Objective: To observe and explore the effects and mechanism of apoptosis on canine induced by Laser. Try to find a new approach to treat of armpit odor with no traumatism. Method: We used different power of semiconductor Laser to irradiate the black hair canine to observe and evaluate the tissue effects with electroscope, flow cytometry and Tunel technique at different period of time after irradiation. Result: The apoptosis has been observed within the hair follicle cells and apocrine gland cells after irradiation. After repeat irradiation in low power level, more apoptosis has been observed. Conclusion: Apoptosis exists in hair follicle cells and apocrine gland cells after Laser irradiation.
{"title":"Experimental study on apoptosis induced by semiconductor laser to hair removal and armpit odor treatment","authors":"Hongmin Shi, Min Yan, Meijue Zhang","doi":"10.1117/12.639199","DOIUrl":"https://doi.org/10.1117/12.639199","url":null,"abstract":"Objective: To observe and explore the effects and mechanism of apoptosis on canine induced by Laser. Try to find a new approach to treat of armpit odor with no traumatism. Method: We used different power of semiconductor Laser to irradiate the black hair canine to observe and evaluate the tissue effects with electroscope, flow cytometry and Tunel technique at different period of time after irradiation. Result: The apoptosis has been observed within the hair follicle cells and apocrine gland cells after irradiation. After repeat irradiation in low power level, more apoptosis has been observed. Conclusion: Apoptosis exists in hair follicle cells and apocrine gland cells after Laser irradiation.","PeriodicalId":325950,"journal":{"name":"Shanghai International Conference on Laser Medicine and Surgery","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117346316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To observe the effect of Ho:YAG laser in treatment of urethra cauncle. Methods: The patients suffering from urethra cauncle were treated by Ho:YAG laser, the energy of per pulse is 0.5J. The frequency of pulse is 5~15Hz, and the average power of the laser is 2.5~7.5W. Results: Among the patients 188 cases of urethra cauncle were only cured for one time, twice for 12 cases. No stricture on the peristome of urethra or urethrovaginal fistula was observed. Conclusions: The technique of treatment of urethra cauncle with Ho:YAG laser is an effect and safe therapeutics with the merit of excellent homeostasis, improved visualization, minimal thermal damage to surrounding tissue, shorter period of recovery and easy to operate. It is better than CO2 laser and Nd:YAG laser.
{"title":"Analysis on the effect of urethra caruncle treated by Ho:YAG laser","authors":"Meijue Zhang, Jing Zhu, Hongmin Shi","doi":"10.1117/12.639370","DOIUrl":"https://doi.org/10.1117/12.639370","url":null,"abstract":"Objective: To observe the effect of Ho:YAG laser in treatment of urethra cauncle. Methods: The patients suffering from urethra cauncle were treated by Ho:YAG laser, the energy of per pulse is 0.5J. The frequency of pulse is 5~15Hz, and the average power of the laser is 2.5~7.5W. Results: Among the patients 188 cases of urethra cauncle were only cured for one time, twice for 12 cases. No stricture on the peristome of urethra or urethrovaginal fistula was observed. Conclusions: The technique of treatment of urethra cauncle with Ho:YAG laser is an effect and safe therapeutics with the merit of excellent homeostasis, improved visualization, minimal thermal damage to surrounding tissue, shorter period of recovery and easy to operate. It is better than CO2 laser and Nd:YAG laser.","PeriodicalId":325950,"journal":{"name":"Shanghai International Conference on Laser Medicine and Surgery","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116414350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nowadays, much attention has been paid to keep long-term patency after vascular anastomosis especially for small-caliber vessels in vascular surgery. From these standpoints, low energy CO2 laser was used to make an anastomosis especially for small-caliber vessels. And then an availability of vascular anastomosis by laser could be apparently recognized.
