Farmatsevtichnii zhurnal最新文献

{"title":"Study of dynamics of accumulation of tanning substances in raw materials of plants of the genus Geum L. flora of Ukraine","authors":"С. А. Козира, О. В. Радько, О. С. Мала, С. І. Степанова, Л. П. Міронець, О. М. Бабенко","doi":"10.32352/0367-3057.2.22.08","DOIUrl":"https://doi.org/10.32352/0367-3057.2.22.08","url":null,"abstract":"Recently, in the pharmaceutical market, much attention is paid to medicinal products obtained from medicinal plant raw materials. Of great current interest is a search for new plants with sufficient domestic raw material base in order to introduce them into medical practice as well as to develop herbal preparations. \u0000Promising sources of medicinal plant raw materials for the development of herbal preparations with antimicrobial, astringent, anti-inflammatory and hemostatic properties are species of Gravilate genus (Geum L.), which accumulate a wide range of biologically active substances, including polyphenols. \u0000Plants of Geum L. genus (Gravilate) belong to Rosoideae (Rosaceae family). Two species, Geum urbanum L. (Wood Avens) and G. montanum L. (Mountain Gravilate), grow in Ukraine, and are used in folk medicine as anti-inflammatory, astringent, hemostatic and wound healing agents. \u0000A significant amount of research articles devoted to the chemical composition and use of Geum L. species indicate the prospects for the study of domestic raw materials of Ukrainian flora. \u0000An aimof the present study was to quantify tannins and oxidizable phenolic compounds in the vegetative organs of G. urbanum L. and G. montanum L. \u0000The objects of the study were herb and rhizomes with roots of G. urbanum L. and G. montanum L. harvested in Sumskaya and Ivano-Frankivsk regions in April–September 2020–2021. The content of oxidizable phenolic compounds and tannins was determined by permanganometric titration and complexometric titration. The results obtained were in the range from 8.30% to 28.10%, and 2.66% to 14.35%, respectively. \u0000As a result, in herb and rhizomes with roots of G. urbanum L. and G. montanum L., oxidizable phenolic compounds and tannins were quantified using permanganometric titration and complexometric titration. Taking into account the high content of tannins in vegetative organs of the studied Geum species, these species can be classified as tannin-bearing plant materials. In G. urbanum L. herb, the maximum content of tannins was determined at flowering stage, while in rhizomes with roots – at the end of the vegetative stage (in autumn). Given the data obtained, the abovementioned vegetative stages are set as optimal for the procurement of G. urbanum L. plant materials.","PeriodicalId":32942,"journal":{"name":"Farmatsevtichnii zhurnal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41519679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of the range list of medicines for the treatment of arterial hypertension in accordance with domestic and international clinical guidelines","authors":"Н. В. Шолойко, А. О. Гончар","doi":"10.32352/0367-3057.1.22.03","DOIUrl":"https://doi.org/10.32352/0367-3057.1.22.03","url":null,"abstract":"Cardiovascular disease is the most common cause of death and disability worldwide. There are more than 12 million patients with hypertension in Ukraine. Timely prescription of medicines patients with AH in accordance with current clinical guidelines significantly improves the quality of life and survival of patients. \u0000The purpose of the study was to conduct a comparative analysis of the international and domestic range of modern medicines for the treatment of hypertension according to INN and ATC-classification and to investigate the status of their registration and inclusion in the reimbursement lists in Ukraine in order to determine the potential physical availability of drugs for the treatment of hypertension. \u0000An analysis of the domestic regulatory framework showed that international CG for the treatment of hypertension and national CPs can be used in Ukraine. The content analysis of the CG showed that international CG include classes of medicines for initial and maintenance therapy of hypertension: ACE inhibitors, ARBs, diuretics (thiazide and thiazide-like), calcium antagonists and beta-blockers, while preference is given to combinations of these drugs due to better adherence patients for treatment. \u0000It was found that according to the ATC classification, 41 ACE inhibitors and their combinations are represented on the international pharmaceutical market for the treatment of hypertension; of which 16 are single-component drugs, 25 are combined; ARB II and their combinations ‒ 32, single-component 