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Adapt to Translate 适应翻译
Q4 ETHICS Pub Date : 2021-11-26 DOI: 10.31820/ejap.17.3.2
Daria Jadreškić
The article presents the advantages and limitations of adaptive clinical trials for assessing the effectiveness of medical interventions and specifies the conditions that contributed to their development and implementation in clinical practice. I advance two arguments by discussing different cases of adaptive trials. The normative argument is that responsible adaptation should be taken seriously as a new way of doing clinical research insofar as a valid justification, sufficient understanding, and adequate operational conditions are provided. The second argument is historical. The development of adaptive trials can be related to lessons learned from research in cases of urgency and to the decades-long efforts to end the productivity crisis of pharmaceutical research, which led to the emergence of translational, personalized, and, recently, precision medicine movements.
本文介绍了评估医疗干预有效性的适应性临床试验的优势和局限性,并详细说明了有助于其在临床实践中发展和实施的条件。我通过讨论适应性试验的不同案例提出了两个论点。规范性的论点是,只要提供有效的理由、充分的理解和充分的操作条件,就应该认真对待负责任的适应,将其作为一种新的临床研究方式。第二个论点是历史性的。适应性试验的发展可能与从紧急情况下的研究中吸取的教训有关,也可能与数十年来为结束药物研究的生产力危机所做的努力有关,这导致了转化、个性化以及最近的精准医学运动的出现。
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引用次数: 1
Diagnostic Justice 诊断正义
Q4 ETHICS Pub Date : 2021-11-24 DOI: 10.31820/ejap.17.3.1
Ashley Kennedy, B. Cwik
Diagnostic testing can be used for many purposes, including testing to facilitate the clinical care of individual patients, testing as an inclusion criterion for clinical trial participation, and both passive and active surveillance testing of the general population in order to facilitate public health outcomes, such as the containment or mitigation of an infectious disease. As such, diagnostic testing presents us with ethical questions that are, in part, already addressed in the literature on clinical care as well as clinical research (such as the rights of patients to refuse testing or treatment in the clinical setting or the rights of participants in randomized controlled trials to withdraw from the trial at any time). However, diagnostic testing, for the purpose of disease surveillance also raises ethical issues that we do not encounter in these settings, and thus have not been much discussed. In this paper we will be concerned with the similarities and differences between the ethical considerations in these three domains: clinical care, clinical research, and public health, as they relate to diagnostic testing specifically. Via an examination of the COVID-19 case we will show how an appeal to the concept of diagnostic justice helps us to make sense of the (at times competing) ethical considerations in these three domains.
诊断性检测可用于多种目的,包括促进个体患者临床护理的检测,作为临床试验参与的纳入标准的检测,以及对普通人群进行被动和主动监测检测,以促进公共卫生结果,如控制或缓解传染病。因此,诊断测试向我们提出了一些伦理问题,这些问题在一定程度上已经在临床护理和临床研究的文献中得到了解决(例如患者在临床环境中拒绝测试或治疗的权利,或者随机对照试验参与者随时退出试验的权利)。然而,以疾病监测为目的的诊断测试也提出了我们在这些环境中没有遇到的伦理问题,因此没有得到太多讨论。在这篇论文中,我们将关注这三个领域的伦理考虑之间的异同:临床护理、临床研究和公共卫生,因为它们具体涉及诊断测试。通过对新冠肺炎病例的研究,我们将展示对诊断正义概念的呼吁如何帮助我们理解这三个领域的道德考虑(有时是相互竞争的)。
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引用次数: 1
Centrifugal and Centripetal Thinking About the Biopsychosocial Model in Psychiatry 精神病学生物心理社会模式的离心与向心思考
Q4 ETHICS Pub Date : 2021-10-30 DOI: 10.31820/ejap.17.2.4
Kathryn Tabb
The biopsychosocial model, which was deeply influential on psychiatry following its introduction by George L. Engel in 1977, has recently made a comeback. Derek Bolton and Grant Gillett have argued that Engel’s original formulation offered a promising general framework for thinking about health and disease, but that this promise requires new empirical and philosophical tools in order to be realized. In particular, Bolton and Gillett offer an original analysis of the ontological relations between Engel’s biological, social, and psychological levels of analysis. I argue that Bolton and Gillett’s updated model, while providing an intriguing new metaphysical framework for medicine, cannot resolve some of the most vexing problems facing psychiatry, which have to do with how to prioritize different sorts of research. These problems are fundamentally ethical, rather than ontological. Without the right prudential motivation, in other words, the unification of psychiatry under a single conceptual framework seems doubtful, no matter how compelling the model. An updated biopsychosocial model should include explicit normative commitments about the aims of medicine that can give guidance about the sorts of causal connections to be prioritized as research and clinical targets.
