Marwa M. Hussein, H. Swelim, Sawsan M. Abd El Moneim, Shimaa M. Elsayed, Fatma A. Abu Zahra, Amany M. Maher
In this study, the gene expression of some cancer-related genes was measured to differentiate between two types of therapeutic media in which hepatocellular carcinoma (HuH7) were harvested. The first was a conditional medium in which umbilical cord mesenchymal stem cells were harvested then diluted by DMEM media (1: 1) and the second was Co-culture medium that mesenchymal stem cells and HuH7 cells (1:1) together were incubated for 3 days in a medium. The latter was called Co- culture medium. Comparison of the Results of gene expression of Surviving, PCNA, Beta-Catenin, Telomerase and VEGF by using real-time PCR in several four-four-time intervals (48-72-96 hrs.) showed that in conditioned media and co-culture media, hepatoma cell line (HuH7) expressed a significant down-regulation in Surviving (p< 0.001), PCNA (p<0.001), VEGF(p<0.001) and Beta- Catenin(p=0.022) but not significant in Telomerase (p= 0.617). In our study, the measure of gene expression at different time (ALT), Aspartate aminotransferase (AST), Albumin, Alkaline phosphate, gamma GT, alpha- fetoprotein when compared regarding time Results in a significant in Alpha-fetoprotein (p < 0.001), ALT (p < 0.001) and AST (p < 0.001) while the results of Albumin (p = 0.650), Alkaline phosphatase (p = 0.329) and Gamma GT (p = 0.844) were non-significant.
{"title":"An Ultra Structural Analysis of The Huh7 Hepatocellular Carcinoma Cell Line's Response to Conditioned and Co-Culture Media","authors":"Marwa M. Hussein, H. Swelim, Sawsan M. Abd El Moneim, Shimaa M. Elsayed, Fatma A. Abu Zahra, Amany M. Maher","doi":"10.58489/2836-5038/012","DOIUrl":"https://doi.org/10.58489/2836-5038/012","url":null,"abstract":"In this study, the gene expression of some cancer-related genes was measured to differentiate between two types of therapeutic media in which hepatocellular carcinoma (HuH7) were harvested. The first was a conditional medium in which umbilical cord mesenchymal stem cells were harvested then diluted by DMEM media (1: 1) and the second was Co-culture medium that mesenchymal stem cells and HuH7 cells (1:1) together were incubated for 3 days in a medium. The latter was called Co- culture medium. Comparison of the Results of gene expression of Surviving, PCNA, Beta-Catenin, Telomerase and VEGF by using real-time PCR in several four-four-time intervals (48-72-96 hrs.) showed that in conditioned media and co-culture media, hepatoma cell line (HuH7) expressed a significant down-regulation in Surviving (p< 0.001), PCNA (p<0.001), VEGF(p<0.001) and Beta- Catenin(p=0.022) but not significant in Telomerase (p= 0.617). In our study, the measure of gene expression at different time (ALT), Aspartate aminotransferase (AST), Albumin, Alkaline phosphate, gamma GT, alpha- fetoprotein when compared regarding time Results in a significant in Alpha-fetoprotein (p < 0.001), ALT (p < 0.001) and AST (p < 0.001) while the results of Albumin (p = 0.650), Alkaline phosphatase (p = 0.329) and Gamma GT (p = 0.844) were non-significant.","PeriodicalId":330380,"journal":{"name":"International Journal of Stem Cells and Medicine","volume":"234 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139349982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carlos de la Hoz, Phillippe Wuilleumier, Amy Riumbau, Carla Cerra
Stem cells are undifferentiated cells that can divide and differentiate into various types of cells. This special ability makes stem cells a hopeful treatment for regenerating damaged tissue and restoring diminished or completely lost function. In this case study, we discuss a 19-year-old soccer player who presented with a Grade III MCL tear on the right knee. Treatment for a Grade III MCL tear is controversial being that both surgical and non-surgical approaches have been effective. However, due to the patient’s sports background, the patient came to our clinic seeking a faster recovery using a non-surgical treatment. After extensive medical examinations, the patient began a treatment based on adipose tissue-derived stem cells injection. Adipose tissue-derived stem cells were harvested and injected into the distal insertion of the superficial MCL and on the deep MCL origin. After 122 days the patient was able to practice full contact sports which is a significant decrease compared to a recent study that averaged surgical recovery time to 181 days. The recovery was supported by an MRI which demonstrated full regeneration of the previously damaged MCL. This case study demonstrates the potential stem cells have in both complementing and replacing surgical treatments for tissue repair. In addition, this case study demonstrates the efficacy of accelerating recovery of MCL tears using stem cells which inspires hope of using stem cells in similar pathologies. Therefore, more clinical trials should be conducted to further expand research on stem cell treatment in regenerative medicine.
