Pub Date : 2022-12-21DOI: 10.1109/ICBME57741.2022.10052866
Sara Movahedi, Farshad Bahramian, Fatemeh Ghorbani-Bidkorbeh
Nanoparticle characteristics play a significant role in determining to proper nanocarrier for drug delivery. The improvement of cell response can obtain by simply manipulating the size of the implemented nanocarrier. This study aims to optimize nanoparticle characteristics (size and the polydispersity of chitosan, a common polymer, for further investigation. We used both numerical and experimental studies for this purpose. The coaxial microfluidic device was fabricated for the semi-automatic synthesis of nanoparticles. A real three-dimensional model of the chip was modeled in COMSOL Multiphysics (version 6.0) to evaluate the optimum mixing condition. In the result, the nanoparticle synthesized via microfluidic had a hydrodynamic size of 314 nm with narrow dispersity presented by low polydispersity. Consequently, the correlation between the nanoparticle's size, flow ratio, and mixing condition was discussed briefly.
{"title":"An experimental and numerical study of microfluidic preparation of chitosan nanoparticle","authors":"Sara Movahedi, Farshad Bahramian, Fatemeh Ghorbani-Bidkorbeh","doi":"10.1109/ICBME57741.2022.10052866","DOIUrl":"https://doi.org/10.1109/ICBME57741.2022.10052866","url":null,"abstract":"Nanoparticle characteristics play a significant role in determining to proper nanocarrier for drug delivery. The improvement of cell response can obtain by simply manipulating the size of the implemented nanocarrier. This study aims to optimize nanoparticle characteristics (size and the polydispersity of chitosan, a common polymer, for further investigation. We used both numerical and experimental studies for this purpose. The coaxial microfluidic device was fabricated for the semi-automatic synthesis of nanoparticles. A real three-dimensional model of the chip was modeled in COMSOL Multiphysics (version 6.0) to evaluate the optimum mixing condition. In the result, the nanoparticle synthesized via microfluidic had a hydrodynamic size of 314 nm with narrow dispersity presented by low polydispersity. Consequently, the correlation between the nanoparticle's size, flow ratio, and mixing condition was discussed briefly.","PeriodicalId":319196,"journal":{"name":"2022 29th National and 7th International Iranian Conference on Biomedical Engineering (ICBME)","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126594578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-21DOI: 10.1109/ICBME57741.2022.10052910
Melina Bagher, Reza Karimzadeh, M. Jahed, B. Khalaj
Single individual haplotype reconstruction refers to the computational problem of inferring the two distinct copies of each chromosome. Determination of haplotypes offers many advantages for genomic-based studies in various fields of human genetics. Although many methods have been proposed to obtain haplotypes with high accuracy, the rapid and accurate solution of haplotype assembly is still a challenging problem. The largeness of the high-throughput sequence data and the length of the human genome emphasize the importance of the speed of algorithms. In this paper, we propose QuickHap, a heuristic algorithm to achieve a high speed of haplotyping with acceptable accuracy. Our algorithm contains two phases; first, a partial haplotype is built and expanded during several iterations. In this phase, we utilize a new metric to measure the quality of the reconstructed haplotype in each iteration to achieve the optimum solution. The second phase is applied to refine the reconstructed haplotypes to improve accuracy. The result demonstrates that the proposed method can reconstruct the haplotypes with promising accuracy. It outperforms the comparing methods in speed, particularly in dealing with high coverage sequencing data.