生物心理社会模型在1977年由乔治·l·恩格尔(George L. Engel)提出后对精神病学产生了深远影响,最近又卷土重来。德里克·博尔顿(Derek Bolton)和格兰特·吉列特(Grant Gillett)认为,恩格尔的原始公式为思考健康和疾病提供了一个有希望的总体框架,但这一承诺需要新的经验和哲学工具才能实现。特别是,博尔顿和吉列特对恩格尔的生物、社会和心理层面的分析之间的本体论关系提供了独到的分析。我认为,博尔顿和吉列特的更新模型,虽然为医学提供了一个有趣的新的形而上学框架,但不能解决精神病学面临的一些最棘手的问题,这些问题与如何优先考虑不同类型的研究有关。这些问题基本上是伦理问题,而不是本体论问题。换句话说,如果没有正确的审慎动机,精神病学在单一概念框架下的统一似乎是值得怀疑的,无论这个模型多么引人注目。一个更新的生物心理社会模型应该包括关于医学目标的明确的规范承诺,这可以对作为研究和临床目标优先考虑的各种因果关系提供指导。
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引用次数: 3
How to Be a Holist Who Rejects the Biopsychosocial Model 如何成为拒绝生物心理社会模式的整体主义者
Q4 ETHICS Pub Date : 2021-10-28 DOI: 10.31820/ejap.17.2.5
D. O’Leary
After nearly fifty years of mea culpas and explanatory additions, the biopsychosocial model is no closer to a life of its own. Bolton and Gillett give it a strong philosophical boost in The Biopsychosocial Model of Health and Disease, but they overlook the model’s deeply inconsistent position on dualism. Moreover, because metaphysical confusion has clinical ramifications in medicine, their solution sidesteps the model’s most pressing clinical faults. But the news is not all bad. We can maintain the merits of holism as we let go of the inchoate bag of platitudes that is the biopsychosocial model. We can accept holism as the metaphysical open door that it is, just a willingness to recognize the reality of human experience, and the sense in which that reality forces medicine to address biological, psychological, and social aspects of health. This allows us to finally characterize Engel’s driving idea in accurate philosophical terms, as acceptance of (phenomenal) consciousness in the context of medical science. This will not entirely pin down medicine’s stance on dualism, but it will position it clearly enough to readily improve patient care.
经过近五十年的道歉和解释性补充,生物心理社会模式并没有更接近自己的生活。博尔顿和吉列在《健康与疾病的生物心理社会模型》中对其进行了强有力的哲学推动,但他们忽视了该模型在二元论上极不一致的立场。此外,由于形而上学的困惑在医学中具有临床影响,他们的解决方案避开了该模型最紧迫的临床缺陷。但这个消息并不全是坏消息。我们可以保持整体主义的优点,因为我们放弃了早期的陈词滥调,即生物心理社会模式。我们可以接受整体主义是一扇形而上学的敞开之门,它只是一种承认人类经验现实的意愿,以及这种现实迫使医学解决健康的生物、心理和社会方面的问题。这使我们最终能够用准确的哲学术语将恩格尔的驱动思想定性为在医学背景下对(现象)意识的接受。这并不能完全确定医学对二元论的立场,但它将足够明确地定位它,以随时改善患者护理。
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引用次数: 2
From Engel to Enactivism 从恩格尔到激进主义
Q4 ETHICS Pub Date : 2021-10-26 DOI: 10.31820/ejap.17.2.3
A. Aftab, Kristopher Nielsen
In this article we offer a two-part commentary on Bolton and Gillett’s reconceptualization of Engel’s biopsychosocial model. In the first section we present a conceptual and historical assessment of the biopsychosocial model that differs from the analysis by Bolton and Gillett. Specifically, we point out that Engel in his vision of the biopsychosocial model was less concerned with the ontological possibility and nature of psychosocial causes, and more concerned with psychosocial influences in the form of illness interpretation and presentation, sick role, seeking or rejection of care, the doctor-patient therapeutic relationship, and role of personality factors and family relationships in recovery from illness, etc. On the basis of this assessment, we then question Bolton and Gillett’s restricted focus on accounting for biopsychosocial causal interactions. The second section compares Bolton and Gillett’s account with a recent enactivist account of mental disorder that tackles similar conceptual problems of causal interactions. Bolton and Gillett’s utilize elements of the 4E cognition, but they combine these proto-ideas with an information-processing paradigm. Given their explicit endorsement of 4E approaches to mind and cognition, we illustrate some key ways in which a more fleshed out enactive account, particularly one that doesn’t rely on notions of information-processing, differs from the account proposed by Bolton and Gillett.