{"title":"Adipose-Derived Stem Cell Injection on a Grade III Medial Collateral Ligament Tear in a Soccer Player: A Case Report","authors":"Carlos de la Hoz, Phillippe Wuilleumier, Amy Riumbau, Carla Cerra","doi":"10.58489/2836-5038/010","DOIUrl":"https://doi.org/10.58489/2836-5038/010","url":null,"abstract":"Stem cells are undifferentiated cells that can divide and differentiate into various types of cells. This special ability makes stem cells a hopeful treatment for regenerating damaged tissue and restoring diminished or completely lost function. In this case study, we discuss a 19-year-old soccer player who presented with a Grade III MCL tear on the right knee. Treatment for a Grade III MCL tear is controversial being that both surgical and non-surgical approaches have been effective. However, due to the patient’s sports background, the patient came to our clinic seeking a faster recovery using a non-surgical treatment. After extensive medical examinations, the patient began a treatment based on adipose tissue-derived stem cells injection. Adipose tissue-derived stem cells were harvested and injected into the distal insertion of the superficial MCL and on the deep MCL origin. After 122 days the patient was able to practice full contact sports which is a significant decrease compared to a recent study that averaged surgical recovery time to 181 days. The recovery was supported by an MRI which demonstrated full regeneration of the previously damaged MCL. This case study demonstrates the potential stem cells have in both complementing and replacing surgical treatments for tissue repair. In addition, this case study demonstrates the efficacy of accelerating recovery of MCL tears using stem cells which inspires hope of using stem cells in similar pathologies. Therefore, more clinical trials should be conducted to further expand research on stem cell treatment in regenerative medicine.","PeriodicalId":330380,"journal":{"name":"International Journal of Stem Cells and Medicine","volume":"66 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139350079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hypercholesterolemia and atherosclerosis are still the main cause of mortality in Central Asia. Study of the molecular mechanisms of endothelial dysfunction with changes in the nitroergic system in experimental hypercholesterolemia. The experiments were carried out on 28 Chinchilla rabbits with an average weight of 2.5-3.0 kg. The action of drugs was studied in dynamics: the initial 3-month condition and after one month of drug administration. The results obtained were compared with those of the control and intact groups. The activity of the enzyme nitrate reductase in the blood serum on the 30th day of the introduction of exogenous cholesterol increases only 1.15 times, then on the 60th and 90th days of the introduction - 1.3 and 1.76 times. In the dynamics of hypercholesterolemia and atherosclerosis in the blood serum, there are noticeable disturbances in the NO-ergic system.
{"title":"Dynamics of the Nitrergic System in Experimental Hypercholesterolemia","authors":"Baykulov Azim, Ph.D.","doi":"10.58489/2836-5038/011","DOIUrl":"https://doi.org/10.58489/2836-5038/011","url":null,"abstract":"Hypercholesterolemia and atherosclerosis are still the main cause of mortality in Central Asia. Study of the molecular mechanisms of endothelial dysfunction with changes in the nitroergic system in experimental hypercholesterolemia. The experiments were carried out on 28 Chinchilla rabbits with an average weight of 2.5-3.0 kg. The action of drugs was studied in dynamics: the initial 3-month condition and after one month of drug administration. The results obtained were compared with those of the control and intact groups. The activity of the enzyme nitrate reductase in the blood serum on the 30th day of the introduction of exogenous cholesterol increases only 1.15 times, then on the 60th and 90th days of the introduction - 1.3 and 1.76 times. In the dynamics of hypercholesterolemia and atherosclerosis in the blood serum, there are noticeable disturbances in the NO-ergic system.","PeriodicalId":330380,"journal":{"name":"International Journal of Stem Cells and Medicine","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139350052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The article provides statistics on the volume of surgical interventions on the extrahepatic bile ducts, the number of iatrogenic cicatricial strictures after traditional and laparoscopic cholecystectomies. The authors also provide figures of complications and mortality after various reconstructive and reconstructive interventions for iatrogenic strictures of the extrahepatic bile ducts. The article highlights the causes of hepatic choledochus strictures. Particular attention is paid to the increase in these complications after laparoscopic cholecystectomy. The article describes the classification of the level of cicatricial stricture of hepaticoholedoch according to E.I. Halperin and N.F. Kuzovlev, which is most convenient for practical application. The results of various reconstructive and reconstructive operations with iatrogenic strictures of hepaticoholedoch are critically evaluated and the importance of new, modern minimally invasive methods is emphasized. It is also emphasized that, despite the introduction of high-tech minimally invasive methods of diagnosis and treatment in surgical hepatology, and the progress in reconstructive surgery of the biliary tract, only the evaluation of the long-term results of treatment in this category of patients can give an objective assessment of the correctness of the chosen direction.