{"title":"QuickHap: a Quick heuristic algorithm for the single individual Haplotype reconstruction problem","authors":"Melina Bagher, Reza Karimzadeh, M. Jahed, B. Khalaj","doi":"10.1109/ICBME57741.2022.10052910","DOIUrl":"https://doi.org/10.1109/ICBME57741.2022.10052910","url":null,"abstract":"Single individual haplotype reconstruction refers to the computational problem of inferring the two distinct copies of each chromosome. Determination of haplotypes offers many advantages for genomic-based studies in various fields of human genetics. Although many methods have been proposed to obtain haplotypes with high accuracy, the rapid and accurate solution of haplotype assembly is still a challenging problem. The largeness of the high-throughput sequence data and the length of the human genome emphasize the importance of the speed of algorithms. In this paper, we propose QuickHap, a heuristic algorithm to achieve a high speed of haplotyping with acceptable accuracy. Our algorithm contains two phases; first, a partial haplotype is built and expanded during several iterations. In this phase, we utilize a new metric to measure the quality of the reconstructed haplotype in each iteration to achieve the optimum solution. The second phase is applied to refine the reconstructed haplotypes to improve accuracy. The result demonstrates that the proposed method can reconstruct the haplotypes with promising accuracy. It outperforms the comparing methods in speed, particularly in dealing with high coverage sequencing data.","PeriodicalId":319196,"journal":{"name":"2022 29th National and 7th International Iranian Conference on Biomedical Engineering (ICBME)","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114390725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-21DOI: 10.1109/ICBME57741.2022.10052878
R. Khodadadi, Alireza Balaei, M. Eghbal, J. Fallah, K. Abrinia
Rheumatoid factor is a biomarker for diagnosing rheumatoid arthritis and other inflammatory diseases, and latex agglutination is a qualitative method for Rheumatoid factor evaluation. In this study, in addition to manufacturing a portable and low-cost centrifugal device, a microfluidic disc was designed and manufactured to meter 400 µl of a whole blood sample. Next, it separates serum from whole blood and meters 40 µl of serum to mix it with coated latex buffer on the detection chamber surfaces. Finally, Qualitative examinations of the mixed samples were performed by checking the detection chambers, positive or negative in terms of agglutination. As a result, 100% agreement was observed between manual and microfluidic disc-based methods. Accordingly, centrifugal microfluidic discs showed excellent potential for integrating and automating several latex-based assays such as C-Reactive Protein (CRP), D-dimer, and blood type in a disc for utilization in a low resource setting, clinics, and as a point of care test (POC).
{"title":"Fully Automated Centrifugal Microfluidic Disc for Qualitative Evaluation of Rheumatoid Factor (RF) Utilizing Portable and Low-Cost Centrifugal Device","authors":"R. Khodadadi, Alireza Balaei, M. Eghbal, J. Fallah, K. Abrinia","doi":"10.1109/ICBME57741.2022.10052878","DOIUrl":"https://doi.org/10.1109/ICBME57741.2022.10052878","url":null,"abstract":"Rheumatoid factor is a biomarker for diagnosing rheumatoid arthritis and other inflammatory diseases, and latex agglutination is a qualitative method for Rheumatoid factor evaluation. In this study, in addition to manufacturing a portable and low-cost centrifugal device, a microfluidic disc was designed and manufactured to meter 400 µl of a whole blood sample. Next, it separates serum from whole blood and meters 40 µl of serum to mix it with coated latex buffer on the detection chamber surfaces. Finally, Qualitative examinations of the mixed samples were performed by checking the detection chambers, positive or negative in terms of agglutination. As a result, 100% agreement was observed between manual and microfluidic disc-based methods. Accordingly, centrifugal microfluidic discs showed excellent potential for integrating and automating several latex-based assays such as C-Reactive Protein (CRP), D-dimer, and blood type in a disc for utilization in a low resource setting, clinics, and as a point of care test (POC).","PeriodicalId":319196,"journal":{"name":"2022 29th National and 7th International Iranian Conference on Biomedical Engineering (ICBME)","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115126523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-21DOI: 10.1109/ICBME57741.2022.10052990
M. S. Z. Dehabadi, M. Jahed
Medical ultrasonic array transducers are prone to various defects due to hardware malfunction, mechanical damages, aging, and fatigue issues. Faulty elements result in distorted acoustic field, higher side lobe level (SLL), and image resolution degradation. Fault detection of piezoelectric array element is an obvious and important prerequisite for any restoration or compensative reaction. In this work, an inverse optimization approach on the few measured samples of the radiated acoustic field is proposed to estimate the contribution of the element, its position and severity of its faulty condition. The proposed method is evaluated by 100 random simulated test datasets, based on finite element model (FEM) of a linear array transducer. Three element faulty types inclusive of Intact,Weak, and Dead, are considered in the datasets to measure a lateral profile of the radiated far-field acoustic field from the transducer. The problem on the acoustic field is solved by Particle Swarm Optimization (PSO) algorithm. The high detection accuracy of about 99%, as depicted in the results section, demonstrates the effectiveness of this method to detect Weak and Dead elements. The proposed method outperforms the electrical test equipment to check the sensitivity and capacitance of individual elements, especially for the 2D transducers containing large number of elements and physically unavailable sub-elements for the electrical tests.
