Pub Date : 2023-03-01DOI: 10.37489/2588-0519-2022-4-24-37
A. S. Fedorenko, A. Burbello, L. B. Gaikova, E. Orishak, E. L. Lataria, O. V. Granatovich, M. Pokladova, M. A. Korosteleva
{"title":"Optimization of laboratory support costs in a multidisciplinary hospital: possible solutions. Emphasis on the medical information system","authors":"A. S. Fedorenko, A. Burbello, L. B. Gaikova, E. Orishak, E. L. Lataria, O. V. Granatovich, M. Pokladova, M. A. Korosteleva","doi":"10.37489/2588-0519-2022-4-24-37","DOIUrl":"https://doi.org/10.37489/2588-0519-2022-4-24-37","url":null,"abstract":"","PeriodicalId":326764,"journal":{"name":"Kachestvennaya Klinicheskaya Praktika = Good Clinical Practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126347771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-01DOI: 10.37489/2588-0519-2022-4-50-59
A. Kolbin, A. Kasimova, S. R. Gilyarevskiy
{"title":"Comparative pharmacoeconomic analysis of the use of apixaban, rivaroxaban and dabigatran for prevention of stroke and embolism in the vessels of the systemic circulation in patients with non-valvular atrial fibrillation","authors":"A. Kolbin, A. Kasimova, S. R. Gilyarevskiy","doi":"10.37489/2588-0519-2022-4-50-59","DOIUrl":"https://doi.org/10.37489/2588-0519-2022-4-50-59","url":null,"abstract":"","PeriodicalId":326764,"journal":{"name":"Kachestvennaya Klinicheskaya Praktika = Good Clinical Practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131703468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-01DOI: 10.37489/2588-0519-2022-4-73-82
G. I. Syraeva, V. Vasilyuk, A. Verveda, M. V. Faraponova, A. Kolbin, V. Borovskaya
{"title":"Toxic reactions of non-steroidal anti-inflammatory drugs in the Russian Federation, analysis of the national database “Pharmacovigilance”","authors":"G. I. Syraeva, V. Vasilyuk, A. Verveda, M. V. Faraponova, A. Kolbin, V. Borovskaya","doi":"10.37489/2588-0519-2022-4-73-82","DOIUrl":"https://doi.org/10.37489/2588-0519-2022-4-73-82","url":null,"abstract":"","PeriodicalId":326764,"journal":{"name":"Kachestvennaya Klinicheskaya Praktika = Good Clinical Practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128295690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-01DOI: 10.37489/2588-0519-2022-4-13-23
S. Milovanov
{"title":"Factors, influencing to the recruitment of international multicenter clinical trials of II–III phases","authors":"S. Milovanov","doi":"10.37489/2588-0519-2022-4-13-23","DOIUrl":"https://doi.org/10.37489/2588-0519-2022-4-13-23","url":null,"abstract":"","PeriodicalId":326764,"journal":{"name":"Kachestvennaya Klinicheskaya Praktika = Good Clinical Practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126326539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-01DOI: 10.37489/2588-0519-2022-4-4-12
Y. Belousova, V. Rafalsky, E. D. Kislova
{"title":"Specifics of motivation of volunteers participating in in a clinical trial of the COVID-19 vaccine","authors":"Y. Belousova, V. Rafalsky, E. D. Kislova","doi":"10.37489/2588-0519-2022-4-4-12","DOIUrl":"https://doi.org/10.37489/2588-0519-2022-4-4-12","url":null,"abstract":"","PeriodicalId":326764,"journal":{"name":"Kachestvennaya Klinicheskaya Praktika = Good Clinical Practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128498916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-01DOI: 10.37489/2588-0519-2022-4-60-72
G. Batischeva, O. Zhdanova, N. N. Perova, T. E. Kotelnikova, N. Goncharova, K. A. Ryaskin
{"title":"Adverse reactions of high-osmolar and low-osmolar radiographic contrast media in clinical practice","authors":"G. Batischeva, O. Zhdanova, N. N. Perova, T. E. Kotelnikova, N. Goncharova, K. A. Ryaskin","doi":"10.37489/2588-0519-2022-4-60-72","DOIUrl":"https://doi.org/10.37489/2588-0519-2022-4-60-72","url":null,"abstract":"","PeriodicalId":326764,"journal":{"name":"Kachestvennaya Klinicheskaya Praktika = Good Clinical Practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133254965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-14DOI: 10.37489/2588-0519-2022-3-10-18
E. Eliseeva, O. Perelomova, E. S. Maneeva, D. V. Savitskaya
Evaluation of the effectiveness of Preferential Medicinal Providing is due to the need for rational pharmacotherapy for patients from certain categories of citizens. There are not enough technologies for such an assessment, which requires their creation and implementation.The purpose of the study. To develop the Integrative Scale for Evaluating the Effectiveness of the Program for Providing Certain Categories of Citizens with the Necessary Medicines on the model of the Far Eastern Federal District as an informative way to establish the effectiveness of the preferential segment of medicinal providing, to show the advantages of this Scale compared to other methods and to propose a set of measures to improve the effectiveness of the Program.Materials and methods. The results of the patient survey, compliance of the structure of purchased medicines with the regulatory framework and clinical recommendations of the Ministry of Health of the Russian Federation regulating Preferential Medicinal Providing were analyzed. The structure of the incidence of patients who were initially and repeatedly recognized as disabled.Results. Based on the analysis of compliance with the most important principles of medicinal providing, a technology for evaluating the effectiveness of the Program has been created that allows the participants of the Preferential Medicinal Providing, doctors, Health care organizers, specialists in the field of medicinal procurement, to carry out rational prescribing and purchase of medicines and it is advisable to allocate financial resources taking into account the priority of vital medicines.Conclusion. The Integrative Scale will contribute to improving the clinical and economic efficiency of the Program and will make a significant contribution to improving and maintenance the quality of life of patients receiving pharmacotherapy in the preferential segment, both at the level of the subject of the Russian Federation and at the level of the national system of Preferential Medicinal Providing.