在这篇文章中,我们对博尔顿和吉列对恩格尔的生物心理社会模型的重新定义进行了分为两部分的评论。在第一节中,我们对生物心理社会模型进行了概念和历史评估,该模型不同于Bolton和Gillett的分析。具体而言,我们指出,恩格尔在其生物心理社会模型的视野中,不太关心心理社会原因的本体论可能性和性质,而更关心疾病解释和表现、疾病角色、寻求或拒绝护理、医患治疗关系等形式的心理社会影响,以及人格因素和家庭关系在疾病康复中的作用等。在这一评估的基础上,我们质疑Bolton和Gillett对生物-心理-社会因果互动的有限关注。第二部分将博尔顿和吉列的描述与最近一个关于精神障碍的行为主义者的描述进行了比较,后者解决了因果互动的类似概念问题。Bolton和Gillett利用了4E认知的元素,但他们将这些原始思想与信息处理范式相结合。鉴于他们明确支持4E的思维和认知方法,我们展示了一些关键的方式,在这些方式中,一个更丰富的行为描述,特别是一个不依赖于信息处理概念的描述,与Bolton和Gillett提出的描述不同。
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引用次数: 8
Causation and Causal Selection in the Biopsychosocial Model of Health and Disease 健康和疾病的生物心理社会模型中的因果关系和因果选择
Q4 ETHICS Pub Date : 2021-10-25 DOI: 10.31820/ejap.17.2.6
H. Maung
In The Biopsychosocial Model of Health and Disease, Derek Bolton and Grant Gillett argue that a defensible updated version of the biopsychosocial model requires a metaphysically adequate account of disease causation that can accommodate biological, psychological, and social factors. This present paper offers a philosophical critique of their account of biopsychosocial causation. I argue that their account relies on claims about the normativity and the semantic content of biological information that are metaphysically contentious. Moreover, I suggest that these claims are unnecessary for a defence of biopsychosocial causation, as the roles of multiple and diverse factors in disease causation can be readily accommodated by a more widely accepted and less metaphysically contentious account of causation. I then raise the more general concern that they are misdiagnosing the problem with the traditional version of the biopsychosocial model. The challenge when developing an explanatorily valuable version of the biopsychosocial model, I argue, is not so much providing an adequate account of biopsychosocial causation, but providing an adequate account of causal selection. Finally, I consider how this problem may be solved to arrive at a more explanatorily valuable and clinically useful version of the biopsychosocial model.
