Shirley Adriana, Molek, Lola Marta Elisabet Pasaribu
Background: Gingivitis is a dental and oral health problem caused by the bacteria Staphylococcus aureus. This research utilized the antibacterial effect of the chlorogenic acid compound content of green Arabica coffee beans (Coffea arabica L.) on the activity of the Staphylococcus aureus bacteria. The aim of the research was to determine the effect of chlorogenic acid from green Arabica coffee beans and its inhibitory diameter on the activity of Staphylococcus aureus bacteria. Methods: The research method used was laboratory experimental with post-test only with a control group design. The research samples were green Arabica coffee bean extract with various concentrations of 25%, 50%, 75%, and 100%, which is compared to various concentrations of pure chlorogenic acid (95% Sigma-Aldrich). The chlorogenic acid content in the extract was analyzed with liquid chromatography LC-MS/MS. The large sample was determined using the Federer formula with a total sample size of 24 samples. The parameter measured was the diameter of the growth inhibition zone for Staphylococcus aureus bacteria. Data were analyzed statistically using One-way ANOVA and Post Hoc LSD, and the research results were shown in regression graphs. Results: The results of the analysis of chlorogenic acid content of green arabica coffee bean extract amounted to 4.29% The results of this study showed that the average diameter of the inhibition zone of green Arabica coffee bean extract with concentrations of 25%, 50%, 75% and 100% on the growth of Staphylococcus aureus bacteria was 7.65 ± 0.289 mm; 9.63 ± 0.550 mm, 10.50 ± 0.374 mm, and 12.75 ± 0.370 mm. Research shows that the higher the concentration of green Arabica coffee bean extract, the larger the diameter of the inhibition zone. 95% pure chlorogenic acid from Sigma-Aldrich displays an inhibition zone above 12.5%. Conclusion: Chlorogenic acid exerts a substantial inhibitory impact on the proliferation of Staphylococcus aureus bacteria.
{"title":"The Effect of Chlorogenic Acid in Green Arabica Coffee Beans on the Activity of Staphylococcus aureus","authors":"Shirley Adriana, Molek, Lola Marta Elisabet Pasaribu","doi":"10.37275/ijr.v14i3.287","DOIUrl":"https://doi.org/10.37275/ijr.v14i3.287","url":null,"abstract":"Background: Gingivitis is a dental and oral health problem caused by the bacteria Staphylococcus aureus. This research utilized the antibacterial effect of the chlorogenic acid compound content of green Arabica coffee beans (Coffea arabica L.) on the activity of the Staphylococcus aureus bacteria. The aim of the research was to determine the effect of chlorogenic acid from green Arabica coffee beans and its inhibitory diameter on the activity of Staphylococcus aureus bacteria. \u0000Methods: The research method used was laboratory experimental with post-test only with a control group design. The research samples were green Arabica coffee bean extract with various concentrations of 25%, 50%, 75%, and 100%, which is compared to various concentrations of pure chlorogenic acid (95% Sigma-Aldrich). The chlorogenic acid content in the extract was analyzed with liquid chromatography LC-MS/MS. The large sample was determined using the Federer formula with a total sample size of 24 samples. The parameter measured was the diameter of the growth inhibition zone for Staphylococcus aureus bacteria. Data were analyzed statistically using One-way ANOVA and Post Hoc LSD, and the research results were shown in regression graphs. \u0000Results: The results of the analysis of chlorogenic acid content of green arabica coffee bean extract amounted to 4.29% The results of this study showed that the average diameter of the inhibition zone of green Arabica coffee bean extract with concentrations of 25%, 50%, 75% and 100% on the growth of Staphylococcus aureus bacteria was 7.65 ± 0.289 mm; 9.63 ± 0.550 mm, 10.50 ± 0.374 mm, and 12.75 ± 0.370 mm. Research shows that the higher the concentration of green Arabica coffee bean extract, the larger the diameter of the inhibition zone. 95% pure chlorogenic acid from Sigma-Aldrich displays an inhibition zone above 12.5%. \u0000Conclusion: Chlorogenic acid exerts a substantial inhibitory impact on the proliferation of Staphylococcus aureus bacteria.","PeriodicalId":32894,"journal":{"name":"Indonesian Journal of Rheumatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139864843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shirley Adriana, Molek, Lola Marta Elisabet Pasaribu
