{"title":"Animal-based ketogenic diet puts severe anorexia nervosa into multi-year remission: A case series","authors":"Nicholas G. Norwitz, Michelle Hurn, F. Forcén","doi":"10.4102/jir.v6i1.84","DOIUrl":"https://doi.org/10.4102/jir.v6i1.84","url":null,"abstract":"","PeriodicalId":32155,"journal":{"name":"Journal of Insulin Resistance","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46352261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Look in or book in: The case for type 2 diabetes remission to prevent diabetic retinopathy","authors":"J. Cripps, Mark Cucuzzella","doi":"10.4102/jir.v6i1.79","DOIUrl":"https://doi.org/10.4102/jir.v6i1.79","url":null,"abstract":"","PeriodicalId":32155,"journal":{"name":"Journal of Insulin Resistance","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48484977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sodium restriction and insulin resistance: A review of 23 clinical trials","authors":"J. DiNicolantonio, J. O’Keefe","doi":"10.4102/jir.v6i1.78","DOIUrl":"https://doi.org/10.4102/jir.v6i1.78","url":null,"abstract":"","PeriodicalId":32155,"journal":{"name":"Journal of Insulin Resistance","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44151760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Opoku, Caroline R. de Beer-Brandon, J. Quartey, N. Mshunqane
{"title":"Effects of brisk walking on fasting blood glucose and blood pressure in diabetic patients","authors":"B. Opoku, Caroline R. de Beer-Brandon, J. Quartey, N. Mshunqane","doi":"10.4102/jir.v6i1.77","DOIUrl":"https://doi.org/10.4102/jir.v6i1.77","url":null,"abstract":"","PeriodicalId":32155,"journal":{"name":"Journal of Insulin Resistance","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41468296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sabine Kleissl-Muir, C. Zinn, B. Rasmussen, A. Owen, A. Driscoll
{"title":"Low carbohydrate diet for diabetic cardiomyopathy: Protocol for a randomised controlled trial","authors":"Sabine Kleissl-Muir, C. Zinn, B. Rasmussen, A. Owen, A. Driscoll","doi":"10.4102/jir.v5i1.73","DOIUrl":"https://doi.org/10.4102/jir.v5i1.73","url":null,"abstract":"","PeriodicalId":32155,"journal":{"name":"Journal of Insulin Resistance","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42363992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background In response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), several new pharmaceutical agents have been administered to billions of people worldwide, including the young and healthy at little risk from the virus. Considerable leeway has been afforded in terms of the pre-clinical and clinical testing of these agents, despite an entirely novel mechanism of action and concerning biodistribution characteristics. Aim To gain a better understanding of the true benefits and potential harms of the messenger ribonucleic acid (mRNA) coronavirus disease (COVID) vaccines. Methods A narrative review of the evidence from randomised trials and real world data of the COVID mRNA products with special emphasis on BionTech/Pfizer vaccine. Results In the non-elderly population the “number needed to treat” to prevent a single death runs into the thousands. Re-analysis of randomised controlled trials using the messenger ribonucleic acid (mRNA) technology suggests a greater risk of serious adverse events from the vaccines than being hospitalised from COVID-19. Pharmacovigilance systems and real-world safety data, coupled with plausible mechanisms of harm, are deeply concerning, especially in relation to cardiovascular safety. Mirroring a potential signal from the Pfizer Phase 3 trial, a significant rise in cardiac arrest calls to ambulances in England was seen in 2021, with similar data emerging from Israel in the 16–39-year-old age group. Conclusion It cannot be said that the consent to receive these agents was fully informed, as is required ethically and legally. A pause and reappraisal of global vaccination policies for COVID-19 is long overdue. Contribution This article highlights the importance of addressing metabolic health to reduce chronic disease and that insulin resistance is also a major risk factor for poor outcomes from COVID-19.