{"title":"Fault Detection of Piezoelectric Array Element Using Acoustic Field and Particle Swarm Optimization","authors":"M. S. Z. Dehabadi, M. Jahed","doi":"10.1109/ICBME57741.2022.10052990","DOIUrl":"https://doi.org/10.1109/ICBME57741.2022.10052990","url":null,"abstract":"Medical ultrasonic array transducers are prone to various defects due to hardware malfunction, mechanical damages, aging, and fatigue issues. Faulty elements result in distorted acoustic field, higher side lobe level (SLL), and image resolution degradation. Fault detection of piezoelectric array element is an obvious and important prerequisite for any restoration or compensative reaction. In this work, an inverse optimization approach on the few measured samples of the radiated acoustic field is proposed to estimate the contribution of the element, its position and severity of its faulty condition. The proposed method is evaluated by 100 random simulated test datasets, based on finite element model (FEM) of a linear array transducer. Three element faulty types inclusive of Intact,Weak, and Dead, are considered in the datasets to measure a lateral profile of the radiated far-field acoustic field from the transducer. The problem on the acoustic field is solved by Particle Swarm Optimization (PSO) algorithm. The high detection accuracy of about 99%, as depicted in the results section, demonstrates the effectiveness of this method to detect Weak and Dead elements. The proposed method outperforms the electrical test equipment to check the sensitivity and capacitance of individual elements, especially for the 2D transducers containing large number of elements and physically unavailable sub-elements for the electrical tests.","PeriodicalId":319196,"journal":{"name":"2022 29th National and 7th International Iranian Conference on Biomedical Engineering (ICBME)","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115401085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-21DOI: 10.1109/ICBME57741.2022.10053070
Navid Razavi, N. Nemati, S. Sardari
Metal-organic frameworks (MOFs) are suitable as carriers for drug delivery systems (DDSs) due to their large specific surface area and high biocompatibility. In the present study, paclitaxel (PTX) as an anticancer drug was loaded into MIL-100 (Fe) to reduce the abuse side effects of PTX and enhance its efficacy through the controlled release of PTX from MOF. MIL-100 (Fe) was synthesized via the hydrothermal technique and characterized through BET, FESEM, FTIR, and XRD analysis. The BET surface area of MIL-100 (Fe) was found to be 1336 m2g-1. Drug release profiles from synthesized MIL-100 (Fe) and pharmacokinetic studies were investigated. The PTX release data of MIL-100 (Fe) was evaluated under pH values of 5.5, and 7.4, at temperatures of 37 °C. The biocompatibility of drug-loaded MIL-100 (Fe) was also assessed by incubating them in MCF-7 breast cancer cells. The maximum cytotoxicity of MCF-7 cancer cells treated with MIL-100 (Fe)/PTX 10 µg mL-1 was found to be 77%. It can be concluded that MIL-100 (Fe) can be used as an effective pH-sensitive carrier to load anticancer drugs. Therefore, all these findings indicate that MIL-100(Fe) is a promising drug delivery platform for PTX and the treatment of various cancers.
