s disease","authors":"R. Pérez-González, S. Martínez-Horta, Elisa Rivas-Asensio, J. Pérez-Pérez, Marta Garcia-Forn, E. Pérez-Navarro, J. Kulisevsky","doi":"10.1136/jnnp-2022-ehdn.76","DOIUrl":"https://doi.org/10.1136/jnnp-2022-ehdn.76","url":null,"abstract":"","PeriodicalId":318593,"journal":{"name":"D: Wet biomarkers","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129346598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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