{"title":"Curing the pandemic of misinformation on COVID-19 mRNA vaccines through real evidence-based medicine - Part 1","authors":"Aseem Malhotra","doi":"10.4102/jir.v5i1.71","DOIUrl":"https://doi.org/10.4102/jir.v5i1.71","url":null,"abstract":"Background In response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), several new pharmaceutical agents have been administered to billions of people worldwide, including the young and healthy at little risk from the virus. Considerable leeway has been afforded in terms of the pre-clinical and clinical testing of these agents, despite an entirely novel mechanism of action and concerning biodistribution characteristics. Aim To gain a better understanding of the true benefits and potential harms of the messenger ribonucleic acid (mRNA) coronavirus disease (COVID) vaccines. Methods A narrative review of the evidence from randomised trials and real world data of the COVID mRNA products with special emphasis on BionTech/Pfizer vaccine. Results In the non-elderly population the “number needed to treat” to prevent a single death runs into the thousands. Re-analysis of randomised controlled trials using the messenger ribonucleic acid (mRNA) technology suggests a greater risk of serious adverse events from the vaccines than being hospitalised from COVID-19. Pharmacovigilance systems and real-world safety data, coupled with plausible mechanisms of harm, are deeply concerning, especially in relation to cardiovascular safety. Mirroring a potential signal from the Pfizer Phase 3 trial, a significant rise in cardiac arrest calls to ambulances in England was seen in 2021, with similar data emerging from Israel in the 16–39-year-old age group. Conclusion It cannot be said that the consent to receive these agents was fully informed, as is required ethically and legally. A pause and reappraisal of global vaccination policies for COVID-19 is long overdue. Contribution This article highlights the importance of addressing metabolic health to reduce chronic disease and that insulin resistance is also a major risk factor for poor outcomes from COVID-19.","PeriodicalId":32155,"journal":{"name":"Journal of Insulin Resistance","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48769189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background Authorities and sections of the medical profession have supported unethical, coercive, and misinformed policies such as vaccine mandates and vaccine passports, undermining the principles of ethical evidence-based medical practice and informed consent. These regrettable actions are a symptom of the ‘medical information mess’: The tip of a mortality iceberg where prescribed medications are estimated to be the third most common cause of death globally after heart disease and cancer. Aim To identify the major root causes of these public health failures. Methods A narrative review of both current and historical driving factors that underpin the pandemic of medical misinformation. Results Underlying causes for this failure include regulatory capture – guardians that are supposed to protect the public are in fact funded by the corporations that stand to gain from the sale of those medications. A failure of public health messaging has also resulted in wanton waste of resources and a missed opportunity to help individuals lead healthier lives with relatively simple – and low cost – lifestyle changes. Conclusion There is a strong scientific, ethical and moral case to be made that the current COVID vaccine administration must stop until all the raw data has been subjected to fully independent scrutiny. Looking to the future the medical and public health professions must recognise these failings and eschew the tainted dollar of the medical-industrial complex. It will take a lot of time and effort to rebuild trust in these institutions, but the health – of both humanity and the medical profession – depends on it. Contribution This article highlights the importance of addressing metabolic health to reduce chronic disease and that insulin resistance is also a major risk factor for poor outcomes from COVID-19.
{"title":"Curing the pandemic of misinformation on COVID-19 mRNA vaccines through real evidence-based medicine - Part 2","authors":"Aseem Malhotra","doi":"10.4102/jir.v5i1.72","DOIUrl":"https://doi.org/10.4102/jir.v5i1.72","url":null,"abstract":"Background Authorities and sections of the medical profession have supported unethical, coercive, and misinformed policies such as vaccine mandates and vaccine passports, undermining the principles of ethical evidence-based medical practice and informed consent. These regrettable actions are a symptom of the ‘medical information mess’: The tip of a mortality iceberg where prescribed medications are estimated to be the third most common cause of death globally after heart disease and cancer. Aim To identify the major root causes of these public health failures. Methods A narrative review of both current and historical driving factors that underpin the pandemic of medical misinformation. Results Underlying causes for this failure include regulatory capture – guardians that are supposed to protect the public are in fact funded by the corporations that stand to gain from the sale of those medications. A failure of public health messaging has also resulted in wanton waste of resources and a missed opportunity to help individuals lead healthier lives with relatively simple – and low cost – lifestyle changes. Conclusion There is a strong scientific, ethical and moral case to be made that the current COVID vaccine administration must stop