{"title":"The Integrative Scale as an innovative method to increase the effectiveness of the Program for Providing Certain Categories of Citizens with Necessary Medicines","authors":"E. Eliseeva, O. Perelomova, E. S. Maneeva, D. V. Savitskaya","doi":"10.37489/2588-0519-2022-3-10-18","DOIUrl":"https://doi.org/10.37489/2588-0519-2022-3-10-18","url":null,"abstract":"Evaluation of the effectiveness of Preferential Medicinal Providing is due to the need for rational pharmacotherapy for patients from certain categories of citizens. There are not enough technologies for such an assessment, which requires their creation and implementation.The purpose of the study. To develop the Integrative Scale for Evaluating the Effectiveness of the Program for Providing Certain Categories of Citizens with the Necessary Medicines on the model of the Far Eastern Federal District as an informative way to establish the effectiveness of the preferential segment of medicinal providing, to show the advantages of this Scale compared to other methods and to propose a set of measures to improve the effectiveness of the Program.Materials and methods. The results of the patient survey, compliance of the structure of purchased medicines with the regulatory framework and clinical recommendations of the Ministry of Health of the Russian Federation regulating Preferential Medicinal Providing were analyzed. The structure of the incidence of patients who were initially and repeatedly recognized as disabled.Results. Based on the analysis of compliance with the most important principles of medicinal providing, a technology for evaluating the effectiveness of the Program has been created that allows the participants of the Preferential Medicinal Providing, doctors, Health care organizers, specialists in the field of medicinal procurement, to carry out rational prescribing and purchase of medicines and it is advisable to allocate financial resources taking into account the priority of vital medicines.Conclusion. The Integrative Scale will contribute to improving the clinical and economic efficiency of the Program and will make a significant contribution to improving and maintenance the quality of life of patients receiving pharmacotherapy in the preferential segment, both at the level of the subject of the Russian Federation and at the level of the national system of Preferential Medicinal Providing. ","PeriodicalId":326764,"journal":{"name":"Kachestvennaya Klinicheskaya Praktika = Good Clinical Practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126235991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-14DOI: 10.37489/2588-0519-2022-3-4-9
M. A. Truuts, A. A. Kurilev, A. Kolbin
In 2022, ISPOR released an updated checklist on economic evaluation of health care, since the latter several years have passed, the circumstances have changed, and science has progressed that it demanded fresh relevant changes. To support decision-making in accordance with the principles of evidence-based medicine, expanding participants, the involvement of as many sides as possible for more coordinated and high-quality work. The paper contains the main principles included into the ISPOR CHEERS 2022 check-list.
{"title":"Updated guidelines of reporting pharmacoeconomics and health technology assessment results from 2022 ISPOR (CHEERS 2022)","authors":"M. A. Truuts, A. A. Kurilev, A. Kolbin","doi":"10.37489/2588-0519-2022-3-4-9","DOIUrl":"https://doi.org/10.37489/2588-0519-2022-3-4-9","url":null,"abstract":"In 2022, ISPOR released an updated checklist on economic evaluation of health care, since the latter several years have passed, the circumstances have changed, and science has progressed that it demanded fresh relevant changes. To support decision-making in accordance with the principles of evidence-based medicine, expanding participants, the involvement of as many sides as possible for more coordinated and high-quality work. The paper contains the main principles included into the ISPOR CHEERS 2022 check-list.","PeriodicalId":326764,"journal":{"name":"Kachestvennaya Klinicheskaya Praktika = Good Clinical Practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115066427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-14DOI: 10.37489/2588-0519-2022-3-52-61
A. Sharaeva, A. Zurdinova
World statistics shows increasing numbers of aging population and increasing number of patients with multiple comorbidities, i. e. polymorbidity, which today is an urgent problem of modern clinical geriatric practice. During clinical examination of elderly and senile patients, at least 4-5 diseases and manifestations of pathological processes are diagnosed on the average. Because of this many medicines are prescribed to elderly patients at the same time, unfortunately, often unreasonably, which becomes a widespread phenomenon and is called polypharmacy. Polypharmacy is associated with an increased risk of adverse reactions that can lead to hospitalization or even death, as well as a significant increase in health care costs.In this regard, an analysis of medication prescribing in elderly inpatients with cardiovascular disease using the Medication Rationality Index (MAI) was conducted. As a result, it was found that professionals who provide care to patients are not sufficiently aware of the peculiarities of the use of drugs in elderly patients and in our health care sector there are no regulatory documents on the care of elderly patients.