在《健康与疾病的生物心理社会模型》中,Derek Bolton和Grant Gillett认为,生物心理社会模式的可辩护更新版本需要对疾病因果关系进行形而上学的充分解释,以适应生物、心理和社会因素。本文对他们对生物心理社会因果关系的描述进行了哲学批判。我认为,他们的叙述依赖于关于生物学信息的规范性和语义内容的主张,这些主张在形而上学上是有争议的。此外,我认为,这些主张对于生物心理社会因果关系的辩护是不必要的,因为对因果关系的更广泛接受和更不具形而上学争议的解释可以很容易地适应多种多样因素在疾病因果关系中的作用。然后,我提出了更普遍的担忧,即他们用传统版本的生物心理社会模型错误诊断了这个问题。我认为,在开发一个有解释价值的生物-心理-社会模型时,面临的挑战与其说是提供对生物-心理社会因果关系的充分解释,不如说是提供因果选择的充分解释。最后,我考虑如何解决这个问题,从而得出一个更具解释价值和临床实用的生物心理社会模型。
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引用次数: 4
Logical Relativism Through Logical Contexts 从逻辑语境看逻辑相对论
Q4 ETHICS Pub Date : 2021-10-21 DOI: 10.31820/ejap.17.2.2
J. B. Becker Arenhart
We advance an approach to logical contexts that grounds the claim that logic is a local matter: distinct contexts require distinct logics. The approach results from a concern about context individuation, and holds that a logic may be constitutive of a context or domain of application. We add a naturalistic component: distinct domains are more than mere technical curiosities; as intuitionistic mathematics testifies, some of the distinct forms of inference in different domains are actively pursued as legitimate fields of research in current mathematics, so, unless one is willing to revise the current scientific practice, generalism must go. The approach is advanced by discussing some tenets of a similar argument advanced by Shapiro, in the context of logic as models approach. In order to make our view more appealing, we reformulate a version of logic as models approach following naturalistic lines, and bring logic closer to the use of models in science.
我们提出了一种逻辑语境的方法,该方法支持逻辑是局部事物的说法:不同的语境需要不同的逻辑。该方法源于对上下文个性化的关注,并认为逻辑可能是上下文或应用领域的组成部分。我们添加了一个自然主义成分:不同的领域不仅仅是技术上的好奇;正如直觉数学所证明的那样,不同领域中的一些不同形式的推理被积极地作为当前数学的合法研究领域,因此,除非人们愿意修改当前的科学实践,否则通才必须走。该方法是通过讨论Shapiro在逻辑即模型方法的背景下提出的类似论点的一些原则而提出的。为了使我们的观点更具吸引力,我们将逻辑的一个版本重新表述为遵循自然主义路线的模型方法,并使逻辑更接近于模型在科学中的使用。
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引用次数: 0
Famine, Affluence, and Amorality 饥荒、富裕和不道德
Q4 ETHICS Pub Date : 2021-09-30 DOI: 10.31820/ejap.17.2.1
David Sackris
I argue that the debate concerning the nature of first-person moral judgment, namely, whether such moral judgments are inherently motivating (internalism) or whether moral judgments can be made in the absence of motivation (externalism), may be founded on a faulty assumption: that moral judgments form a distinct kind that must have some shared, essential features in regards to motivation to act. I argue that there is little reason to suppose that first-person moral judgments form a homogenous class in this respect by considering an ordinary case: student readers of Peter Singer’s “Famine, Affluence, and Morality”. Neither internalists nor externalists can provide a satisfying account as to why our students fail to act in this particular case, but are motivated to act by their moral judgments in most cases. I argue that the inability to provide a satisfying account is rooted in this shared assumption about the nature of moral judgments. Once we consider rejecting the notion that first-person moral decision- making forms a distinct kind in the way it is typically assumed, the internalist/externalist debate may be rendered moot.
我认为,关于第一人称道德判断的性质的争论,即这种道德判断是否具有内在的动机(内在主义),或者道德判断是否可以在没有动机的情况下进行(外在主义),可能建立在一个错误的假设上:道德判断是一种独特的类型,在行动动机方面必须具有一些共同的基本特征。我认为,通过考虑一个普通的案例,没有什么理由认为第一人称道德判断在这方面形成了一个同质的阶层:彼得·辛格的《饥荒、富裕和道德》的学生读者。内在主义者和外在主义者都无法提供令人满意的解释,解释为什么我们的学生在这种特殊情况下没有采取行动,但在大多数情况下,他们的道德判断会激励他们采取行动。我认为,无法提供令人满意的描述源于对道德判断性质的共同假设。一旦我们考虑拒绝接受第一人称道德决策以通常假设的方式形成一种独特的观点,那么内部主义/外部主义的辩论可能会变得毫无意义。
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引用次数: 3
Is There Change on the B-Theory of Time? 时间的B理论有变化吗?