{"title":"Laser application in the field of vascular anastomosis: experimental and clinical study","authors":"M. Okada","doi":"10.1117/12.639343","DOIUrl":"https://doi.org/10.1117/12.639343","url":null,"abstract":"Nowadays, much attention has been paid to keep long-term patency after vascular anastomosis especially for small-caliber vessels in vascular surgery. From these standpoints, low energy CO2 laser was used to make an anastomosis especially for small-caliber vessels. And then an availability of vascular anastomosis by laser could be apparently recognized.","PeriodicalId":325950,"journal":{"name":"Shanghai International Conference on Laser Medicine and Surgery","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128533790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective To explore the feasibility and clinical value of treatment for intranasal synechiae by CO2 laser with reduce the incidence of complication in endoscopic sinus surgery. Methods A retrospective study was made of 31 cases treated for intranasal synechiae by CO2 laser. A CO2 laser was used to facilitate removed intranasal adhesion between the middle turbinate and the lateral nasal wall with minimal blood loss under endoscopic visualization. Results 31 cases were followed up beyond 24 months. The overall effective rate was 90.3%. 3 patients underwent a revision endoscopic procedure. Conclusions The method has many advantages such as clear operative field, safe and satisfactory. So it is a good way to treatment for intranasal synechiae.
{"title":"Treatment for intranasal synechiae by CO2 laser under endoscopic visualization","authors":"Yunhai Feng, S. Yin","doi":"10.1117/12.639313","DOIUrl":"https://doi.org/10.1117/12.639313","url":null,"abstract":"Objective To explore the feasibility and clinical value of treatment for intranasal synechiae by CO2 laser with reduce the incidence of complication in endoscopic sinus surgery. Methods A retrospective study was made of 31 cases treated for intranasal synechiae by CO2 laser. A CO2 laser was used to facilitate removed intranasal adhesion between the middle turbinate and the lateral nasal wall with minimal blood loss under endoscopic visualization. Results 31 cases were followed up beyond 24 months. The overall effective rate was 90.3%. 3 patients underwent a revision endoscopic procedure. Conclusions The method has many advantages such as clear operative field, safe and satisfactory. So it is a good way to treatment for intranasal synechiae.","PeriodicalId":325950,"journal":{"name":"Shanghai International Conference on Laser Medicine and Surgery","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130346166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To evaluate the biological effect of Nd:YAP laser in different power and irradiation time on canine stomach in vitro. Methods: The canine stomach in vitro was irradiated by Nd:YAP laser with different power and irradiation time. The damage with naked eye, micro and ultramicro structure was observed. Results: The thermal coagulation effect is mostly and the ablation effect is subordinate on biological effect of Nd:YAP laser on canine stomach in vitro. Thermal coagulation and denaturalization time of whole stratum in pathology is 10W, 5s; 20W, 4s; 30W, 2s; 40~60W, 1s. Conclusions: Safety dose of laser beam on canine stomach in vitro is 10W, time less than 5s; 20W, time less than 4s; 30W, time less than 2s. The ablation and thermal coagulation effects of Nd:YAP laser on canine stomach in vitro is positive correlative with power and time.