{"title":"Outcome of reconstructive surgeries with application of minimally invasive technique for correction of iatrogenic damage to the extra hepatic biliary tracts.","authors":"Uktam Nurmamatovich Turakulov, Saatov R.R, Akbarov M.M.","doi":"10.58489/2836-5038/009","DOIUrl":"https://doi.org/10.58489/2836-5038/009","url":null,"abstract":"The article provides statistics on the volume of surgical interventions on the extrahepatic bile ducts, the number of iatrogenic cicatricial strictures after traditional and laparoscopic cholecystectomies. The authors also provide figures of complications and mortality after various reconstructive and reconstructive interventions for iatrogenic strictures of the extrahepatic bile ducts. The article highlights the causes of hepatic choledochus strictures. Particular attention is paid to the increase in these complications after laparoscopic cholecystectomy. The article describes the classification of the level of cicatricial stricture of hepaticoholedoch according to E.I. Halperin and N.F. Kuzovlev, which is most convenient for practical application. The results of various reconstructive and reconstructive operations with iatrogenic strictures of hepaticoholedoch are critically evaluated and the importance of new, modern minimally invasive methods is emphasized. It is also emphasized that, despite the introduction of high-tech minimally invasive methods of diagnosis and treatment in surgical hepatology, and the progress in reconstructive surgery of the biliary tract, only the evaluation of the long-term results of treatment in this category of patients can give an objective assessment of the correctness of the chosen direction.","PeriodicalId":330380,"journal":{"name":"International Journal of Stem Cells and Medicine","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139351067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives. This article's objective was to assess the reciprocating single-file systems Reciproc Blue 25.08 and Pro design R 25.06's cyclic and torsion fatigue resistance. The systems Reciproc Blue R25 (RB #25.08 taper), Prodesign R (PDR #25.06 taper), and WaveOne Gold (WOG #25.07 taper) (n = 20) were utilized to make sixty reciprocating instruments. The period to breakdown in an artificial stainless-steel canal with a 60° angle of curvature and a 5-mm radius was measured during cyclic fatigue resistance testing (n = 10). The torque and angle of rotation at failure of new instruments (n = 10) were assessed during the torsional test (ISO 3630-1) in the area 3 mm from the tip. Scanning electron microscopy was also used to view each fragment's shattered surface (SEM). In addition, a supplementary examination was performed to measure the cross- sectional area of each instrument 3 and 5 mm from the tip. The data were analyzed using one-way ANOVA and Tukey’s test, and the level of significance was set at 5%. Cycle Fatigue Resistance scores for PDR 25.06 were much higher (P 0.05). Both WOG 25.07 and RB 25.08 showed less resistance to fatigue (P 0.05). Based on the torsional analysis, PDR 25.06 had weaker torsional strength (P 0.05). No changes were found with RB 25.08 and WOG 25.07 (P > 0.05). PDR 25.06 showed higher angular rotation values than RB 25.08 and WOG 25.07. (P 0.05). Greater angular rotation was seen in both WOG 25.07 and RB 25.08. (P 0.05). The cross-sectional area analysis revealed that PDR 25.06 had the smallest cross-sectional areas at 3 and 5 mm from the tip (P 0.05). In comparison to RB 25.08 and WOG 25.07, PDR 25.06 had the highest cyclic fatigue resistance and angular rotation until fracture. Additionally, torsional strength was higher in RB 25.08 and WOG 25.07 than PDR 25.06. Clinical applicability in endodontic practise, reciprocating instruments that have undergone thermal treatment are used to prepare the root canals of canals that are curved and constrained; as a result, these instruments must exhibit high flexibility and suitable torsional strength to reduce the risk of instrument deformation.