Background: Gingivitis is a dental and oral health problem caused by the bacteria Staphylococcus aureus. This research utilized the antibacterial effect of the chlorogenic acid compound content of green Arabica coffee beans (Coffea arabica L.) on the activity of the Staphylococcus aureus bacteria. The aim of the research was to determine the effect of chlorogenic acid from green Arabica coffee beans and its inhibitory diameter on the activity of Staphylococcus aureus bacteria. Methods: The research method used was laboratory experimental with post-test only with a control group design. The research samples were green Arabica coffee bean extract with various concentrations of 25%, 50%, 75%, and 100%, which is compared to various concentrations of pure chlorogenic acid (95% Sigma-Aldrich). The chlorogenic acid content in the extract was analyzed with liquid chromatography LC-MS/MS. The large sample was determined using the Federer formula with a total sample size of 24 samples. The parameter measured was the diameter of the growth inhibition zone for Staphylococcus aureus bacteria. Data were analyzed statistically using One-way ANOVA and Post Hoc LSD, and the research results were shown in regression graphs. Results: The results of the analysis of chlorogenic acid content of green arabica coffee bean extract amounted to 4.29% The results of this study showed that the average diameter of the inhibition zone of green Arabica coffee bean extract with concentrations of 25%, 50%, 75% and 100% on the growth of Staphylococcus aureus bacteria was 7.65 ± 0.289 mm; 9.63 ± 0.550 mm, 10.50 ± 0.374 mm, and 12.75 ± 0.370 mm. Research shows that the higher the concentration of green Arabica coffee bean extract, the larger the diameter of the inhibition zone. 95% pure chlorogenic acid from Sigma-Aldrich displays an inhibition zone above 12.5%. Conclusion: Chlorogenic acid exerts a substantial inhibitory impact on the proliferation of Staphylococcus aureus bacteria.
{"title":"The Effect of Chlorogenic Acid in Green Arabica Coffee Beans on the Activity of Staphylococcus aureus","authors":"Shirley Adriana, Molek, Lola Marta Elisabet Pasaribu","doi":"10.37275/ijr.v14i3.287","DOIUrl":"https://doi.org/10.37275/ijr.v14i3.287","url":null,"abstract":"Background: Gingivitis is a dental and oral health problem caused by the bacteria Staphylococcus aureus. This research utilized the antibacterial effect of the chlorogenic acid compound content of green Arabica coffee beans (Coffea arabica L.) on the activity of the Staphylococcus aureus bacteria. The aim of the research was to determine the effect of chlorogenic acid from green Arabica coffee beans and its inhibitory diameter on the activity of Staphylococcus aureus bacteria. \u0000Methods: The research method used was laboratory experimental with post-test only with a control group design. The research samples were green Arabica coffee bean extract with various concentrations of 25%, 50%, 75%, and 100%, which is compared to various concentrations of pure chlorogenic acid (95% Sigma-Aldrich). The chlorogenic acid content in the extract was analyzed with liquid chromatography LC-MS/MS. The large sample was determined using the Federer formula with a total sample size of 24 samples. The parameter measured was the diameter of the growth inhibition zone for Staphylococcus aureus bacteria. Data were analyzed statistically using One-way ANOVA and Post Hoc LSD, and the research results were shown in regression graphs. \u0000Results: The results of the analysis of chlorogenic acid content of green arabica coffee bean extract amounted to 4.29% The results of this study showed that the average diameter of the inhibition zone of green Arabica coffee bean extract with concentrations of 25%, 50%, 75% and 100% on the growth of Staphylococcus aureus bacteria was 7.65 ± 0.289 mm; 9.63 ± 0.550 mm, 10.50 ± 0.374 mm, and 12.75 ± 0.370 mm. Research shows that the higher the concentration of green Arabica coffee bean extract, the larger the diameter of the inhibition zone. 95% pure chlorogenic acid from Sigma-Aldrich displays an inhibition zone above 12.5%. \u0000Conclusion: Chlorogenic acid exerts a substantial inhibitory impact on the proliferation of Staphylococcus aureus bacteria.","PeriodicalId":32894,"journal":{"name":"Indonesian Journal of Rheumatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139805029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction. Candida albicans commonly causes oral thrush, an opportunistic illness that affects