{"title":"Experimental study of biological effect on canine stomach in vitro by Nd:YAP laser","authors":"Meijue Zhang, Jing Zhu, Hui-guo Zhang","doi":"10.1117/12.639192","DOIUrl":"https://doi.org/10.1117/12.639192","url":null,"abstract":"Objective: To evaluate the biological effect of Nd:YAP laser in different power and irradiation time on canine stomach in vitro. Methods: The canine stomach in vitro was irradiated by Nd:YAP laser with different power and irradiation time. The damage with naked eye, micro and ultramicro structure was observed. Results: The thermal coagulation effect is mostly and the ablation effect is subordinate on biological effect of Nd:YAP laser on canine stomach in vitro. Thermal coagulation and denaturalization time of whole stratum in pathology is 10W, 5s; 20W, 4s; 30W, 2s; 40~60W, 1s. Conclusions: Safety dose of laser beam on canine stomach in vitro is 10W, time less than 5s; 20W, time less than 4s; 30W, time less than 2s. The ablation and thermal coagulation effects of Nd:YAP laser on canine stomach in vitro is positive correlative with power and time.","PeriodicalId":325950,"journal":{"name":"Shanghai International Conference on Laser Medicine and Surgery","volume":"136 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116391280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Several photosensitisers are known to accumulate selectively in atheromas, regardless of the size of the involved artery. The new photosensitizer, mono-L-aspartyl chlorin e6 (NPe6), specifically accumulates in the atheroma. In the presence of NPe6, the atheroma could be recognized by detecting the specific fluorescence spectrum of NPe6 using a spectrophotometer. We developed a spectrum analysis system and reported that the fluorescence spectra of NPe6 emitted from atherosclerotic plaques on the descending thoracic aorta were recognized by this analysis system with an angioscopic approach in the animal model of atherosclerosis. We also detected the fluorescence spectrum peak at 675 nm of NPe6 laparoscopically only in parts of the abdominal aorta with an atheroma. This spectrum analysis system is useful to recognize the atheroma, but not to recognize the atherosclerotic lesions of the artery as a whole. So, we developed a fluorescence endoscope. Using the endoscopic analysis system, atheromas on the carotid artery were visualized as reddish spots from inside and outside the artery. Then we developed an epifluorescence stereoscope system, and using this device we visualized small coronary atherosclerosis specifically at the beating heart surface. We extensively examined the effects of photodynamic therapy with NPe6 on the atheroma. We studied the change in the lipid components of the atheroma using Fourier transform infrared (FTIR) microspectroscopy. FTIR microspectroscopic analysis showed a dissociation of ester bonds of cholesterol esters in the atheroma after photodynamic therapy. The framework of the atheroma and the lipids accumulated in the atheroma were destroyed. We also evaluated the change in the elastic framework in the atheroma using scanning electron microscopy. The destruction of the architecture of the elastic fiber network in the atheroma was revealed.
{"title":"Basic research in PDT","authors":"J. Hayashi, K. Aizawa","doi":"10.1117/12.639219","DOIUrl":"https://doi.org/10.1117/12.639219","url":null,"abstract":"Several photosensitisers are known to accumulate selectively in atheromas, regardless of the size of the involved artery. The new photosensitizer, mono-L-aspartyl chlorin e6 (NPe6), specifically accumulates in the atheroma. In the presence of NPe6, the atheroma could be recognized by detecting the specific fluorescence spectrum of NPe6 using a spectrophotometer. We developed a spectrum analysis system and reported that the fluorescence spectra of NPe6 emitted from atherosclerotic plaques on the descending thoracic aorta were recognized by this analysis system with an angioscopic approach in the animal model of atherosclerosis. We also detected the fluorescence spectrum peak at 675 nm of NPe6 laparoscopically only in parts of the abdominal aorta with an atheroma. This spectrum analysis system is useful to recognize the atheroma, but not to recognize the atherosclerotic lesions of the artery as a whole. So, we developed a fluorescence endoscope. Using the endoscopic analysis system, atheromas on the carotid artery were visualized as reddish spots from inside and outside the artery. Then we developed an epifluorescence stereoscope system, and using this device we visualized small coronary atherosclerosis specifically at the beating heart surface. We extensively examined the effects of photodynamic therapy with NPe6 on the atheroma. We studied the change in the lipid components of the atheroma using Fourier transform infrared (FTIR) microspectroscopy. FTIR microspectroscopic analysis showed a dissociation of ester bonds of cholesterol esters in the atheroma after photodynamic therapy. The framework of the atheroma and the lipids accumulated in the atheroma were destroyed. We also evaluated the change in the elastic framework in the atheroma using scanning electron microscopy. The destruction of the architecture of the elastic fiber network in the atheroma was revealed.","PeriodicalId":325950,"journal":{"name":"Shanghai International Conference on Laser Medicine and Surgery","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129696639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The effects of intravascular low level laser irradiation of He-Ne on rat MCAo-induced cerebral injury were studied. The results showed that control rats (subjected to MCAo injury without laser treatment) at 7d exhibited striatal and cortical brain infarction in the right hemisphere from approximately 3 to 11mm from the front pole. the total infarct volume in this group was 34.5±8.1mm3. For experimental rats (with laser management), the total infarct volume was 29.0±9.0mm3. P was gained less than 0.05. The neurological score of control group was 4.7±0.6 and it was 5.2±1.0 in experimental group, comparison by statistical analysis showed P less than 0.05. The cerebral pathological damages in the control group were more severe than in experimental group. We concluded that the intravascular low level laser irradiation has no remarked complication and is helpful to reduce ischemic damage. There is clinically potential for the application of intravascular He-Ne low level laser irradiation in ischemia stroke.