until all the raw data has been subjected to fully independent scrutiny. Looking to the future the medical and public health professions must recognise these failings and eschew the tainted dollar of the medical-industrial complex. It will take a lot of time and effort to rebuild trust in these institutions, but the health – of both humanity and the medical profession – depends on it. Contribution This article highlights the importance of addressing metabolic health to reduce chronic disease and that insulin resistance is also a major risk factor for poor outcomes from COVID-19.","PeriodicalId":32155,"journal":{"name":"Journal of Insulin Resistance","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49138630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hyperinsulinaemia in pregnancy and gestational outcomes: A case series","authors":"Sylvia North, C. Crofts, C. Zinn","doi":"10.4102/jir.v5i1.69","DOIUrl":"https://doi.org/10.4102/jir.v5i1.69","url":null,"abstract":"","PeriodicalId":32155,"journal":{"name":"Journal of Insulin Resistance","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46961871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrea C. Salcedo, Hannah Shehata, Abigail Berry, Christopher Riba
Background: Studies indicate the presence of cardiovascular disease risk amongst patients with uterine fibroids and polycystic ovarian syndrome.Aim: The researchers aimed to examine the prevalence of cardiovascular disease risk factors and independent predictors of insulin resistance (IR) amongst women with abnormal uterine bleeding (AUB).Methods: This observational study examined 77 premenopausal subjects with AUB. Their medical history, body mass index (BMI), waist–hip ratio (WHR), fasting insulin (FI), haemoglobin A1c, creatinine and lipids were evaluated. Subjects were subdivided using insulin levels and compared. Insulin resistance was defined at two FI levels: 10 μU/mL and 15 μU/mL.Results: A total of 91% of participants had smoking history, 62% had a WHR 0.80, 45% were obese and most had dyslipidaemia. In all, 38% – 66% were insulin resistant, depending on cut-off used. At FI 10 μU/mL, subjects were significantly more likely to have a WHR 0.8, be obese and have low HDL. At FI 15 μU/mL, subjects were significantly more likely to have low HDL, elevated triglycerides, a WHR 0.8 and be obese. Univariate analysis showed significant associations between IR in AUB and BMI, WHR and HDL for both FI cut-offs. Multivariate analysis using the lower FI cut-off revealed BMI and WHR were significant independent predictors of IR in AUB.Conclusion: This study reveals the prevalence of IR (66%) and other predictors of cardiovascular disease are greater in AUB in this population than the general US population. Body mass index and WHR are independent predictors of IR in AUB. Low HDL, elevated triglycerides and ethnicity are also significantly associated with IR in AUB depending on the definition used.
{"title":"Insulin resistance and other risk factors of cardiovascular disease amongst women with abnormal uterine bleeding","authors":"Andrea C. Salcedo, Hannah Shehata, Abigail Berry, Christopher Riba","doi":"10.4102/jir.v5i1.67","DOIUrl":"https://doi.org/10.4102/jir.v5i1.67","url":null,"abstract":"Background: Studies indicate the presence of cardiovascular disease risk amongst patients with uterine fibroids and polycystic ovarian syndrome.Aim: The researchers aimed to examine the prevalence of cardiovascular disease risk factors and independent predictors of insulin resistance (IR) amongst women with abnormal uterine bleeding (AUB).Methods: This observational study examined 77 premenopausal subjects with AUB. Their medical history, body mass index (BMI), waist–hip ratio (WHR), fasting insulin (FI), haemoglobin A1c, creatinine and lipids were evaluated. Subjects were subdivided using insulin levels and compared. Insulin resistance was defined at two FI levels: 10 μU/mL and 15 μU/mL.Results: A total of 91% of participants had smoking history, 62% had a WHR 0.80, 45% were obese and most had dyslipidaemia. In all, 38% – 66% were insulin resistant, depending on cut-off used. At FI 10 μU/mL, subjects were significantly more likely to have a WHR 0.8, be obese and have low HDL. At FI 15 μU/mL, subjects were significantly more likely to have low HDL, elevated triglycerides, a WHR 0.8 and be obese. Univariate analysis showed significant associations between IR in AUB and BMI, WHR and HDL for both FI cut-offs. Multivariate analysis using the lower FI cut-off revealed BMI and WHR were significant independent predictors of IR in AUB.Conclusion: This study reveals the prevalence of IR (66%) and other predictors of cardiovascular disease are greater in AUB in this population than the general US population. Body mass index and WHR are independent predictors of IR in AUB. Low HDL, elevated triglycerides and ethnicity are also significantly associated with IR in AUB depending on the definition used.","PeriodicalId":32155,"journal":{"name":"Journal of Insulin Resistance","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49605647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Interpreting quantification: Is this the Achilles heel of insulin diagnostics?","authors":"C. Zinn, C. Crofts","doi":"10.4102/jir.v5i1.70","DOIUrl":"https://doi.org/10.4102/jir.v5i1.70","url":null,"abstract":"No abstract available.","PeriodicalId":32155,"journal":{"name":"Journal of Insulin Resistance","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41513230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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