10, combinations ‒ 22; calcium channel blockers and their combinations ‒ 21, single-component ‒ 18, combinations ‒ 2, thiazide diuretics ‒ 10, thiazide-like diuretics ‒ 11. \u0000An analysis of the status of registration in Ukraine according to certain INN and ATC classification showed that 56 drugs were registered, which is 48.69% of the possible 115 (drugs and ACE inhibitors and their combinations 22 (53.65%), ARBs II and their combinations 21 (65.63%); CCBs and their combinations ‒ 8 (38.10%); thiazide diuretics ‒ 1 (10%), thiazide-like diuretics ‒ 3 (27.27%)).","PeriodicalId":32942,"journal":{"name":"Farmatsevtichnii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41645799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of the content of carbonic acids in the herbs of Сapsella bursa-pastoris (L.) Medik","authors":"Г. П. Смойловська, О. О. Малюгіна, О. К. Єренко, Т. В. Хортецька","doi":"10.32352/0367-3057.1.22.08","DOIUrl":"https://doi.org/10.32352/0367-3057.1.22.08","url":null,"abstract":"Carboxylic acids are key compounds that play an important role in metabolism. They activate the endocrine glands, affect human immune status, have antioxidant, antimicrobial and anti-inflammatory effects. Plants rich in carboxylic acids are recommended for the prevention of various diseases. A promising source of biologically active substances are Capsella bursa-pastoris, which has a significant content of vitamins, flavonoids, organic, hydroxycinnamic, fatty acids, macro-and micronutrients, tannins. Capsella bursa-pastoris is known for such healing properties as wound healing, antimicrobial, antibacterial, antitumor, anti-inflammatory, antioxidant, antihypertensive, hepatoprotective. The plant material of Capsella bursa-pastoris has a hemostatic effect and stimulates the contractile activity of the uterus. \u0000The aim of the study was to study the qualitative composition and quantitative content of carboxylic acids in the herb of Capsella bursa-pastoris (L.) Medik. by chromato-mass spectrometry. \u0000For the study, we used the herb of Capsella bursa-pastoris (L.) Medik., which was collected during flowering period. Qualitative analysis of the content of organic acids was carried out by thin layer chromatography. Identification and quantitative content of carboxylic acids were performed by chromato-mass spectrometry on an Agilent Technology 6890N chromatograph with a mass spectrometric detector 5973N. \u000033 carboxylic acids were identified in the herb of Capsella bursa-pastoris – 14 organic and 19 fatty acids. The total content of organic acids is 8 041.60 ± 84.00 mg/kg with a predominance of aliphatic acids (citric, malic, fumaric and succinic). The fatty acid complex of the Capsella bursa-pastoris herb is represented by 11 saturated and 9 unsaturated fatty acids. The content of total fatty acids was 21 161.90 ± 256.45 mg/kg, of which the proportion of unsaturated acids is significantly higher than saturated. Linolenic, linoleic, palmitic acidsare dominant. \u0000The obtained resultsmake it possible to predict the antioxidant and anti-inflammatory activity of herbal medicines based on the raw materials of Capsella bursa-pastoris.","PeriodicalId":32942,"journal":{"name":"Farmatsevtichnii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47615218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decision-making regulatory framework of the introduction of health technologies at the hospitals in Ukraine","authors":"О. М. Філінюк, Д. В. Алешко, М. М. Бабенко, К. Л. Косяченко, Р. Кахвечі","doi":"10.32352/0367-3057.1.22.01","DOIUrl":"https://doi.org/10.32352/0367-3057.1.22.01","url":null,"abstract":"The limited resources of the health care system and the COVID-19 pandemic encourage more rational and cost-effective administrative and clinical decisions. To achieve the best health care within available resources, the introduction of the most efficient technologies should be supported, considering organizational, social and ethical issues. Assessment of health technologies at different levels, namely national/regional and hospital, is becoming increasingly important. Adherence to cost-effective approaches to administrative and clinical decision-making will ensure the rational use of the state budget and improve clinical outcomes, improve the quality and life expectancy of patients. \u0000The purpose of the study was to analyze the current regulatory framework for the introduction of health technologies (medicines and medical devices) at the hospital level. During the research the methods of content analysis, historical, system-analytical, generalization was used. \u0000According to the analysis of the decision-making regulatory framework for the