{"title":"Fabrication of MIL-100 (Fe) metal-organic framework nanocarrier for the controlled release of Paclitaxel against MCF-7 breast cancer cells","authors":"Navid Razavi, N. Nemati, S. Sardari","doi":"10.1109/ICBME57741.2022.10053070","DOIUrl":"https://doi.org/10.1109/ICBME57741.2022.10053070","url":null,"abstract":"Metal-organic frameworks (MOFs) are suitable as carriers for drug delivery systems (DDSs) due to their large specific surface area and high biocompatibility. In the present study, paclitaxel (PTX) as an anticancer drug was loaded into MIL-100 (Fe) to reduce the abuse side effects of PTX and enhance its efficacy through the controlled release of PTX from MOF. MIL-100 (Fe) was synthesized via the hydrothermal technique and characterized through BET, FESEM, FTIR, and XRD analysis. The BET surface area of MIL-100 (Fe) was found to be 1336 m2g-1. Drug release profiles from synthesized MIL-100 (Fe) and pharmacokinetic studies were investigated. The PTX release data of MIL-100 (Fe) was evaluated under pH values of 5.5, and 7.4, at temperatures of 37 °C. The biocompatibility of drug-loaded MIL-100 (Fe) was also assessed by incubating them in MCF-7 breast cancer cells. The maximum cytotoxicity of MCF-7 cancer cells treated with MIL-100 (Fe)/PTX 10 µg mL-1 was found to be 77%. It can be concluded that MIL-100 (Fe) can be used as an effective pH-sensitive carrier to load anticancer drugs. Therefore, all these findings indicate that MIL-100(Fe) is a promising drug delivery platform for PTX and the treatment of various cancers.","PeriodicalId":319196,"journal":{"name":"2022 29th National and 7th International Iranian Conference on Biomedical Engineering (ICBME)","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121714777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-21DOI: 10.1109/ICBME57741.2022.10053042
Mohammad Mahdi Eskandari Sani, Mahdi Aliverdinia, R. Javidi, Shaghayegh Mirhosseini, M M Zand
Devices that imitate the functions of human skin are known as “electronic skin,” and they must have characteristics like high sensitivity, a wide dynamic range, high spatial homogeneity, cheap cost, wide area easy processing, and the ability to distinguish between diverse external inputs. Here, we describe a flexible droplet-based microfluidic-assisted emulsion self-assembly (DMESA) method for producing highly efficient capacitive pressure sensors based on three-dimensional microstructures for electronic skin applications. Our method may produce evenly sized micropores that self-assemble across a vast area in an ordered close-packed manner, leading to excellent spatial homogeneity. Dynamic amplitude and sensitivity were readily regulated to as high as 0.62 kPa -1and up to 100 kPa by adjusting the micropore size, which can be simply adjusted from 100 to 600 µm. Our gadget may be molded into a variety of forms and printed on curved surfaces. These examples show how our method and sensors may be used for a broad range of e-skin applications.