the mouth. Both topical and systemic antifungal medications effectively treat oral thrush. The study compared tomato leaf (Lycopersicum esculatum Mill) antifungal effects on Candida albicans growth at two different concentrations: 25% and 70%. Methods. This research utilizes laboratory trials employing post-test-only control groups. The Microbiology Laboratory Universitas Sumatera Utara supplied the investigation with a pure culture isolate of Candida albicans. To figure out the sample size, we used the Federer formula six times, once for each group of tomato leaves at 25% and 70% concentrations and once for the nystatin (positive control) and DMSO (negative control) groups. Use of a digital caliper for measuring the resistance diameter. We used the Mann-Whitney U test and the Kruskal-Wallis test to look at the data. Result. Tomato leaves at 25% and 70% concentrations successfully limit Candida albicans development, according to the Kruskal-Wallis and Mann-Whitney tests. The efficiency of tomato leaves at 25% and 70% concentrations in inhibiting the development of Candida albicans was shown by mean inhibitory diameters of 7.73 ± 0.366 mm and 10.21 ± 0.948 mm, respectively. Nystatin, the positive control, had an average inhibitory diameter of 25.77 ± 0.505 mm, whereas DMSO solvent, the negative control, showed no inhibition at all. Between the groups, there was a significantly different inhibitory diameter of Candida albicans growth, as shown by the Kruskal-Wallis test (p=0.000; p?0.05). At doses ranging from 25% to 75%, the Mann-Whitney test showed that there was a significant difference (p?0.05) in the effectiveness of tomato leaf extracts in inhibiting the development of Candida albicans compared to the negative control group. Conclusion. Tomato leaves inhibit the development of Candida albicans. The antifungal efficacy of tomato leaves is higher at a concentration of 70% compared to 25%.
{"title":"Comparative Analysis of the Antifungal Efficacy of Tomato Leaves (Lycopersicum esculatum Mill) at Concentrations of 25% and 70% on the Growth of Candida albicans","authors":"Cindy Denhara Wijaya, Shieny Lokanata, Rosion Hadameon Eka Putri Panggabean","doi":"10.37275/ijr.v14i3.286","DOIUrl":"https://doi.org/10.37275/ijr.v14i3.286","url":null,"abstract":"Introduction. Candida albicans commonly causes oral thrush, an opportunistic illness that affects the mouth. Both topical and systemic antifungal medications effectively treat oral thrush. The study compared tomato leaf (Lycopersicum esculatum Mill) antifungal effects on Candida albicans growth at two different concentrations: 25% and 70%. \u0000Methods. This research utilizes laboratory trials employing post-test-only control groups. The Microbiology Laboratory Universitas Sumatera Utara supplied the investigation with a pure culture isolate of Candida albicans. To figure out the sample size, we used the Federer formula six times, once for each group of tomato leaves at 25% and 70% concentrations and once for the nystatin (positive control) and DMSO (negative control) groups. Use of a digital caliper for measuring the resistance diameter. We used the Mann-Whitney U test and the Kruskal-Wallis test to look at the data. \u0000Result. Tomato leaves at 25% and 70% concentrations successfully limit Candida albicans development, according to the Kruskal-Wallis and Mann-Whitney tests. The efficiency of tomato leaves at 25% and 70% concentrations in inhibiting the development of Candida albicans was shown by mean inhibitory diameters of 7.73 ± 0.366 mm and 10.21 ± 0.948 mm, respectively. Nystatin, the positive control, had an average inhibitory diameter of 25.77 ± 0.505 mm, whereas DMSO solvent, the negative control, showed no inhibition at all. Between the groups, there was a significantly different inhibitory diameter of Candida albicans growth, as shown by the Kruskal-Wallis test (p=0.000; p?0.05). At doses ranging from 25% to 75%, the Mann-Whitney test showed that there was a significant difference (p?0.05) in the effectiveness of tomato leaf extracts in inhibiting the development of Candida albicans compared to the negative control group. \u0000Conclusion. Tomato leaves inhibit the development of Candida albicans. The antifungal efficacy of tomato leaves is higher at a concentration of 70% compared to 25%.","PeriodicalId":32894,"journal":{"name":"Indonesian Journal of Rheumatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140474468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: In the present day, the utilization