{"title":"Evaluation of Cyclic Fatigue and Torsional Strength of Three Different Thermally Treated Reciprocating Nickel-Titanium Instruments","authors":"Dr. Ritika Singh, Dr. Anustha Kushwaha","doi":"10.58489/2836-5038/008","DOIUrl":"https://doi.org/10.58489/2836-5038/008","url":null,"abstract":"Objectives. This article's objective was to assess the reciprocating single-file systems Reciproc Blue 25.08 and Pro design R 25.06's cyclic and torsion fatigue resistance. The systems Reciproc Blue R25 (RB #25.08 taper), Prodesign R (PDR #25.06 taper), and WaveOne Gold (WOG #25.07 taper) (n = 20) were utilized to make sixty reciprocating instruments. The period to breakdown in an artificial stainless-steel canal with a 60° angle of curvature and a 5-mm radius was measured during cyclic fatigue resistance testing (n = 10). The torque and angle of rotation at failure of new instruments (n = 10) were assessed during the torsional test (ISO 3630-1) in the area 3 mm from the tip. Scanning electron microscopy was also used to view each fragment's shattered surface (SEM). In addition, a supplementary examination was performed to measure the cross- sectional area of each instrument 3 and 5 mm from the tip. The data were analyzed using one-way ANOVA and Tukey’s test, and the level of significance was set at 5%. Cycle Fatigue Resistance scores for PDR 25.06 were much higher (P 0.05). Both WOG 25.07 and RB 25.08 showed less resistance to fatigue (P 0.05). Based on the torsional analysis, PDR 25.06 had weaker torsional strength (P 0.05). No changes were found with RB 25.08 and WOG 25.07 (P > 0.05). PDR 25.06 showed higher angular rotation values than RB 25.08 and WOG 25.07. (P 0.05). Greater angular rotation was seen in both WOG 25.07 and RB 25.08. (P 0.05). The cross-sectional area analysis revealed that PDR 25.06 had the smallest cross-sectional areas at 3 and 5 mm from the tip (P 0.05). In comparison to RB 25.08 and WOG 25.07, PDR 25.06 had the highest cyclic fatigue resistance and angular rotation until fracture. Additionally, torsional strength was higher in RB 25.08 and WOG 25.07 than PDR 25.06. Clinical applicability in endodontic practise, reciprocating instruments that have undergone thermal treatment are used to prepare the root canals of canals that are curved and constrained; as a result, these instruments must exhibit high flexibility and suitable torsional strength to reduce the risk of instrument deformation.","PeriodicalId":330380,"journal":{"name":"International Journal of Stem Cells and Medicine","volume":"134 Supplement_1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116077072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Platelet concentrates have gained popularity in periodontal regenerative therapy because of its autologous nature. it promotes wound healing after surgical periodontal therapy. Aim: to study the platelet count and antimicrobial efficacy of various platelet concentrates, such as PRP, PRF and IPRF Methodology: An Observational Study was carried out at Department of Periodontology & Implantology at Babu Banarasi das College of Dental Sciences. Sample size was 45. Ten ml of blood was drawn from the patient out of which 3ml each of blood will be used for PRP, PRF and I-PRF preparation and remaining 1ml of blood was used for determining the platelet count. For I-PRF preparation, 3ml of blood wias used, d centrifuged at 700 rpm for 3 minutes. For PRF preparation, Agar plates will be inoculated with plaque sample of same patient and will be labelled and divided into 3 compartments. Wells was prepared in the inoculated agar plate and 0.1 ml of PRP, PRF and I-PRF will be placed in those wells. Inoculated blood agar plates was then incubated aerobically at 37℃ for 24 hours to 48 hours. Results: The platelet count of i-PRF was statistically significant when compared to control (P < 0.001). It was also significant when compared to PRP (P < 0.01) and PRF (P < 0.001). Mean zone of inhibition around i-PRF (P < 0.01) and PRF (P < 0.05) reached statistical significance. Although a distinct zone of inhibition was seen with PRP, it was not statistically significant (P > 0.05). Conclusion: In the present study, although a distinct zone of inhibition was obtained with all test samples, it was significant with only i-PRF and PRF.