health technology’s introduction, it was drawn the next conclusions. The active HTA development in Ukraine is noted. In a short time, a legal framework for state HTA for medicines was created and approved, amendments were made to the Law of Ukraine ‘On Public Procurement’ and other Ukraine’s laws on medicine procurement under managed entry agreements, the further steps for development of the HTA ecosystem in Ukraine were identified. \u0000The legal framework for the circulation of medical devices needs to be updated in Ukraine, starting with technical regulations in accordance with EU regulations №745 and №746 and further approval of the Law on Medical Devices. \u0000Procedures for evaluation and selection of medicines and medical devices at the level of medical institutions are absent in Ukraine and require separate elaboration. The introduction of HB-HTA will help hospital managers to make independent, transparent, reasonable, and impartial management decisions on the selection of drugs and medical devices. \u0000The obtained results prove the need for further research of everyday decision-making practices on the introduction of health technologies at the hospitals, development of methodology for hospital-based HTA and update regulation of HB-HTA in the current legal framework of Ukraine.","PeriodicalId":32942,"journal":{"name":"Farmatsevtichnii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43721458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the assortment of antibiotics in the State Medicines Formulary according to the WHO AWaRe classification with the purpose of their rational use and reducing the risk of antimicrobial resistance","authors":"Л. В. Яковлєва, І. М. Романенко","doi":"10.32352/0367-3057.1.22.02","DOIUrl":"https://doi.org/10.32352/0367-3057.1.22.02","url":null,"abstract":"Rational use of antimicrobials have been recognized as one of the strategies to fight AMR. In 2017 WHO proposed the classification of antibioticsAWaRe, dividing them into groups Access, Watch, Reserve, which takes into account the potential of AMR and emphasizes the importance of rational antibiotic therapy. In Ukraine, the State Formulary of Medicines (State Formulary of Ukraine) is the manual on the rational use of medicines. \u0000The aim of the work was to analyse the assortment of systemic antibiotics (J01) of the State Formulary of Ukraine, their compliance with the classification of antibiotics AWaRe according to the WHO database, which will contribute to rational antibiotic therapy. \u0000The objects of the study were antibiotics (J01), of the 13th version of the State Formulary of Ukraine, data on the belonging of antibiotics to the group Access, Observations, Reserve on WHO AWaRe antibiotic classification database.The following research methods were used in the work: system-review, analytical, method of comparison and generalization. \u0000According to the analysis, the group Access includes 23 INN antibiotics (J01) of the State Formulary of Ukraine. For 16 INNs of these antibioticsWHO provides recommendations for rational antibiotic therapy as the first choice for 31 infectious diseases and the second choice for 13 infectious diseases. The Observations group includes 31 INN antibiotics (J01) of the State Formulary of Ukraine. For 18 INNs of these antibiotics WHO provides recommendations for rational antibiotic therapy as the first choice for 21 infectious diseases and the second choice for 17 infectious diseases. The Reserve group includes 3 INN antibiotics (J01) of the State Formulary of Ukraine. \u0000The State Formulary of Ukraine includes 64 INN antibiotics of systemic action (J01), 23 INNs according to the WHO AWaRe antibiotic classification are assigned to the group Access, 31 ‒ Observations and 3 ‒ Reserve group. The analysis provides WHO recommendations for rational antibiotic therapy for the treatment of common infectious diseases, taking into account the degree of counteraction to the development of AMR. The results of the work can be used in the development of guidelines for the rational choice of antibiotics for the treatment of infectious diseases.","PeriodicalId":32942,"journal":{"name":"Farmatsevtichnii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48118549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Training of specialists of Health Technology Assessment: experience of foreign countries","authors":"Н. А. Білоусова, О. В. Гетало, О. С. Яковлева","doi":"10.32352/0367-3057.1.22.06","DOIUrl":"https://doi.org/10.32352/0367-3057.1.22.06","url":null,"abstract":"According to the main values of international HTA organizations regarding the development of scientific potential and training of specialists in