{"title":"Microstructured Droplet Based Porous Capacitive Pressure Sensor","authors":"Mohammad Mahdi Eskandari Sani, Mahdi Aliverdinia, R. Javidi, Shaghayegh Mirhosseini, M M Zand","doi":"10.1109/ICBME57741.2022.10053042","DOIUrl":"https://doi.org/10.1109/ICBME57741.2022.10053042","url":null,"abstract":"Devices that imitate the functions of human skin are known as “electronic skin,” and they must have characteristics like high sensitivity, a wide dynamic range, high spatial homogeneity, cheap cost, wide area easy processing, and the ability to distinguish between diverse external inputs. Here, we describe a flexible droplet-based microfluidic-assisted emulsion self-assembly (DMESA) method for producing highly efficient capacitive pressure sensors based on three-dimensional microstructures for electronic skin applications. Our method may produce evenly sized micropores that self-assemble across a vast area in an ordered close-packed manner, leading to excellent spatial homogeneity. Dynamic amplitude and sensitivity were readily regulated to as high as 0.62 kPa -1and up to 100 kPa by adjusting the micropore size, which can be simply adjusted from 100 to 600 µm. Our gadget may be molded into a variety of forms and printed on curved surfaces. These examples show how our method and sensors may be used for a broad range of e-skin applications.","PeriodicalId":319196,"journal":{"name":"2022 29th National and 7th International Iranian Conference on Biomedical Engineering (ICBME)","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131367622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-21DOI: 10.1109/ICBME57741.2022.10052847
Saeed Torbati, Alireza Heidari, A. Daneshmehr, H. Pouraliakbar, S. H. Tafti, D. Shum-Tim
Despite recent advances in the computational modeling of cardiovascular diseases and therapies, the effect of post-ischemic remodeling has not been thoroughly studied while considering the unloaded ventricles. Further evaluation is, therefore, needed in order to better understand the effect of alterations in myocardial structure. Herein, we have developed a patient-specific computational model of ischemic cardiomyopathy to assess the influence of microstructure and material change on passive ventricular mechanics. The biventricular geometry has been built and unloaded based on cardiac magnetic resonance (CMR) images of a 64-year-old male patient at end-diastole (ED). Different fiber orientations and material scales were assumed for the model. Results indicated that although some fiber structures produce similar end-diastolic pressure-volume relationships (EDPVRs), differences in initial stress-free shapes and strain patterns determine the subsequent damage to the myocardium. Moreover, stiffening the healthy region means lower myofiber strain. However, material change in the ischemic areas of the ventricles does not alter the passive fiber strain considerably. Such evaluations are required when choosing optimal therapies to alleviate the adverse effects of ischemic cardiomyopathy.
{"title":"Patient-Specific Study of Post-Ischemic Cardiac Ventricular Remodeling: A Passive Simulation of Structural Changes in Myofiber Orientation and Stiffness","authors":"Saeed Torbati, Alireza Heidari, A. Daneshmehr, H. Pouraliakbar, S. H. Tafti, D. Shum-Tim","doi":"10.1109/ICBME57741.2022.10052847","DOIUrl":"https://doi.org/10.1109/ICBME57741.2022.10052847","url":null,"abstract":"Despite recent advances in the computational modeling of cardiovascular diseases and therapies, the effect of post-ischemic remodeling has not been thoroughly studied while considering the unloaded ventricles. Further evaluation is, therefore, needed in order to better understand the effect of alterations in myocardial structure. Herein, we have developed a patient-specific computational model of ischemic cardiomyopathy to assess the influence of microstructure and material change on passive ventricular mechanics. The biventricular geometry has been built and unloaded based on cardiac magnetic resonance (CMR) images of a 64-year-old male patient at end-diastole (ED). Different fiber orientations and material scales were assumed for the model. Results indicated that although some fiber structures produce similar end-diastolic pressure-volume relationships (EDPVRs), differences in initial stress-free shapes and strain patterns determine the subsequent damage to the myocardium. Moreover, stiffening the healthy region means lower myofiber strain. However, material change in the ischemic areas of the ventricles does not alter the passive fiber strain considerably. Such evaluations are required when choosing optimal therapies to alleviate the adverse effects of ischemic cardiomyopathy.","PeriodicalId":319196,"journal":{"name":"2022 29th National and 7th International Iranian Conference on Biomedical Engineering (ICBME)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131386220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-21DOI: 10.1109/ICBME57741.2022.10052881
Shirin Farsi, S. Naserkhaki
Basic information of anatomical parameters such as cross-sectional area (CSA) and moment arms (MA) of muscles are required for musculoskeletal modeling. Previous studies outlined muscle parameters based on in vivo imaging but extracting these data is invasive and costly. To provide a more realistic musculoskeletal model, for the profile of each individual lumbar spine, 3D vertebral model of each individual was constructed and the anterior-posterior (AP) and medial-lateral (ML) cross-sectional areas (CSAs) and moment arms of all muscles at each lumbar disc level were measured and all these parameters obtained from CT scan images. The CSA of spinal muscles had significant difference between men and women at all muscles and most of level as well as the AP and ML muscles moment arm were significantly different between men and women at all muscles and spinal levels. The geometrical data of the group of subjects of this study can utilized for development of subject-specific model and can help assess spinal loads in different tasks.