{"title":"Observational Survey to Assess Platelet Concentration and Ani - Microbial Potency of Different Blood Extracts","authors":"Arjun Singh","doi":"10.58489/2836-5038/006","DOIUrl":"https://doi.org/10.58489/2836-5038/006","url":null,"abstract":"Introduction: Platelet concentrates have gained popularity in periodontal regenerative therapy because of its autologous nature. it promotes wound healing after surgical periodontal therapy. Aim: to study the platelet count and antimicrobial efficacy of various platelet concentrates, such as PRP, PRF and IPRF Methodology: An Observational Study was carried out at Department of Periodontology & Implantology at Babu Banarasi das College of Dental Sciences. Sample size was 45. Ten ml of blood was drawn from the patient out of which 3ml each of blood will be used for PRP, PRF and I-PRF preparation and remaining 1ml of blood was used for determining the platelet count. For I-PRF preparation, 3ml of blood wias used, d centrifuged at 700 rpm for 3 minutes. For PRF preparation, Agar plates will be inoculated with plaque sample of same patient and will be labelled and divided into 3 compartments. Wells was prepared in the inoculated agar plate and 0.1 ml of PRP, PRF and I-PRF will be placed in those wells. Inoculated blood agar plates was then incubated aerobically at 37℃ for 24 hours to 48 hours. Results: The platelet count of i-PRF was statistically significant when compared to control (P < 0.001). It was also significant when compared to PRP (P < 0.01) and PRF (P < 0.001). Mean zone of inhibition around i-PRF (P < 0.01) and PRF (P < 0.05) reached statistical significance. Although a distinct zone of inhibition was seen with PRP, it was not statistically significant (P > 0.05). Conclusion: In the present study, although a distinct zone of inhibition was obtained with all test samples, it was significant with only i-PRF and PRF.","PeriodicalId":330380,"journal":{"name":"International Journal of Stem Cells and Medicine","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124051976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study is an attempt to identify some Sudanese Sweet Sorghum (Ankolib) [Sorghum bicolor (L.) Moench.] accessions using two types of DNA-based markers: RAPD and SSR. Seven (Ankolib) accessions were assayed, namely: Black Ankolib, Black White Ankolib, Dark Red Ankolib, Red Yellow Ankolib, White Ankolib, White Black Ankolib and Bengaga. All of the accessions were uniquely identified and fingerprinted. The levels of polymorphism among the accessions as revealed by (22) RAPD primers and (16) SSR primer pairs were (58%) and (76%) respectively, indicating that SSRs markers were highly polymorphic. The scored data of the two markers were analyzed using the Dice Coefficient to assess genetic relationships among the (7) (Ankolib) accessions. The results of the statistical analysis revealed that the accession Bengaga was distantly related to the other (6) accessions which all showed a close genetic similarity among them. UPGMA cluster analysis generated a dendrogram for each marker alone and for the combined data of the two markers. It was observed that in all of the dendrogram the accession Bengaga was found in a unique cluster thus indicating its uniqueness, since it is the only accession that has seeds that produce flour besides its juicy sweet stem.
{"title":"Molecular Genetic Identification of Some Sweet Sorghum - Sorghum bicolor L. (Ankolib) Accessions - Sudan","authors":"Asaad Alsiddig Ahmed","doi":"10.58489/2836-5038/007","DOIUrl":"https://doi.org/10.58489/2836-5038/007","url":null,"abstract":"This study is an attempt to identify some Sudanese Sweet Sorghum (Ankolib) [Sorghum bicolor (L.) Moench.] accessions using two types of DNA-based markers: RAPD and SSR. Seven (Ankolib) accessions were assayed, namely: Black Ankolib, Black White Ankolib, Dark Red Ankolib, Red Yellow Ankolib, White Ankolib, White Black Ankolib and Bengaga. All of the accessions were uniquely identified and fingerprinted. The levels of polymorphism among the accessions as revealed by (22) RAPD primers and (16) SSR primer pairs were (58%) and (76%) respectively, indicating that SSRs markers were highly polymorphic. The scored data of the two markers were analyzed using the Dice Coefficient to assess genetic relationships among the (7) (Ankolib) accessions. The results of the statistical analysis revealed that the accession Bengaga was distantly related to the other (6) accessions which all showed a close genetic similarity among them. UPGMA cluster analysis generated a dendrogram for each marker alone and for the combined data of the two markers. It was observed that in all of the dendrogram the accession Bengaga was found in a unique cluster thus indicating its uniqueness, since it is the only accession that has seeds that produce flour besides its juicy sweet stem.","PeriodicalId":330380,"journal":{"name":"International Journal of Stem Cells and Medicine","volume":"81 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121270627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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