of cardiac implanted electronic devices is increasing globally due to advancements in medical technology. However, a significant concern arises in the form of serious and life-threatening consequences such as mediastinitis and deep sternal wound infections. Poor control of mediastinitis significantly increases morbidity and mortality rates associated with it. Case presentation: A 44-year-old male presents with a palpable mass on the left jaw that has been present for four days before admission. The patient is currently experiencing symptoms of fever and dyspnea. The patient's medical history from six months ago reveals the insertion of a permanent pacemaker VVIR (dual sensor ventricular demand rate responsive) due to a sinus pause with ventricular escape beat. The patient was admitted to the Intensive Care Unit (ICU) with a diagnosis of post-sternotomy for a submandibular abscess with intra-thoracic extension, respiratory failure, sinus arrest caused by the insertion of the permanent pacemaker, and sepsis. By the third day in the Intensive Care Unit (ICU), the patient's hemodynamic condition had reached a stable state. Conclusion: Upon assessing the patient's reliance on permanent pacemakers (PPM), it is advisable to contemplate the possibility of reprogramming or resetting the implanted PPM. Thorough treatment of critically ill patients is necessary for those who are undergoing surgery with an implanted cardiac device.
{"title":"Post-Operative Management in Patients with Permanent Pacemakers Who Underwent Sternotomy e.c. Mediastinitis Complicated from Submandibular Absces in Intensive Care Unit: A Case Report","authors":"Liliriawati Ananta Kahar","doi":"10.37275/ijr.v14i3.283","DOIUrl":"https://doi.org/10.37275/ijr.v14i3.283","url":null,"abstract":"Background: In the present day, the utilization of cardiac implanted electronic devices is increasing globally due to advancements in medical technology. However, a significant concern arises in the form of serious and life-threatening consequences such as mediastinitis and deep sternal wound infections. Poor control of mediastinitis significantly increases morbidity and mortality rates associated with it. \u0000Case presentation: A 44-year-old male presents with a palpable mass on the left jaw that has been present for four days before admission. The patient is currently experiencing symptoms of fever and dyspnea. The patient's medical history from six months ago reveals the insertion of a permanent pacemaker VVIR (dual sensor ventricular demand rate responsive) due to a sinus pause with ventricular escape beat. The patient was admitted to the Intensive Care Unit (ICU) with a diagnosis of post-sternotomy for a submandibular abscess with intra-thoracic extension, respiratory failure, sinus arrest caused by the insertion of the permanent pacemaker, and sepsis. By the third day in the Intensive Care Unit (ICU), the patient's hemodynamic condition had reached a stable state. \u0000Conclusion: Upon assessing the patient's reliance on permanent pacemakers (PPM), it is advisable to contemplate the possibility of reprogramming or resetting the implanted PPM. Thorough treatment of critically ill patients is necessary for those who are undergoing surgery with an implanted cardiac device.","PeriodicalId":32894,"journal":{"name":"Indonesian Journal of Rheumatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140486883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ventilator-associated pneumonia (VAP) is a kind of pneumonia that arises within 48–72 hours or later after the insertion of a breathing tube into the windpipe. The fundamental idea of preventing ventilator-associated pneumonia is to minimize the length of time a patient is on mechanical ventilation and to extubate them as early as possible. Adhering to the bundle of care can influence the risk of VAP. Researchers conducted several studies between 2020 and 2023 to assess the effectiveness of a ventilation care bundle in preventing ventilator-associated pneumonia. Each study varied in terms of the specific version of the care bundle used, compliance rates, sample size, and duration of the research. The conclusion drawn on the effectiveness in question may be impacted by these disparities. Proper execution of an effective ventilator care package can decrease the occurrence of ventilator-associated pneumonia in patients who are critically ill. Employing a variety of tactics backed by long-term teaching initiatives is crucial to ensure adherence to the care bundle.