{"title":"Measurements of the Lumbar Spine Anatomical Parameters for Use in Musculoskeletal Modeling","authors":"Shirin Farsi, S. Naserkhaki","doi":"10.1109/ICBME57741.2022.10052881","DOIUrl":"https://doi.org/10.1109/ICBME57741.2022.10052881","url":null,"abstract":"Basic information of anatomical parameters such as cross-sectional area (CSA) and moment arms (MA) of muscles are required for musculoskeletal modeling. Previous studies outlined muscle parameters based on in vivo imaging but extracting these data is invasive and costly. To provide a more realistic musculoskeletal model, for the profile of each individual lumbar spine, 3D vertebral model of each individual was constructed and the anterior-posterior (AP) and medial-lateral (ML) cross-sectional areas (CSAs) and moment arms of all muscles at each lumbar disc level were measured and all these parameters obtained from CT scan images. The CSA of spinal muscles had significant difference between men and women at all muscles and most of level as well as the AP and ML muscles moment arm were significantly different between men and women at all muscles and spinal levels. The geometrical data of the group of subjects of this study can utilized for development of subject-specific model and can help assess spinal loads in different tasks.","PeriodicalId":319196,"journal":{"name":"2022 29th National and 7th International Iranian Conference on Biomedical Engineering (ICBME)","volume":"79 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125104117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-21DOI: 10.1109/ICBME57741.2022.10053080
Yashar Ebadi, F. Farahmand
Standard implants are available in a wide variety of models and sizes to meet the needs of the normal population. Such implants, however, cannot be used for patients with abnormal hip joint anatomy. This study assessed the mechanical strength and the range of motion of a mini stem, designed for juvenile arthritis patients with substantially small femoral bones. The geometry of the mini stem, designed based on the cemented force-closed philosophy, was determined such that it could accommodate in the very narrow intramedullary canal of a sample patient. A 3D finite element model of the bone-cement-implant construct was developed to assess the strength of the mini stem against yield and fatigue failure, the strength of the cement mantle against yield, and the subsidence of the stem in cement due to the cement creep. Also, the range of motion of the hip implant was estimated by an impingement analysis in which the interference of the femur-pelvis or stem-acetabular cup was examined while rotating the femoral bone in the anatomical planes. Results indicated factors of safety of 7.33 and 4.76 for the mini stem against yield and fatigue failure, and 4 for the cement against yield. The subsidence of the mini stem in the cement over time was obtained as 1.6 micrometers for a 50-hour loading period. Finally, the designed implant could provide large ranges of motion in different planes with no impingement between the implant components and the bones in daily activities. It was concluded that the designed mini stem could satisfy the biomechanical requirements for successful total hip arthroplasty of juvenile arthritis patients.