{"title":"Polypharmacy problems in geriatric practice of Kyrgyz Republic","authors":"A. Sharaeva, A. Zurdinova","doi":"10.37489/2588-0519-2022-3-52-61","DOIUrl":"https://doi.org/10.37489/2588-0519-2022-3-52-61","url":null,"abstract":"World statistics shows increasing numbers of aging population and increasing number of patients with multiple comorbidities, i. e. polymorbidity, which today is an urgent problem of modern clinical geriatric practice. During clinical examination of elderly and senile patients, at least 4-5 diseases and manifestations of pathological processes are diagnosed on the average. Because of this many medicines are prescribed to elderly patients at the same time, unfortunately, often unreasonably, which becomes a widespread phenomenon and is called polypharmacy. Polypharmacy is associated with an increased risk of adverse reactions that can lead to hospitalization or even death, as well as a significant increase in health care costs.In this regard, an analysis of medication prescribing in elderly inpatients with cardiovascular disease using the Medication Rationality Index (MAI) was conducted. As a result, it was found that professionals who provide care to patients are not sufficiently aware of the peculiarities of the use of drugs in elderly patients and in our health care sector there are no regulatory documents on the care of elderly patients.","PeriodicalId":326764,"journal":{"name":"Kachestvennaya Klinicheskaya Praktika = Good Clinical Practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115941292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-14DOI: 10.37489/2588-0519-2022-3-31-34
M. V. Markovtseva, E. N. Zguralskaya
Relevance. Chronic lymphocytic leukemia (CLL) is one of the most common lymphoproliferative diseases of the European population with an increase in the elderly and senile age frequency. In this category of patients standard approaches to predicting overall survival do not take into account the presence of comorbid pathology and have low accuracy. In view of this, the search for parameters that affect the overall survival rate of patients with CLL is of particular relevance.The aim of the study is to identify factors affecting the CLL patients overall survival at the stage of CLL diagnosis.Materials and methods. The data of 132 CLL patients with stage A-C according to Binet with known overall survival were retrospectively analyzed. The problem was solved by data mining methods, namely using logical classification algorithms.Results. The glomerular filtration rate is defined as a parameter that objectively justifies the real terms deviation of the patients overall survival from the calculated ones according to the standard Binet staging system. For this parameter, an if…then rule is formed, which makes it possible to predict the patient’s survival. If the GFR value at the time of diagnosis of CLL is more than 76 ml/min /1.73 m2, we can say that the patient will overcome the calculated median survival data for the corresponding stage of CLL according to Binet. Otherwise, the overall survival of the CLL patient will be less than the estimated median survival according to Binet.Conclusion. The analysis of the study allows us to conclude that it is advisable to use data mining methods in predicting the patients overall survival with CLL. The clinical examples given in the article show their effectiveness. According to the study results, an application for invention No. 2022104419 was issued.
{"title":"Chronic lymphocytic leukemia prediction using data mining methods","authors":"M. V. Markovtseva, E. N. Zguralskaya","doi":"10.37489/2588-0519-2022-3-31-34","DOIUrl":"https://doi.org/10.37489/2588-0519-2022-3-31-34","url":null,"abstract":"Relevance. Chronic lymphocytic leukemia (CLL) is one of the most common lymphoproliferative diseases of the European population with an increase in the elderly and senile age frequency. In this category of patients standard approaches to predicting overall survival do not take into account the presence of comorbid pathology and have low accuracy. In view of this, the search for parameters that affect the overall survival rate of patients with CLL is of particular relevance.The aim of the study is to identify factors affecting the CLL patients overall survival at the stage of CLL diagnosis.Materials and methods. The data of 132 CLL patients with stage A-C according to Binet with known overall survival were retrospectively analyzed. The problem was solved by data mining methods, namely using logical classification algorithms.Results. The glomerular filtration rate is defined as a parameter that objectively justifies the real terms deviation of the patients overall survival from the calculated ones according to the standard Binet staging system. For this parameter, an if…then rule is formed, which makes it possible to predict the patient’s survival. If the GFR value at the time of diagnosis of CLL is more than 76 ml/min /1.73 m2, we can say that the patient will overcome the calculated median survival data for the corresponding stage of CLL according to Binet. Otherwise, the overall survival of the CLL patient will be less than the estimated median survival according to Binet.Conclusion. The analysis of the study allows us to conclude that it is advisable to use data mining methods in predicting the patients overall survival with CLL. The clinical examples given in the article show their effectiveness. According to the study results, an application for invention No. 2022104419 was issued.","PeriodicalId":326764,"journal":{"name":"Kachestvennaya Klinicheskaya Praktika = Good Clinical Practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127900483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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