{"title":"Efficacy of A Ventilation Care Bundle to Prevent Ventilator-Associated Pneumonia: A Literature Review","authors":"Liliriawati Ananta Kahar","doi":"10.37275/ijr.v14i3.282","DOIUrl":"https://doi.org/10.37275/ijr.v14i3.282","url":null,"abstract":"Ventilator-associated pneumonia (VAP) is a kind of pneumonia that arises within 48–72 hours or later after the insertion of a breathing tube into the windpipe. The fundamental idea of preventing ventilator-associated pneumonia is to minimize the length of time a patient is on mechanical ventilation and to extubate them as early as possible. Adhering to the bundle of care can influence the risk of VAP. Researchers conducted several studies between 2020 and 2023 to assess the effectiveness of a ventilation care bundle in preventing ventilator-associated pneumonia. Each study varied in terms of the specific version of the care bundle used, compliance rates, sample size, and duration of the research. The conclusion drawn on the effectiveness in question may be impacted by these disparities. Proper execution of an effective ventilator care package can decrease the occurrence of ventilator-associated pneumonia in patients who are critically ill. Employing a variety of tactics backed by long-term teaching initiatives is crucial to ensure adherence to the care bundle.","PeriodicalId":32894,"journal":{"name":"Indonesian Journal of Rheumatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140487028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Streptococcus sanguinis is a pioneer bacteria in the formation of dental plaque that causes caries. Fenugreek (Trigonella-foenum-graecum L.) is a medicinal plant that has antibacterial properties because it contains alkaloids, tannins, flavonoids, glycosides, and terpenoids. The aim of this research was to determine the effectiveness of fenugreek seed extract with concentrations of 25%, 50%, 75%, and 100% on bacterial growth of S. sanguinis. Methods: This study is the post-test-only control group. The research sample is a pure culture of Streptococcus sanguinis bacteria ATCC 10556. Antibacterial testing uses the disc diffusion method by sight diameter bacterial inhibition zone. Data was analyzed using the Kruskal-Wallis test. Results: The test results showed that the ethanol extract of fenugreek seeds with concentrations of 25%, 50%, 75%, and 100% had an inhibitory zone against the growth of Streptococcus sanguinis bacteria with the average diameter of the inhibitory zone for each concentration being 7.77 ± 6.13 mm. 9.90 ± 8.09, 12.22 ± 5.05, and 14.75 ± 4.83 mm, but the antibacterial effectiveness did not have a significant difference with a value of p = 0.12. Conclusion: The ethanol extract of fenugreek seeds has antibacterial activity against the Streptococcus sanguinis bacteria but is not significant.
{"title":"Effectiveness Evaluation of Fenugreek Seeds Ethanol Extract (Trigonella foenum-graecum) Against Bacterial Growth Streptococcus sanguinis: In Vitro Study","authors":"Firdha Muharraran, Idamawati Nababan, Usvah","doi":"10.37275/ijr.v13i3.278","DOIUrl":"https://doi.org/10.37275/ijr.v13i3.278","url":null,"abstract":"Introduction: Streptococcus sanguinis is a pioneer bacteria in the formation of dental plaque that causes caries. Fenugreek (Trigonella-foenum-graecum L.) is a medicinal plant that has antibacterial properties because it contains alkaloids, tannins, flavonoids, glycosides, and terpenoids. The aim of this research was to determine the effectiveness of fenugreek seed extract with concentrations of 25%, 50%, 75%, and 100% on bacterial growth of S. sanguinis. \u0000Methods: This study is the post-test-only control group. The research sample is a pure culture of Streptococcus sanguinis bacteria ATCC 10556. Antibacterial testing uses the disc diffusion method by sight diameter bacterial inhibition zone. Data was analyzed using the Kruskal-Wallis test. \u0000Results: The test results showed that the ethanol extract of fenugreek seeds with concentrations of 25%, 50%, 75%, and 100% had an inhibitory zone against the growth of Streptococcus sanguinis bacteria with the average diameter of the inhibitory zone for each concentration being 7.77 ± 6.13 mm. 9.90 ± 8.09, 12.22 ± 5.05, and 14.75 ± 4.83 mm, but the antibacterial effectiveness did not have a significant difference with a value of p = 0.12. \u0000Conclusion: The ethanol extract of fenugreek seeds has antibacterial activity against the Streptococcus sanguinis bacteria but is not significant.","PeriodicalId":32894,"journal":{"name":"Indonesian Journal of Rheumatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139450372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Postpartum