{"title":"The neuroprotective effects of intravascular low level laser irradiation on cerebral ischemia rats","authors":"Yongming Qiu, Zhaofeng Lu, Zhongguan Wang, Ji-yao Jiang","doi":"10.1117/12.639317","DOIUrl":"https://doi.org/10.1117/12.639317","url":null,"abstract":"The effects of intravascular low level laser irradiation of He-Ne on rat MCAo-induced cerebral injury were studied. The results showed that control rats (subjected to MCAo injury without laser treatment) at 7d exhibited striatal and cortical brain infarction in the right hemisphere from approximately 3 to 11mm from the front pole. the total infarct volume in this group was 34.5±8.1mm3. For experimental rats (with laser management), the total infarct volume was 29.0±9.0mm3. P was gained less than 0.05. The neurological score of control group was 4.7±0.6 and it was 5.2±1.0 in experimental group, comparison by statistical analysis showed P less than 0.05. The cerebral pathological damages in the control group were more severe than in experimental group. We concluded that the intravascular low level laser irradiation has no remarked complication and is helpful to reduce ischemic damage. There is clinically potential for the application of intravascular He-Ne low level laser irradiation in ischemia stroke.","PeriodicalId":325950,"journal":{"name":"Shanghai International Conference on Laser Medicine and Surgery","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125321693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To summarize the PDT short-term effect on malignant tumors. Method: Made follow-up observation and analysis of 23 cases of various kinds and different stages malignant tumors received photodynamic therapy. Results: Within the 23 cases, through 1-6 months follow-up, the results of tumor lesions treated by PDT are as follows: 15 cases revealed CR, 8 cases had PR and 5 patients died of other causes, nothing involving PDT. Of the 23 cases, 6 early stage tumor patients showed complete remission and no relapse occurred in the follow-up period; 17 cases of advanced stage patients revealed CR or PR effective results. Conclusion: The confined lesion of early stage malignant tumors can be cured by PDT, the advanced stage malignant tumor cases can also present good short-term effect or palliative results. So, PDT is one of the effective therapies for malignant tumors.
{"title":"A short-term follow-up study of photodynamic therapy on 23 cases of malignant tumors","authors":"Zhuo-Zheng Huang, Chuang Chen, Rong-bin Yang, Ying Zhao","doi":"10.1117/12.639209","DOIUrl":"https://doi.org/10.1117/12.639209","url":null,"abstract":"Objective: To summarize the PDT short-term effect on malignant tumors. Method: Made follow-up observation and analysis of 23 cases of various kinds and different stages malignant tumors received photodynamic therapy. Results: Within the 23 cases, through 1-6 months follow-up, the results of tumor lesions treated by PDT are as follows: 15 cases revealed CR, 8 cases had PR and 5 patients died of other causes, nothing involving PDT. Of the 23 cases, 6 early stage tumor patients showed complete remission and no relapse occurred in the follow-up period; 17 cases of advanced stage patients revealed CR or PR effective results. Conclusion: The confined lesion of early stage malignant tumors can be cured by PDT, the advanced stage malignant tumor cases can also present good short-term effect or palliative results. So, PDT is one of the effective therapies for malignant tumors.","PeriodicalId":325950,"journal":{"name":"Shanghai International Conference on Laser Medicine and Surgery","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117060097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To obtain a new therapy for port-wine stain (PWS) with good effect and few side effects, the Leghorn chicken combs chosen as the animal models and treated by small dose HpD and variable pulsed 532nm laser were evaluated clinically using four different scoring systems commonly used in previous publication. Result: It was shown significant difference among 5 groups (p<0.01), and the treatment groups have better effect than the control groups. There's also difference among the four treatment groups and the higher dose of HpD has better effect. In all groups the higher the fluency of laser was used, the better the effect produce. Conclusion: The results provide evidence that small dose HpD and variable pulsed 532nm laser can increase the efficacy of treatment in PWS. Increasing the fluency of laser and the dose of HpD can improve the efficacy.
