Pub Date : 1900-01-01DOI: 10.5336/NEURO.2014-43053
Burcu Ekmekci, Sadullah Sağlam, Z. A. Tak, Ilhan Cag, Hacı Taner Bulut, M. Yılmaz
{"title":"Açık Kalp Ameliyatı Sonrasında Alt Ekstremite Tremoru Gelişen İki Olgu","authors":"Burcu Ekmekci, Sadullah Sağlam, Z. A. Tak, Ilhan Cag, Hacı Taner Bulut, M. Yılmaz","doi":"10.5336/NEURO.2014-43053","DOIUrl":"https://doi.org/10.5336/NEURO.2014-43053","url":null,"abstract":"","PeriodicalId":322260,"journal":{"name":"Turkiye Klinikleri Journal of Neurology","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125951698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.5336/neuro.2016-51118
İ. Sönmez, Senem Mut, A. Bozkurt
{"title":"Multipl Sklerozda Görülen Psikiyatrik Bulgular ve Bozukluklar","authors":"İ. Sönmez, Senem Mut, A. Bozkurt","doi":"10.5336/neuro.2016-51118","DOIUrl":"https://doi.org/10.5336/neuro.2016-51118","url":null,"abstract":"","PeriodicalId":322260,"journal":{"name":"Turkiye Klinikleri Journal of Neurology","volume":"151 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131587352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.5336/NEURO.2017-57919
T. Kamaşak, A. Cansu, E. Arslan, S. Şahin, Betül Diler Durgut, Beril Dilber, Tuğba Kurt, M. Terzi, C. Boz
{"title":"A Comparison of Pediatric- and Adult-Onset Multiple Sclerosis","authors":"T. Kamaşak, A. Cansu, E. Arslan, S. Şahin, Betül Diler Durgut, Beril Dilber, Tuğba Kurt, M. Terzi, C. Boz","doi":"10.5336/NEURO.2017-57919","DOIUrl":"https://doi.org/10.5336/NEURO.2017-57919","url":null,"abstract":"","PeriodicalId":322260,"journal":{"name":"Turkiye Klinikleri Journal of Neurology","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123120384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.5336/neuro.2014-40240
A. Çoban, Tuğçe Mengi, M. Çelebisoy
A 25-years-old woman presented with headache and diplopia following spinal anesthesia. Magnetic resonance imaging (MRI) showed findings compatible with intracranial hypotension. The patient was diagnosed as having 6th cranial nerve palsy secondary to cerebrospinal fluid (CSF) leakage following dural puncture and had intravenous hydration treatment. Complete resolution of the diplopia occured 24 hours after the hydration theraphy. Orthostatic headache, low CSF opening pressure and characteristic MRI findings are essential criteria for diagnosis of intracranial hypotension. Abducens nevre palsy following spinal anesthesia is a rare and reversible complication, which is thought to be secondary to the traction of abducens nerve due to intracranial hypotension following cerebrospinal fluid leakage.
{"title":"Abdusens Felci ile Prezente Olan İntrakraniyal Hipotansiyon","authors":"A. Çoban, Tuğçe Mengi, M. Çelebisoy","doi":"10.5336/neuro.2014-40240","DOIUrl":"https://doi.org/10.5336/neuro.2014-40240","url":null,"abstract":"A 25-years-old woman presented with headache and diplopia following spinal anesthesia. Magnetic resonance imaging (MRI) showed findings compatible with intracranial hypotension. The patient was diagnosed as having 6th cranial nerve palsy secondary to cerebrospinal fluid (CSF) leakage following dural puncture and had intravenous hydration treatment. Complete resolution of the diplopia occured 24 hours after the hydration theraphy. Orthostatic headache, low CSF opening pressure and characteristic MRI findings are essential criteria for diagnosis of intracranial hypotension. Abducens nevre palsy following spinal anesthesia is a rare and reversible complication, which is thought to be secondary to the traction of abducens nerve due to intracranial hypotension following cerebrospinal fluid leakage.","PeriodicalId":322260,"journal":{"name":"Turkiye Klinikleri Journal of Neurology","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122991095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.5336/NEURO.2014-42494
Amber Eker, A. Tuncer, Rana Karabudak
{"title":"Multipl Skleroz Seyrinde İzlenen Nadir Atak Şekilleri ve Semptomlar: Geniş Bir Multipl Sklerozlu Hasta Grubunda Retrospektif İnceleme","authors":"Amber Eker, A. Tuncer, Rana Karabudak","doi":"10.5336/NEURO.2014-42494","DOIUrl":"https://doi.org/10.5336/NEURO.2014-42494","url":null,"abstract":"","PeriodicalId":322260,"journal":{"name":"Turkiye Klinikleri Journal of Neurology","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127694306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.5336/NEURO.2015-43571
Y. Arslan, Y. Zorlu, B. Tiftikçioğlu, Irem Ilgezdi
ABS TRACT Inflammatory bowel disease (IBD) and neuroimmune disorders have a close relationship to their diseases pattern and immunologic cascade with considerable morbidity and mortality. They may have common immunological pathways related with vitamin D deficiency or hygiene hypotheses and also with T cell autoimmunity. We herein report two neuroimmune disorders with low serum vitamin D levels; multiple sclerosis and acute sensory motor axonal polyneuropathy in the course of ulcerative colitis to discuss the common immunologic mechanisms. The exact incidence of neurological IBD is unknown, with reports varying from 0.25% to 35.7%. Although a reliable differentiation may clinically not always be possible, three major pathogenic entities can be differentiated: (i) cerebrovascular disease (ii) systemic and cerebral vasculitis; (iii) immune mediated neuropathy and cerebral demyelination. IBD patients should be consulted to a neurologist and examined by neuroimaging and neurophysiological studies routinely once a year, additionally serum vitamin D levels need to be assayed and replaced in these cases.