hemorrhage life-threatening condition, with a prevalence of approximately 1%-10% of all deliveries. Postpartum hemorrhage is one of the leading causes of maternal death. Case presentation: A 33-year-old female patient came to the emergency department with decreased consciousness 1 hour before hospital admission, with postpartum hemorrhage, placental abruption following cesarean section, and uterine atonia following B-Linch. The patient underwent a B-Linch operation after undergoing a cesarean section at a previous Hospital due to antepartum hemorrhage and placental abruption. The patient also experienced ongoing bleeding during the treatment due to uterine atonia. Following surgery, a post-operative laboratory evaluation revealed significant thrombocytopenia (platelets: 45.000/mm3) and anemia (Hb: 4,6 g/dl). Conclusion: The management of postpartum hemorrhage, especially with shock, requires comprehensive critical care management. Appropriate management with good multidisciplinary team involvement will improve patient outcomes and prevent multi-organ failure.
{"title":"Management of Decreased Consciousness Caused by Hypovolemic Shock ec Postpartum Hemorrhage in Critical Care Setting","authors":"Liliriawati Ananta Kahar","doi":"10.37275/ijr.v13i3.274","DOIUrl":"https://doi.org/10.37275/ijr.v13i3.274","url":null,"abstract":"Introduction: Postpartum hemorrhage life-threatening condition, with a prevalence of approximately 1%-10% of all deliveries. Postpartum hemorrhage is one of the leading causes of maternal death. \u0000Case presentation: A 33-year-old female patient came to the emergency department with decreased consciousness 1 hour before hospital admission, with postpartum hemorrhage, placental abruption following cesarean section, and uterine atonia following B-Linch. The patient underwent a B-Linch operation after undergoing a cesarean section at a previous Hospital due to antepartum hemorrhage and placental abruption. The patient also experienced ongoing bleeding during the treatment due to uterine atonia. Following surgery, a post-operative laboratory evaluation revealed significant thrombocytopenia (platelets: 45.000/mm3) and anemia (Hb: 4,6 g/dl). \u0000Conclusion: The management of postpartum hemorrhage, especially with shock, requires comprehensive critical care management. Appropriate management with good multidisciplinary team involvement will improve patient outcomes and prevent multi-organ failure.","PeriodicalId":32894,"journal":{"name":"Indonesian Journal of Rheumatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138953358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Migraine is a complex health problem and causes disability, especially in women. The current pathophysiology of migraine is a combination of vascular, neurogenic, and neuroinflammatory theories. PACAP-38 is a vasoactive neuropeptide that increases during migraine attacks. Endothelial dysfunction results in impaired vasomotor reactivity. Analysis of vasomotor reactivity is determined by measuring the breath-holding index (BHI) and migraine vascular index (MVI), where there is a decrease in vasomotor reactivity values ??in migraine sufferers. This study aims to determine PACAP-38 levels in chronic migraine sufferers and their relationship to cerebrovascular vasomotor reactivity. Methods: This research is a comparative study (cross-sectional) that is carried out in hospitals and health centers spread across the city of Padang from May 2022 to June 2023. The research sample consisted of 30 chronic migraine sufferers and 30 healthy controls. Vasomotor reactivity was assessed by determining BHI and MVI values ??using transcranial Doppler. Plasma PACAP-38 levels were measured using the ELISA method. Data analysis was carried out using SPSS. Results: The mean value of vasomotor reactivity in chronic migraine sufferers is 0.355. There is a negative correlation between the frequency and duration of migraine attacks and vasomotor reactivity (frequency p=0.032; duration p=0.022). The mean value of PACAP-38 levels in chronic migraine sufferers was 6.15 pg/ml, and in healthy controls, 4.85 pg/ml; there was a significant difference between plasma PACAP-38 levels in chronic migraine sufferers compared to healthy controls. However, there was no significant difference between plasma PACAP-38 levels and vasomotor reactivity in chronic migraine sufferers. Conclusion: There is an increase in plasma PACAP-38 levels in chronic migraine sufferers, but there is no significant relationship between plasma PACAP-38 levels and vasomotor reactivity values.