Q4 ETHICS Pub Date : 2021-07-09 DOI: 10.31820/EJAP.17.1.7
L. Banfi
The purpose of this paper is to explore the connection between change and the B-theory of time, sometimes also called the Scientific view of time, according to which reality is a four-dimensional spacetime manifold, where past, present and future things equally exist, and the present time and non-present times are metaphysically the same. I argue in favour of a novel response to the much-vexed question of whether there is change on the B-theory or not. In fact, B-theorists are often said to hold a ‘static’ view of time. But this far from being innocent label: if the B-theory of time presents a model of temporal reality that is static, then there is no change on the B-theory. From this, one can reasonably think as follows: of course, there is change, so the B-theory must be false. What I plan to do in this paper is to argue that in some sense there is change on the B-theory, but in some other sense, there is no change on the B-theory. To do so, I present three instances of change: Existential Change, namely the view that things change with respect to their existence over time; Qualitative Change, the view that things change with respect to how they are over time; Propositional Change, namely the view that things (i.e. propositions) change with respect to truth value over time. I argue that while there is a reading of these three instances of change that is true on the B-theory, and so there is change on the B-theory in this sense, there is a B-theoretical reading of each of them that is not true on the B-theory, and therefore there is no change on the B-theory in this other sense.
本文的目的是探讨变化与时间的b理论之间的联系,b理论有时也被称为科学的时间观,根据该理论,现实是一个四维时空流形,过去、现在和未来的事物同样存在,现在和非现在的时间在形而上学上是相同的。对于b理论是否会发生变化这一备受争议的问题,我支持一种新颖的回应。事实上,b理论学家经常被认为持有一种“静态”的时间观。但这远远不是一个无辜的标签:如果时间的b理论提出了一个静态的时间现实模型,那么b理论就没有变化。由此,人们可以合理地这样想:当然,变化是存在的,所以b理论一定是错的。我在这篇论文中要做的是论证在某种意义上b理论发生了变化,但在另一种意义上,b理论没有变化。为此,我提出了三个变化的例子:存在变化,即事物随着时间的推移而变化的观点;质变是指事物随时间变化的观点;命题变化,即事物(即命题)随着时间的推移而随真值变化的观点。我认为,虽然对这三个变化实例的解读在b理论上是正确的,所以在这个意义上b理论是有变化的,但对它们中的每一个的b理论解读在b理论上是不正确的,因此在另一个意义上b理论没有变化。
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引用次数: 0
Pure Powers Are Not Powerful Qualities 纯粹的力量不是强大的品质
Q4 ETHICS Pub Date : 2021-02-05 DOI: 10.31820/EJAP.17.1.2
Joaquim Giannotti
There is no consensus on the most adequate conception of the fundamental properties of our world. The pure powers view and the identity theory of powerful qualities claim to be promising alternatives to categoricalism, the view that all fundamental properties essentially contribute to the qualitative make-up of things that have them. The pure powers view holds that fundamental properties essentially empower things that have them with a distinctive causal profile. On the identity theory, fundamental properties are dispositional as well as qualitative, or powerful qualities. Despite the manifest difference, Taylor (2018) argues that pure powers and powerful qualities collapse into the same ontology. If this collapse objection were sound, the debate between the pure powers view and the identity theory of powerful qualities would be illusory: these views could claim the same advantages and would suffer the same problems. Here I defend an ontologically robust distinction between pure powers and powerful qualities. To accomplish this aim, I show that the collapse between pure powers and powerful qualities can be resisted. I conclude by drawing some positive implications of this result.
对于我们世界的基本性质的最恰当的概念,还没有达成共识。纯权力观和强大品质的同一性理论声称是分类主义的有前途的替代品,即所有基本性质本质上都有助于事物的质量构成。纯权力观认为,基本属性本质上赋予拥有它们的事物以独特的因果特征。在同一性理论中,基本性质是倾向性的,也是定性的,或强大的品质。尽管存在明显的差异,Taylor(2018)认为,纯粹的力量和强大的品质会坍塌为同一本体论。如果这种崩溃的反对意见是合理的,那么纯粹权力观和强大品质的同一性理论之间的辩论将是虚幻的:这些观点可能会宣称同样的优势,也会遭受同样的问题。在这里,我为纯粹的力量和强大的品质之间的本体论上的有力区别辩护。为了实现这一目标,我表明,纯粹的力量和强大的品质之间的崩溃是可以抵抗的。最后,我从这一结果中得出一些积极的启示。
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引用次数: 1
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European Journal of Analytic Philosophy
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