this field and taking into account the conditions of implementation of medical technology assessment in Ukraine, the scientific interest includes the professional training of HTA users and developers. In this regard, the need of studying the foreign experience and best practices in the use of various curricula, the introduction of forms, methods and technologies is actualized. The author pays special attention to the issue of training these specialists in the system of postgraduate education. \u0000The aim of the article was to analyze the use of modern forms, methods and technologies in vocational education and training of specialists in the assessment of medical technologies. \u0000Materials and methods of the research were strategic programs of EU and Ukraine development, normative and legal documents regulating the implementation of HTA, legislative acts on education development in Ukraine, publications in scientometric databases of Scopus, Web of Science and others. \u0000Research methods used: systematic search of information using search engines, databases and websites by keywords; content analysis of documents; situational and comparative analysis; generalization; prognostication. \u0000According to the results of the analysis of scientific works, the study of international experience revealed that in foreign countries all types of education are used to train specialists in HTA: formal, non-formal, informal. It was found out that the most common forms of obtaining this specialty in the system of formal education are bachelor’s degree, master’s degree, training of doctors of philosophy. At the same time, for the training of such specialists in the middle-income countries, the programs of various duration in the system of non-formal education are used the most often. Among them: courses, trainings, seminars, internships, apprenticeships, mentoring, etc. Certification upon completion of the training is required. \u0000Based on the foreign experience and the analysis of scientific literature, the feasibility of creating and implementing various programs (long-term and short-term, in-service and non-in-service, distance, extramural, full-time, etc.) of the HTA specialists’ training in non-formal education completion of training was proved.","PeriodicalId":32942,"journal":{"name":"Farmatsevtichnii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43086771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and optimization of quantitative composition of rectal suppositories with diosmin and hesperidin by the method of mathematical planning of the experiment","authors":"Є. А. Борко, І. В. Ковалевська, О. А. Рубан, О. В. Кутова","doi":"10.32352/0367-3057.1.22.07","DOIUrl":"https://doi.org/10.32352/0367-3057.1.22.07","url":null,"abstract":"In the development of suppositories biphasic media are rarely used. It is due to the occurrence of possible instabilities within the system «dispersed phase and a dispersing medium». To solve such problems, it is rational to use the methods of mathematical planning of the experiment. The method of mathematical planning of the experiment feature is the diversity of approaches to model construction. This means that these methods are theoretically predict the results of a future experiment, analyze the data obtained, prevent the repetition of experiments and optimize the technology of medicine. \u0000The aim of the present research was to develop and optimize of quantitative composition of rectal suppositories with diosmin and hesperidin by the method of mathematical planning of experiment. \u0000Objects of the study were samples of suppositories of the biphasic type with diosmin and hesperidin. The dispersing medium of these samples consisted of hydrophobic (Witepsol W35 and emulsifiers) and hydrophilic parts (sodium alginate gel with the addition of Ca2+ as a complexing cation). Preliminary results of determining the percentage limits of the hydrophobic part of the dispersed medium were carried out by studying the indicators of the release of active substances from the dosage form and the laser diffraction method. As responses of experiments was used such indicator as: disintegration time, hardness and mucoadhesion. \u0000As a result of the studies, the functional dependence of the indicators on the amount of components of the suppository dispersed medium was established. It was found that acceptable values of the responses should conform to the following conditions: hardness and mucoadhesion should be close to the maximum, and the disintegration time – to the minimum. \u0000According to the results of the study it was found that the optimal content of the mixture of emulsifiers – 6.29%, solid fat – 39.51%, the