{"title":"Relationship of Plasma Pituitary Adenylate Cyclase-Activating Polypeptide-38 (PACAP-38) Levels with Cerebrovascular Vasomotor Reactivity in Chronic Migraine Sufferers","authors":"Eka Putri Pertiwi, R. Susanti, Syarif Indra, Yuliarni Syafrita, Dedi Sutia, Fanny Adhy Putri","doi":"10.37275/ijr.v13i3.273","DOIUrl":"https://doi.org/10.37275/ijr.v13i3.273","url":null,"abstract":"Introduction: Migraine is a complex health problem and causes disability, especially in women. The current pathophysiology of migraine is a combination of vascular, neurogenic, and neuroinflammatory theories. PACAP-38 is a vasoactive neuropeptide that increases during migraine attacks. Endothelial dysfunction results in impaired vasomotor reactivity. Analysis of vasomotor reactivity is determined by measuring the breath-holding index (BHI) and migraine vascular index (MVI), where there is a decrease in vasomotor reactivity values ??in migraine sufferers. This study aims to determine PACAP-38 levels in chronic migraine sufferers and their relationship to cerebrovascular vasomotor reactivity. \u0000Methods: This research is a comparative study (cross-sectional) that is carried out in hospitals and health centers spread across the city of Padang from May 2022 to June 2023. The research sample consisted of 30 chronic migraine sufferers and 30 healthy controls. Vasomotor reactivity was assessed by determining BHI and MVI values ??using transcranial Doppler. Plasma PACAP-38 levels were measured using the ELISA method. Data analysis was carried out using SPSS. \u0000Results: The mean value of vasomotor reactivity in chronic migraine sufferers is 0.355. There is a negative correlation between the frequency and duration of migraine attacks and vasomotor reactivity (frequency p=0.032; duration p=0.022). The mean value of PACAP-38 levels in chronic migraine sufferers was 6.15 pg/ml, and in healthy controls, 4.85 pg/ml; there was a significant difference between plasma PACAP-38 levels in chronic migraine sufferers compared to healthy controls. However, there was no significant difference between plasma PACAP-38 levels and vasomotor reactivity in chronic migraine sufferers. \u0000Conclusion: There is an increase in plasma PACAP-38 levels in chronic migraine sufferers, but there is no significant relationship between plasma PACAP-38 levels and vasomotor reactivity values.","PeriodicalId":32894,"journal":{"name":"Indonesian Journal of Rheumatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138958855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Massive pleural effusion occurs in association with malignancy. In Western countries, lung cancer is the leading cause of death, and 8-15% of cancer patients require treatment in an intensive care unit. Case presentation: A 56-year-old woman has complained of increased shortness of breath for the past three days. Lung examination from percussion found dullness on the right, resonance on the left, palpation decreased vocal fremitus on the right and auscultation, Diminished or absent breath sounds on the right, and bronchovesicular breath sounds on the left. Chest X-ray examination results with the conclusion of massive pleural effusion dextra. Bronchoscopy was performed under general anesthesia (GA), and a pigtail catheter was inserted. One day after bronchoscopy, a repeat thoracic X-ray was performed with the impression of atelectasis in the right lung, and a bronchoscopy and bronchial toilet were planned. Conclusion: Pleural effusion with lung tumor and atelectasis are common cases in critical care. The management provided can help in reducing patient morbidity.