{"title":"Relationship Between Neuroimmune Disorders and Inflammatory Bowel Diseases: Case Report","authors":"Y. Arslan, Y. Zorlu, B. Tiftikçioğlu, Irem Ilgezdi","doi":"10.5336/NEURO.2015-43571","DOIUrl":"https://doi.org/10.5336/NEURO.2015-43571","url":null,"abstract":"ABS TRACT Inflammatory bowel disease (IBD) and neuroimmune disorders have a close relationship to their diseases pattern and immunologic cascade with considerable morbidity and mortality. They may have common immunological pathways related with vitamin D deficiency or hygiene hypotheses and also with T cell autoimmunity. We herein report two neuroimmune disorders with low serum vitamin D levels; multiple sclerosis and acute sensory motor axonal polyneuropathy in the course of ulcerative colitis to discuss the common immunologic mechanisms. The exact incidence of neurological IBD is unknown, with reports varying from 0.25% to 35.7%. Although a reliable differentiation may clinically not always be possible, three major pathogenic entities can be differentiated: (i) cerebrovascular disease (ii) systemic and cerebral vasculitis; (iii) immune mediated neuropathy and cerebral demyelination. IBD patients should be consulted to a neurologist and examined by neuroimaging and neurophysiological studies routinely once a year, additionally serum vitamin D levels need to be assayed and replaced in these cases.","PeriodicalId":322260,"journal":{"name":"Turkiye Klinikleri Journal of Neurology","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132656446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.5336/NEURO.2018-61932
S. Mungan, N. Öztekin, I. Güzel, S. Uysal
Objective: Multiple sclerosis (MS) is an inflammatory, autoimmune, demyelinating disease characterized by multifocal inflammation, progressive myelin loss and consequent axonal demyelination. Pathogenic mechanisms of MS are oligodendrocyte damage as a result of leukocyte chemotaxis to central nervous system and production of inflammatory mediators, demyelination and neuronal injury. CXCL12 (SDF-1 alpha) is a basic chemokine which is chemoattractant for resting and activated T cells. We aimed to evaluate whether CXCL12 levels may be a predictive marker of neuroinflammation in MS patients. Material and Methods: We designed a prospective case control study of fifty-four MS patients and twenty-eight healthy controls were enrolled to the study. Plasma CXCL12 levels of the groups were measured in blood samples. The groups were compared in terms of plasma CXCL12 levels. Lymphocyte count, which is a marker of inflammation, was also compared. In the study group subsequent analysis was demonstrated the association between clinical parameters and plasma CXCL12 levels. Results: CXCL12 levels were statistically higher than the control group. Mean CXCL12 level of MS patients was 2026,5±398,7 pg/ml and the mean CXCL12 level of the controls was 1840,6±256,0 pg/ml. Lymphocyte count of the patients was also statistically higher in the study group. According to the receiver operator characteristic (ROC) curve analysis mean CXCL12 levels were discriminative factors in patients in the study group. There was no statistically significant association between plasma CXCL12 levels and clinical parameters. Conclusion: We conclude that elevations in CXCL12 levels might be a promising marker pointing out the pathogenic role of inflammation in multiple sclerosis.
{"title":"The Predictive Role of CXCL12 (SDF-1 alpha) in Multiple Sclerosis","authors":"S. Mungan, N. Öztekin, I. Güzel, S. Uysal","doi":"10.5336/NEURO.2018-61932","DOIUrl":"https://doi.org/10.5336/NEURO.2018-61932","url":null,"abstract":"Objective: Multiple sclerosis (MS) is an inflammatory, autoimmune, demyelinating disease characterized by multifocal inflammation, progressive myelin loss and consequent axonal demyelination. Pathogenic mechanisms of MS are oligodendrocyte damage as a result of leukocyte chemotaxis to central nervous system and production of inflammatory mediators, demyelination and neuronal injury. CXCL12 (SDF-1 alpha) is a basic chemokine which is chemoattractant for resting and activated T cells. We aimed to evaluate whether CXCL12 levels may be a predictive marker of neuroinflammation in MS patients. Material and Methods: We designed a prospective case control study of fifty-four MS patients and twenty-eight healthy controls were enrolled to the study. Plasma CXCL12 levels of the groups were measured in blood samples. The groups were compared in terms of plasma CXCL12 levels. Lymphocyte count, which is a marker of inflammation, was also compared. In the study group subsequent analysis was demonstrated the association between clinical parameters and plasma CXCL12 levels. Results: CXCL12 levels were statistically higher than the control group. Mean CXCL12 level of MS patients was 2026,5±398,7 pg/ml and the mean CXCL12 level of the controls was 1840,6±256,0 pg/ml. Lymphocyte count of the patients was also statistically higher in the study group. According to the receiver operator characteristic (ROC) curve analysis mean CXCL12 levels were discriminative factors in patients in the study group. There was no statistically significant association between plasma CXCL12 levels and clinical parameters. Conclusion: We conclude that elevations in CXCL12 levels might be a promising marker pointing out the pathogenic role of inflammation in multiple sclerosis.","PeriodicalId":322260,"journal":{"name":"Turkiye Klinikleri Journal of Neurology","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116952228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.5336/neuro.2016-54357
Y. Eren, Hayat Güven, S. Çomoğlu
{"title":"Possible Ethylene Oxide Neuropathy: Case Report","authors":"Y. Eren, Hayat Güven, S. Çomoğlu","doi":"10.5336/neuro.2016-54357","DOIUrl":"https://doi.org/10.5336/neuro.2016-54357","url":null,"abstract":"","PeriodicalId":322260,"journal":{"name":"Turkiye Klinikleri Journal of Neurology","volume":"148 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116321356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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