hydrophilic part of the biphasic medium – 29.58%. Responses that will provide the system with the necessary structural-mechanical and pharmaco-technological properties are within: y1 (2.713); y2 (22.639); y3 (439.283). The obtained data will be used in further studies to optimize the composition and technology of rectal suppositories with diosmin and hesperidin.","PeriodicalId":32942,"journal":{"name":"Farmatsevtichnii zhurnal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69534922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical characteristics and the study of acute toxicity of extracts from fruit Рrunus domestica","authors":"І. В. Сенюк, В. М. Кравченко, Бенарафа Ібрахім Амін","doi":"10.32352/0367-3057.1.22.09","DOIUrl":"https://doi.org/10.32352/0367-3057.1.22.09","url":null,"abstract":"The increased demand for modern phytopreparations is dictated by their wide application in the complex treatment of various diseases, the presence of low toxicity and the pharmacoeconomic component. Phytochemical analysis of medicinal plants reveals not only potential therapeutic effects, but also assumes their toxicological properties. In this context, the Prunus domestica, widely spread on the territory of our country and well known for its medicinal properties and applications in folk medicine, has attracted our attention. \u0000The aim of the work was to investigate the phytochemical composition of extracts obtained from fruit Prunus domestica and to study their toxic properties. \u0000Phytochemical analysis of the extracts obtained from fruits Prunus domestica was carried out according to the original method of extracting biologically active compounds, using instrumental research methods using modern laboratory analytical equipment. \u0000Studies of the safety of four extracts from Prunus domestica (liquid EC-1, EC-2 and dry CEPC, CEV) with the calculation of median lethal doses were carried out on mice and rats with the single intragastric and intraperitoneal routes of administration according to the method of T. V. Pastushenko. The degree of toxicity was determined according to the classification of K. K. Sidorov. \u0000Phytochemical study of extracts from fruit Prunus domestica provided information on the presence in their chemical composition of flavonoids, the sum of phenolic compounds, anthocyanins, neutral sugars, amino acids, organic and hydroxycinnamic acids. A higher content of the sum of phenolic compounds in the aqueous (ЕС-1) and alcoholic extracts (ЕС-2) as well as the presence of neutral sugars as products of hydrolysis of homopolysaccharides (СEV extract) and heteropolysaccharides (CEPC extract). \u0000Experimental studies proved that EC-1, EC-2, CEPC and SEV extracts had low toxicity beyond 15 000 mg/kg when administered orally and 3 000 mg/kg when administered intraperitoneally. The LD50 of the studied extracts of mice and rats after intraperitoneal injection was determined, which was more than 3 000 mg/kg. \u0000The chemical composition of biologically active compounds of extracts from the fruit Prunus domestica, which provides promising directions for further study of their pharmacological properties, has been investigated. \u0000Analysis of experimental data on acute toxicity of the studied extracts showed that they belong to the IV class of toxicity “relatively harmless substances\", according to K. K. Sidorov classification. The LD50 of extracts from the fruit Prunus domestica for oral administration could not be determined, and the LD50 of the studied extracts for mice and rats after intraperitoneal administration was more than 3 000 mg/kg.","PeriodicalId":32942,"journal":{"name":"Farmatsevtichnii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42791210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biosimilar insulins in international and domestic practice of pharmacist","authors":"І. О. Власенко, І. В. Ніженковська","doi":"10.32352/0367-3057.1.22.05","DOIUrl":"https://doi.org/10.32352/0367-3057.1.22.05","url":null,"abstract":"In Ukraine, people with diabetes receive insulin, including insulin biosimilars in pharmacies, so pharmacists should increase their knowledge about biosimilar because they become more available in the coming years. \u0000The aim of the work was to summarize current information on insulin biosimilars. \u0000Research materials ‒ regulatory database information and scientific publications on biosimilars. Content analysis, bibliosemantic, analytical, generalizing analyzes were used. \u0000The terminology related to reproducible biological drugs (biosimilars) is difference and it depend on the regulatory agency or the country that controls the approve of drugs. Insulin was the