背景：大量胸腔积液与恶性肿瘤有关。在西方国家，肺癌是导致死亡的主要原因，8%-15% 的癌症患者需要在重症监护室接受治疗。病例介绍：一名 56 岁的妇女主诉过去三天来气短加剧。肺部检查发现，叩诊右侧肺部钝痛，左侧肺部共鸣，触诊右侧声带游离减少，听诊右侧呼吸音减弱或消失，左侧支气管呼吸音减弱或消失。胸部 X 光检查结果为大量胸腔积液。在全身麻醉（GA）下进行了支气管镜检查，并插入了一根尾纤导管。支气管镜检查后一天，再次进行胸部X光检查，结果显示右肺有肺不张，于是计划进行支气管镜检查和支气管厕所检查。结论胸腔积液伴肺部肿瘤和肺不张是重症监护中的常见病例。所提供的处理方法有助于降低患者的发病率。
{"title":"Critical Management of Atelectasis ec Adenomous Cell Carcinoma of the Right Lung with Pleural Effusion: A Case Report","authors":"Liliriawati Ananta Kahar","doi":"10.37275/ijr.v13i3.272","DOIUrl":"https://doi.org/10.37275/ijr.v13i3.272","url":null,"abstract":"Background: Massive pleural effusion occurs in association with malignancy. In Western countries, lung cancer is the leading cause of death, and 8-15% of cancer patients require treatment in an intensive care unit. \u0000Case presentation: A 56-year-old woman has complained of increased shortness of breath for the past three days. Lung examination from percussion found dullness on the right, resonance on the left, palpation decreased vocal fremitus on the right and auscultation, Diminished or absent breath sounds on the right, and bronchovesicular breath sounds on the left. Chest X-ray examination results with the conclusion of massive pleural effusion dextra. Bronchoscopy was performed under general anesthesia (GA), and a pigtail catheter was inserted. One day after bronchoscopy, a repeat thoracic X-ray was performed with the impression of atelectasis in the right lung, and a bronchoscopy and bronchial toilet were planned. \u0000Conclusion: Pleural effusion with lung tumor and atelectasis are common cases in critical care. The management provided can help in reducing patient morbidity.","PeriodicalId":32894,"journal":{"name":"Indonesian Journal of Rheumatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138994385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andi Raga Ginting, Reza Mahardika, Mustafa Ali, Azmi Lubis, Muhammad Thariq Siregar, Article Info
Background. Systemic lupus erythematosus (SLE) is an autoimmune disease that can attack multiple organs and has a high prevalence in women. Due to its treatment and resulting pathological conditions, SLE makes the patient susceptible to infections. Furthermore, physiological changes in the body that occur during pregnancy renders pregnant women with SLE vulnerable to disease exacerbation. Therefore, the management of such cases necessitates the evaluation and intervention of a multidisciplinary medical team. Case Presentation. We present the case of a female patient in her second trimester of pregnancy who complained of shortness of breath. The patient has a history of SLE diagnosed five years ago. Within 7 days of treatment, the patient experienced an improvement in symptoms. Conclusion. This is a rare case, and we report on the outcomes of treatment and our limitations to ensure better future treatment for pregnant women with SLE to prevent maternal and fetal death.
{"title":"Secondary Trimester Pregnancy in Systemic Lupus Erythematosus Patients with Pneumonia: A Case Report","authors":"Andi Raga Ginting, Reza Mahardika, Mustafa Ali, Azmi Lubis, Muhammad Thariq Siregar, Article Info","doi":"10.37275/ijr.v15i2.244","DOIUrl":"https://doi.org/10.37275/ijr.v15i2.244","url":null,"abstract":"Background. Systemic lupus erythematosus (SLE) is an autoimmune disease that can attack multiple organs and has a high prevalence in women. Due to its treatment and resulting pathological conditions, SLE makes the patient susceptible to infections. Furthermore, physiological changes in the body that occur during pregnancy renders pregnant women with SLE vulnerable to disease exacerbation. Therefore, the management of such cases necessitates the evaluation and intervention of a multidisciplinary medical team. \u0000Case Presentation. We present the case of a female patient in her second trimester of pregnancy who complained of shortness of breath. The patient has a history of SLE diagnosed five years ago. Within 7 days of treatment, the patient experienced an improvement in symptoms. \u0000Conclusion. This is a rare case, and we report on the outcomes of treatment and our limitations to ensure better future treatment for pregnant women with SLE to prevent maternal and fetal death.","PeriodicalId":32894,"journal":{"name":"Indonesian Journal of Rheumatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138962615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：