{"title":"Experimental study on port-wine stain treated by small dose HpD and variable pulsed 532nm laser","authors":"Meixiang Qin, Jing Zhu, Xiawen Yuan","doi":"10.1117/12.639245","DOIUrl":"https://doi.org/10.1117/12.639245","url":null,"abstract":"To obtain a new therapy for port-wine stain (PWS) with good effect and few side effects, the Leghorn chicken combs chosen as the animal models and treated by small dose HpD and variable pulsed 532nm laser were evaluated clinically using four different scoring systems commonly used in previous publication. Result: It was shown significant difference among 5 groups (p<0.01), and the treatment groups have better effect than the control groups. There's also difference among the four treatment groups and the higher dose of HpD has better effect. In all groups the higher the fluency of laser was used, the better the effect produce. Conclusion: The results provide evidence that small dose HpD and variable pulsed 532nm laser can increase the efficacy of treatment in PWS. Increasing the fluency of laser and the dose of HpD can improve the efficacy.","PeriodicalId":325950,"journal":{"name":"Shanghai International Conference on Laser Medicine and Surgery","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122895238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To observe the difference of biological effects on canine uterus by Nd:YAP laser with different power and different irradiation time. Methods: The canine uteri were irradiated with different power and different irradiation time. The effects of ablation and thermal coagulation in different laser settings were observed. The damage scale was evaluated macroscopically, with lightscope and with electroscope. Results: The thermal coagulation is primary and the ablation is secondary. The dose of perforation is 30w, 2s; 20w, 4s and 10w, 5s. Conclusions: The thermal coagulation is primary and the ablation is secondary of Nd:YAP laser on canine uterus. Safety dose is less than 30w, 2s; 20w, 4s or 10w, 5s. The ablation and thermal coagulation effects of Nd:YAP laser on canine uterus are correlation to mean power and irradiation time.
{"title":"Biological effects on canine uterus by Nd:YAP laser: an experimental study","authors":"Xiaoqing Bao, Jing Zhu, Hui-guo Zhang","doi":"10.1117/12.639198","DOIUrl":"https://doi.org/10.1117/12.639198","url":null,"abstract":"Objective: To observe the difference of biological effects on canine uterus by Nd:YAP laser with different power and different irradiation time. Methods: The canine uteri were irradiated with different power and different irradiation time. The effects of ablation and thermal coagulation in different laser settings were observed. The damage scale was evaluated macroscopically, with lightscope and with electroscope. Results: The thermal coagulation is primary and the ablation is secondary. The dose of perforation is 30w, 2s; 20w, 4s and 10w, 5s. Conclusions: The thermal coagulation is primary and the ablation is secondary of Nd:YAP laser on canine uterus. Safety dose is less than 30w, 2s; 20w, 4s or 10w, 5s. The ablation and thermal coagulation effects of Nd:YAP laser on canine uterus are correlation to mean power and irradiation time.","PeriodicalId":325950,"journal":{"name":"Shanghai International Conference on Laser Medicine and Surgery","volume":"5967 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130103587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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