first biopharmaceutical drug which was developed. For approving biosimilars, it is necessary to establish similarity with the reference drug in terms of safety, purity and efficacy. Regulatory of biosimilars and requirements for demonstration the biosimilarity are specified in regulatory of the EMA and WHO. The regulatory of the approving of biosimilar  in Ukraine is harmonized with European regulatory. The rules on interchangeability are not determined by all regulatory agency. The International Diabetes Federation emphasizes the role of the pharmacist, stating that they should be well informed about the forms of insulin, includes biosimilars. In Ukraine, pharmacists must dispense insulin, including biosimilars, exactly in accordance to the prescription in which the trade name of insulin (or biosimilars) is indicated. Insulin biosimilars can be an alternative to original insulins that have lost patent protection by increasing the availability of drugs, which can lead to increased market competition and access insulin for patients. \u0000Based on the analysis of current information on biosimilars, generalizations about their terminology, aspects of manufecture, regulatory, interchangeability, prospects in the treatment of diabetes and their replacement of referens insulins are presented. The potential impact of biosimilar insulins to patients and the health care system was determinated. The importance of awareness of these drugs by pharmacists as part of the diabetic team are highlighted.","PeriodicalId":32942,"journal":{"name":"Farmatsevtichnii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48222206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the epidemiological state of mental disorders and pharmaceutical provision of patients with medicines by the government of Ukraine.","authors":"А. С. Немченко, А. В. Ляденко","doi":"10.32352/0367-3057.1.22.04","DOIUrl":"https://doi.org/10.32352/0367-3057.1.22.04","url":null,"abstract":"The number of patients with mental disorders is growing every year, which has a significant impact on the increase in cases of disability and loss of one of the five years of healthy life. In Ukraine, the incidence of depressive disorders and disorders caused by alcohol consumption exceeds that of Eastern Europe. The COVID-2019 global pandemic has affected the rapid spread of new cases of depressive disorders (53.2 million or 27.6%) and anxiety disorders (76.2 million or 25.6%) in 2020. These trends in Ukraine and the world have led to changes in the formation and implementation of the National Mental Health Policy, as most disorders are successfully treated with access to medicine and availability of medicines for patients. \u0000The aim of the work was to assess the current state of morbidity and prevalence of mental disorders in Ukraine and the world, as well as to analyse the access of medicines for patients according to current government programs. \u0000The objectі of the study were the data of the Center for Mental Health and Monitoring of Drugs and Alcohol of the Ministry of Health of Ukraine, regulations documents, analytical reports, international websites. The study used methods of analysis, systematization, generalization, analytical and graphical. \u0000The study found an annual increase in outpatient mental health care and a sharp decline in inpatient and day care. Depressive disorders show a growth trend of 6.25% in Ukraine for the period 2018–2020, for comparison – only in 2020 in the world such growth was 27.6%. Analysis of medical practice shows that most mental disorders are not diagnosed as special cases, and are treated as concomitant diseases, which significantly affects the incidence and prevalence and as a consequence of the formation of government programs to provide patients with vital medicines in outpatient treatment. \u0000The provision of drugs to patients on an outpatient basis today occurs according to the list of diseases defined by the Resolution of the Cabinet of Ministers of Ukraine No. 1303. Since October 1, the program of reimbursement of medicine for 9 INN has been expanded, which allowed patients with mental disorders to receive medicines free of charge or with a surcharge, without reference to their location. \u0000The study revealed negative trends in the incidence and prevalence of mental disorders in Ukraine as a whole and in regions compared to similar indicators in the world, as well as identify key issues affecting the formation of government programs to provide patients with basic medicines.","PeriodicalId":32942,"journal":{"name":"Farmatsevtichnii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47420017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}