{"title":"Biomechanical Analysis of A Mini Force-Closed Cemented Hip Stem for Juvenile Arthritis Patients","authors":"Yashar Ebadi, F. Farahmand","doi":"10.1109/ICBME57741.2022.10053080","DOIUrl":"https://doi.org/10.1109/ICBME57741.2022.10053080","url":null,"abstract":"Standard implants are available in a wide variety of models and sizes to meet the needs of the normal population. Such implants, however, cannot be used for patients with abnormal hip joint anatomy. This study assessed the mechanical strength and the range of motion of a mini stem, designed for juvenile arthritis patients with substantially small femoral bones. The geometry of the mini stem, designed based on the cemented force-closed philosophy, was determined such that it could accommodate in the very narrow intramedullary canal of a sample patient. A 3D finite element model of the bone-cement-implant construct was developed to assess the strength of the mini stem against yield and fatigue failure, the strength of the cement mantle against yield, and the subsidence of the stem in cement due to the cement creep. Also, the range of motion of the hip implant was estimated by an impingement analysis in which the interference of the femur-pelvis or stem-acetabular cup was examined while rotating the femoral bone in the anatomical planes. Results indicated factors of safety of 7.33 and 4.76 for the mini stem against yield and fatigue failure, and 4 for the cement against yield. The subsidence of the mini stem in the cement over time was obtained as 1.6 micrometers for a 50-hour loading period. Finally, the designed implant could provide large ranges of motion in different planes with no impingement between the implant components and the bones in daily activities. It was concluded that the designed mini stem could satisfy the biomechanical requirements for successful total hip arthroplasty of juvenile arthritis patients.","PeriodicalId":319196,"journal":{"name":"2022 29th National and 7th International Iranian Conference on Biomedical Engineering (ICBME)","volume":"99 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124054864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-21DOI: 10.1109/ICBME57741.2022.10052998
Masoome Moradiniya, Hasan Asadi
The vertebrae are irregular bones with very complex shapes, which the study of the stress and strain distribution in them help to identify and evaluate their behavior. • Several biomechanical studies have been performed to improve the use of peek (Poly Ether Ether Ketone) or titanium cage for posterior lumbar intervertebral fusion (PLIF). This study was conducted to evaluate the biomechanical effect of these implants with different levels of hardness. So that for peek implants, the viscoelastic properties and elastic specific titanium implants are posed. To analyze the mechanical behaviors of a complete segment of the spine, a cage is initially designed in the SALIDWORK software, including the well-known cages for spinal vertebrae fusion, as well as two L3 and L4 vertebrae are designed in Abacus software and it is assembled with cage, the disk between the L3 and L4 vertebrae. According to the results obtained, the stress and strain rate in the vertebrae and cage with the peek material (due to the viscoelastic properties discussed in it) is significantly reduced compared to the titanium material, which is in good agreement with previous studies.
{"title":"Three-Dimensional Finite Element Analysis of a Complete Segment in the Lumbar Region (L3-L4) Under the Influence of Cage with Titanium and Peek Materials","authors":"Masoome Moradiniya, Hasan Asadi","doi":"10.1109/ICBME57741.2022.10052998","DOIUrl":"https://doi.org/10.1109/ICBME57741.2022.10052998","url":null,"abstract":"The vertebrae are irregular bones with very complex shapes, which the study of the stress and strain distribution in them help to identify and evaluate their behavior. • Several biomechanical studies have been performed to improve the use of peek (Poly Ether Ether Ketone) or titanium cage for posterior lumbar intervertebral fusion (PLIF). This study was conducted to evaluate the biomechanical effect of these implants with different levels of hardness. So that for peek implants, the viscoelastic properties and elastic specific titanium implants are posed. To analyze the mechanical behaviors of a complete segment of the spine, a cage is initially designed in the SALIDWORK software, including the well-known cages for spinal vertebrae fusion, as well as two L3 and L4 vertebrae are designed in Abacus software and it is assembled with cage, the disk between the L3 and L4 vertebrae. According to the results obtained, the stress and strain rate in the vertebrae and cage with the peek material (due to the viscoelastic properties discussed in it) is significantly reduced compared to the titanium material, which is in good agreement with previous studies.","PeriodicalId":319196,"journal":{"name":"2022 29th National and 7th International Iranian Conference on Biomedical Engineering (ICBME)","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127873330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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